Added to DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Sean Newcomb | 2021-04-17 | Apr 19 | |
| Drew Smyly | Brewers | 2021-04-16 | Apr 19 |
| Ender Inciarte | 2021-04-16 | Apr 19 | |
| Aristides Aquino | 2021-04-14 | Apr 19 | |
| Nomar Mazara | 2021-04-14 | Apr 19 | |
| Blake Taylor | Giants | 2021-04-17 | Apr 19 |
| Christian Yelich | 2021-04-11 | Apr 12 | |
| Jordan Romano | Pirates | 2021-04-15 | Apr 19 |
| Ross Stripling | 2021-04-14 | Apr 19 | |
| Luis Avilan | 2021-04-16 | Apr 19 |
Removed from DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Willie Calhoun | Cubs | 2021-03-09 | Mar 15 |
| Kwang-Hyun Kim | Mets | 2021-03-13 | Mar 15 |
| Sonny Gray | Twins | 2021-03-14 | Mar 15 |
| Tim Anderson | WhiteSox | 2021-04-04 | Apr 5 |
Removed from DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Rony Garcia | 2021-04-01 | Apr 5 |
Off MLB DL, but hasn't served full time in IBC
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Brock Holt | 2021-04-06 | Apr 12 | |
| Jordy Mercer | 2021-04-06 | Apr 12 | |
| Josh Harrison | 2021-04-06 | Apr 12 | |
| Anthony Misiewicz | Braves | 2021-04-12 | Apr 19 |
| Dylan Cease | Brewers | 2021-04-14 | Apr 19 |
| Dan Winkler | Dodgers | 2021-04-12 | Apr 19 |
| Josh Bell | Indians | 2021-04-06 | Apr 12 |
| Kyle Schwarber | Marlins | 2021-04-06 | Apr 12 |
| Brad Hand | Nationals | 2021-04-06 | Apr 12 |
| Patrick Corbin | Orioles | 2021-04-06 | Apr 12 |
| Alex Avila | Orioles | 2021-04-06 | Apr 12 |
| Brandon Workman | Phillies | 2021-04-12 | Apr 19 |
| J.D. Davis | Rays | 2021-04-06 | Apr 12 |
| Lourdes Gurriel | Reds | 2021-04-09 | Apr 12 |
| Yan Gomes | Rockies | 2021-04-06 | Apr 12 |
| J.D. Martinez | Tigers | 2021-04-10 | Apr 12 |
| Kevin Kiermaier | Yankees | 2021-04-05 | Apr 12 |
Off MLB DL, but hasn't served full time in IBC (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Fernando Tatis Jr. | 2021-04-06 | Apr 12 |
| Matt Duffy | 2021-04-13 | Apr 19 |
