Added to DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Merrill Kelly | RedSox | 2021-05-04 | May 10 |
| Alex Jackson | 2021-05-02 | May 3 | |
| Travis d'Arnaud | 2021-05-01 | May 3 | |
| Nico Hoerner | 2021-05-04 | May 10 | |
| Jake Arrieta | Twins | 2021-05-04 | May 10 |
| Dan Winkler | Dodgers | 2021-05-04 | May 10 |
| Roberto Perez | 2021-05-05 | May 10 | |
| Carlos Estevez | 2021-04-29 | May 3 | |
| Enoli Paredes | 2021-04-08 | Apr 12 | |
| Cam Gallagher | 2021-05-02 | May 3 | |
| Edwin Rios | Orioles | 2021-05-05 | May 10 |
| Dustin May | 2021-05-01 | May 3 | |
| Anthony Rendon | Brewers | 2021-05-04 | May 10 |
| Tony Watson | 2021-05-03 | May 10 | |
| Alex Kirilloff | 2021-05-04 | May 10 | |
| Luis Arraez | DBacks | 2021-05-03 | May 10 |
| Rougned Odor | Yankees | 2021-05-04 | May 10 |
| Brandon Nimmo | 2021-05-02 | May 3 | |
| J.D. Davis | Rays | 2021-05-01 | May 3 |
| Aramis Garcia | Dodgers | 2021-05-04 | May 10 |
| J.B. Wendelken | Reds | 2021-05-03 | May 10 |
| Jesus Luzardo | 2021-05-02 | May 3 | |
| Roman Quinn | 2021-05-04 | May 10 | |
| Ronald Torreyes | 2021-04-19 | Apr 26 | |
| Kevin Gausman | 2021-05-04 | May 10 | |
| Tommy La Stella | 2021-05-03 | May 10 | |
| Keynan Middleton | 2021-05-05 | May 10 | |
| Casey Sadler | 2021-05-02 | May 3 | |
| Jordan Hicks | Twins | 2021-05-01 | May 3 |
| Diego Castillo | 2021-05-05 | May 10 | |
| Michael Wacha | Indians | 2021-05-04 | May 10 |
| Brock Holt | 2021-05-04 | May 10 | |
| Tommy Milone | 2021-05-03 | May 10 | |
| Anthony Castro | 2021-05-03 | May 10 | |
| George Springer | Orioles | 2021-05-02 | May 3 |
Added to DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Dylan File | 2021-02-04 | Feb 8 |
| Matt Joyce | 2021-05-05 | May 10 |
| Daniel Ponce de Leon | 2021-05-01 | May 3 |
| Alejandro Kirk | 2021-05-02 | May 3 |
Removed from DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| JT Riddle | 2021-04-21 | Apr 26 | |
| Tyler Chatwood | 2021-04-20 | Apr 26 | |
| Juan Soto | Astros | 2021-04-20 | Apr 26 |
| Miguel Sano | Astros | 2021-04-21 | Apr 26 |
| Brian Anderson | BlueJays | 2021-04-21 | Apr 26 |
| Tyson Miller | Cubs | 2021-04-01 | Apr 5 |
| Pete Fairbanks | Cubs | 2021-04-09 | Apr 12 |
| Max Fried | DBacks | 2021-04-13 | Apr 19 |
| Keone Kela | DBacks | 2021-04-22 | Apr 26 |
| Dinelson Lamet | DBacks | 2021-04-22 | Apr 26 |
| Max Kepler | Marlins | 2021-04-20 | Apr 26 |
| Collin McHugh | Mets | 2021-04-18 | Apr 19 |
| T.J. Zeuch | Mets | 2021-04-20 | Apr 26 |
| Will Harris | Phillies | 2021-03-19 | Mar 22 |
| Christian Walker | RedSox | 2021-04-11 | Apr 12 |
| Mike Moustakas | Reds | 2021-04-20 | Apr 26 |
| Cody Reed | Rockies | 2021-04-20 | Apr 26 |
| Lorenzo Cain | Royals | 2021-04-13 | Apr 19 |
| Joakim Soria | Tigers | 2021-04-04 | Apr 5 |
| Tim Locastro | Twins | 2021-04-18 | Apr 19 |
| Ross Stripling | Yankees | 2021-04-14 | Apr 19 |
Removed from DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Taylor Jones | 2021-04-20 | Apr 26 |
Off MLB DL, but hasn't served full time in IBC
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Brock Burke | 2019-09-27 | Oct 4 | |
| Jacob Nottingham | Padres | 2020-12-30 | Jan 3 |
| Mitch White | Reds | 2021-04-27 | May 3 |
