Added to DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Ian Happ | 2021-05-04 | May 10 | |
| Joey Votto | Reds | 2021-05-05 | May 10 |
| Erasmo Ramirez | 2021-05-08 | May 10 | |
| Derek Holland | 2021-05-06 | May 10 | |
| Wilson Ramos | 2021-05-06 | May 10 | |
| Scott Alexander | 2021-05-04 | May 10 | |
| Alex Cobb | 2021-05-08 | May 10 | |
| Max Stassi | Royals | 2021-05-06 | May 10 |
| Byron Buxton | Marlins | 2021-05-06 | May 10 |
| Mike Fiers | 2021-05-08 | May 10 | |
| JoJo Romero | 2021-05-06 | May 10 | |
| Keone Kela | DBacks | 2021-05-08 | May 10 |
| Aaron Sanchez | 2021-05-08 | May 10 | |
| Alex Dickerson | 2021-05-04 | May 10 | |
| Francisco Mejia | Indians | 2021-05-07 | May 10 |
| David Phelps | 2021-05-06 | May 10 |
Added to DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Enrique Hernandez | 2021-05-06 | May 10 |
| Chris Rodríguez | 2021-05-06 | May 10 |
Removed from DL
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Burch Smith | 2021-04-06 | Apr 12 | |
| Jarlin Garcia | 2021-04-24 | Apr 26 | |
| Joe Kelly | Brewers | 2021-03-07 | Mar 8 |
| Jean Segura | Brewers | 2021-04-20 | Apr 26 |
| Khris Davis | Cubs | 2021-03-23 | Mar 29 |
| Hyun-Jin Ryu | Dodgers | 2021-04-25 | Apr 26 |
| Nomar Mazara | Rockies | 2021-04-14 | Apr 19 |
| Miguel Andujar | Yankees | 2021-03-15 | Mar 22 |
Removed from DL (Team Not Determined)
| Player | MLB DL | IBC DL |
|---|---|---|
| Shogo Akiyama | 2021-03-13 | Mar 15 |
Off MLB DL, but hasn't served full time in IBC
| Player | Team | MLB DL | IBC DL |
|---|---|---|---|
| Brock Burke | 2019-09-27 | Oct 4 | |
| Mike Yastrzemski | Giants | 2021-04-28 | May 3 |
| Manny Pina | Nationals | 2021-04-27 | May 3 |
| Jacob Nottingham | Padres | 2020-12-30 | Jan 3 |
| Kevin Gausman | Phillies | 2021-05-04 | May 10 |
| Yadier Molina | Pirates | 2021-04-27 | May 3 |
| Merrill Kelly | RedSox | 2021-05-04 | May 10 |
| Mitch White | Reds | 2021-04-27 | May 3 |
| Garrett Crochet | WhiteSox | 2021-04-29 | May 3 |
