| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/6/2022 | Hou | Acevedo | Traded away | Pit | | After |
| 4/6/2022 | Hou | Chafin | Acquired via trade | Pit | | After |
| 4/6/2022 | Hou | Cishek | Traded away | Pit | | After |
| 4/6/2022 | Sea | Coleman | Traded away | Mia | | After |
| 4/6/2022 | Sea | Murphy,C | Acquired via trade | Mia | | After |
| 4/10/2022 | LAA | Pruitt,A | Traded away | Mil | | After |
| 4/10/2022 | LAA | Pruitt,A | Traded away | Mil | | After |
| 4/10/2022 | LAA | Pruitt,A | Acquired via trade | Mil | | After |
| 4/11/2022 | Cle | Giolito | Demoted to reserve roster | | | Before |
| 4/11/2022 | KC | Daza | Demoted to reserve roster | | | Before |
| 4/11/2022 | KC | Miley | Demoted to reserve roster | | | Before |
| 4/11/2022 | KC | Norris | Demoted to reserve roster | | | Before |
| 4/11/2022 | KC | Urias,L | Demoted to reserve roster | | | Before |
| 4/11/2022 | Min | Celestino | Released | | | Before |
| 4/11/2022 | Min | Celestino | Signed | | | Before |
| 4/11/2022 | Min | Celestino | Signed | | | Before |
| 4/11/2022 | Min | Julien | Promoted to active roster | | | Before |
| 4/11/2022 | Min | Wade Jr. | Demoted to reserve roster | | | Before |
| 4/11/2022 | Tam | Solak | Promoted to active roster | | | Before |
| 4/18/2022 | Bos | Adams,A | Demoted to reserve roster | | | Before |
| 4/18/2022 | Bos | Steer | Promoted to active roster | | | Before |
| 4/18/2022 | ChA | Mize | Demoted to reserve roster | | | Before |
| 4/18/2022 | Cle | Cain | Promoted to active roster | | | Before |
| 4/18/2022 | Cle | Fletcher,Da | Demoted to reserve roster | | | Before |
| 4/18/2022 | Cle | Garcia,Ad | Promoted to active roster | | | Before |
| 4/18/2022 | Hou | Castro,S | Demoted to reserve roster | | | Before |
| 4/18/2022 | Hou | Pressly | Demoted to reserve roster | | | Before |
| 4/18/2022 | LAA | Frazier,C | Demoted to reserve roster | | | Before |
| 4/18/2022 | LAA | Frazier,C | Promoted to active roster | | | Before |
| 4/18/2022 | Oak | Duggar | Demoted to reserve roster | | | Before |
| 4/18/2022 | Oak | Kirilloff | Promoted to active roster | | | Before |
| 4/24/2022 | Cle | Finnegan,K | Acquired via trade | Atl | | After |
| 4/24/2022 | Hou | Slater | Traded away | Phi | | After |
| 4/24/2022 | Hou | Urshela | Acquired via trade | Phi | | After |
| 4/25/2022 | Bos | Aranda | Promoted to active roster | | | Before |
| 4/25/2022 | Bos | Reyes,V | Demoted to reserve roster | | | Before |
| 4/25/2022 | Bos | Shewmake | Released | | | Before |
| 4/25/2022 | Cle | Cain | Demoted to reserve roster | | | Before |
| 4/25/2022 | Det | Mejia,F | Demoted to reserve roster | | | Before |
| 4/25/2022 | KC | DeSclafani | Demoted to reserve roster | | | Before |
| 4/25/2022 | LAA | Boxberger | Demoted to reserve roster | | | Before |
| 4/25/2022 | LAA | Contreras,R | Demoted to reserve roster | | | Before |
| 4/25/2022 | LAA | Fedde | Released | | | Before |
| 4/25/2022 | LAA | Frazier,C | Demoted to reserve roster | | | Before |
| 4/25/2022 | LAA | Hogan | Signed | | | Before |
| 4/25/2022 | LAA | Hogan | Promoted to active roster | | | Before |
| 4/25/2022 | LAA | Petit | Signed | | | Before |
| 4/25/2022 | LAA | Petit | Promoted to active roster | | | Before |
| 4/25/2022 | LAA | Stashak | Signed | | | Before |
| 4/25/2022 | LAA | Stashak | Promoted to active roster | | | Before |
| 4/25/2022 | Min | Apostel | Promoted to active roster | | | Before |
| 4/25/2022 | Min | Garcia,LA | Promoted to active roster | | | Before |
| 4/25/2022 | Min | Haase | Promoted to active roster | | | Before |
| 4/25/2022 | Min | India | Demoted to reserve roster | | | Before |
| 4/25/2022 | Min | Manning | Demoted to reserve roster | | | Before |
| 4/25/2022 | Min | Nova,F | Promoted to active roster | | | Before |
| 4/25/2022 | Min | Pallante | Promoted to active roster | | | Before |
| 4/25/2022 | Min | Pinder,Chad | Signed | | | Before |
| 4/25/2022 | Min | Plawecki | Demoted to reserve roster | | | Before |
| 4/25/2022 | Min | Quantrill | Demoted to reserve roster | | | Before |
| 4/25/2022 | Min | Stephenson,T | Demoted to reserve roster | | | Before |
| 4/25/2022 | Oak | Calhoun,K | Promoted to active roster | | | Before |
| 4/25/2022 | Oak | Harrison,J | Demoted to reserve roster | | | Before |
| 4/25/2022 | Oak | Harrison,J | Promoted to active roster | | | Before |
| 4/25/2022 | Oak | Hernandez,Ce | Demoted to reserve roster | | | Before |
| 4/25/2022 | Oak | Madris | Signed | | | Before |
| 5/2/2022 | Bos | Acuna Jr. | Promoted to active roster | | | Before |
| 5/2/2022 | Bos | Aranda | Demoted to reserve roster | | | Before |
| 5/2/2022 | Cle | Rosario,Ed | Demoted to reserve roster | | | Before |
| 5/2/2022 | Det | Bryant | Demoted to reserve roster | | | Before |
| 5/2/2022 | KC | Kelly,Z | Promoted to active roster | | | Before |
| 5/2/2022 | KC | Norris | Demoted to reserve roster | | | Before |
| 5/2/2022 | KC | Norris | Promoted to active roster | | | Before |
| 5/2/2022 | LAA | Castro,H | Released | | | Before |
| 5/2/2022 | LAA | Kelly,Me | Demoted to reserve roster | | | Before |
| 5/2/2022 | LAA | Stewart,C | Signed | | | Before |
| 5/2/2022 | LAA | Stewart,C | Promoted to active roster | | | Before |
| 5/2/2022 | Min | India | Promoted to active roster | | | Before |
| 5/2/2022 | Min | Nova,F | Demoted to reserve roster | | | Before |
| 5/2/2022 | Min | Ober | Demoted to reserve roster | | | Before |
| 5/2/2022 | Sea | Matos | Demoted to reserve roster | | | Before |
| 5/2/2022 | Sea | Murphy,C | Demoted to reserve roster | | | Before |
| 5/2/2022 | Sea | Murphy,C | Promoted to active roster | | | Before |
| 5/2/2022 | Sea | Rutschman | Promoted to active roster | | | Before |
| 5/2/2022 | Tex | Horwitz | Signed | | | Before |
| 5/9/2022 | Bos | Castillo,L | Promoted to active roster | | | Before |
| 5/9/2022 | Bos | Clevinger | Promoted to active roster | | | Before |
| 5/9/2022 | Bos | Cousins | Demoted to reserve roster | | | Before |
| 5/9/2022 | ChA | Tarnok | Demoted to reserve roster | | | Before |
| 5/9/2022 | ChA | White,Mit | Promoted to active roster | | | Before |
| 5/9/2022 | Cle | Giolito | Promoted to active roster | | | Before |
| 5/9/2022 | Cle | Walton | Promoted to active roster | | | Before |
| 5/9/2022 | Cle | Yarbrough | Demoted to reserve roster | | | Before |
| 5/9/2022 | Hou | Casey | Promoted to active roster | | | Before |
| 5/9/2022 | LAA | Boxberger | Promoted to active roster | | | Before |
| 5/9/2022 | LAA | Murphy,T | Demoted to reserve roster | | | Before |
| 5/16/2022 | ChA | Gore,M | Promoted to active roster | | | Before |
| 5/16/2022 | ChA | Olivares | Demoted to reserve roster | | | Before |
| 5/16/2022 | ChA | Outman | Promoted to active roster | | | Before |
| 5/16/2022 | ChA | Seabold | Demoted to reserve roster | | | Before |
| 5/16/2022 | ChA | Suwinski | Signed | | | Before |
| 5/16/2022 | ChA | Tarnok | Promoted to active roster | | | Before |
| 5/16/2022 | Cle | Crawford,J | Promoted to active roster | | | Before |
| 5/16/2022 | Cle | Madrigal | Demoted to reserve roster | | | Before |
| 5/16/2022 | Det | Kershaw | Demoted to reserve roster | | | Before |
| 5/16/2022 | Hou | Sano | Demoted to reserve roster | | | Before |
| 5/16/2022 | KC | May,T | Demoted to reserve roster | | | Before |
| 5/16/2022 | LAA | Baddoo | Demoted to reserve roster | | | Before |
| 5/16/2022 | LAA | Berti | Demoted to reserve roster | | | Before |
| 5/16/2022 | LAA | Bleday | Promoted to active roster | | | Before |
| 5/16/2022 | LAA | Boxberger | Demoted to reserve roster | | | Before |
| 5/16/2022 | LAA | Contreras,R | Promoted to active roster | | | Before |
| 5/16/2022 | LAA | Frazier,C | Promoted to active roster | | | Before |
| 5/16/2022 | LAA | Hogan | Demoted to reserve roster | | | Before |
| 5/16/2022 | LAA | Lowe,B | Demoted to reserve roster | | | Before |
| 5/16/2022 | LAA | Mercedes | Signed | | | Before |
| 5/16/2022 | LAA | Mercedes | Promoted to active roster | | | Before |
| 5/16/2022 | LAA | Miller,O | Promoted to active roster | | | Before |
| 5/16/2022 | LAA | Shenton | Released | | | Before |
| 5/16/2022 | Min | India | Demoted to reserve roster | | | Before |
| 5/16/2022 | Oak | Bradley Jr. | Released | | | Before |
| 5/16/2022 | Oak | Bummer | Demoted to reserve roster | | | Before |
| 5/16/2022 | Oak | Hernandez,Ce | Demoted to reserve roster | | | Before |
| 5/16/2022 | Oak | Hernandez,Ce | Promoted to active roster | | | Before |
| 5/16/2022 | Oak | Kahnle | Promoted to active roster | | | Before |
| 5/16/2022 | Oak | Kelly,C | Demoted to reserve roster | | | Before |
| 5/16/2022 | Oak | Pinto,Re | Promoted to active roster | | | Before |
| 5/16/2022 | Oak | Refsnyder | Signed | | | Before |
| 5/16/2022 | Sea | Feltner | Released | | | Before |
| 5/16/2022 | Tex | Correa,C | Demoted to reserve roster | | | Before |
| 5/16/2022 | Tor | Swanson,E | Demoted to reserve roster | | | Before |
| 5/23/2022 | Hou | Kowar | Promoted to active roster | | | Before |
| 5/23/2022 | Hou | Pineda | Demoted to reserve roster | | | Before |
| 5/23/2022 | KC | Daza | Promoted to active roster | | | Before |
| 5/23/2022 | KC | Duffy,M | Demoted to reserve roster | | | Before |
| 5/23/2022 | KC | Floro | Promoted to active roster | | | Before |
| 5/23/2022 | KC | Miley | Promoted to active roster | | | Before |
| 5/23/2022 | KC | Renfroe | Demoted to reserve roster | | | Before |
| 5/23/2022 | KC | Stroman | Demoted to reserve roster | | | Before |
| 5/23/2022 | KC | Urias,L | Promoted to active roster | | | Before |
| 5/23/2022 | Min | Apostel | Demoted to reserve roster | | | Before |
| 5/23/2022 | Min | Haase | Demoted to reserve roster | | | Before |
| 5/23/2022 | Min | Pinder,Chad | Promoted to active roster | | | Before |
| 5/23/2022 | Min | Plawecki | Promoted to active roster | | | Before |
| 5/23/2022 | Min | Quantrill | Promoted to active roster | | | Before |
| 5/23/2022 | Min | Wade Jr. | Promoted to active roster | | | Before |
| 5/23/2022 | NYA | Scherzer | Demoted to reserve roster | | | Before |
| 5/30/2022 | Bal | Zerpa | Signed | | | Before |
| 5/30/2022 | Cle | Abreu,B | Promoted to active roster | | | Before |
| 5/30/2022 | Cle | Acevedo | Promoted to active roster | | | Before |
| 5/30/2022 | Cle | Castillo,D | Demoted to reserve roster | | | Before |
| 5/30/2022 | Cle | Maton,P | Promoted to active roster | | | Before |
| 5/30/2022 | Cle | White,C | Demoted to reserve roster | | | Before |
| 5/30/2022 | Cle | Yarbrough | Promoted to active roster | | | Before |
| 5/30/2022 | Hou | Hicks,Jor | Demoted to reserve roster | | | Before |
| 5/30/2022 | LAA | Almonte,A | Signed | | | Before |
| 5/30/2022 | LAA | Almonte,A | Promoted to active roster | | | Before |
| 5/30/2022 | LAA | Berti | Promoted to active roster | | | Before |
| 5/30/2022 | LAA | Boxberger | Promoted to active roster | | | Before |
| 5/30/2022 | LAA | Gamel | Demoted to reserve roster | | | Before |
| 5/30/2022 | LAA | Hall,Da | Signed | | | Before |
| 5/30/2022 | LAA | Hogan | Released | | | Before |
| 5/30/2022 | LAA | Kelly,Me | Promoted to active roster | | | Before |
| 5/30/2022 | LAA | Kremer | Signed | | | Before |
| 5/30/2022 | LAA | Lopez,A | Signed | | | Before |
| 5/30/2022 | LAA | Lopez,A | Promoted to active roster | | | Before |
| 5/30/2022 | LAA | MacKinnon | Signed | | | Before |
| 5/30/2022 | LAA | MacKinnon | Promoted to active roster | | | Before |
| 5/30/2022 | LAA | Middleton | Demoted to reserve roster | | | Before |
| 5/30/2022 | LAA | Miller,O | Demoted to reserve roster | | | Before |
| 5/30/2022 | LAA | Morgan,A | Released | | | Before |
| 5/30/2022 | LAA | Murphy,T | Released | | | Before |
| 5/30/2022 | LAA | Petit | Released | | | Before |
| 5/30/2022 | LAA | Rodriguez,Ad | Released | | | Before |
| 5/30/2022 | LAA | Solano | Signed | | | Before |
| 5/30/2022 | LAA | Stewart,C | Released | | | Before |
| 5/30/2022 | Min | Civale | Demoted to reserve roster | | | Before |
| 5/30/2022 | Min | Jax | Promoted to active roster | | | Before |
| 5/30/2022 | Min | Ryan,J | Demoted to reserve roster | | | Before |
| 5/30/2022 | Min | Smeltzer | Promoted to active roster | | | Before |
| 5/30/2022 | NYA | Chapman,A | Demoted to reserve roster | | | Before |
| 5/30/2022 | Oak | Bummer | Promoted to active roster | | | Before |
| 5/30/2022 | Oak | Daniel,D | Released | | | Before |
| 5/30/2022 | Oak | Kahnle | Demoted to reserve roster | | | Before |
| 5/30/2022 | Oak | Martin,M | Released | | | Before |
| 5/30/2022 | Tor | Carlson | Demoted to reserve roster | | | Before |
| 6/6/2022 | Bal | Franco,W | Demoted to reserve roster | | | Before |
| 6/6/2022 | Bal | Rios,E | Demoted to reserve roster | | | Before |
| 6/6/2022 | Bos | Grossman | Demoted to reserve roster | | | Before |
| 6/6/2022 | Bos | Woodruff | Demoted to reserve roster | | | Before |
| 6/6/2022 | Hou | Anderson,Ti | Demoted to reserve roster | | | Before |
| 6/6/2022 | Hou | Conine,G | Promoted to active roster | | | Before |
| 6/6/2022 | Hou | Feyereisen | Demoted to reserve roster | | | Before |
| 6/6/2022 | Hou | Junk | Promoted to active roster | | | Before |
| 6/6/2022 | Hou | Waldichuk | Promoted to active roster | | | Before |
| 6/6/2022 | Hou | Whitcomb | Promoted to active roster | | | Before |
| 6/6/2022 | KC | Barnes,M | Demoted to reserve roster | | | Before |
| 6/6/2022 | KC | Duffy,M | Promoted to active roster | | | Before |
| 6/6/2022 | KC | Holton,T | Promoted to active roster | | | Before |
| 6/6/2022 | KC | Miley | Demoted to reserve roster | | | Before |
| 6/6/2022 | KC | Norris | Demoted to reserve roster | | | Before |
| 6/6/2022 | KC | Norris | Promoted to active roster | | | Before |
| 6/6/2022 | KC | Seymour | Demoted to reserve roster | | | Before |
| 6/6/2022 | KC | Stroman | Promoted to active roster | | | Before |
| 6/6/2022 | KC | Suzuki,S | Demoted to reserve roster | | | Before |
| 6/6/2022 | KC | Wood,H | Promoted to active roster | | | Before |
| 6/6/2022 | LAA | Arano | Demoted to reserve roster | | | Before |
| 6/6/2022 | LAA | Blackburn | Promoted to active roster | | | Before |
| 6/6/2022 | LAA | Coulombe | Demoted to reserve roster | | | Before |
| 6/6/2022 | LAA | Howard,Sp | Promoted to active roster | | | Before |
| 6/6/2022 | LAA | Middleton | Promoted to active roster | | | Before |
| 6/6/2022 | LAA | Stashak | Demoted to reserve roster | | | Before |
| 6/6/2022 | Tam | Baez,M | Promoted to active roster | | | Before |
| 6/6/2022 | Tam | Bender | Demoted to reserve roster | | | Before |
| 6/6/2022 | Tam | Lynch | Demoted to reserve roster | | | Before |
| 6/6/2022 | Tam | Quijada | Promoted to active roster | | | Before |
| 6/6/2022 | Tam | Suarez,Ro | Demoted to reserve roster | | | Before |
| 6/13/2022 | ChA | Outman | Demoted to reserve roster | | | Before |
| 6/13/2022 | ChA | Suwinski | Promoted to active roster | | | Before |
| 6/13/2022 | Cle | Buehler | Demoted to reserve roster | | | Before |
| 6/13/2022 | Cle | Castillo,D | Promoted to active roster | | | Before |
| 6/13/2022 | Cle | Madrigal | Promoted to active roster | | | Before |
| 6/13/2022 | Cle | Walton | Demoted to reserve roster | | | Before |
| 6/13/2022 | LAA | Almonte,A | Released | | | Before |
| 6/13/2022 | LAA | Bleday | Demoted to reserve roster | | | Before |
| 6/13/2022 | LAA | Feltner | Signed | | | Before |
| 6/13/2022 | LAA | Higgins,P | Signed | | | Before |
| 6/13/2022 | LAA | Higgins,P | Promoted to active roster | | | Before |
| 6/13/2022 | LAA | Holderman | Signed | | | Before |
| 6/13/2022 | LAA | Lopez,A | Released | | | Before |
| 6/13/2022 | LAA | Miller,O | Promoted to active roster | | | Before |
| 6/13/2022 | LAA | Solano | Promoted to active roster | | | Before |
| 6/13/2022 | LAA | Stashak | Released | | | Before |
| 6/13/2022 | Oak | Calhoun,K | Released | | | Before |
| 6/13/2022 | Oak | Foley | Signed | | | Before |
| 6/13/2022 | Oak | Hernandez,Ce | Released | | | Before |
| 6/13/2022 | Oak | Kelly,C | Promoted to active roster | | | Before |
| 6/13/2022 | Oak | Noda | Promoted to active roster | | | Before |
| 6/13/2022 | Oak | Pinto,Re | Demoted to reserve roster | | | Before |
| 6/13/2022 | Sea | Brito,J | Signed | | | Before |
| 6/13/2022 | Sea | Vest | Released | | | Before |
| 6/13/2022 | Tam | Williams,Tr | Signed | | | Before |
| 6/14/2022 | Hou | Gonzalez,V | Demoted to reserve roster | | | Before |
| 6/14/2022 | Hou | Pressly | Promoted to active roster | | | Before |
| 6/20/2022 | Cle | Madrigal | Demoted to reserve roster | | | Before |
| 6/20/2022 | Cle | Walton | Promoted to active roster | | | Before |
| 6/20/2022 | Hou | Polanco,J | Demoted to reserve roster | | | Before |
| 6/20/2022 | KC | Norris | Promoted to active roster | | | Before |
| 6/20/2022 | KC | Schwindel | Demoted to reserve roster | | | Before |
| 6/20/2022 | KC | Stroman | Demoted to reserve roster | | | Before |
| 6/20/2022 | Min | Carpenter,M | Signed | | | Before |
| 6/20/2022 | Oak | Bummer | Demoted to reserve roster | | | Before |
| 6/20/2022 | Oak | Bundy | Promoted to active roster | | | Before |
| 6/20/2022 | Oak | Eovaldi | Demoted to reserve roster | | | Before |
| 6/20/2022 | Oak | Giles | Promoted to active roster | | | Before |
| 6/20/2022 | Oak | Leclerc | Promoted to active roster | | | Before |
| 6/20/2022 | Oak | Whitlock | Demoted to reserve roster | | | Before |
| 6/23/2022 | Bos | Albies | Demoted to reserve roster | | | Before |
| 6/27/2022 | Bal | Bradish | Demoted to reserve roster | | | Before |
| 6/27/2022 | Bal | Margot | Demoted to reserve roster | | | Before |
| 6/27/2022 | Bos | Battenfield,P | Promoted to active roster | | | Before |
| 6/27/2022 | Bos | Canzone | Demoted to reserve roster | | | Before |
| 6/27/2022 | Bos | Grossman | Promoted to active roster | | | Before |
| 6/27/2022 | Bos | Reyes,V | Promoted to active roster | | | Before |
| 6/27/2022 | ChA | Hurtubise | Demoted to reserve roster | | | Before |
| 6/27/2022 | ChA | Olivares | Promoted to active roster | | | Before |
| 6/27/2022 | Cle | Betts | Demoted to reserve roster | | | Before |
| 6/27/2022 | Det | Hudson,Dan | Demoted to reserve roster | | | Before |
| 6/27/2022 | KC | Alvarez,J | Demoted to reserve roster | | | Before |
| 6/27/2022 | KC | Norris | Demoted to reserve roster | | | Before |
| 6/27/2022 | NYA | Kiermaier | Demoted to reserve roster | | | Before |
| 7/3/2022 | Cle | Berti | Acquired via trade | LAA | | After |
| 7/3/2022 | Cle | Junis | Traded away | LAA | | After |
| 7/3/2022 | Cle | Lowe,B | Acquired via trade | LAA | | After |
| 7/3/2022 | Cle | Madrigal | Traded away | LAA | | After |
| 7/3/2022 | Cle | Marsh,B | Traded away | LAA | | After |
| 7/3/2022 | Cle | Mauricio | Traded away | LAA | | After |
| 7/3/2022 | Cle | Tate | Acquired via trade | LAA | | After |
| 7/3/2022 | LAA | Berti | Traded away | Cle | | After |
| 7/3/2022 | LAA | Junis | Acquired via trade | Cle | | After |
| 7/3/2022 | LAA | Lowe,B | Traded away | Cle | | After |
| 7/3/2022 | LAA | Madrigal | Acquired via trade | Cle | | After |
| 7/3/2022 | LAA | Marsh,B | Acquired via trade | Cle | | After |
| 7/3/2022 | LAA | Mauricio | Acquired via trade | Cle | | After |
| 7/3/2022 | LAA | Tate | Traded away | Cle | | After |
| 7/3/2022 | Tor | Alfaro | Traded away | Pit | | After |
| 7/4/2022 | Bal | Knehr | Signed | | | Before |
| 7/4/2022 | Bal | Knehr | Promoted to active roster | | | Before |
| 7/4/2022 | Bal | Zerpa | Promoted to active roster | | | Before |
| 7/4/2022 | Bos | Wilson,S | Demoted to reserve roster | | | Before |
| 7/4/2022 | ChA | Antuna | Released | | | Before |
| 7/4/2022 | Cle | Cain | Released | | | Before |
| 7/4/2022 | Cle | Camargo,Jo | Demoted to reserve roster | | | Before |
| 7/4/2022 | Cle | Cordero,J | Signed | | | Before |
| 7/4/2022 | Hou | Soler | Demoted to reserve roster | | | Before |
| 7/4/2022 | KC | Brantley | Demoted to reserve roster | | | Before |
| 7/4/2022 | LAA | Barlow,J | Promoted to active roster | | | Before |
| 7/4/2022 | LAA | Brantly | Demoted to reserve roster | | | Before |
| 7/4/2022 | LAA | Hall,Da | Promoted to active roster | | | Before |
| 7/4/2022 | LAA | Marsh,B | Promoted to active roster | | | Before |
| 7/4/2022 | Min | Bader | Demoted to reserve roster | | | Before |
| 7/4/2022 | NYA | Harper,B | Demoted to reserve roster | | | Before |
| 7/4/2022 | NYA | Hedges | Demoted to reserve roster | | | Before |
| 7/4/2022 | Oak | Duggar | Released | | | Before |
| 7/4/2022 | Sea | Brito,J | Promoted to active roster | | | Before |
| 7/4/2022 | Sea | Gonzalez,O | Demoted to reserve roster | | | Before |
| 7/4/2022 | Sea | Matos | Promoted to active roster | | | Before |
| 7/4/2022 | Tor | Carlson | Promoted to active roster | | | Before |
| 7/4/2022 | Tor | German,F | Promoted to active roster | | | Before |
| 7/4/2022 | Tor | Johnston,T | Demoted to reserve roster | | | Before |
| 7/4/2022 | Tor | Johnston,T | Promoted to active roster | | | Before |
| 7/4/2022 | Tor | Moll | Demoted to reserve roster | | | Before |
| 7/4/2022 | Tor | Taylor,S | Promoted to active roster | | | Before |
| 7/4/2022 | Tor | Wong,C | Signed | | | Before |
| 7/4/2022 | Tor | Wong,C | Promoted to active roster | | | Before |
| 7/10/2022 | Tor | Ibanez | Traded away | Mia | | After |
| 7/10/2022 | Tor | Ruotolo | Traded away | Mia | | After |
| 7/10/2022 | Tor | Verdugo | Traded away | Mia | | After |
| 7/11/2022 | Bal | Hernandez,Jo | Promoted to active roster | | | Before |
| 7/11/2022 | Bos | Canzone | Released | | | Before |
| 7/11/2022 | Bos | Dirden | Signed | | | Before |
| 7/11/2022 | ChA | Dunning | Demoted to reserve roster | | | Before |
| 7/11/2022 | ChA | Olson,R | Promoted to active roster | | | Before |
| 7/11/2022 | Cle | Betts | Promoted to active roster | | | Before |
| 7/11/2022 | Cle | Tepera | Demoted to reserve roster | | | Before |
| 7/11/2022 | Det | Senzatela | Demoted to reserve roster | | | Before |
| 7/11/2022 | Hou | Hendricks | Demoted to reserve roster | | | Before |
| 7/11/2022 | Hou | Kennedy,I | Demoted to reserve roster | | | Before |
| 7/11/2022 | KC | Gilbert,T | Demoted to reserve roster | | | Before |
| 7/11/2022 | KC | Gilbert,T | Promoted to active roster | | | Before |
| 7/11/2022 | KC | Stroman | Promoted to active roster | | | Before |
| 7/11/2022 | KC | Suzuki,S | Promoted to active roster | | | Before |
| 7/11/2022 | LAA | Megill,Tr | Signed | | | Before |
| 7/11/2022 | Min | India | Promoted to active roster | | | Before |
| 7/11/2022 | Min | McKenzie | Demoted to reserve roster | | | Before |
| 7/11/2022 | Min | Ryan,J | Promoted to active roster | | | Before |
| 7/11/2022 | Oak | Giles | Demoted to reserve roster | | | Before |
| 7/11/2022 | Sea | Brito,J | Released | | | Before |
| 7/11/2022 | Sea | Martin,A | Demoted to reserve roster | | | Before |
| 7/11/2022 | Sea | Morejon | Promoted to active roster | | | Before |
| 7/11/2022 | Sea | Perez,We | Signed | | | Before |
| 7/11/2022 | Sea | Perez,We | Promoted to active roster | | | Before |
| 7/11/2022 | Tam | Hudson,Dak | Demoted to reserve roster | | | Before |
| 7/11/2022 | Tam | Martinez,S | Signed | | | Before |
| 7/11/2022 | Tam | Martinez,S | Promoted to active roster | | | Before |
| 7/11/2022 | Tam | Mead | Promoted to active roster | | | Before |
| 7/11/2022 | Tam | Solak | Demoted to reserve roster | | | Before |
| 7/11/2022 | Tam | Suarez,Ro | Demoted to reserve roster | | | Before |
| 7/11/2022 | Tam | Taylor,T | Demoted to reserve roster | | | Before |
| 7/11/2022 | Tam | Velazquez,N | Promoted to active roster | | | Before |
| 7/11/2022 | Tam | Williams,Tr | Promoted to active roster | | | Before |
| 7/11/2022 | Tor | Castro,R | Promoted to active roster | | | Before |
| 7/11/2022 | Tor | Johnston,T | Promoted to active roster | | | Before |
| 7/11/2022 | Tor | McCarthy,Ja | Promoted to active roster | | | Before |
| 7/11/2022 | Tor | Moll | Promoted to active roster | | | Before |
| 7/11/2022 | Tor | Swanson,E | Promoted to active roster | | | Before |
| 7/11/2022 | Tor | Winckowski | Demoted to reserve roster | | | Before |
| 7/11/2022 | Tor | Yepez | Demoted to reserve roster | | | Before |
| 7/17/2022 | ChA | Brieske | Traded away | KC | | After |
| 7/17/2022 | Cle | Crawford,J | Traded away | Was | | After |
| 7/17/2022 | Cle | Garcia,Ad | Traded away | Tam | | After |
| 7/17/2022 | Cle | Jones,G | Acquired via trade | Tam | | After |
| 7/17/2022 | Cle | Longoria | Acquired via trade | Pit | | After |
| 7/17/2022 | Cle | Merrifield | Acquired via trade | Pit | | After |
| 7/17/2022 | Cle | Suarez,Ra | Acquired via trade | Was | | After |
| 7/17/2022 | Cle | Suarez,Ro | Acquired via trade | Tam | | After |
| 7/17/2022 | Cle | Tepera | Traded away | Tam | | After |
| 7/17/2022 | Cle | Walton | Traded away | Tam | | After |
| 7/17/2022 | Cle | Williams,Tr | Acquired via trade | Tam | | After |
| 7/17/2022 | KC | Brieske | Acquired via trade | ChA | | After |
| 7/17/2022 | Tam | Garcia,Ad | Acquired via trade | Cle | | After |
| 7/17/2022 | Tam | Jones,G | Traded away | Cle | | After |
| 7/17/2022 | Tam | Suarez,Ro | Traded away | Cle | | After |
| 7/17/2022 | Tam | Tepera | Acquired via trade | Cle | | After |
| 7/17/2022 | Tam | Walton | Acquired via trade | Cle | | After |
| 7/17/2022 | Tam | Williams,Tr | Traded away | Cle | | After |
| 7/17/2022 | Tor | Carlson | Traded away | Pit | | After |
| 7/17/2022 | Tor | Carlson | Traded away | Pit | | After |
| 7/17/2022 | Tor | Carlson | Acquired via trade | Pit | | After |
| 7/21/2022 | Bal | Graterol,B | Demoted to reserve roster | | | Before |
| 7/21/2022 | Bos | Aranda | Promoted to active roster | | | Before |
| 7/21/2022 | Bos | Arroyo | Demoted to reserve roster | | | Before |
| 7/21/2022 | Bos | Castro,J | Demoted to reserve roster | | | Before |
| 7/21/2022 | Bos | Perez,CJ | Promoted to active roster | | | Before |
| 7/21/2022 | Bos | Springs | Demoted to reserve roster | | | Before |
| 7/21/2022 | Bos | Wilson,S | Promoted to active roster | | | Before |
| 7/21/2022 | Bos | Woodruff | Promoted to active roster | | | Before |
| 7/21/2022 | ChA | Heuer | Signed | | | Before |
| 7/21/2022 | Cle | Berti | Demoted to reserve roster | | | Before |
| 7/21/2022 | Cle | Camargo,Jo | Promoted to active roster | | | Before |
| 7/21/2022 | Cle | Castillo,D | Demoted to reserve roster | | | Before |
| 7/21/2022 | Cle | Cordero,J | Promoted to active roster | | | Before |
| 7/21/2022 | Cle | Finnegan,K | Demoted to reserve roster | | | Before |
| 7/21/2022 | Cle | Karinchak | Promoted to active roster | | | Before |
| 7/21/2022 | Cle | Lowe,B | Promoted to active roster | | | Before |
| 7/21/2022 | Cle | Rosario,Ed | Promoted to active roster | | | Before |
| 7/21/2022 | Cle | Strahm | Demoted to reserve roster | | | Before |
| 7/21/2022 | Cle | Suarez,Ra | Promoted to active roster | | | Before |
| 7/21/2022 | Cle | Williams,Tr | Demoted to reserve roster | | | Before |
| 7/21/2022 | Hou | Bradley Jr. | Signed | | | Before |
| 7/21/2022 | KC | Castro,M | Demoted to reserve roster | | | Before |
| 7/21/2022 | NYA | Pujols | Signed | | | Before |
| 7/21/2022 | Tam | Tepera | Promoted to active roster | | | Before |
| 7/21/2022 | Tam | Velazquez,N | Demoted to reserve roster | | | Before |
| 7/21/2022 | Tam | Walton | Demoted to reserve roster | | | Before |
| 7/21/2022 | Tex | Severino,L | Demoted to reserve roster | | | Before |
| 7/21/2022 | Tor | Encarnacion,J | Signed | | | Before |
| 7/21/2022 | Tor | Munguia | Released | | | Before |
| 7/21/2022 | Tor | Nunez,M | Signed | | | Before |
| 7/21/2022 | Tor | Sanchez,L | Released | | | Before |
| 7/21/2022 | Tor | Solomon | Released | | | Before |
| 7/25/2022 | Bos | Aranda | Demoted to reserve roster | | | Before |
| 7/25/2022 | Bos | Battenfield,P | Demoted to reserve roster | | | Before |
| 7/25/2022 | Bos | Jackson,J | Signed | | | Before |
| 7/25/2022 | Bos | Jackson,J | Promoted to active roster | | | Before |
| 7/25/2022 | Bos | Springs | Promoted to active roster | | | Before |
| 7/25/2022 | Cle | Devers,R | Demoted to reserve roster | | | Before |
| 7/25/2022 | Cle | Longoria | Promoted to active roster | | | Before |
| 7/25/2022 | KC | Baker,L | Released | | | Before |
| 7/25/2022 | KC | Renfroe | Promoted to active roster | | | Before |
| 7/25/2022 | LAA | Barlow,J | Demoted to reserve roster | | | Before |
| 7/25/2022 | Min | Thielbar | Demoted to reserve roster | | | Before |
| 7/25/2022 | Oak | Allen,G | Promoted to active roster | | | Before |
| 7/25/2022 | Oak | Eovaldi | Promoted to active roster | | | Before |
| 7/25/2022 | Oak | Gray,Jon | Demoted to reserve roster | | | Before |
| 7/25/2022 | Oak | Story | Demoted to reserve roster | | | Before |
| 7/25/2022 | Oak | Whitlock | Promoted to active roster | | | Before |
| 7/25/2022 | Tex | Alvarez,Yo | Demoted to reserve roster | | | Before |
| 7/25/2022 | Tor | Nunez,M | Promoted to active roster | | | Before |
| 7/25/2022 | Tor | Winckowski | Promoted to active roster | | | Before |
| 7/28/2022 | ChA | McGuire | Traded away | Cle | | After |
| 7/28/2022 | Cle | Castillo,D | Traded away | Min | | After |
| 7/28/2022 | Cle | McGuire | Acquired via trade | ChA | | After |
| 7/28/2022 | Cle | Yarbrough | Traded away | KC | | After |
| 7/28/2022 | Hou | Gallen | Acquired via trade | Mia | | After |
| 7/28/2022 | Hou | Rogers,Tr | Traded away | Mia | | After |
| 7/28/2022 | Hou | Waldichuk | Traded away | SD | | After |
| 7/28/2022 | KC | Yarbrough | Acquired via trade | Cle | | After |
| 7/28/2022 | Min | Castillo,D | Acquired via trade | Cle | | After |
| 7/28/2022 | Min | Gomes | Acquired via trade | Col | | After |
| 7/28/2022 | Min | Gray,So | Acquired via trade | Col | | After |
| 7/28/2022 | Min | Haniger | Acquired via trade | Col | | After |
| 7/28/2022 | Min | Manning | Traded away | Col | | After |
| 7/28/2022 | Min | McKenzie | Traded away | Col | | After |
| 7/28/2022 | Sea | Gray,Jos | Traded away | SD | | After |
| 7/29/2022 | Bos | Bride | Released | | | Before |
| 7/29/2022 | ChA | Dunning | Promoted to active roster | | | Before |
| 7/29/2022 | ChA | Gore,M | Demoted to reserve roster | | | Before |
| 7/29/2022 | ChA | Hurtubise | Released | | | Before |
| 7/29/2022 | ChA | Hurtubise | Signed | | | Before |
| 7/29/2022 | ChA | Meyer,M | Demoted to reserve roster | | | Before |
| 7/29/2022 | ChA | Seabold | Promoted to active roster | | | Before |
| 7/29/2022 | ChA | Viloria | Signed | | | Before |
| 7/29/2022 | Cle | Finnegan,K | Promoted to active roster | | | Before |
| 7/29/2022 | Cle | Longoria | Demoted to reserve roster | | | Before |
| 7/29/2022 | Det | Akin | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Bryant | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Cabrera,M | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Gordon,N | Demoted to reserve roster | | | Before |
| 7/29/2022 | Det | Irvin | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Kershaw | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Kuhl | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Mejia,F | Promoted to active roster | | | Before |
| 7/29/2022 | Det | Stammen | Demoted to reserve roster | | | Before |
| 7/29/2022 | KC | Melendez,J | Signed | | | Before |
| 7/29/2022 | KC | Parker | Released | | | Before |
| 7/29/2022 | Min | Castillo,D | Promoted to active roster | | | Before |
| 7/29/2022 | Min | Celestino | Promoted to active roster | | | Before |
| 7/29/2022 | Min | Garcia,LA | Demoted to reserve roster | | | Before |
| 7/29/2022 | Min | Gutierrez,V | Released | | | Before |
| 7/29/2022 | Min | Pinder,Chad | Demoted to reserve roster | | | Before |
| 7/29/2022 | Min | Rocchio | Demoted to reserve roster | | | Before |
| 7/29/2022 | Sea | Pacheco | Signed | | | Before |
| 7/29/2022 | Sea | Pacheco | Promoted to active roster | | | Before |
| 7/29/2022 | Tam | Amaya,M | Promoted to active roster | | | Before |
| 7/29/2022 | Tam | Feliciano | Demoted to reserve roster | | | Before |
| 7/29/2022 | Tam | King,M | Demoted to reserve roster | | | Before |
| 7/31/2022 | ChA | Stott | Traded away | Phi | | After |
| 7/31/2022 | Cle | Tate | Traded away | Min | | After |
| 7/31/2022 | Min | Tate | Acquired via trade | Cle | | After |
| 8/1/2022 | Bal | Zerpa | Demoted to reserve roster | | | Before |
| 8/1/2022 | ChA | Allen,N | Promoted to active roster | | | Before |
| 8/1/2022 | ChA | Viloria | Promoted to active roster | | | Before |
| 8/1/2022 | Cle | Astudillo | Demoted to reserve roster | | | Before |
| 8/1/2022 | Cle | Fletcher,Da | Promoted to active roster | | | Before |
| 8/1/2022 | Cle | Tate | Demoted to reserve roster | | | Before |
| 8/1/2022 | Cle | Williams,Tr | Promoted to active roster | | | Before |
| 8/1/2022 | Det | Mejia,F | Demoted to reserve roster | | | Before |
| 8/1/2022 | LAA | Hoffman | Demoted to reserve roster | | | Before |
| 8/1/2022 | LAA | Middleton | Demoted to reserve roster | | | Before |
| 8/1/2022 | Min | Castillo,D | Demoted to reserve roster | | | Before |
| 8/1/2022 | Tam | Hudson,Dak | Promoted to active roster | | | Before |
| 8/1/2022 | Tam | Martinez,S | Demoted to reserve roster | | | Before |
| 8/1/2022 | Tam | Martinez,S | Promoted to active roster | | | Before |
| 8/1/2022 | Tam | Sosa,E | Demoted to reserve roster | | | Before |
| 8/1/2022 | Tam | Sosa,E | Promoted to active roster | | | Before |
| 8/1/2022 | Tam | Taylor,T | Demoted to reserve roster | | | Before |
| 8/1/2022 | Tam | Taylor,T | Promoted to active roster | | | Before |
| 8/5/2022 | Bal | Ortiz,Jo | Signed | | | Before |
| 8/5/2022 | Bal | Rodriguez,Ju | Demoted to reserve roster | | | Before |
| 8/5/2022 | Bos | Adams,A | Released | | | Before |
| 8/5/2022 | ChA | Zavala | Signed | | | Before |
| 8/5/2022 | Cle | Astudillo | Released | | | Before |
| 8/5/2022 | Cle | Devers,R | Promoted to active roster | | | Before |
| 8/5/2022 | Cle | Turner,J | Demoted to reserve roster | | | Before |
| 8/5/2022 | Hou | Adon,J | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | Anderson,Ti | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | Bradley Jr. | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | Crim | Demoted to reserve roster | | | Before |
| 8/5/2022 | Hou | Crim | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | Crim | Demoted to reserve roster | | | Before |
| 8/5/2022 | Hou | Gose | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | Hicks,Jor | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | Kennedy,I | Promoted to active roster | | | Before |
| 8/5/2022 | Hou | O'Hoppe | Demoted to reserve roster | | | Before |
| 8/5/2022 | Hou | Polanco,J | Promoted to active roster | | | Before |
| 8/5/2022 | Tam | Baker,B | Signed | | | Before |
| 8/5/2022 | Tam | Baker,B | Promoted to active roster | | | Before |
| 8/5/2022 | Tam | Bednar | Demoted to reserve roster | | | Before |
| 8/5/2022 | Tam | Bender | Promoted to active roster | | | Before |
| 8/5/2022 | Tam | Feliciano | Released | | | Before |
| 8/5/2022 | Tam | Lynch | Promoted to active roster | | | Before |
| 8/5/2022 | Tam | Martinez,S | Released | | | Before |
| 8/5/2022 | Tam | Skubal | Demoted to reserve roster | | | Before |
| 8/5/2022 | Tam | Taylor,T | Promoted to active roster | | | Before |
| 8/5/2022 | Tam | Walker,C | Demoted to reserve roster | | | Before |
| 8/8/2022 | Bos | Arroyo | Promoted to active roster | | | Before |
| 8/8/2022 | Bos | Cabrera,O | Signed | | | Before |
| 8/8/2022 | Bos | Castro,J | Released | | | Before |
| 8/8/2022 | Bos | Garlick | Demoted to reserve roster | | | Before |
| 8/8/2022 | Bos | Kluber | Demoted to reserve roster | | | Before |
| 8/8/2022 | Bos | Kluber | Promoted to active roster | | | Before |
| 8/8/2022 | Bos | Wilson,S | Demoted to reserve roster | | | Before |
| 8/8/2022 | Det | Bryant | Demoted to reserve roster | | | Before |
| 8/8/2022 | Det | Kershaw | Demoted to reserve roster | | | Before |
| 8/8/2022 | Min | Castillo,D | Promoted to active roster | | | Before |
| 8/8/2022 | Min | Haniger | Promoted to active roster | | | Before |
| 8/8/2022 | Min | Javier,C | Demoted to reserve roster | | | Before |
| 8/8/2022 | Min | Thielbar | Promoted to active roster | | | Before |
| 8/8/2022 | Min | Wade Jr. | Demoted to reserve roster | | | Before |
| 8/8/2022 | NYA | Stripling | Demoted to reserve roster | | | Before |
| 8/8/2022 | Oak | Kirilloff | Demoted to reserve roster | | | Before |
| 8/8/2022 | Oak | Refsnyder | Demoted to reserve roster | | | Before |
| 8/8/2022 | Oak | Scott,C | Promoted to active roster | | | Before |
| 8/8/2022 | Oak | Wisely | Promoted to active roster | | | Before |
| 8/8/2022 | Tam | Mead | Demoted to reserve roster | | | Before |
| 8/8/2022 | Tam | Walker,C | Promoted to active roster | | | Before |
| 8/8/2022 | Tor | Johnston,T | Released | | | Before |
| 8/11/2022 | Cle | Cabrera,E | Acquired via trade | SD | | After |
| 8/11/2022 | Cle | Kieboom | Traded away | SD | | After |
| 8/11/2022 | Cle | Swaggerty | Acquired via trade | SD | | After |
| 8/12/2022 | Bal | Alcala | Released | | | Before |
| 8/12/2022 | Bal | Antuna | Signed | | | Before |
| 8/12/2022 | Bal | Castillo,DA | Released | | | Before |
| 8/12/2022 | Bal | Wantz | Signed | | | Before |
| 8/12/2022 | Bal | Zerpa | Released | | | Before |
| 8/12/2022 | Bos | Yates | Promoted to active roster | | | Before |
| 8/12/2022 | Cle | Cabrera,E | Demoted to reserve roster | | | Before |
| 8/12/2022 | Cle | Camargo,Jo | Demoted to reserve roster | | | Before |
| 8/12/2022 | Cle | Finnegan,K | Demoted to reserve roster | | | Before |
| 8/12/2022 | Cle | Suarez,Ro | Promoted to active roster | | | Before |
| 8/12/2022 | Cle | Turner,J | Promoted to active roster | | | Before |
| 8/12/2022 | Cle | Williams,Tr | Demoted to reserve roster | | | Before |
| 8/12/2022 | Sea | Pacheco | Released | | | Before |
| 8/12/2022 | Tex | Cordero,F | Released | | | Before |
| 8/14/2022 | ChA | De Los Santos | Traded away | SD | | After |
| 8/14/2022 | ChA | Gray,Jos | Acquired via trade | SD | | After |
| 8/14/2022 | ChA | Mitchell,C | Acquired via trade | SD | | After |
| 8/14/2022 | ChA | Pages | Traded away | SD | | After |
| 8/14/2022 | ChA | Sosa,L | Acquired via trade | SD | | After |
| 8/14/2022 | Oak | Rivera,E | Acquired via trade | SD | | After |
| 8/14/2022 | Oak | Rogers,Ty | Traded away | Pit | | After |
| 8/15/2022 | ChA | Hurtubise | Released | | | Before |
| 8/15/2022 | ChA | Olivares | Demoted to reserve roster | | | Before |
| 8/15/2022 | ChA | Sosa,L | Promoted to active roster | | | Before |
| 8/15/2022 | Cle | Cabrera,E | Promoted to active roster | | | Before |
| 8/15/2022 | Cle | Camargo,Jo | Released | | | Before |
| 8/15/2022 | Cle | Swaggerty | Demoted to reserve roster | | | Before |
| 8/15/2022 | Hou | Anderson,Ti | Demoted to reserve roster | | | Before |
| 8/15/2022 | Hou | Diaz,El | Demoted to reserve roster | | | Before |
| 8/15/2022 | KC | Daza | Demoted to reserve roster | | | Before |
| 8/15/2022 | LAA | Arano | Promoted to active roster | | | Before |
| 8/15/2022 | LAA | Blackburn | Demoted to reserve roster | | | Before |
| 8/15/2022 | LAA | Crowe | Promoted to active roster | | | Before |
| 8/15/2022 | LAA | Howard,Sp | Demoted to reserve roster | | | Before |
| 8/15/2022 | LAA | Junis | Promoted to active roster | | | Before |
| 8/15/2022 | LAA | Vasquez,R | Promoted to active roster | | | Before |
| 8/15/2022 | Oak | Giles | Promoted to active roster | | | Before |
| 8/15/2022 | Oak | Noda | Demoted to reserve roster | | | Before |
| 8/15/2022 | Oak | Scott,C | Demoted to reserve roster | | | Before |
| 8/15/2022 | Oak | Short,Z | Signed | | | Before |
| 8/15/2022 | Oak | Short,Z | Promoted to active roster | | | Before |
| 8/15/2022 | Oak | Vest | Signed | | | Before |
| 8/15/2022 | Tor | Muzziotti | Signed | | | Before |
| 8/18/2022 | Bal | Hernandez,Dar | Traded away | Mia | | After |
| 8/18/2022 | Cle | Fletcher,Da | Traded away | Pit | | After |
| 8/18/2022 | Cle | Ozuna,M | Acquired via trade | Pit | | After |
| 8/18/2022 | Cle | Rosenthal | Traded away | Pit | | After |
| 8/18/2022 | Tor | Adames,W | Traded away | Pit | | After |
| 8/18/2022 | Tor | Encarnacion,J | Traded away | Pit | | After |
| 8/18/2022 | Tor | Helsley | Acquired via trade | Pit | | After |
| 8/18/2022 | Tor | Pfaadt | Acquired via trade | Pit | | After |
| 8/19/2022 | Bal | Bradish | Promoted to active roster | | | Before |
| 8/19/2022 | Bal | Dunn,J | Promoted to active roster | | | Before |
| 8/19/2022 | Bal | Rodriguez,Ju | Promoted to active roster | | | Before |
| 8/19/2022 | Bal | Wantz | Promoted to active roster | | | Before |
| 8/19/2022 | ChA | Guillorme | Demoted to reserve roster | | | Before |
| 8/19/2022 | ChA | Zavala | Promoted to active roster | | | Before |
| 8/19/2022 | KC | Melendez,J | Released | | | Before |
| 8/19/2022 | Oak | Haggerty | Signed | | | Before |
| 8/19/2022 | Oak | Madris | Released | | | Before |
| 8/19/2022 | Tam | Bender | Demoted to reserve roster | | | Before |
| 8/21/2022 | Cle | Grandal | Acquired via trade | Pit | | After |
| 8/21/2022 | Cle | Jones,G | Traded away | Pit | | After |
| 8/21/2022 | Cle | Knizner | Traded away | Pit | | After |
| 8/21/2022 | Hou | Chafin | Traded away | Oak | | After |
| 8/21/2022 | Hou | Hicks,Jor | Traded away | Pit | | After |
| 8/21/2022 | Hou | Soler | Traded away | Pit | | After |
| 8/21/2022 | Min | Bader | Traded away | Cin | | After |
| 8/21/2022 | Min | India | Traded away | Cin | | After |
| 8/21/2022 | Min | Snead | Acquired via trade | Cin | | After |
| 8/21/2022 | Min | Springer | Acquired via trade | Cin | | After |
| 8/21/2022 | Min | Williams,D | Acquired via trade | Cin | | After |
| 8/21/2022 | Oak | Chafin | Acquired via trade | Hou | | After |
| 8/22/2022 | Bos | Canzone | Signed | | | Before |
| 8/22/2022 | Bos | Hernandez,Ya | Demoted to reserve roster | | | Before |
| 8/22/2022 | Cle | Cabrera,E | Demoted to reserve roster | | | Before |
| 8/22/2022 | Cle | Lavastida | Signed | | | Before |
| 8/22/2022 | Cle | McGuire | Demoted to reserve roster | | | Before |
| 8/22/2022 | Cle | Strahm | Promoted to active roster | | | Before |
| 8/22/2022 | Hou | Gose | Released | | | Before |
| 8/22/2022 | KC | Escobar,Edu | Demoted to reserve roster | | | Before |
| 8/22/2022 | LAA | Marsh,B | Demoted to reserve roster | | | Before |
| 8/22/2022 | Min | Castillo,D | Demoted to reserve roster | | | Before |
| 8/22/2022 | Min | Julien | Demoted to reserve roster | | | Before |
| 8/22/2022 | Min | Rocchio | Promoted to active roster | | | Before |
| 8/22/2022 | Min | Smeltzer | Released | | | Before |
| 8/22/2022 | Min | Snead | Promoted to active roster | | | Before |
| 8/22/2022 | Oak | Giles | Demoted to reserve roster | | | Before |
| 8/22/2022 | Oak | Giles | Promoted to active roster | | | Before |
| 8/22/2022 | Oak | Holmes,C | Demoted to reserve roster | | | Before |
| 8/22/2022 | Oak | Refsnyder | Promoted to active roster | | | Before |
| 8/22/2022 | Oak | Rivera,E | Demoted to reserve roster | | | Before |
| 8/22/2022 | Oak | Vest | Demoted to reserve roster | | | Before |
| 8/22/2022 | Oak | Vest | Promoted to active roster | | | Before |
| 8/22/2022 | Sea | Garcia,LV | Demoted to reserve roster | | | Before |
| 8/22/2022 | Sea | Gonzalez,O | Promoted to active roster | | | Before |
| 8/22/2022 | Sea | Martin,A | Promoted to active roster | | | Before |
| 8/22/2022 | Sea | Perez,We | Demoted to reserve roster | | | Before |
| 8/22/2022 | Tam | Bender | Released | | | Before |
| 8/22/2022 | Tex | Alvarez,Yo | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Brennan,W | Demoted to reserve roster | | | Before |
| 8/22/2022 | Tex | Brennan,W | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Correa,C | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Effross | Demoted to reserve roster | | | Before |
| 8/22/2022 | Tex | Horwitz | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | McCullers Jr. | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Moncada | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Morris,C | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Patino | Promoted to active roster | | | Before |
| 8/22/2022 | Tex | Rodriguez,G | Demoted to reserve roster | | | Before |
| 8/22/2022 | Tex | Swarmer | Demoted to reserve roster | | | Before |
| 8/26/2022 | Bal | Grove | Signed | | | Before |
| 8/26/2022 | Bos | Battenfield,P | Released | | | Before |
| 8/26/2022 | Bos | Davies | Signed | | | Before |
| 8/26/2022 | ChA | Battenfield,P | Signed | | | Before |
| 8/26/2022 | ChA | Mitchell,C | Released | | | Before |
| 8/26/2022 | Cle | Grandal | Demoted to reserve roster | | | Before |
| 8/26/2022 | Cle | Lavastida | Released | | | Before |
| 8/26/2022 | Cle | McGuire | Promoted to active roster | | | Before |
| 8/26/2022 | Tam | Cordero,F | Signed | | | Before |
| 8/26/2022 | Tam | Mateo | Signed | | | Before |
| 8/26/2022 | Tor | Balazovic | Signed | | | Before |
| 8/26/2022 | Tor | Vierling | Released | | | Before |
| 8/28/2022 | Bos | Davies | Acquired via trade | Tam | | After |
| 8/28/2022 | Tam | Davies | Traded away | Bos | | After |
| 8/29/2022 | Bos | Canzone | Released | | | Before |
| 8/29/2022 | Bos | Cousins | Promoted to active roster | | | Before |
| 8/29/2022 | Bos | Davies | Released | | | Before |
| 8/29/2022 | Bos | Garlick | Promoted to active roster | | | Before |
| 8/29/2022 | Bos | Kluber | Demoted to reserve roster | | | Before |
| 8/29/2022 | Hou | Feliz,M | Promoted to active roster | | | Before |
| 8/29/2022 | Hou | Pressly | Demoted to reserve roster | | | Before |
| 8/29/2022 | KC | Buxton | Demoted to reserve roster | | | Before |
| 8/29/2022 | KC | Wheeler | Demoted to reserve roster | | | Before |
| 8/29/2022 | Oak | Aguilar,J | Demoted to reserve roster | | | Before |
| 8/29/2022 | Oak | Eovaldi | Demoted to reserve roster | | | Before |
| 8/29/2022 | Oak | Holmes,C | Promoted to active roster | | | Before |
| 8/29/2022 | Oak | Story | Promoted to active roster | | | Before |
| 8/29/2022 | Sea | Garcia,LV | Promoted to active roster | | | Before |
| 8/29/2022 | Sea | Santos,G | Demoted to reserve roster | | | Before |
| 8/29/2022 | Tam | Abrams | Promoted to active roster | | | Before |
| 8/29/2022 | Tam | Burleson | Promoted to active roster | | | Before |
| 8/29/2022 | Tam | Chavis | Demoted to reserve roster | | | Before |
| 8/29/2022 | Tam | Cordero,F | Released | | | Before |
| 8/29/2022 | Tam | Davies | Released | | | Before |
| 8/29/2022 | Tam | Davies | Signed | | | Before |
| 8/29/2022 | Tam | Davies | Signed | | | Before |
| 8/29/2022 | Tam | Garrett,B | Demoted to reserve roster | | | Before |
| 8/29/2022 | Tam | Mateo | Released | | | Before |
| 8/29/2022 | Tam | Mazara | Demoted to reserve roster | | | Before |
| 8/29/2022 | Tam | Mead | Promoted to active roster | | | Before |
| 8/29/2022 | Tex | Cordero,F | Signed | | | Before |
| 8/29/2022 | Tex | Mateo | Signed | | | Before |
| 8/29/2022 | Tex | Moncada | Demoted to reserve roster | | | Before |
| 8/29/2022 | Tor | Long | Demoted to reserve roster | | | Before |
| 9/1/2022 | Cle | Davis,JD | Acquired via trade | Tam | | After |
| 9/1/2022 | Cle | Gallegos | Acquired via trade | Was | | After |
| 9/1/2022 | Cle | Longoria | Traded away | KC | | After |
| 9/1/2022 | Cle | Lucchesi | Acquired via trade | Was | | After |
| 9/1/2022 | Cle | Martinez,JD | Acquired via trade | KC | | After |
| 9/1/2022 | Cle | Merrifield | Traded away | NYA | | After |
| 9/1/2022 | Cle | Ozuna,M | Traded away | KC | | After |
| 9/1/2022 | Cle | Ragans | Traded away | Was | | After |
| 9/1/2022 | Cle | Turner,J | Traded away | NYA | | After |
| 9/1/2022 | Cle | Williams,Tr | Traded away | KC | | After |
| 9/1/2022 | Hou | Blackmon | Traded away | Pit | | After |
| 9/1/2022 | Hou | Bumgarner | Acquired via trade | Pit | | After |
| 9/1/2022 | KC | Longoria | Acquired via trade | Cle | | After |
| 9/1/2022 | KC | Martinez,JD | Traded away | Cle | | After |
| 9/1/2022 | KC | Ozuna,M | Acquired via trade | Cle | | After |
| 9/1/2022 | KC | Williams,Tr | Acquired via trade | Cle | | After |
| 9/1/2022 | NYA | Carrasco | Acquired via trade | Mia | | After |
| 9/1/2022 | NYA | Hunter,T | Acquired via trade | Mia | | After |
| 9/1/2022 | NYA | Merrifield | Acquired via trade | Cle | | After |
| 9/1/2022 | NYA | Paddack | Traded away | Mia | | After |
| 9/1/2022 | NYA | Pollock | Acquired via trade | Col | | After |
| 9/1/2022 | NYA | Stumpo | Acquired via trade | Mia | | After |
| 9/1/2022 | NYA | Turner,J | Acquired via trade | Cle | | After |
| 9/1/2022 | Oak | Mercado | Acquired via trade | Atl | | After |
| 9/1/2022 | Tam | Davis,JD | Traded away | Cle | | After |
| 9/2/2022 | Cle | Hampson | Signed | | | Before |
| 9/2/2022 | KC | Alvarez,J | Released | | | Before |
| 9/2/2022 | KC | Meneses | Signed | | | Before |
| 9/2/2022 | KC | Munoz,Y | Released | | | Before |
| 9/2/2022 | Oak | Aguilar,J | Promoted to active roster | | | Before |
| 9/2/2022 | Sea | Pacheco | Signed | | | Before |
| 9/2/2022 | Sea | Santos,G | Released | | | Before |
| 9/2/2022 | Sea | Santos,G | Signed | | | Before |
| 9/2/2022 | Tam | Mazara | Released | | | Before |
| 9/2/2022 | Tam | Otto | Signed | | | Before |
| 9/2/2022 | Tex | Horwitz | Released | | | Before |
| 9/4/2022 | Bos | Davies | Traded away | Tam | | After |
| 9/4/2022 | Tam | Davies | Acquired via trade | Bos | | After |
| 9/5/2022 | Bos | Hernandez,Ya | Released | | | Before |
| 9/5/2022 | ChA | Battenfield,P | Promoted to active roster | | | Before |
| 9/5/2022 | ChA | Hernandez,Day | Demoted to reserve roster | | | Before |
| 9/5/2022 | ChA | Olivares | Promoted to active roster | | | Before |
| 9/5/2022 | Cle | Berti | Promoted to active roster | | | Before |
| 9/5/2022 | Cle | Grandal | Promoted to active roster | | | Before |
| 9/5/2022 | Cle | Kolarek | Signed | | | Before |
| 9/5/2022 | Cle | Loup | Demoted to reserve roster | | | Before |
| 9/5/2022 | Cle | Loup | Promoted to active roster | | | Before |
| 9/5/2022 | Cle | Lowe,B | Demoted to reserve roster | | | Before |
| 9/5/2022 | Cle | McGuire | Demoted to reserve roster | | | Before |
| 9/5/2022 | Cle | Munoz,Y | Signed | | | Before |
| 9/5/2022 | Cle | Munoz,Y | Promoted to active roster | | | Before |
| 9/5/2022 | Cle | Otero | Demoted to reserve roster | | | Before |
| 9/5/2022 | Hou | O'Hoppe | Promoted to active roster | | | Before |
| 9/5/2022 | Hou | Polanco,J | Demoted to reserve roster | | | Before |
| 9/5/2022 | KC | Barnes,M | Promoted to active roster | | | Before |
| 9/5/2022 | KC | Carpenter,K | Promoted to active roster | | | Before |
| 9/5/2022 | KC | Escobar,Edu | Promoted to active roster | | | Before |
| 9/5/2022 | KC | Longoria | Promoted to active roster | | | Before |
| 9/5/2022 | KC | Thompson,R | Demoted to reserve roster | | | Before |
| 9/5/2022 | KC | Williams,Tr | Promoted to active roster | | | Before |
| 9/5/2022 | Min | Benintendi | Demoted to reserve roster | | | Before |
| 9/5/2022 | Min | Julien | Promoted to active roster | | | Before |
| 9/5/2022 | NYA | Betances | Demoted to reserve roster | | | Before |
| 9/5/2022 | NYA | Cobb,A | Promoted to active roster | | | Before |
| 9/5/2022 | NYA | Harper,B | Promoted to active roster | | | Before |
| 9/5/2022 | NYA | Herrera,O | Demoted to reserve roster | | | Before |
| 9/5/2022 | NYA | Hunter,T | Promoted to active roster | | | Before |
| 9/5/2022 | NYA | Scherzer | Promoted to active roster | | | Before |
| 9/5/2022 | NYA | Stripling | Promoted to active roster | | | Before |
| 9/5/2022 | NYA | Verlander | Demoted to reserve roster | | | Before |
| 9/5/2022 | Oak | Giles | Demoted to reserve roster | | | Before |
| 9/5/2022 | Oak | Rojas,M | Signed | | | Before |
| 9/5/2022 | Oak | Rojas,M | Promoted to active roster | | | Before |
| 9/5/2022 | Oak | Scott,C | Released | | | Before |
| 9/5/2022 | Oak | Vest | Promoted to active roster | | | Before |
| 9/5/2022 | Oak | Wisely | Demoted to reserve roster | | | Before |
| 9/5/2022 | Sea | Baty | Demoted to reserve roster | | | Before |
| 9/5/2022 | Sea | McClanahan | Demoted to reserve roster | | | Before |
| 9/5/2022 | Sea | Oviedo,J | Signed | | | Before |
| 9/5/2022 | Sea | Oviedo,J | Promoted to active roster | | | Before |
| 9/5/2022 | Sea | Pacheco | Promoted to active roster | | | Before |
| 9/5/2022 | Sea | Perez,We | Released | | | Before |
| 9/5/2022 | Sea | Robinson,Ca | Released | | | Before |
| 9/5/2022 | Sea | Robinson,Ca | Signed | | | Before |
| 9/5/2022 | Tam | Chavis | Released | | | Before |
| 9/5/2022 | Tam | Otto | Promoted to active roster | | | Before |
| 9/5/2022 | Tam | Tepera | Released | | | Before |
| 9/5/2022 | Tam | Walton | Released | | | Before |
| 9/5/2022 | Tex | Brennan,W | Promoted to active roster | | | Before |
| 9/5/2022 | Tex | Cordero,F | Released | | | Before |
| 9/5/2022 | Tex | Gonsolin | Demoted to reserve roster | | | Before |
| 9/5/2022 | Tex | Mateo | Promoted to active roster | | | Before |
| 9/5/2022 | Tex | Moncada | Promoted to active roster | | | Before |
| 9/5/2022 | Tex | Rodriguez,G | Demoted to reserve roster | | | Before |
| 9/5/2022 | Tex | Rodriguez,G | Promoted to active roster | | | Before |
| 9/5/2022 | Tor | Appel | Signed | | | Before |
| 9/5/2022 | Tor | Johnston,T | Signed | | | Before |
| 9/5/2022 | Tor | Lindow | Released | | | Before |
| 9/5/2022 | Tor | Pilkington | Released | | | Before |
| 9/9/2022 | ChA | Hernandez,Day | Released | | | Before |
| 9/9/2022 | ChA | Viloria | Released | | | Before |
| 9/9/2022 | Cle | Lowe,B | Promoted to active roster | | | Before |
| 9/9/2022 | Cle | Munoz,Y | Demoted to reserve roster | | | Before |
| 9/9/2022 | Hou | de Oca | Signed | | | Before |
| 9/9/2022 | KC | Daza | Promoted to active roster | | | Before |
| 9/9/2022 | KC | Miley | Promoted to active roster | | | Before |
| 9/9/2022 | KC | Wood,H | Demoted to reserve roster | | | Before |
| 9/9/2022 | NYA | Carrasco | Promoted to active roster | | | Before |
| 9/9/2022 | NYA | Scherzer | Demoted to reserve roster | | | Before |
| 9/9/2022 | NYA | Wells,T | Promoted to active roster | | | Before |
| 9/9/2022 | Oak | Bummer | Promoted to active roster | | | Before |
| 9/9/2022 | Oak | Short,Z | Demoted to reserve roster | | | Before |
| 9/12/2022 | Bos | Curry,X | Released | | | Before |
| 9/12/2022 | ChA | Guillorme | Promoted to active roster | | | Before |
| 9/12/2022 | ChA | King,J | Released | | | Before |
| 9/12/2022 | ChA | Lambert,J | Signed | | | Before |
| 9/12/2022 | ChA | Lambert,J | Promoted to active roster | | | Before |
| 9/12/2022 | Cle | Cabrera,E | Promoted to active roster | | | Before |
| 9/12/2022 | Cle | Liberatore | Demoted to reserve roster | | | Before |
| 9/12/2022 | KC | Miley | Demoted to reserve roster | | | Before |
| 9/12/2022 | KC | Norris | Released | | | Before |
| 9/12/2022 | KC | Villar,J | Signed | | | Before |
| 9/12/2022 | KC | Villar,J | Promoted to active roster | | | Before |
| 9/12/2022 | Min | Lauer | Demoted to reserve roster | | | Before |
| 9/12/2022 | NYA | LeMahieu | Demoted to reserve roster | | | Before |
| 9/12/2022 | Oak | Marte,S | Demoted to reserve roster | | | Before |
| 9/12/2022 | Oak | Wisely | Promoted to active roster | | | Before |
| 9/16/2022 | Bal | Antuna | Released | | | Before |
| 9/16/2022 | Bal | Assad | Signed | | | Before |
| 9/16/2022 | Bal | Grove | Released | | | Before |
| 9/16/2022 | Cle | Cabrera,E | Demoted to reserve roster | | | Before |
| 9/16/2022 | Cle | Cabrera,E | Promoted to active roster | | | Before |
| 9/16/2022 | Cle | Hampson | Promoted to active roster | | | Before |
| 9/16/2022 | Cle | Liberatore | Demoted to reserve roster | | | Before |
| 9/16/2022 | Cle | Liberatore | Promoted to active roster | | | Before |
| 9/16/2022 | Cle | Lowe,B | Demoted to reserve roster | | | Before |
| 9/16/2022 | KC | Duffy,D | Released | | | Before |
| 9/16/2022 | KC | Gilbert,T | Released | | | Before |
| 9/16/2022 | KC | Mathias | Signed | | | Before |
| 9/16/2022 | KC | Okert | Signed | | | Before |
| 9/16/2022 | KC | Ritchie | Released | | | Before |
| 9/16/2022 | KC | Sampson | Signed | | | Before |
| 9/16/2022 | KC | Sampson | Demoted to reserve roster | | | Before |
| 9/16/2022 | Oak | Kahnle | Promoted to active roster | | | Before |
| 9/16/2022 | Oak | Vest | Demoted to reserve roster | | | Before |
| 9/16/2022 | Tam | Davies | Released | | | Before |
| 9/16/2022 | Tam | Garrett,B | Promoted to active roster | | | Before |
| 9/16/2022 | Tam | Mead | Demoted to reserve roster | | | Before |
| 9/16/2022 | Tam | Otto | Promoted to active roster | | | Before |
| 9/16/2022 | Tam | Solak | Promoted to active roster | | | Before |
| 9/16/2022 | Tam | Velazquez,N | Promoted to active roster | | | Before |
| 9/16/2022 | Tex | Mateo | Released | | | Before |
| 9/19/2022 | Bal | Dunn,J | Released | | | Before |
| 9/19/2022 | Bal | Grove | Signed | | | Before |
| 9/19/2022 | Bal | Rodriguez,Alb | Released | | | Before |
| 9/19/2022 | Bos | Garlick | Demoted to reserve roster | | | Before |
| 9/19/2022 | Bos | Yates | Demoted to reserve roster | | | Before |
| 9/19/2022 | ChA | Suwinski | Released | | | Before |
| 9/19/2022 | Min | Ober | Promoted to active roster | | | Before |
| 9/19/2022 | NYA | Verlander | Promoted to active roster | | | Before |
| 9/19/2022 | Oak | Nance | Demoted to reserve roster | | | Before |
| 9/19/2022 | Sea | McClanahan | Promoted to active roster | | | Before |
| 9/23/2022 | Cle | Berti | Demoted to reserve roster | | | Before |
| 9/23/2022 | Cle | Munoz,Y | Promoted to active roster | | | Before |
| 9/23/2022 | KC | Carpenter,K | Demoted to reserve roster | | | Before |
| 9/23/2022 | KC | May,T | Promoted to active roster | | | Before |
| 9/23/2022 | KC | Wheeler | Promoted to active roster | | | Before |
| 9/23/2022 | NYA | Herrera,O | Released | | | Before |
| 9/23/2022 | NYA | Scherzer | Promoted to active roster | | | Before |
| 9/23/2022 | Oak | Aguilar,J | Released | | | Before |
| 9/23/2022 | Oak | Murphy,T | Signed | | | Before |
| 9/26/2022 | KC | Schwindel | Released | | | Before |
| 9/26/2022 | KC | Yarbrough | Demoted to reserve roster | | | Before |
| 9/26/2022 | Min | Civale | Promoted to active roster | | | Before |
| 9/26/2022 | Min | Gray,So | Demoted to reserve roster | | | Before |
| 9/26/2022 | Min | Jax | Demoted to reserve roster | | | Before |
| 9/26/2022 | Min | Lauer | Promoted to active roster | | | Before |
| 9/26/2022 | Min | Pinder,Chad | Promoted to active roster | | | Before |
| 9/26/2022 | Min | Rodgers | Demoted to reserve roster | | | Before |
| 9/26/2022 | NYA | Hunter,T | Demoted to reserve roster | | | Before |
| 9/26/2022 | NYA | Peralta,Wa | Demoted to reserve roster | | | Before |
| 9/26/2022 | NYA | Wells,T | Demoted to reserve roster | | | Before |
| 9/26/2022 | Oak | Azocar | Signed | | | Before |
| 9/26/2022 | Oak | Gray,Jon | Promoted to active roster | | | Before |
| 9/26/2022 | Oak | Pinto,Re | Released | | | Before |
| 9/26/2022 | Oak | Short,Z | Promoted to active roster | | | Before |
| 9/26/2022 | Oak | Story | Demoted to reserve roster | | | Before |
| 9/26/2022 | Oak | Whitlock | Demoted to reserve roster | | | Before |
| 9/26/2022 | Sea | Strider | Demoted to reserve roster | | | Before |
| 9/26/2022 | Tam | Anderson,I | Demoted to reserve roster | | | Before |
| 9/26/2022 | Tam | Bednar | Promoted to active roster | | | Before |
| 9/26/2022 | Tam | Cabrera,G | Signed | | | Before |
| 9/26/2022 | Tam | Solak | Demoted to reserve roster | | | Before |
| 9/26/2022 | Tex | Brubaker | Signed | | | Before |
| 9/30/2022 | Bos | Canzone | Signed | | | Before |
| 9/30/2022 | Bos | Fry,J | Released | | | Before |
| 9/30/2022 | ChA | Battenfield,P | Released | | | Before |
| 9/30/2022 | ChA | Battenfield,P | Signed | | | Before |
| 9/30/2022 | Cle | Capel | Signed | | | Before |
| 9/30/2022 | Cle | Kolarek | Released | | | Before |
| 9/30/2022 | Cle | Mateo | Signed | | | Before |
| 9/30/2022 | Oak | Eovaldi | Promoted to active roster | | | Before |
| 9/30/2022 | Oak | Nance | Promoted to active roster | | | Before |
| 9/30/2022 | Sea | Glasnow | Promoted to active roster | | | Before |
| 9/30/2022 | Tam | Cabrera,G | Promoted to active roster | | | Before |
| 10/3/2022 | Bal | Heasley | Released | | | Before |
| 10/3/2022 | Bal | Leblanc | Signed | | | Before |
| 10/3/2022 | Cle | Berti | Promoted to active roster | | | Before |
| 10/3/2022 | Cle | Cabrera,E | Demoted to reserve roster | | | Before |
| 10/3/2022 | LAA | Crowe | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Alexy | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Cerda | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Cox | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Crismatt | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Cruz,Om | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Darvish | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Diekman | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Hedges | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Hoyt | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Judge | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Luetge | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Odor | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Ottavino | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Pujols | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Realmuto | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Scherzer | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Steckenrider | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Steckenrider | Promoted to active roster | | | Before |
| 10/3/2022 | NYA | Stumpo | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Verlander | Demoted to reserve roster | | | Before |
| 10/3/2022 | NYA | Wells,T | Promoted to active roster | | | Before |
| 10/3/2022 | Tam | Castro,W | Demoted to reserve roster | | | Before |
| 10/5/2022 | Bal | Baz | Demoted to reserve roster | | | Before |
| 10/5/2022 | Bal | Pearson | Demoted to reserve roster | | | Before |
| 10/5/2022 | Cle | Giolito | Demoted to reserve roster | | | Before |
| 10/5/2022 | Cle | Liberatore | Promoted to active roster | | | Before |
