Added to DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Luke Weaver | 2021-05-16 | May 17 | |
| Christian Arroyo | 2021-05-06 | May 10 | |
| Alec Mills | 2021-05-16 | May 17 | |
| Ben Bowden | 2021-05-16 | May 17 | |
| Jose Urquidy | 2021-05-12 | May 17 | |
| Danny Duffy | 2021-05-17 | May 24 | |
| Garrett Cleavinger | 2021-05-18 | May 24 | |
| Corey Seager | 2021-05-15 | May 17 | |
| Zach McKinstry | 2021-04-23 | Apr 26 | |
| Mike Trout | 2021-05-17 | May 24 | |
| Lewis Brinson | 2021-05-07 | May 10 | |
| Shaun Anderson | 2021-05-18 | May 24 | |
| Michael Pineda | 2021-05-18 | May 24 | |
| Giancarlo Stanton | Twins | 2021-05-14 | May 17 |
| Aaron Hicks | 2021-05-13 | May 17 | |
| Kevin Pillar | 2021-05-18 | May 24 | |
| Taijuan Walker | 2021-05-17 | May 24 | |
| Jeff McNeil | 2021-05-16 | May 17 | |
| Michael Conforto | Brewers | 2021-05-16 | May 17 |
| Didi Gregorius | 2021-05-12 | May 17 | |
| Drew Pomeranz | Royals | 2021-05-14 | May 17 |
| Wilmer Flores | 2021-05-18 | May 24 | |
| Dylan Moore | Rays | 2021-05-19 | May 24 |
| Tyler O'Neill | 2021-05-16 | May 17 | |
| Luis Patino | 2021-05-19 | May 24 | |
| Cody Reed | Rockies | 2021-05-18 | May 24 |
Removed from DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Jazz Chisholm | 2021-04-27 | May 3 | |
| Ronald Torreyes | 2021-04-19 | Apr 26 | |
| Wilson Ramos | Astros | 2021-05-06 | May 10 |
| Kyle Zimmer | Brewers | 2021-05-01 | May 3 |
| Anthony Rendon | Brewers | 2021-05-04 | May 10 |
| Alex Dickerson | Cubs | 2021-05-04 | May 10 |
| Nico Hoerner | Cubs | 2021-05-04 | May 10 |
| Luis Arraez | DBacks | 2021-05-03 | May 10 |
| Aramis Garcia | Dodgers | 2021-05-04 | May 10 |
| Dan Winkler | Dodgers | 2021-05-04 | May 10 |
| Francisco Mejia | Indians | 2021-05-07 | May 10 |
| David Price | Mets | 2021-04-26 | May 3 |
| Rafael Dolis | Mets | 2021-05-09 | May 10 |
| Enoli Paredes | Nationals | 2021-04-08 | Apr 12 |
| Tony Watson | Orioles | 2021-05-03 | May 10 |
| Kevin Gausman | Phillies | 2021-05-04 | May 10 |
| Archie Bradley | RedSox | 2021-04-14 | Apr 19 |
| Donovan Solano | RedSox | 2021-04-21 | Apr 26 |
| C.J. Cron | RedSox | 2021-05-07 | May 10 |
| Merrill Kelly | RedSox | 2021-05-04 | May 10 |
| Ian Happ | Reds | 2021-05-04 | May 10 |
| Diego Castillo | Tigers | 2021-05-05 | May 10 |
| Jake Arrieta | Twins | 2021-05-04 | May 10 |
| John Nogowski | WhiteSox | 2021-04-24 | Apr 26 |
| Kevin Kiermaier | Yankees | 2021-05-08 | May 10 |
| Christian Yelich | Yankees | 2021-05-04 | May 10 |
| Rougned Odor | Yankees | 2021-05-04 | May 10 |
Removed from DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Daniel Ponce de Leon | 2021-05-01 | May 3 |
| Enrique Hernandez | 2021-05-06 | May 10 |
| Ketel Marte | 2021-04-08 | Apr 12 |
Off MLB DL, but hasn't served full time in IBC
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Brock Burke | 2019-09-27 | Oct 4 | |
| Grant Dayton | 2021-05-12 | May 17 | |
| Jacob Nottingham | 2020-12-30 | Jan 3 | |
| Jorge Mateo | 2021-05-11 | May 17 | |
| Eric Hosmer | Pirates | 2021-05-12 | May 17 |
| Gleyber Torres | Rangers | 2021-05-12 | May 17 |
| Jurickson Profar | Rockies | 2021-05-11 | May 17 |
Off MLB DL, but hasn't served full time in IBC (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Fernando Tatis Jr. | 2021-05-11 | May 17 |
