Added to DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Joakim Soria | 2021-04-04 | Apr 5 | |
| Austin Hays | Rays | 2021-04-04 | Apr 5 |
| Tim Anderson | 2021-04-04 | Apr 5 | |
| Elieser Hernandez | Braves | 2021-04-03 | Apr 5 |
| Brent Rooker | Padres | 2021-04-07 | Apr 12 |
| Edwar Colina | 2021-03-29 | Apr 5 | |
| Reymin Guduan | 2021-04-06 | Apr 12 | |
| Burch Smith | 2021-04-06 | Apr 12 | |
| Chad Pinder | Twins | 2021-04-04 | Apr 5 |
| Ke'Bryan Hayes | 2021-04-03 | Apr 5 | |
| James Paxton | BlueJays | 2021-04-06 | Apr 12 |
| Kevin Kiermaier | 2021-04-05 | Apr 12 | |
| Patrick Corbin | 2021-04-06 | Apr 12 | |
| Jon Lester | 2021-04-06 | Apr 12 | |
| Josh Harrison | 2021-04-06 | Apr 12 | |
| Yan Gomes | 2021-04-06 | Apr 12 | |
| Alex Avila | 2021-04-06 | Apr 12 | |
| Kyle Schwarber | 2021-04-06 | Apr 12 | |
| Brad Hand | 2021-04-06 | Apr 12 | |
| Jordy Mercer | 2021-04-06 | Apr 12 | |
| Josh Bell | 2021-04-06 | Apr 12 | |
| Will Harris | 2021-03-19 | Mar 22 |
Added to DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Tony Gonsolin | 2021-04-04 | Apr 5 |
| Fernando Tatis Jr. | 2021-04-06 | Apr 12 |
| Jake Fraley | 2021-04-07 | Apr 12 |
Removed from DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Javier Guerra | 2021-03-04 | Mar 8 |
Off MLB DL, but hasn't served full time in IBC
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Kyle Crick | Astros | 2021-04-01 | Apr 5 |
