Added to DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Christian Walker | 2021-04-11 | Apr 12 | |
| Cristian Pache | 2021-04-13 | Apr 19 | |
| Max Fried | DBacks | 2021-04-13 | Apr 19 |
| Dylan Cease | 2021-04-14 | Apr 19 | |
| Brandon Workman | 2021-04-12 | Apr 19 | |
| Dan Winkler | 2021-04-12 | Apr 19 | |
| Miguel Cabrera | 2021-04-11 | Apr 12 | |
| Robel Garcia | 2021-04-14 | Apr 19 | |
| Jose Altuve | Indians | 2021-04-14 | Apr 19 |
| Yordan Alvarez | Rangers | 2021-04-14 | Apr 19 |
| Martin Maldonado | 2021-04-14 | Apr 19 | |
| Alex Bregman | Athletics | 2021-03-09 | Mar 15 |
| Jesse Hahn | 2021-04-12 | Apr 19 | |
| Juan Lagares | 2021-04-12 | Apr 19 | |
| Max Stassi | Nationals | 2021-04-12 | Apr 19 |
| Anthony Rendon | 2021-04-10 | Apr 12 | |
| Lorenzo Cain | 2021-04-13 | Apr 19 | |
| Andrelton Simmons | 2021-04-14 | Apr 19 | |
| Archie Bradley | 2021-04-14 | Apr 19 | |
| Adrian Morejon | 2021-04-11 | Apr 12 | |
| LaMonte Wade | 2021-04-14 | Apr 19 | |
| Reyes Moronta | Marlins | 2021-04-11 | Apr 12 |
| Anthony Misiewicz | 2021-04-12 | Apr 19 | |
| Tyler O'Neill | 2021-04-10 | Apr 12 | |
| Ronald Guzman | 2021-04-12 | Apr 19 | |
| Matt Bush | 2021-04-09 | Apr 12 | |
| Teoscar Hernandez | Dodgers | 2021-04-13 | Apr 19 |
| Julian Merryweather | Rangers | 2021-04-13 | Apr 19 |
Added to DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Mac Sceroler | 2021-04-14 | Apr 19 |
| Matt Duffy | 2021-04-13 | Apr 19 |
Removed from DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Robbie Ray | Astros | 2021-03-23 | Mar 29 |
| Kyle Crick | Astros | 2021-04-01 | Apr 5 |
| Austin Romine | Dodgers | 2021-03-11 | Mar 15 |
| Josh Donaldson | Phillies | 2021-04-01 | Apr 5 |
| Zac Gallen | Reds | 2021-03-22 | Mar 29 |
| Nick Ahmed | Rockies | 2021-04-03 | Apr 5 |
Removed from DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Austin Adams | 2021-03-29 | Apr 5 |
Off MLB DL, but hasn't served full time in IBC
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Jordy Mercer | 2021-04-06 | Apr 12 | |
| Josh Harrison | 2021-04-06 | Apr 12 | |
| Josh Bell | Indians | 2021-04-06 | Apr 12 |
| Kyle Schwarber | Marlins | 2021-04-06 | Apr 12 |
| Brad Hand | Nationals | 2021-04-06 | Apr 12 |
| Alex Avila | Orioles | 2021-04-06 | Apr 12 |
| Patrick Corbin | Orioles | 2021-04-06 | Apr 12 |
| Lourdes Gurriel | Reds | 2021-04-09 | Apr 12 |
| Yan Gomes | Rockies | 2021-04-06 | Apr 12 |
| J.D. Martinez | Tigers | 2021-04-10 | Apr 12 |
