| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/17/2025 | Min | Correa,C | Traded away | Mia | | After |
| 3/17/2025 | Min | Gallen | Traded away | Mia | | After |
| 3/17/2025 | Min | Jax | Traded away | Mia | | After |
| 3/17/2025 | Min | Perdomo,G | Acquired via trade | Mia | | After |
| 3/17/2025 | Min | Ryan,J | Acquired via trade | Mia | | After |
| 3/17/2025 | Min | Williams,De | Acquired via trade | Mia | | After |
| 3/31/2025 | Bal | Garcia,Br | Released | | | Before |
| 3/31/2025 | Bal | Guenther | Released | | | Before |
| 3/31/2025 | Bal | Montero,K | Signed | | | Before |
| 3/31/2025 | Cle | Espinal | Released | | | Before |
| 3/31/2025 | Cle | Margot | Signed | | | Before |
| 3/31/2025 | Det | Santana,Ca | Released | | | Before |
| 3/31/2025 | Hou | Coffey,A | Signed | | | Before |
| 3/31/2025 | Hou | Misner | Released | | | Before |
| 3/31/2025 | NYA | Vasquez,R | Signed | | | Before |
| 3/31/2025 | Sea | Morris,K | Signed | | | Before |
| 3/31/2025 | Sea | Seymour,C | Released | | | Before |
| 3/31/2025 | Sea | Sundstrom | Released | | | Before |
| 3/31/2025 | Tam | Baker,L | Released | | | Before |
| 3/31/2025 | Tam | Cabrera,O | Demoted to reserve roster | | | Before |
| 3/31/2025 | Tam | Santana,Ca | Signed | | | Before |
| 3/31/2025 | Tam | Santana,Ca | Promoted to active roster | | | Before |
| 3/31/2025 | Tor | Alcala | Signed | | | Before |
| 3/31/2025 | Tor | Bellozo | Signed | | | Before |
| 3/31/2025 | Tor | Moll | Released | | | Before |
| 4/4/2025 | Bos | Gervase | Signed | | | Before |
| 4/4/2025 | Bos | Gorski | Released | | | Before |
| 4/4/2025 | Cle | Freeman,F | Demoted to reserve roster | | | Before |
| 4/4/2025 | Cle | Margot | Promoted to active roster | | | Before |
| 4/4/2025 | Cle | Rock,J | Promoted to active roster | | | Before |
| 4/7/2025 | Bos | Garcia,Jh | Demoted to reserve roster | | | Before |
| 4/7/2025 | Bos | Gervase | Promoted to active roster | | | Before |
| 4/7/2025 | Bos | Murphy,Se | Promoted to active roster | | | Before |
| 4/7/2025 | Det | Marte,K | Demoted to reserve roster | | | Before |
| 4/7/2025 | Det | Triantos | Promoted to active roster | | | Before |
| 4/7/2025 | Min | Civale | Demoted to reserve roster | | | Before |
| 4/7/2025 | Min | Karinchak | Promoted to active roster | | | Before |
| 4/7/2025 | Sea | Basallo | Demoted to reserve roster | | | Before |
| 4/10/2025 | NYA | Mead | Traded away | Phi | | After |
| 4/10/2025 | NYA | Misiaszek | Traded away | Phi | | After |
| 4/11/2025 | Bal | Adams,T | Released | | | Before |
| 4/11/2025 | Bal | Wiles,N | Signed | | | Before |
| 4/11/2025 | Bos | Braun | Demoted to reserve roster | | | Before |
| 4/11/2025 | Bos | Wichrowski | Released | | | Before |
| 4/11/2025 | Bos | Young,Jar | Promoted to active roster | | | Before |
| 4/11/2025 | Hou | Coffey,A | Promoted to active roster | | | Before |
| 4/11/2025 | KC | Birdsell | Released | | | Before |
| 4/11/2025 | LAA | Moniak | Released | | | Before |
| 4/11/2025 | LAA | Seymour,C | Signed | | | Before |
| 4/11/2025 | NYA | Koperniak | Released | | | Before |
| 4/11/2025 | NYA | Vasquez,R | Released | | | Before |
| 4/11/2025 | Sac | Lao | Signed | | | Before |
| 4/11/2025 | Sac | Noda | Released | | | Before |
| 4/11/2025 | Sea | Burrows,M | Signed | | | Before |
| 4/11/2025 | Tex | Bauers | Signed | | | Before |
| 4/11/2025 | Tex | Bauers | Promoted to active roster | | | Before |
| 4/11/2025 | Tex | Hamilton,I | Promoted to active roster | | | Before |
| 4/11/2025 | Tex | Lopez,P | Demoted to reserve roster | | | Before |
| 4/11/2025 | Tex | Steele | Demoted to reserve roster | | | Before |
| 4/11/2025 | Tex | Wagaman | Released | | | Before |
| 4/14/2025 | Bal | Montero,K | Promoted to active roster | | | Before |
| 4/14/2025 | Bal | Wiles,N | Promoted to active roster | | | Before |
| 4/14/2025 | Hou | Harvey | Demoted to reserve roster | | | Before |
| 4/14/2025 | LAA | Candelario | Demoted to reserve roster | | | Before |
| 4/14/2025 | LAA | Canzone | Promoted to active roster | | | Before |
| 4/14/2025 | LAA | Henry,T | Promoted to active roster | | | Before |
| 4/14/2025 | LAA | Santos,G | Demoted to reserve roster | | | Before |
| 4/14/2025 | Tam | Cronin,D | Demoted to reserve roster | | | Before |
| 4/14/2025 | Tam | Gorman | Promoted to active roster | | | Before |
| 4/14/2025 | Tam | Herrera,I | Demoted to reserve roster | | | Before |
| 4/14/2025 | Tam | Herrera,I | Demoted to reserve roster | | | Before |
| 4/14/2025 | Tam | Rortvedt | Promoted to active roster | | | Before |
| 4/14/2025 | Tam | Rortvedt | Promoted to active roster | | | Before |
| 4/14/2025 | Tor | Alcala | Promoted to active roster | | | Before |
| 4/14/2025 | Tor | Eflin | Demoted to reserve roster | | | Before |
| 4/14/2025 | Tor | Grandal | Promoted to active roster | | | Before |
| 4/14/2025 | Tor | Wong,C | Demoted to reserve roster | | | Before |
| 4/18/2025 | Cle | Detmers | Promoted to active roster | | | Before |
| 4/18/2025 | Cle | Lara,L | Signed | | | Before |
| 4/18/2025 | Cle | Rock,J | Demoted to reserve roster | | | Before |
| 4/18/2025 | NYA | Benson | Signed | | | Before |
| 4/18/2025 | NYA | Brock | Released | | | Before |
| 4/18/2025 | Sac | Foley | Demoted to reserve roster | | | Before |
| 4/18/2025 | Sac | Hoglund | Promoted to active roster | | | Before |
| 4/18/2025 | Sac | Joyce,B | Demoted to reserve roster | | | Before |
| 4/18/2025 | Sac | Lao | Promoted to active roster | | | Before |
| 4/18/2025 | Sea | Reyzelman | Released | | | Before |
| 4/18/2025 | Sea | Vargas,C | Signed | | | Before |
| 4/18/2025 | Tam | Cabrera,O | Released | | | Before |
| 4/18/2025 | Tam | Straw | Signed | | | Before |
| 4/18/2025 | Tex | Junk | Released | | | Before |
| 4/21/2025 | Det | Eisert | Promoted to active roster | | | Before |
| 4/21/2025 | Det | Marsh,B | Demoted to reserve roster | | | Before |
| 4/21/2025 | Det | Morgan,E | Demoted to reserve roster | | | Before |
| 4/21/2025 | Det | Sanchez,Je | Promoted to active roster | | | Before |
| 4/21/2025 | Hou | Norby | Promoted to active roster | | | Before |
| 4/21/2025 | Sea | Isaac | Promoted to active roster | | | Before |
| 4/21/2025 | Sea | Vargas,C | Promoted to active roster | | | Before |
| 4/21/2025 | Tam | Amador | Promoted to active roster | | | Before |
| 4/21/2025 | Tam | Happ | Demoted to reserve roster | | | Before |
| 4/21/2025 | Tam | Horton | Promoted to active roster | | | Before |
| 4/21/2025 | Tam | Rumfield | Promoted to active roster | | | Before |
| 4/21/2025 | Tam | Straw | Promoted to active roster | | | Before |
| 4/21/2025 | Tam | Thomas,L | Demoted to reserve roster | | | Before |
| 4/21/2025 | Tam | Torres,G | Demoted to reserve roster | | | Before |
| 4/21/2025 | Tam | Westburg | Demoted to reserve roster | | | Before |
| 4/21/2025 | Tex | Stewart,B | Promoted to active roster | | | Before |
| 4/25/2025 | Cle | Freeman,F | Promoted to active roster | | | Before |
| 4/25/2025 | Cle | Meidroth | Demoted to reserve roster | | | Before |
| 4/25/2025 | Cle | Meidroth | Promoted to active roster | | | Before |
| 4/25/2025 | Cle | Meidroth | Demoted to reserve roster | | | Before |
| 4/25/2025 | Cle | Seager | Demoted to reserve roster | | | Before |
| 4/25/2025 | Cle | Seager | Promoted to active roster | | | Before |
| 4/25/2025 | KC | Burr | Demoted to reserve roster | | | Before |
| 4/25/2025 | KC | Holman | Promoted to active roster | | | Before |
| 4/25/2025 | Tex | Lopez,P | Promoted to active roster | | | Before |
| 4/25/2025 | Tex | Misiorowski | Demoted to reserve roster | | | Before |
| 4/28/2025 | Bos | Cameron,D | Released | | | Before |
| 4/28/2025 | Bos | Horvath | Signed | | | Before |
| 4/28/2025 | Bos | McAdoo | Released | | | Before |
| 4/28/2025 | Bos | Wallace,Ca | Released | | | Before |
| 4/28/2025 | Cle | Manning | Released | | | Before |
| 4/28/2025 | Cle | Meidroth | Promoted to active roster | | | Before |
| 4/28/2025 | Cle | Robertson,D | Signed | | | Before |
| 4/28/2025 | Cle | Seager | Demoted to reserve roster | | | Before |
| 4/28/2025 | Hou | Noel | Released | | | Before |
| 4/28/2025 | Min | Reifert | Signed | | | Before |
| 4/28/2025 | Min | Webb,R | Released | | | Before |
| 4/28/2025 | NYA | Hoeing | Promoted to active roster | | | Before |
| 4/28/2025 | NYA | Jebb | Signed | | | Before |
| 4/28/2025 | NYA | Pennington | Released | | | Before |
| 4/28/2025 | NYA | Scott,Ch | Promoted to active roster | | | Before |
| 4/28/2025 | Sac | Bouchard | Released | | | Before |
| 4/28/2025 | Sac | Caballero,Jos | Promoted to active roster | | | Before |
| 4/28/2025 | Sac | MacIver | Signed | | | Before |
| 4/28/2025 | Sac | Myers,D | Demoted to reserve roster | | | Before |
| 4/28/2025 | Sac | Myers,D | Promoted to active roster | | | Before |
| 4/28/2025 | Sea | Alvarez,F | Promoted to active roster | | | Before |
| 4/28/2025 | Sea | Basallo | Promoted to active roster | | | Before |
| 4/28/2025 | Sea | Hancock | Promoted to active roster | | | Before |
| 4/28/2025 | Sea | Rodriguez,CF | Demoted to reserve roster | | | Before |
| 4/28/2025 | Sea | Tovar | Demoted to reserve roster | | | Before |
| 4/28/2025 | Sea | Veen | Demoted to reserve roster | | | Before |
| 4/28/2025 | Tam | Rosario,A | Signed | | | Before |
| 4/28/2025 | Tor | Alcala | Released | | | Before |
| 4/28/2025 | Tor | Alcala | Signed | | | Before |
| 4/28/2025 | Tor | Cobb | Signed | | | Before |
| 4/28/2025 | Tor | Lugo,M | Signed | | | Before |
| 4/28/2025 | Tor | Pereda | Signed | | | Before |
| 4/28/2025 | Tor | Rodgers | Released | | | Before |
| 5/2/2025 | Tex | Fitzgerald,T | Demoted to reserve roster | | | Before |
| 5/2/2025 | Tex | Gonsolin | Promoted to active roster | | | Before |
| 5/2/2025 | Tex | Martinez,Ju | Demoted to reserve roster | | | Before |
| 5/2/2025 | Tex | Tawa | Promoted to active roster | | | Before |
| 5/4/2025 | Min | Gurriel,L | Acquired via trade | Cin | | After |
| 5/4/2025 | Min | Martin,A | Traded away | Cin | | After |
| 5/5/2025 | Bos | Riggio | Signed | | | Before |
| 5/5/2025 | Cle | Edman | Demoted to reserve roster | | | Before |
| 5/5/2025 | Cle | Freeland,A | Promoted to active roster | | | Before |
| 5/5/2025 | Cle | Lopez,Jaco | Signed | | | Before |
| 5/5/2025 | Cle | Raley,B | Released | | | Before |
| 5/5/2025 | Cle | Rock,J | Promoted to active roster | | | Before |
| 5/5/2025 | Cle | Sewald | Demoted to reserve roster | | | Before |
| 5/5/2025 | Det | Abbott,A | Promoted to active roster | | | Before |
| 5/5/2025 | Det | d'Arnaud | Demoted to reserve roster | | | Before |
| 5/5/2025 | Det | Eisert | Demoted to reserve roster | | | Before |
| 5/5/2025 | Det | Marsh,B | Promoted to active roster | | | Before |
| 5/5/2025 | Det | Marte,K | Promoted to active roster | | | Before |
| 5/5/2025 | Det | Mitchell,G | Demoted to reserve roster | | | Before |
| 5/5/2025 | Det | Triantos | Demoted to reserve roster | | | Before |
| 5/5/2025 | Det | Varsho | Promoted to active roster | | | Before |
| 5/5/2025 | LAA | Castro,W | Demoted to reserve roster | | | Before |
| 5/5/2025 | LAA | Suarez,Jos | Promoted to active roster | | | Before |
| 5/5/2025 | LAA | Taylor,S | Promoted to active roster | | | Before |
| 5/5/2025 | LAA | Vodnik | Demoted to reserve roster | | | Before |
| 5/5/2025 | Sac | Cavalli | Promoted to active roster | | | Before |
| 5/5/2025 | Sac | Roby,T | Demoted to reserve roster | | | Before |
| 5/5/2025 | Sea | Dobbins | Promoted to active roster | | | Before |
| 5/5/2025 | Sea | Glasnow | Demoted to reserve roster | | | Before |
| 5/5/2025 | Sea | Rodriguez,CF | Released | | | Before |
| 5/5/2025 | Sea | Sundstrom | Signed | | | Before |
| 5/5/2025 | Tam | Amador | Demoted to reserve roster | | | Before |
| 5/5/2025 | Tam | Happ | Promoted to active roster | | | Before |
| 5/5/2025 | Tam | Straw | Demoted to reserve roster | | | Before |
| 5/5/2025 | Tam | Torres,G | Promoted to active roster | | | Before |
| 5/5/2025 | Tex | Bauers | Released | | | Before |
| 5/5/2025 | Tex | Henriquez,R | Signed | | | Before |
| 5/5/2025 | Tex | Junk | Signed | | | Before |
| 5/5/2025 | Tex | Schuemann | Signed | | | Before |
| 5/5/2025 | Tex | Torrens | Signed | | | Before |
| 5/5/2025 | Tor | Alcala | Promoted to active roster | | | Before |
| 5/5/2025 | Tor | Lugo,M | Promoted to active roster | | | Before |
| 5/5/2025 | Tor | Sanchez,G | Demoted to reserve roster | | | Before |
| 5/5/2025 | Tor | Trout | Demoted to reserve roster | | | Before |
| 5/5/2025 | Tor | Vukovich | Promoted to active roster | | | Before |
| 5/5/2025 | Tor | Wong,C | Promoted to active roster | | | Before |
| 5/12/2025 | Bos | Braun | Promoted to active roster | | | Before |
| 5/12/2025 | Bos | Garcia,Jh | Promoted to active roster | | | Before |
| 5/12/2025 | Tam | Happ | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tam | Herrera,I | Promoted to active roster | | | Before |
| 5/12/2025 | Tam | Marte,N | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tam | Rortvedt | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tam | Rosario,A | Promoted to active roster | | | Before |
| 5/12/2025 | Tam | Rumfield | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tam | Straw | Promoted to active roster | | | Before |
| 5/12/2025 | Tam | Thomas,L | Promoted to active roster | | | Before |
| 5/12/2025 | Tex | Alvarez,Y | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tex | De Paula,J | Promoted to active roster | | | Before |
| 5/12/2025 | Tex | Gimenez | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tex | McCullers | Promoted to active roster | | | Before |
| 5/12/2025 | Tex | Schuemann | Promoted to active roster | | | Before |
| 5/12/2025 | Tex | Zeferjahn | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tor | Berrios | Demoted to reserve roster | | | Before |
| 5/12/2025 | Tor | Eflin | Promoted to active roster | | | Before |
| 5/15/2025 | Hou | Jimenez,L | Traded away | Cin | | After |
| 5/15/2025 | Hou | Montgomery,M | Acquired via trade | Cin | | After |
| 5/15/2025 | Tex | Ferris | Traded away | Cin | | After |
| 5/15/2025 | Tex | Lowe,N | Acquired via trade | Cin | | After |
| 5/15/2025 | Tex | Velazquez,R | Traded away | Cin | | After |
| 5/16/2025 | Bal | Montero,K | Released | | | Before |
| 5/16/2025 | Bos | Gibson,K | Signed | | | Before |
| 5/16/2025 | Bos | Horvath | Released | | | Before |
| 5/16/2025 | Det | d'Arnaud | Released | | | Before |
| 5/16/2025 | Hou | Montgomery,M | Promoted to active roster | | | Before |
| 5/16/2025 | LAA | Montas | Signed | | | Before |
| 5/16/2025 | LAA | Silseth | Released | | | Before |
| 5/16/2025 | Min | Fedko | Signed | | | Before |
| 5/16/2025 | NYA | Franklin,C | Signed | | | Before |
| 5/16/2025 | NYA | Freeman,T | Released | | | Before |
| 5/16/2025 | NYA | Hill,Jad | Signed | | | Before |
| 5/16/2025 | Sac | Mazur | Released | | | Before |
| 5/16/2025 | Sac | Seymour,B | Signed | | | Before |
| 5/16/2025 | Tam | Gusto | Signed | | | Before |
| 5/16/2025 | Tex | Bauers | Signed | | | Before |
| 5/16/2025 | Tex | Junk | Released | | | Before |
| 5/16/2025 | Tex | Mendez | Signed | | | Before |
| 5/16/2025 | Tex | Miller,S | Released | | | Before |
| 5/16/2025 | Tex | Otanez | Released | | | Before |
| 5/16/2025 | Tex | Torrens | Released | | | Before |
| 5/16/2025 | Tex | Zeferjahn | Released | | | Before |
| 5/16/2025 | Tor | Bigge | Signed | | | Before |
| 5/16/2025 | Tor | Jordan,B | Signed | | | Before |
| 5/16/2025 | Tor | Lugo,M | Released | | | Before |
| 5/16/2025 | Tor | Vukovich | Released | | | Before |
| 5/19/2025 | Cle | Edman | Promoted to active roster | | | Before |
| 5/19/2025 | Cle | Wagner,W | Demoted to reserve roster | | | Before |
| 5/19/2025 | LAA | Castro,W | Promoted to active roster | | | Before |
| 5/19/2025 | LAA | Kershaw | Promoted to active roster | | | Before |
| 5/19/2025 | LAA | Mikolas | Demoted to reserve roster | | | Before |
| 5/19/2025 | LAA | Taylor,S | Demoted to reserve roster | | | Before |
| 5/19/2025 | Min | Berti | Demoted to reserve roster | | | Before |
| 5/19/2025 | Min | Myers,T | Promoted to active roster | | | Before |
| 5/19/2025 | Min | Nola,Aa | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sac | Clase,J | Promoted to active roster | | | Before |
| 5/19/2025 | Sac | Edwards,X | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sac | Hernaiz | Promoted to active roster | | | Before |
| 5/19/2025 | Sac | Myers,D | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sac | Seymour,B | Promoted to active roster | | | Before |
| 5/19/2025 | Sac | Turney | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sea | Carter | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sea | Horwitz | Promoted to active roster | | | Before |
| 5/19/2025 | Sea | Isaac | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sea | Jimenez,E | Demoted to reserve roster | | | Before |
| 5/19/2025 | Sea | Lewis,R | Promoted to active roster | | | Before |
| 5/19/2025 | Sea | Tovar | Promoted to active roster | | | Before |
| 5/19/2025 | Tam | Rumfield | Promoted to active roster | | | Before |
| 5/19/2025 | Tam | Thomas,L | Demoted to reserve roster | | | Before |
| 5/19/2025 | Tex | Bauers | Promoted to active roster | | | Before |
| 5/19/2025 | Tex | De Paula,J | Demoted to reserve roster | | | Before |
| 5/19/2025 | Tex | Fitzgerald,T | Promoted to active roster | | | Before |
| 5/19/2025 | Tex | Henriquez,R | Promoted to active roster | | | Before |
| 5/19/2025 | Tex | Martinez,E | Demoted to reserve roster | | | Before |
| 5/22/2025 | NYA | Mountcastle | Traded away | Cin | | After |
| 5/22/2025 | NYA | Rodriguez,Je | Acquired via trade | Cin | | After |
| 5/23/2025 | Bal | Elko | Promoted to active roster | | | Before |
| 5/23/2025 | Bal | Holderman | Demoted to reserve roster | | | Before |
| 5/23/2025 | Bal | Kudrna | Promoted to active roster | | | Before |
| 5/23/2025 | Bos | Braun | Demoted to reserve roster | | | Before |
| 5/23/2025 | Bos | Gibson,K | Promoted to active roster | | | Before |
| 5/23/2025 | Bos | Okert | Demoted to reserve roster | | | Before |
| 5/23/2025 | Bos | Povich | Demoted to reserve roster | | | Before |
| 5/23/2025 | Bos | Rom | Signed | | | Before |
| 5/23/2025 | Bos | Rom | Promoted to active roster | | | Before |
| 5/23/2025 | Bos | Wilken | Promoted to active roster | | | Before |
| 5/23/2025 | Cle | Lopez,Jaco | Released | | | Before |
| 5/23/2025 | Min | Antunez | Signed | | | Before |
| 5/23/2025 | NYA | Durbin | Signed | | | Before |
| 5/23/2025 | NYA | Franklin,C | Released | | | Before |
| 5/23/2025 | NYA | Jebb | Released | | | Before |
| 5/23/2025 | NYA | Seigler | Signed | | | Before |
| 5/23/2025 | Sea | Dobbins | Demoted to reserve roster | | | Before |
| 5/23/2025 | Sea | Hancock | Demoted to reserve roster | | | Before |
| 5/23/2025 | Sea | Kirby | Promoted to active roster | | | Before |
| 5/23/2025 | Sea | Strider | Promoted to active roster | | | Before |
| 5/23/2025 | Tam | Mazur | Signed | | | Before |
| 5/23/2025 | Tam | Rortvedt | Released | | | Before |
| 5/23/2025 | Tex | Junk | Signed | | | Before |
| 5/23/2025 | Tex | Martinez,Ju | Promoted to active roster | | | Before |
| 5/23/2025 | Tex | Smith-Shawver | Demoted to reserve roster | | | Before |
| 5/23/2025 | Tor | Alcala | Released | | | Before |
| 5/23/2025 | Tor | Swanson,E | Signed | | | Before |
| 5/26/2025 | Hou | Garcia,Yi | Demoted to reserve roster | | | Before |
| 5/26/2025 | LAA | Seymour,C | Promoted to active roster | | | Before |
| 5/26/2025 | LAA | Suarez,Jos | Demoted to reserve roster | | | Before |
| 5/26/2025 | NYA | Benson | Promoted to active roster | | | Before |
| 5/26/2025 | NYA | Boeve | Promoted to active roster | | | Before |
| 5/26/2025 | NYA | Hill,Jad | Promoted to active roster | | | Before |
| 5/26/2025 | NYA | Hoeing | Demoted to reserve roster | | | Before |
| 5/26/2025 | NYA | Hoeing | Promoted to active roster | | | Before |
| 5/26/2025 | NYA | Montes,L | Promoted to active roster | | | Before |
| 5/26/2025 | NYA | Paris | Demoted to reserve roster | | | Before |
| 5/26/2025 | NYA | Robles,V | Demoted to reserve roster | | | Before |
| 5/26/2025 | NYA | Rodriguez,Je | Promoted to active roster | | | Before |
| 5/26/2025 | NYA | Scott,Ch | Demoted to reserve roster | | | Before |
| 5/26/2025 | Tam | Gusto | Promoted to active roster | | | Before |
| 5/26/2025 | Tam | Happ | Promoted to active roster | | | Before |
| 5/26/2025 | Tam | King,M | Demoted to reserve roster | | | Before |
| 5/26/2025 | Tam | Rumfield | Demoted to reserve roster | | | Before |
| 5/26/2025 | Tor | Areinamo | Promoted to active roster | | | Before |
| 5/26/2025 | Tor | Berrios | Promoted to active roster | | | Before |
| 5/26/2025 | Tor | Jordan,B | Promoted to active roster | | | Before |
| 5/26/2025 | Tor | Senga | Demoted to reserve roster | | | Before |
| 5/26/2025 | Tor | Weston | Promoted to active roster | | | Before |
| 5/29/2025 | Bal | Elko | Demoted to reserve roster | | | Before |
| 5/29/2025 | Bal | Hall,DL | Promoted to active roster | | | Before |
| 5/29/2025 | Sac | Bregman | Demoted to reserve roster | | | Before |
| 5/29/2025 | Sac | Eovaldi | Demoted to reserve roster | | | Before |
| 5/29/2025 | Sac | Roby,T | Promoted to active roster | | | Before |
| 5/29/2025 | Sac | Turney | Released | | | Before |
| 6/1/2025 | Cle | Meidroth | Traded away | SD | | After |
| 6/1/2025 | Cle | Romano,J | Acquired via trade | SD | | After |
| 6/1/2025 | Cle | Westburg | Acquired via trade | SD | | After |
| 6/1/2025 | Hou | Adell | Traded away | NYA | | After |
| 6/1/2025 | Hou | Crow-Armstrong | Acquired via trade | Mia | | After |
| 6/1/2025 | Hou | Devers,R | Traded away | Mia | | After |
| 6/1/2025 | Hou | Harris,M | Traded away | Mia | | After |
| 6/1/2025 | Hou | Liranzo,T | Traded away | NYA | | After |
| 6/1/2025 | Hou | Ramirez,Ag | Acquired via trade | NYA | | After |
| 6/1/2025 | Hou | Riley,A | Acquired via trade | Mia | | After |
| 6/1/2025 | LAA | Kirk | Traded away | Tor | | After |
| 6/1/2025 | LAA | Sanchez,G | Acquired via trade | Tor | | After |
| 6/1/2025 | LAA | Senga | Acquired via trade | Tor | | After |
| 6/1/2025 | LAA | Taylor,S | Traded away | Tor | | After |
| 6/1/2025 | NYA | Adell | Acquired via trade | Hou | | After |
| 6/1/2025 | NYA | Liranzo,T | Acquired via trade | Hou | | After |
| 6/1/2025 | NYA | Ramirez,Ag | Traded away | Hou | | After |
| 6/1/2025 | Tam | Hader | Acquired via trade | SD | | After |
| 6/1/2025 | Tam | Machado,M | Acquired via trade | SD | | After |
| 6/1/2025 | Tam | Rocker | Traded away | SD | | After |
| 6/1/2025 | Tam | Schwarber | Acquired via trade | SD | | After |
| 6/1/2025 | Tam | Westburg | Traded away | SD | | After |
| 6/1/2025 | Tor | Kirk | Acquired via trade | LAA | | After |
| 6/1/2025 | Tor | Sanchez,G | Traded away | LAA | | After |
| 6/1/2025 | Tor | Senga | Traded away | LAA | | After |
| 6/1/2025 | Tor | Taylor,S | Acquired via trade | LAA | | After |
| 6/2/2025 | Bal | Avila,L | Released | | | Before |
| 6/2/2025 | Bal | Avila,L | Signed | | | Before |
| 6/2/2025 | Bal | Bolte | Promoted to active roster | | | Before |
| 6/2/2025 | Bal | McGarry,G | Released | | | Before |
| 6/2/2025 | Bal | Stewart,S | Promoted to active roster | | | Before |
| 6/2/2025 | Bal | Wiles,N | Released | | | Before |
| 6/2/2025 | Bos | Riggio | Released | | | Before |
| 6/2/2025 | Cle | Detmers | Demoted to reserve roster | | | Before |
| 6/2/2025 | Cle | Seager | Promoted to active roster | | | Before |
| 6/2/2025 | Det | Eisert | Promoted to active roster | | | Before |
| 6/2/2025 | Det | Junis | Promoted to active roster | | | Before |
| 6/2/2025 | Det | Mauricio,R | Promoted to active roster | | | Before |
| 6/2/2025 | Det | Renfroe | Demoted to reserve roster | | | Before |
| 6/2/2025 | Det | Rodriguez,W | Demoted to reserve roster | | | Before |
| 6/2/2025 | Det | Thompson,K | Demoted to reserve roster | | | Before |
| 6/2/2025 | Det | Tibbs | Promoted to active roster | | | Before |
| 6/2/2025 | Det | Varsho | Demoted to reserve roster | | | Before |
| 6/2/2025 | Hou | Bergert | Signed | | | Before |
| 6/2/2025 | Hou | Bergert | Promoted to active roster | | | Before |
| 6/2/2025 | Hou | Taylor,N | Promoted to active roster | | | Before |
| 6/2/2025 | LAA | Andujar | Demoted to reserve roster | | | Before |
| 6/2/2025 | LAA | Burke,S | Demoted to reserve roster | | | Before |
| 6/2/2025 | LAA | France,T | Signed | | | Before |
| 6/2/2025 | LAA | France,T | Promoted to active roster | | | Before |
| 6/2/2025 | LAA | Henry,T | Demoted to reserve roster | | | Before |
| 6/2/2025 | LAA | Sabol | Promoted to active roster | | | Before |
| 6/2/2025 | LAA | Selvidge | Released | | | Before |
| 6/2/2025 | LAA | Senga | Promoted to active roster | | | Before |
| 6/2/2025 | LAA | Vodnik | Promoted to active roster | | | Before |
| 6/2/2025 | NYA | Anderson,I | Released | | | Before |
| 6/2/2025 | NYA | Anderson,I | Signed | | | Before |
| 6/2/2025 | NYA | Benson | Released | | | Before |
| 6/2/2025 | NYA | Hoeing | Released | | | Before |
| 6/2/2025 | NYA | Robinson,K | Released | | | Before |
| 6/2/2025 | NYA | Robinson,K | Signed | | | Before |
| 6/2/2025 | NYA | Yarbrough | Signed | | | Before |
| 6/2/2025 | Sac | Bregman | Demoted to reserve roster | | | Before |
| 6/2/2025 | Sac | Edwards,X | Promoted to active roster | | | Before |
| 6/2/2025 | Sac | Eovaldi | Demoted to reserve roster | | | Before |
| 6/2/2025 | Sac | Hernaiz | Demoted to reserve roster | | | Before |
| 6/2/2025 | Sac | Myers,D | Promoted to active roster | | | Before |
| 6/2/2025 | Sac | Roby,T | Promoted to active roster | | | Before |
| 6/2/2025 | Sac | Turney | Released | | | Before |
| 6/2/2025 | Sea | Ashby | Promoted to active roster | | | Before |
| 6/2/2025 | Sea | Vargas,C | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tam | Mazur | Promoted to active roster | | | Before |
| 6/2/2025 | Tam | Rosario,A | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tam | Straw | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tam | Weaver | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tam | Wicks | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tor | Areinamo | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tor | Grandal | Released | | | Before |
| 6/2/2025 | Tor | Grandal | Signed | | | Before |
| 6/2/2025 | Tor | Grandal | Promoted to active roster | | | Before |
| 6/2/2025 | Tor | Jordan,B | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tor | Kavadas | Released | | | Before |
| 6/2/2025 | Tor | Kavadas | Signed | | | Before |
| 6/2/2025 | Tor | Swanson,E | Promoted to active roster | | | Before |
| 6/2/2025 | Tor | Taylor,S | Promoted to active roster | | | Before |
| 6/2/2025 | Tor | Trout | Promoted to active roster | | | Before |
| 6/2/2025 | Tor | Weston | Demoted to reserve roster | | | Before |
| 6/2/2025 | Tor | Wong,C | Demoted to reserve roster | | | Before |
| 6/6/2025 | Bos | Kurtz | Demoted to reserve roster | | | Before |
| 6/6/2025 | Bos | Montgomery,C | Promoted to active roster | | | Before |
| 6/6/2025 | Cle | Detmers | Demoted to reserve roster | | | Before |
| 6/6/2025 | Cle | Detmers | Promoted to active roster | | | Before |
| 6/8/2025 | Bal | Burke,B | Acquired via trade | SD | | After |
| 6/8/2025 | Bal | Elko | Traded away | SD | | After |
| 6/8/2025 | Bal | Kudrna | Traded away | SD | | After |
| 6/8/2025 | Bal | McCray | Traded away | SD | | After |
| 6/8/2025 | Bal | Morton,C | Acquired via trade | SD | | After |
| 6/8/2025 | Bal | Topa | Acquired via trade | SD | | After |
| 6/8/2025 | Bal | Walker,C | Acquired via trade | SD | | After |
| 6/8/2025 | Hou | Maxwell | Traded away | Tam | | After |
| 6/8/2025 | Hou | Rosario,A | Acquired via trade | Tam | | After |
| 6/8/2025 | NYA | Schmidt | Acquired via trade | SD | | After |
| 6/8/2025 | Tam | Maxwell | Acquired via trade | Hou | | After |
| 6/8/2025 | Tam | Rosario,A | Traded away | Hou | | After |
| 6/9/2025 | Bal | Bido,O | Released | | | Before |
| 6/9/2025 | Bal | Mesa | Signed | | | Before |
| 6/9/2025 | Bos | Abreu,W | Demoted to reserve roster | | | Before |
| 6/9/2025 | Bos | Braun | Promoted to active roster | | | Before |
| 6/9/2025 | Bos | Chapman,M | Demoted to reserve roster | | | Before |
| 6/9/2025 | Bos | Kelly,A | Released | | | Before |
| 6/9/2025 | Bos | Kelly,A | Signed | | | Before |
| 6/9/2025 | Bos | Kurtz | Promoted to active roster | | | Before |
| 6/9/2025 | Bos | Okert | Promoted to active roster | | | Before |
| 6/9/2025 | Bos | Rom | Released | | | Before |
| 6/9/2025 | ChA | Cho | Released | | | Before |
| 6/9/2025 | ChA | Irvin,C | Released | | | Before |
| 6/9/2025 | Det | Renfroe | Released | | | Before |
| 6/9/2025 | Det | Rodriguez,W | Released | | | Before |
| 6/9/2025 | Det | Schultz,P | Signed | | | Before |
| 6/9/2025 | Det | Sisk | Signed | | | Before |
| 6/9/2025 | Hou | Belgrave | Signed | | | Before |
| 6/9/2025 | Hou | Belgrave | Promoted to active roster | | | Before |
| 6/9/2025 | Hou | Coffey,A | Demoted to reserve roster | | | Before |
| 6/9/2025 | Hou | Hoffmann | Signed | | | Before |
| 6/9/2025 | Hou | Rosario,A | Promoted to active roster | | | Before |
| 6/9/2025 | NYA | Anderson,I | Released | | | Before |
| 6/9/2025 | NYA | Granillo | Signed | | | Before |
| 6/9/2025 | NYA | Robinson,K | Released | | | Before |
| 6/9/2025 | NYA | Seigler | Released | | | Before |
| 6/9/2025 | Sac | Chafin | Released | | | Before |
| 6/9/2025 | Sac | Reyzelman | Signed | | | Before |
| 6/9/2025 | Tam | Cruz,S | Signed | | | Before |
| 6/9/2025 | Tex | Kolek | Signed | | | Before |
| 6/9/2025 | Tex | Kolek | Promoted to active roster | | | Before |
| 6/9/2025 | Tex | Martinez,E | Released | | | Before |
| 6/9/2025 | Tex | Martinez,Ju | Demoted to reserve roster | | | Before |
| 6/9/2025 | Tor | Grandal | Released | | | Before |
| 6/9/2025 | Tor | Kavadas | Signed | | | Before |
| 6/9/2025 | Tor | Wong,C | Promoted to active roster | | | Before |
| 6/12/2025 | NYA | Goodman | Acquired via trade | SD | | After |
| 6/12/2025 | NYA | Lorenzen | Traded away | Tam | | After |
| 6/12/2025 | NYA | Rodriguez,Je | Traded away | SD | | After |
| 6/12/2025 | Sea | Carter | Promoted to active roster | | | Before |
| 6/12/2025 | Sea | Isaac | Promoted to active roster | | | Before |
| 6/12/2025 | Sea | Tovar | Demoted to reserve roster | | | Before |
| 6/12/2025 | Sea | Vientos | Demoted to reserve roster | | | Before |
| 6/12/2025 | Tam | Lorenzen | Acquired via trade | NYA | | After |
| 6/13/2025 | Bal | Mesa | Released | | | Before |
| 6/13/2025 | Bos | Riggio | Signed | | | Before |
| 6/13/2025 | Cle | Alcala | Signed | | | Before |
| 6/13/2025 | KC | Aleman | Promoted to active roster | | | Before |
| 6/13/2025 | KC | Del Castillo | Demoted to reserve roster | | | Before |
| 6/13/2025 | KC | Falter | Promoted to active roster | | | Before |
| 6/13/2025 | KC | Whisenhunt | Demoted to reserve roster | | | Before |
| 6/13/2025 | KC | Winckowski | Demoted to reserve roster | | | Before |
| 6/13/2025 | KC | Young,Co | Promoted to active roster | | | Before |
| 6/13/2025 | NYA | Freeman,T | Signed | | | Before |
| 6/13/2025 | NYA | Martin,Ri | Signed | | | Before |
| 6/13/2025 | NYA | Richardson,L | Signed | | | Before |
| 6/13/2025 | Tam | Bohrofen | Released | | | Before |
| 6/13/2025 | Tam | Burleson | Demoted to reserve roster | | | Before |
| 6/13/2025 | Tam | Cronin,D | Promoted to active roster | | | Before |
| 6/13/2025 | Tam | Fedde | Demoted to reserve roster | | | Before |
| 6/13/2025 | Tam | Gusto | Demoted to reserve roster | | | Before |
| 6/13/2025 | Tam | Gusto | Promoted to active roster | | | Before |
| 6/13/2025 | Tam | Gusto | Demoted to reserve roster | | | Before |
| 6/13/2025 | Tam | Mazur | Demoted to reserve roster | | | Before |
| 6/13/2025 | Tam | Simpson,W | Released | | | Before |
| 6/13/2025 | Tam | Thomas,L | Promoted to active roster | | | Before |
| 6/13/2025 | Tex | Bauers | Released | | | Before |
| 6/13/2025 | Tex | Lopez,Jaco | Signed | | | Before |
| 6/13/2025 | Tex | Martinez,E | Signed | | | Before |
| 6/13/2025 | Tex | Schuemann | Released | | | Before |
| 6/15/2025 | Bal | Baz | Demoted to reserve roster | | | Before |
| 6/15/2025 | Bal | Perez,E | Promoted to active roster | | | Before |
| 6/15/2025 | NYA | Baez,Je | Traded away | NYN | | After |
| 6/15/2025 | NYA | Clifford | Traded away | NYN | | After |
| 6/15/2025 | NYA | Guerrero,L | Traded away | NYN | | After |
| 6/15/2025 | NYA | Hartwig | Acquired via trade | NYN | | After |
| 6/15/2025 | NYA | Hernandez,Da | Acquired via trade | NYN | | After |
| 6/15/2025 | NYA | Jimenez,J | Acquired via trade | NYN | | After |
| 6/15/2025 | NYA | Schneider | Traded away | NYN | | After |
| 6/15/2025 | NYA | Scott,Ch | Traded away | NYN | | After |
| 6/15/2025 | NYA | Tonkin | Acquired via trade | NYN | | After |
| 6/15/2025 | NYA | Westbrook | Acquired via trade | NYN | | After |
| 6/15/2025 | NYA | Williams,Jet | Acquired via trade | NYN | | After |
| 6/16/2025 | Cle | Margot | Released | | | Before |
| 6/16/2025 | Hou | Belgrave | Released | | | Before |
| 6/16/2025 | Hou | Bergert | Demoted to reserve roster | | | Before |
| 6/16/2025 | Hou | Hoffmann | Promoted to active roster | | | Before |
| 6/16/2025 | Hou | Marquez | Signed | | | Before |
| 6/16/2025 | Hou | Marquez | Promoted to active roster | | | Before |
| 6/16/2025 | Hou | Pecko | Promoted to active roster | | | Before |
| 6/16/2025 | Hou | Taylor,N | Demoted to reserve roster | | | Before |
| 6/16/2025 | LAA | Burke,S | Demoted to reserve roster | | | Before |
| 6/16/2025 | LAA | Burke,S | Promoted to active roster | | | Before |
| 6/16/2025 | LAA | Sabol | Demoted to reserve roster | | | Before |
| 6/16/2025 | LAA | Sanchez,G | Promoted to active roster | | | Before |
| 6/16/2025 | LAA | Senga | Demoted to reserve roster | | | Before |
| 6/16/2025 | LAA | Suarez,Jos | Promoted to active roster | | | Before |
| 6/16/2025 | NYA | Hartwig | Released | | | Before |
| 6/16/2025 | NYA | Martin,Ri | Promoted to active roster | | | Before |
| 6/16/2025 | NYA | Noel | Signed | | | Before |
| 6/16/2025 | NYA | Noel | Promoted to active roster | | | Before |
| 6/16/2025 | NYA | Richardson,L | Promoted to active roster | | | Before |
| 6/16/2025 | NYA | Wesneski | Demoted to reserve roster | | | Before |
| 6/16/2025 | NYA | Westbrook | Released | | | Before |
| 6/16/2025 | NYA | Williams,Jet | Promoted to active roster | | | Before |
| 6/16/2025 | NYA | Yarbrough | Promoted to active roster | | | Before |
| 6/16/2025 | Tex | Gimenez | Promoted to active roster | | | Before |
| 6/16/2025 | Tex | Gonsolin | Demoted to reserve roster | | | Before |
| 6/16/2025 | Tex | Hurt | Signed | | | Before |
| 6/16/2025 | Tex | Junk | Promoted to active roster | | | Before |
| 6/16/2025 | Tex | Lopez,Jaco | Promoted to active roster | | | Before |
| 6/16/2025 | Tex | Lopez,P | Demoted to reserve roster | | | Before |
| 6/16/2025 | Tex | Misiorowski | Promoted to active roster | | | Before |
| 6/16/2025 | Tex | Tawa | Demoted to reserve roster | | | Before |
| 6/17/2025 | NYA | Means | Traded away | NYN | | After |
| 6/20/2025 | Bal | Mesa | Signed | | | Before |
| 6/20/2025 | Bos | Abreu,W | Promoted to active roster | | | Before |
| 6/20/2025 | Bos | Braun | Released | | | Before |
| 6/20/2025 | Cle | Lara,L | Released | | | Before |
| 6/20/2025 | Cle | Selby | Signed | | | Before |
| 6/20/2025 | Det | Owens | Signed | | | Before |
| 6/20/2025 | Sac | Lord | Signed | | | Before |
| 6/20/2025 | Sac | Wisely | Released | | | Before |
| 6/20/2025 | Tam | Herrera,I | Demoted to reserve roster | | | Before |
| 6/20/2025 | Tam | Straw | Promoted to active roster | | | Before |
| 6/20/2025 | Tex | Ehrhard,Z | Signed | | | Before |
| 6/20/2025 | Tex | Francis | Demoted to reserve roster | | | Before |
| 6/20/2025 | Tex | Hilliard | Signed | | | Before |
| 6/20/2025 | Tex | Hilliard | Promoted to active roster | | | Before |
| 6/20/2025 | Tex | Lara,L | Signed | | | Before |
| 6/20/2025 | Tex | McCullers | Demoted to reserve roster | | | Before |
| 6/20/2025 | Tex | Tawa | Promoted to active roster | | | Before |
| 6/20/2025 | Tex | Teodo | Released | | | Before |
| 6/20/2025 | Tor | Kavadas | Released | | | Before |
| 6/20/2025 | Tor | Pinto,A | Signed | | | Before |
| 6/20/2025 | Tor | Zhong-Ao | Released | | | Before |
| 6/22/2025 | KC | Campbell,K | Traded away | Mia | | After |
| 6/22/2025 | KC | Genao | Acquired via trade | Mia | | After |
| 6/22/2025 | KC | Lee,Br | Traded away | Mia | | After |
| 6/22/2025 | KC | Mize | Acquired via trade | Mia | | After |
| 6/22/2025 | KC | Musgrove | Acquired via trade | Mia | | After |
| 6/22/2025 | KC | Yelich | Traded away | Mia | | After |
| 6/22/2025 | NYA | Lee,Br | Acquired via trade | Mia | | After |
| 6/22/2025 | NYA | Liranzo,T | Traded away | Mia | | After |
| 6/23/2025 | Bos | Rivas,Ja | Signed | | | Before |
| 6/23/2025 | KC | Winckowski | Released | | | Before |
| 6/23/2025 | LAA | Diaz,M | Signed | | | Before |
| 6/23/2025 | LAA | Diaz,M | Promoted to active roster | | | Before |
| 6/23/2025 | LAA | Doncon | Released | | | Before |
| 6/23/2025 | LAA | Henry,T | Released | | | Before |
| 6/23/2025 | LAA | Sale | Demoted to reserve roster | | | Before |
| 6/23/2025 | Min | Karinchak | Released | | | Before |
| 6/23/2025 | Min | Sandridge | Signed | | | Before |
| 6/23/2025 | NYA | de los Santos,Y | Released | | | Before |
| 6/23/2025 | NYA | Walters,A | Signed | | | Before |
| 6/23/2025 | Sea | Rutschman | Demoted to reserve roster | | | Before |
| 6/23/2025 | Sea | Sundstrom | Released | | | Before |
| 6/23/2025 | Tam | Heineman | Signed | | | Before |
| 6/23/2025 | Tex | Martinez,E | Released | | | Before |
| 6/23/2025 | Tor | Estrada,A | Signed | | | Before |
| 6/23/2025 | Tor | Pinto,A | Promoted to active roster | | | Before |
| 6/23/2025 | Tor | Swanson,E | Released | | | Before |
| 6/26/2025 | Hou | Urias,L | Acquired via trade | Mia | | After |
| 6/27/2025 | Bal | Hoeing | Signed | | | Before |
| 6/27/2025 | Bal | Hoeing | Promoted to active roster | | | Before |
| 6/27/2025 | Bal | Mesa | Released | | | Before |
| 6/27/2025 | Bal | Snelling | Demoted to reserve roster | | | Before |
| 6/27/2025 | Bos | Anderson,Ty | Released | | | Before |
| 6/27/2025 | Bos | Anderson,Ty | Signed | | | Before |
| 6/27/2025 | Bos | Bachman | Signed | | | Before |
| 6/27/2025 | Bos | Bachman | Demoted to reserve roster | | | Before |
| 6/27/2025 | Bos | Bachman | Promoted to active roster | | | Before |
| 6/27/2025 | Bos | Birdsong | Demoted to reserve roster | | | Before |
| 6/27/2025 | Bos | Birdsong | Promoted to active roster | | | Before |
| 6/27/2025 | Bos | Gibson,K | Released | | | Before |
| 6/27/2025 | Bos | Montgomery,C | Released | | | Before |
| 6/27/2025 | Bos | Riggio | Promoted to active roster | | | Before |
| 6/27/2025 | Bos | Rivas,Ja | Promoted to active roster | | | Before |
| 6/27/2025 | Bos | Tong | Demoted to reserve roster | | | Before |
| 6/27/2025 | Bos | Tong | Promoted to active roster | | | Before |
| 6/27/2025 | Cle | Alcala | Promoted to active roster | | | Before |
| 6/27/2025 | Cle | Kimbrel | Demoted to reserve roster | | | Before |
| 6/27/2025 | Cle | Pivetta | Demoted to reserve roster | | | Before |
| 6/27/2025 | Cle | Scherzer | Promoted to active roster | | | Before |
| 6/27/2025 | Cle | Stanek | Demoted to reserve roster | | | Before |
| 6/27/2025 | Cle | Westburg | Promoted to active roster | | | Before |
| 6/27/2025 | Hou | Coffey,A | Released | | | Before |
| 6/27/2025 | Hou | Pecko | Demoted to reserve roster | | | Before |
| 6/27/2025 | Hou | Urias,L | Promoted to active roster | | | Before |
| 6/27/2025 | LAA | Braun | Signed | | | Before |
| 6/27/2025 | LAA | Mateo,J | Released | | | Before |
| 6/27/2025 | NYA | Baez,L | Released | | | Before |
| 6/27/2025 | NYA | Vasquez,R | Signed | | | Before |
| 6/27/2025 | Sea | Lewis,R | Demoted to reserve roster | | | Before |
| 6/27/2025 | Sea | Vientos | Promoted to active roster | | | Before |
| 6/27/2025 | Tam | Bradford | Released | | | Before |
| 6/27/2025 | Tex | Hilliard | Released | | | Before |
| 6/27/2025 | Tex | Lauer | Signed | | | Before |
| 6/27/2025 | Tex | Montgomery,C | Signed | | | Before |
| 6/27/2025 | Tex | Tawa | Released | | | Before |
| 6/27/2025 | Tor | Anderson,Ty | Released | | | Before |
| 6/27/2025 | Tor | Anderson,Ty | Signed | | | Before |
| 6/27/2025 | Tor | Ortiz,A | Released | | | Before |
| 6/27/2025 | Tor | Winckowski | Signed | | | Before |
| 6/30/2025 | Bal | Miller,Bo | Demoted to reserve roster | | | Before |
| 6/30/2025 | NYA | Freeman,T | Promoted to active roster | | | Before |
| 6/30/2025 | NYA | Vasquez,R | Promoted to active roster | | | Before |
| 6/30/2025 | Sea | Carroll | Demoted to reserve roster | | | Before |
| 6/30/2025 | Tex | Lauer | Promoted to active roster | | | Before |
| 6/30/2025 | Tex | McCullers | Promoted to active roster | | | Before |
| 7/3/2025 | Cle | Flaherty | Traded away | Min | | After |
| 7/3/2025 | Cle | Salas,E | Acquired via trade | Min | | After |
| 7/3/2025 | Cle | Westburg | Traded away | Min | | After |
| 7/3/2025 | Cle | Wrobleski,J | Acquired via trade | Min | | After |
| 7/3/2025 | Hou | Gordon,C | Acquired via trade | Phi | | After |
| 7/3/2025 | Min | Flaherty | Acquired via trade | Cle | | After |
| 7/3/2025 | Min | Salas,E | Traded away | Cle | | After |
| 7/3/2025 | Min | Westburg | Acquired via trade | Cle | | After |
| 7/3/2025 | Min | Wrobleski,J | Traded away | Cle | | After |
| 7/4/2025 | Bal | Snelling | Promoted to active roster | | | Before |
| 7/4/2025 | Bos | Chapman,M | Promoted to active roster | | | Before |
| 7/4/2025 | Bos | Gervase | Demoted to reserve roster | | | Before |
| 7/4/2025 | Bos | Gervase | Promoted to active roster | | | Before |
| 7/4/2025 | Bos | Muncy,Max | Demoted to reserve roster | | | Before |
| 7/4/2025 | Bos | Wilken | Demoted to reserve roster | | | Before |
| 7/4/2025 | Bos | Woodruff | Promoted to active roster | | | Before |
| 7/4/2025 | Cle | Bogaerts | Demoted to reserve roster | | | Before |
| 7/4/2025 | Cle | Bogaerts | Promoted to active roster | | | Before |
| 7/4/2025 | Cle | Englert | Signed | | | Before |
| 7/4/2025 | Cle | Gillies | Signed | | | Before |
| 7/4/2025 | Cle | Kimbrel | Released | | | Before |
| 7/4/2025 | Cle | Pivetta | Promoted to active roster | | | Before |
| 7/4/2025 | Cle | Profar | Promoted to active roster | | | Before |
| 7/4/2025 | Cle | Robertson,D | Released | | | Before |
| 7/4/2025 | Cle | Wagner,W | Promoted to active roster | | | Before |
| 7/4/2025 | Det | Owens | Released | | | Before |
| 7/4/2025 | Det | Turnbull | Released | | | Before |
| 7/4/2025 | Hou | Taylor,N | Released | | | Before |
| 7/4/2025 | KC | Olson,R | Demoted to reserve roster | | | Before |
| 7/4/2025 | KC | Ornelas,T | Demoted to reserve roster | | | Before |
| 7/4/2025 | Min | Castro,M | Demoted to reserve roster | | | Before |
| 7/4/2025 | Min | Civale | Promoted to active roster | | | Before |
| 7/4/2025 | Min | Santander | Demoted to reserve roster | | | Before |
| 7/4/2025 | Sea | Alvarez,F | Demoted to reserve roster | | | Before |
| 7/4/2025 | Sea | Hassell | Promoted to active roster | | | Before |
| 7/4/2025 | Sea | Veen | Promoted to active roster | | | Before |
| 7/4/2025 | Tex | Francis | Released | | | Before |
| 7/4/2025 | Tex | Nunez,Edu | Signed | | | Before |
| 7/6/2025 | KC | Bellinger | Acquired via trade | Tor | | After |
| 7/6/2025 | KC | Evans,L | Traded away | Tor | | After |
| 7/6/2025 | KC | Stephenson,R | Acquired via trade | Tor | | After |
| 7/6/2025 | KC | Turner,Tr | Acquired via trade | Tor | | After |
| 7/6/2025 | KC | Young,Co | Traded away | Tor | | After |
| 7/6/2025 | NYA | Busch | Acquired via trade | Tor | | After |
| 7/6/2025 | NYA | Fernandez,Ya | Traded away | Tor | | After |
| 7/6/2025 | NYA | Hill,Jad | Traded away | Mia | | After |
| 7/6/2025 | NYA | Kayfus | Traded away | Tor | | After |
| 7/6/2025 | NYA | Smith,J | Acquired via trade | Tor | | After |
| 7/6/2025 | Tor | Bellinger | Traded away | KC | | After |
| 7/6/2025 | Tor | Busch | Traded away | NYA | | After |
| 7/6/2025 | Tor | Evans,L | Acquired via trade | KC | | After |
| 7/6/2025 | Tor | Fernandez,Ya | Acquired via trade | NYA | | After |
| 7/6/2025 | Tor | Kayfus | Acquired via trade | NYA | | After |
| 7/6/2025 | Tor | Megill,Tr | Traded away | Pit | | After |
| 7/6/2025 | Tor | Perales | Acquired via trade | Mia | | After |
| 7/6/2025 | Tor | Sands,C | Traded away | Mia | | After |
| 7/6/2025 | Tor | Smith,J | Traded away | NYA | | After |
| 7/6/2025 | Tor | Stephenson,R | Traded away | KC | | After |
| 7/6/2025 | Tor | Strahm,M | Traded away | Pit | | After |
| 7/6/2025 | Tor | Trout | Traded away | Pit | | After |
| 7/6/2025 | Tor | Turner,Tr | Traded away | KC | | After |
| 7/6/2025 | Tor | Young,Co | Acquired via trade | KC | | After |
| 7/7/2025 | Cle | Bogaerts | Demoted to reserve roster | | | Before |
| 7/7/2025 | Cle | Sewald | Promoted to active roster | | | Before |
| 7/7/2025 | Hou | Carpenter,K | Demoted to reserve roster | | | Before |
| 7/7/2025 | Hou | Dodd | Released | | | Before |
| 7/7/2025 | Hou | Dodd | Signed | | | Before |
| 7/7/2025 | Hou | Festa,D | Demoted to reserve roster | | | Before |
| 7/7/2025 | Hou | Gordon,C | Promoted to active roster | | | Before |
| 7/7/2025 | Hou | Neely | Released | | | Before |
| 7/7/2025 | Hou | Pecko | Promoted to active roster | | | Before |
| 7/7/2025 | Hou | Teng | Signed | | | Before |
| 7/7/2025 | Hou | Teng | Promoted to active roster | | | Before |
| 7/7/2025 | KC | Gelof,Z | Promoted to active roster | | | Before |
| 7/7/2025 | KC | Mize | Promoted to active roster | | | Before |
| 7/7/2025 | NYA | Hernandez,Da | Promoted to active roster | | | Before |
| 7/7/2025 | NYA | Paris | Promoted to active roster | | | Before |
| 7/7/2025 | NYA | Richardson,L | Released | | | Before |
| 7/7/2025 | NYA | Schmidt | Demoted to reserve roster | | | Before |
| 7/7/2025 | Tam | Burleson | Promoted to active roster | | | Before |
| 7/7/2025 | Tam | Fedde | Promoted to active roster | | | Before |
| 7/7/2025 | Tam | Heineman | Promoted to active roster | | | Before |
| 7/7/2025 | Tam | Maxwell | Demoted to reserve roster | | | Before |
| 7/7/2025 | Tam | Straw | Demoted to reserve roster | | | Before |
| 7/7/2025 | Tam | Taillon | Demoted to reserve roster | | | Before |
| 7/7/2025 | Tam | Thomas,L | Demoted to reserve roster | | | Before |
| 7/7/2025 | Tam | Weaver | Promoted to active roster | | | Before |
| 7/7/2025 | Tor | Anderson,Ty | Released | | | Before |
| 7/7/2025 | Tor | Cobb | Released | | | Before |
| 7/7/2025 | Tor | Hamilton,D | Released | | | Before |
| 7/7/2025 | Tor | Irvin,J | Released | | | Before |
| 7/10/2025 | Cle | Bleis | Traded away | Tor | | After |
| 7/10/2025 | Cle | Estevez | Acquired via trade | Tor | | After |
| 7/10/2025 | Cle | Schreiber | Acquired via trade | Tor | | After |
| 7/10/2025 | KC | Busch | Acquired via trade | NYA | | After |
| 7/10/2025 | KC | Genao | Traded away | NYA | | After |
| 7/10/2025 | KC | Hernandez,Da | Acquired via trade | NYA | | After |
| 7/10/2025 | KC | Manzardo | Traded away | NYA | | After |
| 7/10/2025 | NYA | Adell | Traded away | Tam | | After |
| 7/10/2025 | NYA | Busch | Traded away | KC | | After |
| 7/10/2025 | NYA | Genao | Acquired via trade | KC | | After |
| 7/10/2025 | NYA | Goodman | Traded away | Tam | | After |
| 7/10/2025 | NYA | Hernandez,Da | Traded away | KC | | After |
| 7/10/2025 | NYA | Jimenez,J | Traded away | Tex | | After |
| 7/10/2025 | NYA | Manzardo | Traded away | Tam | | After |
| 7/10/2025 | NYA | Manzardo | Acquired via trade | KC | | After |
| 7/10/2025 | NYA | Marte,N | Acquired via trade | Tam | | After |
| 7/10/2025 | NYA | Martinez,Ju | Acquired via trade | Tex | | After |
| 7/10/2025 | NYA | Montgomery,C | Acquired via trade | Tex | | After |
| 7/10/2025 | NYA | Smith,J | Traded away | Tex | | After |
| 7/10/2025 | Tam | Adell | Acquired via trade | NYA | | After |
| 7/10/2025 | Tam | Goodman | Acquired via trade | NYA | | After |
| 7/10/2025 | Tam | Manzardo | Acquired via trade | NYA | | After |
| 7/10/2025 | Tam | Marte,N | Traded away | NYA | | After |
| 7/10/2025 | Tex | Jimenez,J | Acquired via trade | NYA | | After |
| 7/10/2025 | Tex | Martinez,Ju | Traded away | NYA | | After |
| 7/10/2025 | Tex | Montgomery,C | Traded away | NYA | | After |
| 7/10/2025 | Tex | Smith,J | Acquired via trade | NYA | | After |
| 7/10/2025 | Tor | Berrios | Traded away | Pit | | After |
| 7/10/2025 | Tor | Bleis | Acquired via trade | Cle | | After |
| 7/10/2025 | Tor | Estevez | Traded away | Cle | | After |
| 7/10/2025 | Tor | Sabrowski | Traded away | Pit | | After |
| 7/10/2025 | Tor | Schreiber | Traded away | Cle | | After |
| 7/10/2025 | Tor | Steer | Traded away | Pit | | After |
| 7/10/2025 | Tor | Thomas,Col | Acquired via trade | Pit | | After |
| 7/10/2025 | Tor | Wacha | Traded away | Pit | | After |
| 7/11/2025 | Bal | Pauley | Signed | | | Before |
| 7/11/2025 | Bos | Rivas,Ja | Demoted to reserve roster | | | Before |
| 7/11/2025 | Bos | Yoshida | Promoted to active roster | | | Before |
| 7/11/2025 | Cle | Gillies | Released | | | Before |
| 7/11/2025 | LAA | Mikolas | Released | | | Before |
| 7/11/2025 | NYA | Fluharty | Signed | | | Before |
| 7/11/2025 | NYA | Tonkin | Promoted to active roster | | | Before |
| 7/11/2025 | Sea | Alderman | Signed | | | Before |
| 7/11/2025 | Sea | Alvarez,F | Promoted to active roster | | | Before |
| 7/11/2025 | Sea | Ashby | Demoted to reserve roster | | | Before |
| 7/11/2025 | Sea | Carroll | Promoted to active roster | | | Before |
| 7/11/2025 | Sea | Cole,Z | Signed | | | Before |
| 7/11/2025 | Sea | Cole,Z | Demoted to reserve roster | | | Before |
| 7/11/2025 | Sea | Cole,Z | Promoted to active roster | | | Before |
| 7/11/2025 | Sea | Fluharty | Released | | | Before |
| 7/11/2025 | Sea | Glasnow | Promoted to active roster | | | Before |
| 7/11/2025 | Sea | Hassell | Demoted to reserve roster | | | Before |
| 7/11/2025 | Sea | Isaac | Demoted to reserve roster | | | Before |
| 7/11/2025 | Sea | Lewis,R | Promoted to active roster | | | Before |
| 7/11/2025 | Sea | Orze | Signed | | | Before |
| 7/11/2025 | Sea | Orze | Promoted to active roster | | | Before |
| 7/11/2025 | Tam | Burleson | Demoted to reserve roster | | | Before |
| 7/11/2025 | Tam | Fedde | Demoted to reserve roster | | | Before |
| 7/11/2025 | Tam | Heineman | Released | | | Before |
| 7/11/2025 | Tam | Irvin,J | Signed | | | Before |
| 7/11/2025 | Tam | Irvin,J | Promoted to active roster | | | Before |
| 7/11/2025 | Tam | Marsh,A | Released | | | Before |
| 7/11/2025 | Tam | Stowers | Demoted to reserve roster | | | Before |
| 7/11/2025 | Tex | Bouchard | Signed | | | Before |
| 7/11/2025 | Tex | Bouchard | Promoted to active roster | | | Before |
| 7/11/2025 | Tex | Gimenez | Demoted to reserve roster | | | Before |
| 7/11/2025 | Tex | Kolek | Released | | | Before |
| 7/11/2025 | Tex | Nunez,Edu | Released | | | Before |
| 7/11/2025 | Tex | Rojas,Joh | Demoted to reserve roster | | | Before |
| 7/11/2025 | Tex | Rojas,Joh | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Areinamo | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Bellozo | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Bleis | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Cabrera,Jea | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Estrada,A | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Evans,L | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Fernandez,Ya | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Henry,C | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Jordan,B | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Miller,E | Demoted to reserve roster | | | Before |
| 7/11/2025 | Tor | Pereda | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Thomas,Col | Promoted to active roster | | | Before |
| 7/11/2025 | Tor | Weston | Promoted to active roster | | | Before |
| 7/12/2025 | Hou | Cruz,F | Demoted to reserve roster | | | Before |
| 7/12/2025 | Hou | Urias,L | Demoted to reserve roster | | | Before |
| 7/12/2025 | Hou | Zastryzny | Demoted to reserve roster | | | Before |
| 7/13/2025 | Cle | Fitzgerald,T | Acquired via trade | Tex | | After |
| 7/13/2025 | Cle | Stanek | Traded away | Tex | | After |
| 7/13/2025 | Hou | Bieber | Acquired via trade | Tor | | After |
| 7/13/2025 | Hou | Lodolo | Traded away | Tam | | After |
| 7/13/2025 | Hou | Stowers | Acquired via trade | Tam | | After |
| 7/13/2025 | Min | Eovaldi | Acquired via trade | Sac | | After |
| 7/13/2025 | NYA | Beck,J | Acquired via trade | StL | | After |
| 7/13/2025 | NYA | Boeve | Traded away | StL | | After |
| 7/13/2025 | Sac | Bummer | Traded away | Pit | | After |
| 7/13/2025 | Sac | Eovaldi | Traded away | Min | | After |
| 7/13/2025 | Sac | Fermin,F | Traded away | Pit | | After |
| 7/13/2025 | Tam | Lodolo | Acquired via trade | Hou | | After |
| 7/13/2025 | Tam | Stowers | Traded away | Hou | | After |
| 7/13/2025 | Tam | Thielbar | Acquired via trade | Pit | | After |
| 7/13/2025 | Tex | Fitzgerald,T | Traded away | Cle | | After |
| 7/13/2025 | Tex | Stanek | Acquired via trade | Cle | | After |
| 7/13/2025 | Tor | Bieber | Traded away | Hou | | After |
| 7/18/2025 | Bos | Bachman | Released | | | Before |
| 7/18/2025 | Bos | Birdsong | Demoted to reserve roster | | | Before |
| 7/18/2025 | Bos | Birdsong | Promoted to active roster | | | Before |
| 7/18/2025 | Bos | Birdsong | Promoted to active roster | | | Before |
| 7/18/2025 | Bos | Francis | Signed | | | Before |
| 7/18/2025 | Bos | Gervase | Released | | | Before |
| 7/18/2025 | Bos | Guzman,D | Signed | | | Before |
| 7/18/2025 | Bos | Guzman,D | Demoted to reserve roster | | | Before |
| 7/18/2025 | Bos | Guzman,D | Promoted to active roster | | | Before |
| 7/18/2025 | Bos | Okert | Demoted to reserve roster | | | Before |
| 7/18/2025 | Bos | Okert | Promoted to active roster | | | Before |
| 7/18/2025 | Bos | Rivas,Ja | Promoted to active roster | | | Before |
| 7/18/2025 | Bos | Thompson,Ry | Demoted to reserve roster | | | Before |
| 7/18/2025 | Bos | Tong | Demoted to reserve roster | | | Before |
| 7/18/2025 | Bos | Tong | Promoted to active roster | | | Before |
| 7/18/2025 | Hou | Bergert | Promoted to active roster | | | Before |
| 7/18/2025 | Hou | Festa,D | Promoted to active roster | | | Before |
| 7/18/2025 | Hou | Norby | Demoted to reserve roster | | | Before |
| 7/18/2025 | Hou | Riley,A | Demoted to reserve roster | | | Before |
| 7/18/2025 | Hou | Stowers | Promoted to active roster | | | Before |
| 7/18/2025 | Hou | Urias,L | Promoted to active roster | | | Before |
| 7/18/2025 | Hou | Zastryzny | Released | | | Before |
| 7/18/2025 | LAA | Sanchez,G | Released | | | Before |
| 7/18/2025 | Min | Antunez | Released | | | Before |
| 7/18/2025 | Sac | Bregman | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | Curet | Demoted to reserve roster | | | Before |
| 7/18/2025 | Sac | Curet | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | Curet | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | Hernaiz | Demoted to reserve roster | | | Before |
| 7/18/2025 | Sac | Hernaiz | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | Hoglund | Demoted to reserve roster | | | Before |
| 7/18/2025 | Sac | Lord | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | MacIver | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | Marte,S | Demoted to reserve roster | | | Before |
| 7/18/2025 | Sac | Nankil | Signed | | | Before |
| 7/18/2025 | Sac | Nankil | Promoted to active roster | | | Before |
| 7/18/2025 | Sac | Reyzelman | Promoted to active roster | | | Before |
| 7/18/2025 | Sea | Cole,Z | Released | | | Before |
| 7/18/2025 | Sea | Jimenez,E | Released | | | Before |
| 7/18/2025 | Sea | Roccaforte | Signed | | | Before |
| 7/18/2025 | Sea | Watson,K | Signed | | | Before |
| 7/18/2025 | Tam | Cronin,D | Demoted to reserve roster | | | Before |
| 7/18/2025 | Tam | Herrera,I | Promoted to active roster | | | Before |
| 7/18/2025 | Tam | Irvin,J | Released | | | Before |
| 7/18/2025 | Tam | Irvin,J | Demoted to reserve roster | | | Before |
| 7/18/2025 | Tam | Pages,P | Demoted to reserve roster | | | Before |
| 7/18/2025 | Tam | Thielbar | Released | | | Before |
| 7/18/2025 | Tex | Nunez,De | Demoted to reserve roster | | | Before |
| 7/18/2025 | Tex | Stanek | Promoted to active roster | | | Before |
| 7/18/2025 | Tex | Thielbar | Signed | | | Before |
| 7/18/2025 | Tor | Bachman | Signed | | | Before |
| 7/21/2025 | Bos | Francis | Released | | | Before |
| 7/21/2025 | Bos | Sosa,T | Signed | | | Before |
| 7/21/2025 | Tam | Burleson | Promoted to active roster | | | Before |
| 7/21/2025 | Tam | Gorman | Demoted to reserve roster | | | Before |
| 7/23/2025 | ChA | Keaschall | Demoted to reserve roster | | | Before |
| 7/23/2025 | Tor | Bachman | Promoted to active roster | | | Before |
| 7/23/2025 | Tor | Eflin | Demoted to reserve roster | | | Before |
| 7/24/2025 | Tor | Baez,H | Acquired via trade | Phi | | After |
| 7/24/2025 | Tor | Bernardino | Traded away | Phi | | After |
| 7/24/2025 | Tor | Eflin | Traded away | Phi | | After |
| 7/24/2025 | Tor | Lukes | Traded away | Phi | | After |
| 7/24/2025 | Tor | Suarez,E | Traded away | Phi | | After |
| 7/24/2025 | Tor | Wong,C | Traded away | Mia | | After |
| 7/25/2025 | Cle | Bogaerts | Promoted to active roster | | | Before |
| 7/25/2025 | Cle | Paredes,I | Demoted to reserve roster | | | Before |
| 7/25/2025 | Cle | Selby | Promoted to active roster | | | Before |
| 7/25/2025 | Cle | Sewald | Demoted to reserve roster | | | Before |
| 7/25/2025 | LAA | Sabol | Promoted to active roster | | | Before |
| 7/25/2025 | LAA | Senga | Promoted to active roster | | | Before |
| 7/25/2025 | LAA | Suarez,Jos | Demoted to reserve roster | | | Before |
| 7/25/2025 | Min | Fedko | Released | | | Before |
| 7/25/2025 | Min | Moniak | Signed | | | Before |
| 7/25/2025 | Sac | Devanney | Signed | | | Before |
| 7/25/2025 | Sea | Garcia,Br | Signed | | | Before |
| 7/25/2025 | Sea | Mayer | Demoted to reserve roster | | | Before |
| 7/25/2025 | Sea | Roccaforte | Released | | | Before |
| 7/25/2025 | Sea | Tovar | Promoted to active roster | | | Before |
| 7/25/2025 | Tam | Fedde | Released | | | Before |
| 7/25/2025 | Tor | Baez,H | Promoted to active roster | | | Before |
| 7/25/2025 | Tor | Irvin,C | Signed | | | Before |
| 7/25/2025 | Tor | Irvin,J | Signed | | | Before |
| 7/25/2025 | Tor | Mikolas | Signed | | | Before |
| 7/25/2025 | Tor | Rodriguez,CF | Signed | | | Before |
| 7/25/2025 | Tor | Wade,L | Released | | | Before |
| 7/27/2025 | Cle | Soler | Acquired via trade | Tor | | After |
| 7/27/2025 | Tor | Soler | Traded away | Cle | | After |
| 7/28/2025 | Bos | Quijada | Signed | | | Before |
| 7/28/2025 | Bos | Quijada | Promoted to active roster | | | Before |
| 7/28/2025 | Bos | Rivas,Ja | Released | | | Before |
| 7/28/2025 | ChA | Chavez,J | Released | | | Before |
| 7/28/2025 | Cle | Bogaerts | Demoted to reserve roster | | | Before |
| 7/28/2025 | Cle | Bogaerts | Promoted to active roster | | | Before |
| 7/28/2025 | Cle | Freeland,A | Demoted to reserve roster | | | Before |
| 7/28/2025 | Cle | Rock,J | Demoted to reserve roster | | | Before |
| 7/28/2025 | Cle | Selby | Demoted to reserve roster | | | Before |
| 7/28/2025 | Cle | Soler | Demoted to reserve roster | | | Before |
| 7/28/2025 | Hou | Carpenter,K | Promoted to active roster | | | Before |
| 7/28/2025 | Hou | Festa,D | Demoted to reserve roster | | | Before |
| 7/28/2025 | Hou | Harvey | Promoted to active roster | | | Before |
| 7/28/2025 | Hou | Marquez | Demoted to reserve roster | | | Before |
| 7/28/2025 | Hou | Riley,A | Promoted to active roster | | | Before |
| 7/28/2025 | KC | Del Castillo | Promoted to active roster | | | Before |
| 7/28/2025 | KC | Holman | Demoted to reserve roster | | | Before |
| 7/28/2025 | KC | Littell | Demoted to reserve roster | | | Before |
| 7/28/2025 | KC | Olson,R | Promoted to active roster | | | Before |
| 7/28/2025 | NYA | Martin,Ri | Released | | | Before |
| 7/28/2025 | NYA | Tonkin | Released | | | Before |
| 7/28/2025 | Sac | Gray,Jon | Promoted to active roster | | | Before |
| 7/28/2025 | Sac | Nankil | Demoted to reserve roster | | | Before |
| 7/28/2025 | Sac | Perkins,B | Promoted to active roster | | | Before |
| 7/28/2025 | Sac | Roby,T | Demoted to reserve roster | | | Before |
| 7/28/2025 | Tam | Gusto | Promoted to active roster | | | Before |
| 7/28/2025 | Tam | Mazur | Demoted to reserve roster | | | Before |
| 7/28/2025 | Tam | Mazur | Promoted to active roster | | | Before |
| 7/28/2025 | Tex | Ehrhard,Z | Released | | | Before |
| 7/28/2025 | Tex | Lara,L | Promoted to active roster | | | Before |
| 7/28/2025 | Tex | McCullers | Demoted to reserve roster | | | Before |
| 7/28/2025 | Tor | Ruiz,K | Signed | | | Before |
| 7/28/2025 | Tor | Ruiz,K | Demoted to reserve roster | | | Before |
| 7/29/2025 | KC | Beavers | Traded away | Tor | | After |
| 7/29/2025 | Tor | Beavers | Acquired via trade | KC | | After |
| 7/31/2025 | Min | Ginkel | Acquired via trade | Cin | | After |
| 8/1/2025 | Bal | Bernabel | Signed | | | Before |
| 8/1/2025 | Cle | Jackson,A | Signed | | | Before |
| 8/1/2025 | Cle | Lee,K | Released | | | Before |
| 8/1/2025 | Hou | Pearson | Signed | | | Before |
| 8/1/2025 | KC | Burr | Released | | | Before |
| 8/1/2025 | KC | Coffey,I | Released | | | Before |
| 8/1/2025 | KC | Ohl | Signed | | | Before |
| 8/1/2025 | LAA | Judge | Demoted to reserve roster | | | Before |
| 8/1/2025 | LAA | Outman | Promoted to active roster | | | Before |
| 8/1/2025 | Min | Civale | Demoted to reserve roster | | | Before |
| 8/1/2025 | Sea | Clase,E | Demoted to reserve roster | | | Before |
| 8/1/2025 | Sea | Rutschman | Promoted to active roster | | | Before |
| 8/1/2025 | Tam | Lorenzen | Demoted to reserve roster | | | Before |
| 8/1/2025 | Tam | Wicks | Promoted to active roster | | | Before |
| 8/1/2025 | Tex | Tate | Signed | | | Before |
| 8/1/2025 | Tor | Beavers | Promoted to active roster | | | Before |
| 8/1/2025 | Tor | Ruiz,K | Promoted to active roster | | | Before |
| 8/3/2025 | Cle | Baez,Je | Acquired via trade | NYN | | After |
| 8/3/2025 | Cle | Diaz,Yai | Acquired via trade | Ari | | After |
| 8/3/2025 | Cle | Freeland,A | Traded away | Ari | | After |
| 8/3/2025 | Cle | Freeman,F | Traded away | NYN | | After |
| 8/3/2025 | Cle | Iglesias,R | Traded away | NYN | | After |
| 8/3/2025 | Cle | Morel,C | Acquired via trade | Ari | | After |
| 8/3/2025 | Cle | O'Hoppe | Traded away | NYN | | After |
| 8/3/2025 | Cle | Perez,S | Acquired via trade | NYN | | After |
| 8/3/2025 | Cle | Ramirez,Jo | Acquired via trade | NYN | | After |
| 8/3/2025 | Cle | Taylor,Br | Traded away | NYN | | After |
| 8/4/2025 | Bos | Muncy,Max | Promoted to active roster | | | Before |
| 8/4/2025 | Bos | Riggio | Demoted to reserve roster | | | Before |
| 8/4/2025 | Cle | Bogaerts | Demoted to reserve roster | | | Before |
| 8/4/2025 | Hou | Pearson | Promoted to active roster | | | Before |
| 8/4/2025 | KC | Olson,R | Demoted to reserve roster | | | Before |
| 8/4/2025 | Sea | Ashby | Promoted to active roster | | | Before |
| 8/4/2025 | Sea | Carter | Demoted to reserve roster | | | Before |
| 8/4/2025 | Tam | Mazur | Promoted to active roster | | | Before |
| 8/4/2025 | Tam | Wicks | Demoted to reserve roster | | | Before |
| 8/4/2025 | Tex | Bubic | Demoted to reserve roster | | | Before |
| 8/4/2025 | Tex | Chourio | Demoted to reserve roster | | | Before |
| 8/4/2025 | Tex | De Paula,J | Promoted to active roster | | | Before |
| 8/4/2025 | Tex | Misiorowski | Demoted to reserve roster | | | Before |
| 8/4/2025 | Tex | Tate | Promoted to active roster | | | Before |
| 8/4/2025 | Tex | Wade,L | Signed | | | Before |
| 8/4/2025 | Tex | Wade,L | Promoted to active roster | | | Before |
| 8/7/2025 | Cle | Bradley,T | Traded away | Atl | | After |
| 8/7/2025 | Cle | Casas | Acquired via trade | Atl | | After |
| 8/7/2025 | Cle | Harrison,Ky | Acquired via trade | Atl | | After |
| 8/7/2025 | Cle | Miller,Br | Acquired via trade | Atl | | After |
| 8/7/2025 | Cle | Rojas,Je | Traded away | Atl | | After |
| 8/7/2025 | Cle | Wrobleski,J | Traded away | Atl | | After |
| 8/7/2025 | NYA | Gil,L | Traded away | SD | | After |
| 8/7/2025 | NYA | Montgomery,C | Traded away | SD | | After |
| 8/7/2025 | NYA | Schlittler | Acquired via trade | SD | | After |
| 8/8/2025 | Bos | Cobb | Signed | | | Before |
| 8/8/2025 | Bos | Ehrhard,Z | Signed | | | Before |
| 8/8/2025 | Bos | Peck | Released | | | Before |
| 8/8/2025 | Bos | Peck | Signed | | | Before |
| 8/8/2025 | Bos | Quijada | Released | | | Before |
| 8/8/2025 | Bos | Schnell | Released | | | Before |
| 8/8/2025 | Bos | Schnell | Signed | | | Before |
| 8/8/2025 | Bos | Sosa,T | Released | | | Before |
| 8/8/2025 | KC | Whisenhunt | Promoted to active roster | | | Before |
| 8/8/2025 | Sac | Cabbage | Released | | | Before |
| 8/8/2025 | Sac | Jebb | Signed | | | Before |
| 8/8/2025 | Sac | Kahnle | Released | | | Before |
| 8/8/2025 | Sac | Roberts,E | Released | | | Before |
| 8/8/2025 | Sac | Teodosio | Signed | | | Before |
| 8/8/2025 | Sea | Freeman,Co | Signed | | | Before |
| 8/8/2025 | Sea | Garcia,Br | Released | | | Before |
| 8/8/2025 | Tam | Cruz,S | Released | | | Before |
| 8/8/2025 | Tam | Garcia,Br | Signed | | | Before |
| 8/8/2025 | Tam | Gorman | Promoted to active roster | | | Before |
| 8/8/2025 | Tam | Gusto | Demoted to reserve roster | | | Before |
| 8/8/2025 | Tam | Gusto | Promoted to active roster | | | Before |
| 8/8/2025 | Tam | Gusto | Demoted to reserve roster | | | Before |
| 8/8/2025 | Tam | King,M | Promoted to active roster | | | Before |
| 8/8/2025 | Tam | Lodolo | Demoted to reserve roster | | | Before |
| 8/11/2025 | Cle | Kiner-Falefa | Signed | | | Before |
| 8/11/2025 | Hou | Halvorsen | Demoted to reserve roster | | | Before |
| 8/11/2025 | Hou | Riley,A | Demoted to reserve roster | | | Before |
| 8/11/2025 | Hou | Rosario,A | Demoted to reserve roster | | | Before |
| 8/11/2025 | KC | Santa | Signed | | | Before |
| 8/11/2025 | LAA | Andujar | Promoted to active roster | | | Before |
| 8/11/2025 | LAA | Arenado | Demoted to reserve roster | | | Before |
| 8/11/2025 | LAA | Candelario | Promoted to active roster | | | Before |
| 8/11/2025 | LAA | Springer | Demoted to reserve roster | | | Before |
| 8/11/2025 | Sea | Ashby | Demoted to reserve roster | | | Before |
| 8/11/2025 | Sea | Freeman,Co | Promoted to active roster | | | Before |
| 8/11/2025 | Sea | Roccaforte | Signed | | | Before |
| 8/11/2025 | Sea | Rosario,K | Signed | | | Before |
| 8/11/2025 | Sea | Watson,K | Released | | | Before |
| 8/11/2025 | Tex | McGee | Signed | | | Before |
| 8/11/2025 | Tex | McGee | Promoted to active roster | | | Before |
| 8/11/2025 | Tex | Mendez | Promoted to active roster | | | Before |
| 8/11/2025 | Tex | Severino,L | Demoted to reserve roster | | | Before |
| 8/11/2025 | Tex | Wade,L | Released | | | Before |
| 8/11/2025 | Tor | Ortiz,A | Signed | | | Before |
| 8/14/2025 | Cle | Campbell,K | Acquired via trade | Mia | | After |
| 8/14/2025 | Cle | Crews | Acquired via trade | Col | | After |
| 8/14/2025 | Cle | DeLauter | Acquired via trade | Col | | After |
| 8/14/2025 | Cle | Detmers | Traded away | Mia | | After |
| 8/14/2025 | Cle | Edman | Traded away | Hou | | After |
| 8/14/2025 | Cle | Estevez | Traded away | Col | | After |
| 8/14/2025 | Cle | Herrin | Acquired via trade | Col | | After |
| 8/14/2025 | Cle | Kwan | Traded away | Col | | After |
| 8/14/2025 | Cle | Larnach | Acquired via trade | Hou | | After |
| 8/14/2025 | Cle | Naylor,B | Traded away | Mia | | After |
| 8/14/2025 | Cle | Paredes,I | Traded away | Mia | | After |
| 8/14/2025 | Cle | Santos,W | Acquired via trade | Col | | After |
| 8/14/2025 | Cle | Schreiber | Traded away | Col | | After |
| 8/14/2025 | Hou | Edman | Acquired via trade | Cle | | After |
| 8/14/2025 | Hou | Larnach | Traded away | Cle | | After |
| 8/15/2025 | Bos | Riggio | Released | | | Before |
| 8/15/2025 | Cle | Crews | Promoted to active roster | | | Before |
| 8/15/2025 | Cle | Jackson,A | Released | | | Before |
| 8/15/2025 | Cle | Kiner-Falefa | Promoted to active roster | | | Before |
| 8/15/2025 | Cle | Selby | Released | | | Before |
| 8/15/2025 | Hou | Leiter,M | Signed | | | Before |
| 8/15/2025 | Hou | Quijada | Signed | | | Before |
| 8/15/2025 | KC | Murphy,Sh | Signed | | | Before |
| 8/15/2025 | LAA | Kelenic | Signed | | | Before |
| 8/15/2025 | Min | Graceffo | Demoted to reserve roster | | | Before |
| 8/15/2025 | Min | Javier | Promoted to active roster | | | Before |
| 8/15/2025 | NYA | Headrick | Signed | | | Before |
| 8/15/2025 | Tam | Lorenzen | Released | | | Before |
| 8/15/2025 | Tam | Santana,Ca | Released | | | Before |
| 8/15/2025 | Tex | Gonsolin | Released | | | Before |
| 8/18/2025 | Bal | Jackson,L | Demoted to reserve roster | | | Before |
| 8/18/2025 | Bal | Snelling | Promoted to active roster | | | Before |
| 8/18/2025 | Bos | Ehrhard,Z | Promoted to active roster | | | Before |
| 8/18/2025 | Bos | Guzman,D | Promoted to active roster | | | Before |
| 8/18/2025 | Bos | Muncy,Max | Demoted to reserve roster | | | Before |
| 8/18/2025 | Cle | Harris,Ha | Signed | | | Before |
| 8/18/2025 | Cle | Harris,Ha | Promoted to active roster | | | Before |
| 8/18/2025 | Cle | Kiner-Falefa | Demoted to reserve roster | | | Before |
| 8/18/2025 | Cle | Oviedo,J | Promoted to active roster | | | Before |
| 8/18/2025 | Cle | Pivetta | Demoted to reserve roster | | | Before |
| 8/18/2025 | Hou | Edman | Demoted to reserve roster | | | Before |
| 8/18/2025 | Hou | Harvey | Demoted to reserve roster | | | Before |
| 8/18/2025 | Hou | Leiter,M | Promoted to active roster | | | Before |
| 8/18/2025 | Hou | Quijada | Promoted to active roster | | | Before |
| 8/18/2025 | Hou | Stowers | Demoted to reserve roster | | | Before |
| 8/18/2025 | LAA | Candelario | Demoted to reserve roster | | | Before |
| 8/18/2025 | LAA | Canzone | Demoted to reserve roster | | | Before |
| 8/18/2025 | LAA | Judge | Promoted to active roster | | | Before |
| 8/18/2025 | LAA | Springer | Promoted to active roster | | | Before |
| 8/18/2025 | Min | Graceffo | Promoted to active roster | | | Before |
| 8/18/2025 | Min | Yates | Demoted to reserve roster | | | Before |
| 8/18/2025 | Sea | Cruz,On | Demoted to reserve roster | | | Before |
| 8/18/2025 | Sea | Rosario,K | Promoted to active roster | | | Before |
| 8/18/2025 | Tam | Cronin,D | Promoted to active roster | | | Before |
| 8/18/2025 | Tam | Hader | Demoted to reserve roster | | | Before |
| 8/18/2025 | Tam | King,M | Demoted to reserve roster | | | Before |
| 8/18/2025 | Tam | Maxwell | Promoted to active roster | | | Before |
| 8/18/2025 | Tam | Taillon | Promoted to active roster | | | Before |
| 8/18/2025 | Tam | Wicks | Demoted to reserve roster | | | Before |
| 8/18/2025 | Tam | Wicks | Promoted to active roster | | | Before |
| 8/18/2025 | Tex | Gimenez | Promoted to active roster | | | Before |
| 8/18/2025 | Tex | Lowe,N | Demoted to reserve roster | | | Before |
| 8/18/2025 | Tex | Misiorowski | Promoted to active roster | | | Before |
| 8/18/2025 | Tex | Stewart,B | Demoted to reserve roster | | | Before |
| 8/20/2025 | NYA | Emerson | Signed | | | Before |
| 8/20/2025 | NYA | Janek | Signed | | | Before |
| 8/20/2025 | NYA | Schlittler | Promoted to active roster | | | Before |
| 8/21/2025 | Hou | Laureano | Acquired via trade | Mia | | After |
| 8/21/2025 | Hou | Olson,M | Traded away | Mia | | After |
| 8/21/2025 | LAA | Hicks,L | Acquired via trade | Mia | | After |
| 8/21/2025 | NYA | Genao | Traded away | Mia | | After |
| 8/21/2025 | NYA | Roupp | Traded away | Tam | | After |
| 8/21/2025 | Tam | Roupp | Acquired via trade | NYA | | After |
| 8/22/2025 | Bal | Bernabel | Promoted to active roster | | | Before |
| 8/22/2025 | Bal | Bolte | Promoted to active roster | | | Before |
| 8/22/2025 | Bal | Kjerstad | Demoted to reserve roster | | | Before |
| 8/22/2025 | Bal | Snelling | Promoted to active roster | | | Before |
| 8/22/2025 | Cle | Harris,Ha | Demoted to reserve roster | | | Before |
| 8/22/2025 | Cle | Harrison,Ky | Demoted to reserve roster | | | Before |
| 8/22/2025 | Cle | Miller,Br | Promoted to active roster | | | Before |
| 8/22/2025 | Cle | Pivetta | Promoted to active roster | | | Before |
| 8/22/2025 | Cle | Valera,G | Signed | | | Before |
| 8/22/2025 | Cle | Matthews,B | Traded away | Atl | | After |
| 8/22/2025 | Hou | Diaz,Yi | Released | | | Before |
| 8/22/2025 | KC | France,JP | Promoted to active roster | | | Before |
| 8/22/2025 | KC | King,Jo | Demoted to reserve roster | | | Before |
| 8/22/2025 | KC | Stephenson,R | Promoted to active roster | | | Before |
| 8/22/2025 | LAA | Jackson,A | Signed | | | Before |
| 8/22/2025 | LAA | Montas | Released | | | Before |
| 8/22/2025 | LAA | Seymour,C | Released | | | Before |
| 8/22/2025 | NYA | Elko | Signed | | | Before |
| 8/22/2025 | NYA | Elko | Promoted to active roster | | | Before |
| 8/22/2025 | NYA | Emerson | Promoted to active roster | | | Before |
| 8/22/2025 | NYA | Fabian,J | Released | | | Before |
| 8/22/2025 | NYA | Marte,N | Promoted to active roster | | | Before |
| 8/22/2025 | Tex | Alvarado,E | Signed | | | Before |
| 8/22/2025 | Tex | Lowe,N | Promoted to active roster | | | Before |
| 8/22/2025 | Tex | McCullers | Promoted to active roster | | | Before |
| 8/22/2025 | Tex | Nunez,De | Released | | | Before |
| 8/22/2025 | Tex | Tate | Released | | | Before |
| 8/24/2025 | KC | Bellinger | Traded away | Min | | After |
| 8/24/2025 | KC | Garcia,LA | Traded away | Min | | After |
| 8/24/2025 | KC | Littell | Traded away | Min | | After |
| 8/24/2025 | KC | Pages,A | Acquired via trade | Min | | After |
| 8/24/2025 | LAA | Braun | Traded away | NYA | | After |
| 8/24/2025 | LAA | Robles,V | Acquired via trade | NYA | | After |
| 8/24/2025 | LAA | Volpe | Acquired via trade | NYA | | After |
| 8/24/2025 | Min | Bellinger | Acquired via trade | KC | | After |
| 8/24/2025 | Min | Garcia,LA | Acquired via trade | KC | | After |
| 8/24/2025 | Min | Littell | Acquired via trade | KC | | After |
| 8/24/2025 | Min | Milner | Acquired via trade | Cin | | After |
| 8/24/2025 | Min | Morris,A | Traded away | Cin | | After |
| 8/24/2025 | Min | Pages,A | Traded away | KC | | After |
| 8/24/2025 | NYA | Beck,J | Traded away | Atl | | After |
| 8/24/2025 | NYA | Braun | Acquired via trade | LAA | | After |
| 8/24/2025 | NYA | Robles,V | Traded away | LAA | | After |
| 8/24/2025 | NYA | Volpe | Traded away | LAA | | After |
| 8/25/2025 | Bal | Bradish | Promoted to active roster | | | Before |
| 8/25/2025 | Bal | Snelling | Demoted to reserve roster | | | Before |
| 8/25/2025 | Bos | Abreu,W | Demoted to reserve roster | | | Before |
| 8/25/2025 | Bos | Tong | Promoted to active roster | | | Before |
| 8/25/2025 | Cle | Pivetta | Demoted to reserve roster | | | Before |
| 8/25/2025 | Cle | Rock,J | Promoted to active roster | | | Before |
| 8/25/2025 | Hou | Bieber | Promoted to active roster | | | Before |
| 8/25/2025 | Hou | Rosario,A | Promoted to active roster | | | Before |
| 8/25/2025 | LAA | Burke,S | Promoted to active roster | | | Before |
| 8/25/2025 | LAA | Fontenelle | Released | | | Before |
| 8/25/2025 | LAA | France,T | Demoted to reserve roster | | | Before |
| 8/25/2025 | LAA | Garver | Demoted to reserve roster | | | Before |
| 8/25/2025 | LAA | Jackson,A | Promoted to active roster | | | Before |
| 8/25/2025 | LAA | Outman | Demoted to reserve roster | | | Before |
| 8/25/2025 | LAA | Robles,V | Promoted to active roster | | | Before |
| 8/25/2025 | LAA | Suarez,Jos | Released | | | Before |
| 8/25/2025 | Min | Arcia | Released | | | Before |
| 8/25/2025 | Min | Berti | Released | | | Before |
| 8/25/2025 | Min | Ginkel | Demoted to reserve roster | | | Before |
| 8/25/2025 | Min | Graceffo | Demoted to reserve roster | | | Before |
| 8/25/2025 | Min | Littell | Promoted to active roster | | | Before |
| 8/25/2025 | Min | Pallante | Demoted to reserve roster | | | Before |
| 8/25/2025 | Min | Sandridge | Released | | | Before |
| 8/25/2025 | NYA | Braun | Promoted to active roster | | | Before |
| 8/25/2025 | NYA | Seymour,C | Signed | | | Before |
| 8/25/2025 | NYA | Tonkin | Signed | | | Before |
| 8/25/2025 | Sac | Canha | Demoted to reserve roster | | | Before |
| 8/25/2025 | Sac | Devanney | Promoted to active roster | | | Before |
| 8/25/2025 | Sac | Gray,Jon | Demoted to reserve roster | | | Before |
| 8/25/2025 | Sac | Marte,S | Promoted to active roster | | | Before |
| 8/25/2025 | Sac | Refsnyder | Demoted to reserve roster | | | Before |
| 8/25/2025 | Sea | Alvarez,F | Demoted to reserve roster | | | Before |
| 8/25/2025 | Sea | Ashby | Promoted to active roster | | | Before |
| 8/25/2025 | Sea | Harrington | Demoted to reserve roster | | | Before |
| 8/25/2025 | Sea | Rutschman | Demoted to reserve roster | | | Before |
| 8/28/2025 | Cle | Harris,Ha | Traded away | KC | | After |
| 8/28/2025 | Cle | Stephenson,R | Acquired via trade | KC | | After |
| 8/28/2025 | KC | Harris,Ha | Acquired via trade | Cle | | After |
| 8/28/2025 | KC | Stephenson,R | Traded away | Cle | | After |
| 8/28/2025 | NYA | Toglia | Acquired via trade | Sea | | After |
| 8/28/2025 | Sea | Thomas,Al | Traded away | Pit | | After |
| 8/28/2025 | Sea | Toglia | Traded away | NYA | | After |
| 8/28/2025 | Tam | Burleson | Traded away | Cin | | After |
| 8/28/2025 | Tam | Lee,C | Acquired via trade | Cin | | After |
| 8/28/2025 | Tam | Maxwell | Traded away | Cin | | After |
| 8/28/2025 | Tam | Rodon | Acquired via trade | Cin | | After |
| 8/28/2025 | Tam | Roupp | Traded away | Cin | | After |
| 8/28/2025 | Tam | Zerpa | Acquired via trade | Cin | | After |
| 8/29/2025 | Bal | Jackson,L | Released | | | Before |
| 8/29/2025 | Bal | Pauley | Released | | | Before |
| 8/29/2025 | ChA | Alexander,T | Promoted to active roster | | | Before |
| 8/29/2025 | ChA | Bedell | Demoted to reserve roster | | | Before |
| 8/29/2025 | ChA | Cox,A | Promoted to active roster | | | Before |
| 8/29/2025 | ChA | Cox,J | Promoted to active roster | | | Before |
| 8/29/2025 | ChA | Lobus | Promoted to active roster | | | Before |
| 8/29/2025 | ChA | Schultz,N | Demoted to reserve roster | | | Before |
| 8/29/2025 | ChA | Wilson,Ja | Demoted to reserve roster | | | Before |
| 8/29/2025 | Cle | Bogaerts | Promoted to active roster | | | Before |
| 8/29/2025 | Cle | Danner | Released | | | Before |
| 8/29/2025 | Cle | Danner | Signed | | | Before |
| 8/29/2025 | Cle | Englert | Released | | | Before |
| 8/29/2025 | Cle | Kiner-Falefa | Released | | | Before |
| 8/29/2025 | Cle | Phillips,T | Signed | | | Before |
| 8/29/2025 | Cle | Pivetta | Demoted to reserve roster | | | Before |
| 8/29/2025 | Cle | Seager | Demoted to reserve roster | | | Before |
| 8/29/2025 | Cle | Urquidy | Signed | | | Before |
| 8/29/2025 | Hou | Cruz,F | Promoted to active roster | | | Before |
| 8/29/2025 | Hou | Davis,Brenn | Signed | | | Before |
| 8/29/2025 | Hou | Davis,Brenn | Promoted to active roster | | | Before |
| 8/29/2025 | Min | Nola,Aa | Promoted to active roster | | | Before |
| 8/29/2025 | Min | Rodriguez,Ed | Demoted to reserve roster | | | Before |
| 8/29/2025 | Sac | Canha | Released | | | Before |
| 8/29/2025 | Sac | Dodd | Signed | | | Before |
| 8/29/2025 | Sac | Gray,Jon | Released | | | Before |
| 8/29/2025 | Sac | Leasure | Signed | | | Before |
| 8/29/2025 | Sac | Myers,D | Released | | | Before |
| 8/29/2025 | Sac | Schnell | Signed | | | Before |
| 8/29/2025 | Sea | Cruz,On | Promoted to active roster | | | Before |
| 8/29/2025 | Sea | Roccaforte | Promoted to active roster | | | Before |
| 8/29/2025 | Sea | Vargas,C | Released | | | Before |
| 8/29/2025 | Tam | Wicks | Released | | | Before |
| 8/29/2025 | Tex | Alvarado,E | Promoted to active roster | | | Before |
| 8/29/2025 | Tex | Alvarez,Y | Promoted to active roster | | | Before |
| 8/29/2025 | Tex | De Paula,J | Demoted to reserve roster | | | Before |
| 8/29/2025 | Tex | De Paula,J | Promoted to active roster | | | Before |
| 8/29/2025 | Tex | Junk | Demoted to reserve roster | | | Before |
| 8/29/2025 | Tex | Lopez,Jaco | Demoted to reserve roster | | | Before |
| 8/29/2025 | Tex | Mendez | Demoted to reserve roster | | | Before |
