Team game results -- 2021 Kansas City Royals
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/1/2021 | | | Tex | W | 8-2 | | Boyd | L | Boyd | Yarbrough | Lopez,P | R |
| 4/3/2021 | | | Tex | L | 6-7 | | Kershaw | L | Kershaw | | Means | L |
| 4/4/2021 | | | Tex | W | 10-2 | | Stroman | R | Stroman | Lopez,Jo | McCullers Jr. | R |
| 4/5/2021 | | @ | Cle | L | 3-6 | | Yarbrough | L | Yarbrough | | Wacha | R |
| 4/7/2021 | | @ | Cle | W | 5-3 | 11 | Thompson,J | R | Hembree | | Montgomery,J | L |
| 4/8/2021 | | @ | ChA | W | 2-0 | | Lopez,Jo | R | Feltman | | Duplantier | R |
| 4/10/2021 | | @ | ChA | W | 5-1 | | Boyd | L | Boyd | | Flores,B | L |
| 4/11/2021 | | @ | ChA | L | 1-2 | | Kershaw | L | Kershaw | | de la Cruz,J | R |
| 4/12/2021 | | | LAA | W | 4-2 | | Stroman | R | Stroman | Thompson,J | Banda | L |
| 4/13/2021 | | | LAA | W | 6-5 | | Velazquez,H | R | Feltman | | Anderson,Bre | L |
| 4/14/2021 | | | LAA | W | 16-11 | | Thompson,J | R | Hand | | Megill | R |
| 4/15/2021 | | | Tor | L | 1-2 | | Boyd | L | Pomeranz | | Richards,G | R |
| 4/16/2021 | | | Tor | W | 8-4 | | Yarbrough | L | Feltman | | Cashner | R |
| 4/17/2021 | | | Tor | W | 5-4 | | Kershaw | L | Lopez,Jo | | Flaherty | R |
| 4/18/2021 | | | Tor | W | 13-2 | | Lopez,Jo | R | Lopez,Jo | | Corbin | L |
| 4/19/2021 | | | Tam | L | 4-6 | | Stroman | R | Thompson,J | | Lyles | R |
| 4/20/2021 | | | Tam | L | 5-6 | 10 | Boyd | L | Brach | | Smeltzer | L |
| 4/21/2021 | | | Tam | W | 11-2 | | Yarbrough | L | Yarbrough | | King,M | R |
| 4/23/2021 | | @ | Det | L | 7-11 | | Kershaw | L | Kershaw | | Castillo,D | R |
| 4/24/2021 | | @ | Det | L | 1-6 | | Thompson,J | R | Thompson,J | | Giolito | R |
| 4/25/2021 | | @ | Det | L | 0-8 | | Boyd | L | Boyd | | Buehler | R |
| 4/26/2021 | | @ | Det | L | 4-8 | | Stroman | R | Stroman | | Berrios | R |
| 4/27/2021 | | @ | Pit | L | 3-4 | 10 | Kershaw | L | Brach | | Velasquez | R |
| 4/28/2021 | | @ | Pit | L | 4-6 | | Velazquez,H | R | Velazquez,H | | Martinez,C | R |
| 4/30/2021 | | @ | Min | L | 0-4 | | Lopez,Jo | R | Lopez,Jo | | Rodriguez,E | L |
| 5/1/2021 | | @ | Min | W | 5-3 | | Boyd | L | Boyd | Feltman | Maeda | R |
| 5/2/2021 | | @ | Min | L | 5-6 | | Kershaw | L | Kershaw | | Gray,S | R |
| 5/3/2021 | | | Cle | W | 4-1 | | Thompson,J | R | Feltman | | Wacha | R |
| 5/4/2021 | | | Cle | W | 5-2 | | Yarbrough | L | Yarbrough | Brach | Keller,M | R |
| 5/5/2021 | | | Cle | L | 1-7 | | Stroman | R | Stroman | | Weaver | R |
| 5/6/2021 | | | Cle | L | 2-6 | | Boyd | L | Boyd | | Montgomery,J | L |
| 5/7/2021 | | | ChA | W | 6-5 | | Kershaw | L | Brach | | Kikuchi | L |
| 5/8/2021 | | | ChA | L | 4-7 | | Lopez,Jo | R | Thompson,J | | Duplantier | R |
| 5/9/2021 | | | ChA | W | 7-4 | | Yarbrough | L | Yarbrough | Velazquez,H | Flores,B | L |
| 5/11/2021 | | @ | Det | W | 6-3 | | Boyd | L | Boyd | Parker,B | Giolito | R |
| 5/12/2021 | | @ | Det | W | 3-0 | | Stroman | R | Stroman | | Buehler | R |
| 5/13/2021 | | @ | Det | L | 3-4 | | Thompson,J | R | Thompson,J | | Berrios | R |
| 5/14/2021 | | @ | ChA | W | 7-2 | | Velazquez,H | R | Velazquez,H | Yarbrough | Duplantier | R |
| 5/15/2021 | | @ | ChA | W | 5-0 | | Kershaw | L | Kershaw | | Flores,B | L |
| 5/16/2021 | | @ | ChA | W | 7-0 | | Boyd | L | Boyd | | de la Cruz,J | R |
| 5/18/2021 | | | Mil | L | 2-6 | | Yarbrough | L | Yarbrough | | Andriese | R |
| 5/19/2021 | | | Mil | W | 3-1 | | Stroman | R | Stroman | Velazquez,H | Manaea | L |
| 5/21/2021 | | | Det | L | 2-3 | 11 | Lopez,Jo | R | Brach | | Castillo,D | R |
| 5/22/2021 | | | Det | L | 3-4 | | Boyd | L | Boyd | | Giolito | R |
| 5/23/2021 | | | Det | W | 11-4 | | Kershaw | L | Kershaw | Yarbrough | Buehler | R |
| 5/25/2021 | | @ | Tam | W | 8-1 | | Thompson,J | R | Thompson,J | | Zimmermann,B | L |
| 5/26/2021 | | @ | Tam | W | 6-4 | 10 | Yarbrough | L | Lopez,Jo | Brach | Skubal | L |
| 5/27/2021 | | @ | Tam | W | 5-3 | | Boyd | L | Hand | Hembree | King,M | R |
| 5/28/2021 | | @ | Min | W | 12-5 | | Stroman | R | Stroman | Parker,B | Arrieta | R |
| 5/29/2021 | | @ | Min | W | 1-0 | | Kershaw | L | Kershaw | | Maeda | R |
| 5/30/2021 | | @ | Min | L | 1-2 | | Wheeler | R | Rosenthal | | Gray,S | R |
| 5/31/2021 | | | Pit | W | 10-5 | | Yarbrough | L | Brach | | Odorizzi | R |
| 6/1/2021 | | | Pit | L | 4-6 | | Stroman | R | Stroman | | Velasquez | R |
| 6/3/2021 | | | Min | L | 3-6 | 11 | Kershaw | L | Velazquez,H | | Manning | R |
| 6/4/2021 | | | Min | W | 6-4 | | Boyd | L | Boyd | Parker,B | Thornton | R |
| 6/5/2021 | | | Min | W | 2-0 | | Wheeler | R | Wheeler | Rosenthal | Civale | R |
| 6/6/2021 | | | Min | W | 6-5 | | Yarbrough | L | Garcia,Y | | Ober | R |
| 6/7/2021 | | @ | LAA | L | 0-2 | | Stroman | R | Stroman | | Rondon,A | R |
| 6/8/2021 | | @ | LAA | L | 4-9 | | Kershaw | L | Kershaw | | Howard,Sp | R |
| 6/9/2021 | | @ | LAA | L | 2-3 | 12 | Boyd | L | Brach | | Anderson,Bre | L |
| 6/10/2021 | | @ | Oak | L | 2-6 | | Wheeler | R | Wheeler | | Bundy | R |
| 6/11/2021 | | @ | Oak | L | 1-4 | | Yarbrough | L | Yarbrough | | Howard,Sa | L |
| 6/12/2021 | | @ | Oak | W | 3-2 | | Stroman | R | Pomeranz | Parker,B | Peterson,Da | L |
| 6/13/2021 | | @ | Oak | L | 3-4 | | Kershaw | L | Garcia,Y | | Cole,G | R |
| 6/14/2021 | | | Det | L | 6-9 | | Boyd | L | Parker,B | | Buehler | R |
| 6/15/2021 | | | Det | W | 2-1 | 10 | Wheeler | R | Brach | | Berrios | R |
| 6/16/2021 | | | Det | L | 1-2 | | Yarbrough | L | Garcia,Y | | Hendricks | R |
| 6/18/2021 | | | Bos | L | 1-9 | | Stroman | R | Stroman | | Castillo,L | R |
| 6/19/2021 | | | Bos | L | 2-5 | | Kershaw | L | Kershaw | | Marquez,G | R |
| 6/20/2021 | | | Bos | W | 10-4 | | Boyd | L | Boyd | | Rasmussen | R |
| 6/22/2021 | | @ | NYA | L | 3-5 | | Wheeler | R | Wheeler | | Urena,J | R |
| 6/23/2021 | | @ | NYA | L | 1-10 | | Yarbrough | L | Yarbrough | | Stripling | R |
| 6/24/2021 | | @ | NYA | L | 3-4 | 11 | Stroman | R | Parker,B | | Darvish | R |
| 6/25/2021 | | @ | Tex | W | 7-3 | | Kershaw | L | Kershaw | Pomeranz | Lopez,P | R |
| 6/26/2021 | | @ | Tex | W | 6-5 | 10 | Boyd | L | Pomeranz | Rosenthal | Ohtani | R |
| 6/27/2021 | | @ | Tex | L | 1-4 | | Wheeler | R | Wheeler | | Reyes,A | R |
| 6/28/2021 | | @ | Bos | W | 9-4 | | Yarbrough | L | Yarbrough | | Marquez,G | R |
| 6/29/2021 | | @ | Bos | W | 6-4 | | Stroman | R | Stroman | Hand | Alcantara,Sa | R |
| 6/30/2021 | | @ | Bos | L | 0-3 | | Kershaw | L | Garcia,Y | | Woodruff | R |
| 7/1/2021 | | @ | Bos | L | 2-8 | | Boyd | L | Boyd | | Castillo,L | R |
| 7/2/2021 | | | Min | L | 2-7 | | Wheeler | R | Wheeler | | Gutierrez,V | R |
| 7/3/2021 | | | Min | W | 7-4 | | Yarbrough | L | Yarbrough | Garcia,Y | Civale | R |
| 7/4/2021 | | | Min | W | 2-1 | | Stroman | R | Stroman | Hand | Ober | R |
| 7/5/2021 | | | Cin | W | 2-1 | | Kershaw | L | Rosenthal | | Davies | R |
| 7/6/2021 | | | Cin | W | 2-1 | | Boyd | L | Boyd | Parker,B | Neidert | R |
| 7/7/2021 | | | Cin | W | 6-5 | | Wheeler | R | Wheeler | Hand | Nelson,Ji | R |
| 7/8/2021 | | @ | Cle | W | 9-3 | 10 | Yarbrough | L | Garcia,Y | | Montgomery,J | L |
| 7/9/2021 | | @ | Cle | L | 5-12 | | Stroman | R | Stroman | | Wacha | R |
| 7/10/2021 | | @ | Cle | L | 1-4 | | Kershaw | L | Kershaw | | Weaver | R |
| 7/11/2021 | | @ | Cle | L | 4-5 | | Turnbull | R | Hand | | Kuhl | R |
| 7/16/2021 | | | Bal | W | 7-4 | | Turnbull | R | Lopez,Jo | | deGrom | R |
| 7/17/2021 | | | Bal | L | 2-6 | | Wheeler | R | Wheeler | | Snell | L |
| 7/18/2021 | | | Bal | W | 8-2 | | Stroman | R | Stroman | | Taillon | R |
| 7/20/2021 | | @ | Mil | L | 1-5 | | Gonzales | L | Gonzales | | Bassitt | R |
| 7/21/2021 | | @ | Mil | W | 7-2 | | Yarbrough | L | Pomeranz | | Andriese | R |
| 7/23/2021 | | | Det | L | 3-4 | 11 | Turnbull | R | Floro | | Castillo,D | R |
| 7/24/2021 | | | Det | W | 12-3 | | Wheeler | R | Wheeler | | Buehler | R |
| 7/25/2021 | | | Det | L | 6-9 | | Stroman | R | Stroman | | Giolito | R |
| 7/26/2021 | | | ChA | W | 5-2 | | Gonzales | L | Gonzales | | Seabold | R |
| 7/27/2021 | | | ChA | W | 6-3 | | Yarbrough | L | Yarbrough | May,T | White,Mit | R |
| 7/28/2021 | | | ChA | W | 12-5 | | Miley | L | Miley | | de la Cruz,J | R |
| 7/29/2021 | | | ChA | W | 12-5 | | Wheeler | R | May,T | | Megill | R |
| 7/30/2021 | | @ | Tor | W | 4-1 | | Stroman | R | Stroman | Garcia,Y | Richards,G | R |
| 7/31/2021 | | @ | Tor | W | 7-6 | | Gonzales | L | Parker,B | Garcia,Y | Cashner | R |
| 8/1/2021 | | @ | Tor | W | 9-6 | | Yarbrough | L | Lopez,Jo | May,T | Harvey,H | R |
| 8/3/2021 | | @ | ChA | W | 5-2 | | DeSclafani | R | DeSclafani | Pomeranz | de la Cruz,J | R |
| 8/4/2021 | | @ | ChA | W | 7-2 | | Wheeler | R | Wheeler | | Megill | R |
| 8/5/2021 | | @ | ChA | L | 8-9 | 11 | Stroman | R | Brach | | Mize | R |
| 8/6/2021 | | @ | StL | W | 8-6 | | Gonzales | L | Gonzales | May,T | Wilson,Bry | R |
| 8/7/2021 | | @ | StL | W | 9-8 | 10 | Miley | L | May,T | | Muller | L |
| 8/8/2021 | | @ | StL | W | 9-0 | | DeSclafani | R | DeSclafani | | Martin,Co | R |
| 8/9/2021 | | | NYA | W | 7-4 | | Wheeler | R | Wheeler | Peacock,B | Darvish | R |
| 8/10/2021 | | | NYA | W | 3-2 | | Stroman | R | Floro | | Scherzer | R |
| 8/11/2021 | | | NYA | W | 3-1 | | Lopez,Jo | R | Lopez,Jo | Peacock,B | Stripling | R |
| 8/13/2021 | | | StL | W | 5-4 | 10 | DeSclafani | R | May,T | | Muller | L |
| 8/14/2021 | | | StL | L | 1-3 | | Montgomery,J | L | Montgomery,J | | Martin,Co | R |
| 8/15/2021 | | | StL | W | 7-1 | | Velazquez,H | R | Velazquez,H | | Chavez,J | R |
| 8/16/2021 | | | Hou | L | 9-11 | | Wheeler | R | Peacock,B | | Hendricks | R |
| 8/17/2021 | | | Hou | L | 3-6 | | Stroman | R | Peacock,B | | Matz | L |
| 8/18/2021 | | | Hou | W | 2-1 | | Lopez,Jo | R | Lopez,Jo | Brach | Ray,R | L |
| 8/19/2021 | | | Hou | W | 5-4 | | Montgomery,J | L | Floro | | Brubaker | R |
| 8/20/2021 | | @ | ChN | L | 3-4 | | Velazquez,H | R | Velazquez,H | | Kittredge | R |
| 8/21/2021 | | @ | ChN | W | 2-1 | 10 | Wheeler | R | Pomeranz | May,T | Keuchel | L |
| 8/22/2021 | | @ | ChN | L | 5-6 | | Stroman | R | Alvarez,J | | Minor | L |
| 8/23/2021 | | @ | Hou | W | 13-7 | | Lopez,Jo | R | Lopez,Jo | | Ray,R | L |
| 8/24/2021 | | @ | Hou | L | 3-9 | | Montgomery,J | L | Montgomery,J | | Brubaker | R |
| 8/25/2021 | | @ | Hou | L | 6-8 | | Velazquez,H | R | Floro | | Rogers,Tr | L |
| 8/26/2021 | | @ | Sea | L | 1-6 | | Wheeler | R | Wheeler | | Garcia,LuisH | R |
| 8/27/2021 | | @ | Sea | L | 1-3 | | Stroman | R | Stroman | | Ynoa,H | R |
| 8/28/2021 | | @ | Sea | W | 6-0 | | Lopez,Jo | R | Lopez,Jo | Baez,P | Abreu,B | R |
| 8/29/2021 | | @ | Sea | W | 11-0 | | Montgomery,J | L | Montgomery,J | | Gray,Jos | R |
| 8/31/2021 | | | Cle | L | 0-2 | | Velazquez,H | R | Velazquez,H | | Wacha | R |
| 9/1/2021 | | | Cle | W | 10-4 | | Wheeler | R | Wheeler | | Brault | L |
| 9/2/2021 | | | Cle | W | 4-3 | | Stroman | R | Peacock,B | Pomeranz | Kuhl | R |
| 9/3/2021 | | | ChA | W | 2-1 | | Lopez,Jo | R | Pomeranz | | Mize | R |
| 9/4/2021 | | | ChA | L | 6-7 | | Montgomery,J | L | Brach | | Seabold | R |
| 9/5/2021 | | | ChA | W | 4-2 | | Velazquez,H | R | Velazquez,H | Parker,B | White,Mit | R |
| 9/6/2021 | | @ | Bal | L | 6-17 | | DeSclafani | R | Baez,P | | Ramirez,Yo | R |
| 9/7/2021 | | @ | Bal | W | 10-4 | | Wheeler | R | Wheeler | | Sanchez,Aa | R |
| 9/8/2021 | | @ | Bal | L | 2-14 | | Stroman | R | Stroman | | Alcala | R |
| 9/9/2021 | | @ | Bal | W | 12-5 | | Lopez,Jo | R | Lopez,Jo | | Machado,A | R |
| 9/10/2021 | | @ | Min | L | 4-9 | | Montgomery,J | L | Montgomery,J | | Gutierrez,V | R |
| 9/11/2021 | | @ | Min | L | 5-9 | | DeSclafani | R | Parker,B | | Thornton | R |
| 9/12/2021 | | @ | Min | L | 3-8 | | Wheeler | R | Wheeler | | Ober | R |
| 9/14/2021 | | | Oak | W | 5-1 | | Stroman | R | Stroman | | Cole,G | R |
| 9/15/2021 | | | Oak | W | 4-3 | | Lopez,Jo | R | Doolittle | | Webb,L | R |
| 9/16/2021 | | | Oak | L | 0-3 | | Montgomery,J | L | Montgomery,J | | Eovaldi | R |
| 9/17/2021 | | | Sea | W | 4-3 | | DeSclafani | R | Pomeranz | Doolittle | Garcia,LuisH | R |
| 9/18/2021 | | | Sea | W | 6-2 | | Wheeler | R | Wheeler | | Ynoa,H | R |
| 9/19/2021 | | | Sea | W | 7-6 | | Stroman | R | Pomeranz | Doolittle | Abreu,B | R |
| 9/20/2021 | | @ | Cle | W | 6-4 | | Lopez,Jo | R | Lopez,Jo | Baez,P | Senzatela | R |
| 9/21/2021 | | @ | Cle | W | 5-2 | 10 | Montgomery,J | L | Floro | | Valdez,F | L |
| 9/22/2021 | | @ | Cle | W | 14-6 | | DeSclafani | R | May,T | | Wacha | R |
| 9/24/2021 | | @ | Det | L | 3-4 | 10 | Wheeler | R | Doolittle | | Greinke | R |
| 9/25/2021 | | @ | Det | L | 1-5 | | Stroman | R | Stroman | | Berrios | R |
| 9/26/2021 | | @ | Det | W | 6-4 | | Lopez,Jo | R | Lopez,Jo | Doolittle | Gonzales | L |
| 9/28/2021 | | | Cle | W | 7-5 | | Montgomery,J | L | Montgomery,J | Doolittle | Wacha | R |
| 9/29/2021 | | | Cle | W | 7-1 | | DeSclafani | R | DeSclafani | | Brault | L |
| 9/30/2021 | | | Cle | L | 3-6 | | Wheeler | R | Wheeler | | Kuhl | R |
| 10/1/2021 | | | Min | W | 10-3 | | Stroman | R | Stroman | | Ober | R |
| 10/2/2021 | | | Min | W | 2-1 | | Lopez,Jo | R | Doolittle | | Civale | R |
| 10/3/2021 | | | Min | W | 3-2 | | Montgomery,J | L | May,T | Doolittle | Quantrill | R |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/1/2021 | | | Tex | W | Cain | 8 | 2 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/3/2021 | | | Tex | L | | 6 | 7 | 1 | 1 | .500 | 1-1 | L1 | 2 |
| 4/4/2021 | | | Tex | W | Pillar | 10 | 2 | 2 | 1 | .667 | 2-1 | W1 | 3 |
| 4/5/2021 | | @ | Cle | L | | 3 | 6 | 2 | 2 | .500 | 2-2 | L1 | 4 |
| 4/7/2021 | | @ | Cle | W | Rodriguez,S | 5 | 3 | 3 | 2 | .600 | 3-2 | W1 | 5 |
| 4/8/2021 | | @ | ChA | W | Varsho | 2 | 0 | 4 | 2 | .667 | 4-2 | W2 | 6 |
| 4/10/2021 | | @ | ChA | W | Bogaerts | 5 | 1 | 5 | 2 | .714 | 5-2 | W3 | 7 |
| 4/11/2021 | | @ | ChA | L | | 1 | 2 | 5 | 3 | .625 | 5-3 | L1 | 8 |
| 4/12/2021 | | | LAA | W | Cain | 4 | 2 | 6 | 3 | .667 | 6-3 | W1 | 9 |
| 4/13/2021 | | | LAA | W | Bogaerts | 6 | 5 | 7 | 3 | .700 | 7-3 | W2 | 10 |
| 4/14/2021 | | | LAA | W | Bogaerts | 16 | 11 | 8 | 3 | .727 | 7-3 | W3 | 11 |
| 4/15/2021 | | | Tor | L | | 1 | 2 | 8 | 4 | .667 | 7-3 | L1 | 12 |
| 4/16/2021 | | | Tor | W | Pillar | 8 | 4 | 9 | 4 | .692 | 7-3 | W1 | 13 |
| 4/17/2021 | | | Tor | W | Bogaerts | 5 | 4 | 10 | 4 | .714 | 8-2 | W2 | 14 |
| 4/18/2021 | | | Tor | W | Bogaerts | 13 | 2 | 11 | 4 | .733 | 8-2 | W3 | 15 |
| 4/19/2021 | | | Tam | L | | 4 | 6 | 11 | 5 | .688 | 7-3 | L1 | 16 |
| 4/20/2021 | | | Tam | L | | 5 | 6 | 11 | 6 | .647 | 6-4 | L2 | 17 |
| 4/21/2021 | | | Tam | W | Bogaerts | 11 | 2 | 12 | 6 | .667 | 7-3 | W1 | 18 |
| 4/23/2021 | | @ | Det | L | | 7 | 11 | 12 | 7 | .632 | 6-4 | L1 | 19 |
| 4/24/2021 | | @ | Det | L | | 1 | 6 | 12 | 8 | .600 | 5-5 | L2 | 20 |
| 4/25/2021 | | @ | Det | L | | 0 | 8 | 12 | 9 | .571 | 4-6 | L3 | 21 |
| 4/26/2021 | | @ | Det | L | | 4 | 8 | 12 | 10 | .545 | 4-6 | L4 | 22 |
| 4/27/2021 | | @ | Pit | L | | 3 | 4 | 12 | 11 | .522 | 3-7 | L5 | 23 |
| 4/28/2021 | | @ | Pit | L | | 4 | 6 | 12 | 12 | .500 | 2-8 | L6 | 24 |
| 4/30/2021 | | @ | Min | L | | 0 | 4 | 12 | 13 | .480 | 1-9 | L7 | 25 |
| 5/1/2021 | | @ | Min | W | Sogard | 5 | 3 | 13 | 13 | .500 | 2-8 | W1 | 26 |
| 5/2/2021 | | @ | Min | L | | 5 | 6 | 13 | 14 | .481 | 2-8 | L1 | 27 |
| 5/3/2021 | | | Cle | W | Cain | 4 | 1 | 14 | 14 | .500 | 2-8 | W1 | 28 |
| 5/4/2021 | | | Cle | W | Pillar | 5 | 2 | 15 | 14 | .517 | 3-7 | W2 | 29 |
| 5/5/2021 | | | Cle | L | | 1 | 7 | 15 | 15 | .500 | 3-7 | L1 | 30 |
| 5/6/2021 | | | Cle | L | | 2 | 6 | 15 | 16 | .484 | 3-7 | L2 | 31 |
| 5/7/2021 | | | ChA | W | Wilson,Ja | 6 | 5 | 16 | 16 | .500 | 4-6 | W1 | 32 |
| 5/8/2021 | | | ChA | L | | 4 | 7 | 16 | 17 | .485 | 4-6 | L1 | 33 |
| 5/9/2021 | | | ChA | W | Wilson,Ja | 7 | 4 | 17 | 17 | .500 | 5-5 | W1 | 34 |
| 5/11/2021 | | @ | Det | W | d'Arnaud | 6 | 3 | 18 | 17 | .514 | 6-4 | W2 | 35 |
| 5/12/2021 | | @ | Det | W | Pillar | 3 | 0 | 19 | 17 | .528 | 6-4 | W3 | 36 |
| 5/13/2021 | | @ | Det | L | | 3 | 4 | 19 | 18 | .514 | 6-4 | L1 | 37 |
| 5/14/2021 | | @ | ChA | W | Sogard | 7 | 2 | 20 | 18 | .526 | 6-4 | W1 | 38 |
| 5/15/2021 | | @ | ChA | W | Rodriguez,S | 5 | 0 | 21 | 18 | .538 | 6-4 | W2 | 39 |
| 5/16/2021 | | @ | ChA | W | Gonzalez,Ma | 7 | 0 | 22 | 18 | .550 | 7-3 | W3 | 40 |
| 5/18/2021 | | | Mil | L | | 2 | 6 | 22 | 19 | .537 | 7-3 | L1 | 41 |
| 5/19/2021 | | | Mil | W | Bogaerts | 3 | 1 | 23 | 19 | .548 | 7-3 | W1 | 42 |
| 5/21/2021 | | | Det | L | | 2 | 3 | 23 | 20 | .535 | 7-3 | L1 | 43 |
| 5/22/2021 | | | Det | L | | 3 | 4 | 23 | 21 | .523 | 6-4 | L2 | 44 |
| 5/23/2021 | | | Det | W | Gonzalez,Ma | 11 | 4 | 24 | 21 | .533 | 6-4 | W1 | 45 |
| 5/25/2021 | | @ | Tam | W | Wilson,Ja | 8 | 1 | 25 | 21 | .543 | 6-4 | W2 | 46 |
| 5/26/2021 | | @ | Tam | W | d'Arnaud | 6 | 4 | 26 | 21 | .553 | 7-3 | W3 | 47 |
| 5/27/2021 | | @ | Tam | W | Cain | 5 | 3 | 27 | 21 | .563 | 7-3 | W4 | 48 |
| 5/28/2021 | | @ | Min | W | Reddick | 12 | 5 | 28 | 21 | .571 | 7-3 | W5 | 49 |
| 5/29/2021 | | @ | Min | W | Reddick | 1 | 0 | 29 | 21 | .580 | 7-3 | W6 | 50 |
| 5/30/2021 | | @ | Min | L | | 1 | 2 | 29 | 22 | .569 | 7-3 | L1 | 51 |
| 5/31/2021 | | | Pit | W | Machado,M | 10 | 5 | 30 | 22 | .577 | 7-3 | W1 | 52 |
| 6/1/2021 | | | Pit | L | | 4 | 6 | 30 | 23 | .566 | 7-3 | L1 | 53 |
| 6/3/2021 | | | Min | L | | 3 | 6 | 30 | 24 | .556 | 7-3 | L2 | 54 |
| 6/4/2021 | | | Min | W | Flores,W | 6 | 4 | 31 | 24 | .564 | 7-3 | W1 | 55 |
| 6/5/2021 | | | Min | W | Lowe,N | 2 | 0 | 32 | 24 | .571 | 7-3 | W2 | 56 |
| 6/6/2021 | | | Min | W | Pillar | 6 | 5 | 33 | 24 | .579 | 7-3 | W3 | 57 |
| 6/7/2021 | | @ | LAA | L | | 0 | 2 | 33 | 25 | .569 | 6-4 | L1 | 58 |
| 6/8/2021 | | @ | LAA | L | | 4 | 9 | 33 | 26 | .559 | 5-5 | L2 | 59 |
| 6/9/2021 | | @ | LAA | L | | 2 | 3 | 33 | 27 | .550 | 4-6 | L3 | 60 |
| 6/10/2021 | | @ | Oak | L | | 2 | 6 | 33 | 28 | .541 | 4-6 | L4 | 61 |
| 6/11/2021 | | @ | Oak | L | | 1 | 4 | 33 | 29 | .532 | 3-7 | L5 | 62 |
| 6/12/2021 | | @ | Oak | W | Lowe,N | 3 | 2 | 34 | 29 | .540 | 4-6 | W1 | 63 |
| 6/13/2021 | | @ | Oak | L | | 3 | 4 | 34 | 30 | .531 | 4-6 | L1 | 64 |
| 6/14/2021 | | | Det | L | | 6 | 9 | 34 | 31 | .523 | 3-7 | L2 | 65 |
| 6/15/2021 | | | Det | W | Bogaerts | 2 | 1 | 35 | 31 | .530 | 3-7 | W1 | 66 |
| 6/16/2021 | | | Det | L | | 1 | 2 | 35 | 32 | .522 | 2-8 | L1 | 67 |
| 6/18/2021 | | | Bos | L | | 1 | 9 | 35 | 33 | .515 | 2-8 | L2 | 68 |
| 6/19/2021 | | | Bos | L | | 2 | 5 | 35 | 34 | .507 | 2-8 | L3 | 69 |
| 6/20/2021 | | | Bos | W | Gonzalez,Ma | 10 | 4 | 36 | 34 | .514 | 3-7 | W1 | 70 |
| 6/22/2021 | | @ | NYA | L | | 3 | 5 | 36 | 35 | .507 | 3-7 | L1 | 71 |
| 6/23/2021 | | @ | NYA | L | | 1 | 10 | 36 | 36 | .500 | 3-7 | L2 | 72 |
| 6/24/2021 | | @ | NYA | L | | 3 | 4 | 36 | 37 | .493 | 2-8 | L3 | 73 |
| 6/25/2021 | | @ | Tex | W | Bogaerts | 7 | 3 | 37 | 37 | .500 | 3-7 | W1 | 74 |
| 6/26/2021 | | @ | Tex | W | Lowe,N | 6 | 5 | 38 | 37 | .507 | 4-6 | W2 | 75 |
| 6/27/2021 | | @ | Tex | L | | 1 | 4 | 38 | 38 | .500 | 3-7 | L1 | 76 |
| 6/28/2021 | | @ | Bos | W | Bogaerts | 9 | 4 | 39 | 38 | .506 | 4-6 | W1 | 77 |
| 6/29/2021 | | @ | Bos | W | Brantley | 6 | 4 | 40 | 38 | .513 | 5-5 | W2 | 78 |
| 6/30/2021 | | @ | Bos | L | | 0 | 3 | 40 | 39 | .506 | 5-5 | L1 | 79 |
| 7/1/2021 | | @ | Bos | L | | 2 | 8 | 40 | 40 | .500 | 4-6 | L2 | 80 |
| 7/2/2021 | | | Min | L | | 2 | 7 | 40 | 41 | .494 | 4-6 | L3 | 81 |
| 7/3/2021 | | | Min | W | Ford | 7 | 4 | 41 | 41 | .500 | 5-5 | W1 | 82 |
| 7/4/2021 | | | Min | W | Bogaerts | 2 | 1 | 42 | 41 | .506 | 6-4 | W2 | 83 |
| 7/5/2021 | | | Cin | W | Machado,M | 2 | 1 | 43 | 41 | .512 | 6-4 | W3 | 84 |
| 7/6/2021 | | | Cin | W | Gonzalez,Ma | 2 | 1 | 44 | 41 | .518 | 6-4 | W4 | 85 |
| 7/7/2021 | | | Cin | W | Brantley | 6 | 5 | 45 | 41 | .523 | 7-3 | W5 | 86 |
| 7/8/2021 | | @ | Cle | W | Lowe,N | 9 | 3 | 46 | 41 | .529 | 7-3 | W6 | 87 |
| 7/9/2021 | | @ | Cle | L | | 5 | 12 | 46 | 42 | .523 | 6-4 | L1 | 88 |
| 7/10/2021 | | @ | Cle | L | | 1 | 4 | 46 | 43 | .517 | 6-4 | L2 | 89 |
| 7/11/2021 | | @ | Cle | L | | 4 | 5 | 46 | 44 | .511 | 6-4 | L3 | 90 |
| 7/16/2021 | | | Bal | W | Flores,W | 7 | 4 | 47 | 44 | .516 | 7-3 | W1 | 91 |
| 7/17/2021 | | | Bal | L | | 2 | 6 | 47 | 45 | .511 | 6-4 | L1 | 92 |
| 7/18/2021 | | | Bal | W | Stassi | 8 | 2 | 48 | 45 | .516 | 6-4 | W1 | 93 |
| 7/20/2021 | | @ | Mil | L | | 1 | 5 | 48 | 46 | .511 | 5-5 | L1 | 94 |
| 7/21/2021 | | @ | Mil | W | Gonzalez,Ma | 7 | 2 | 49 | 46 | .516 | 5-5 | W1 | 95 |
| 7/23/2021 | | | Det | L | | 3 | 4 | 49 | 47 | .510 | 4-6 | L1 | 96 |
| 7/24/2021 | | | Det | W | Ford | 12 | 3 | 50 | 47 | .515 | 4-6 | W1 | 97 |
| 7/25/2021 | | | Det | L | | 6 | 9 | 50 | 48 | .510 | 4-6 | L1 | 98 |
| 7/26/2021 | | | ChA | W | Stassi | 5 | 2 | 51 | 48 | .515 | 5-5 | W1 | 99 |
| 7/27/2021 | | | ChA | W | Machado,M | 6 | 3 | 52 | 48 | .520 | 6-4 | W2 | 100 |
| 7/28/2021 | | | ChA | W | Machado,M | 12 | 5 | 53 | 48 | .525 | 6-4 | W3 | 101 |
| 7/29/2021 | | | ChA | W | Rizzo,A | 12 | 5 | 54 | 48 | .529 | 7-3 | W4 | 102 |
| 7/30/2021 | | @ | Tor | W | Federowicz | 4 | 1 | 55 | 48 | .534 | 7-3 | W5 | 103 |
| 7/31/2021 | | @ | Tor | W | Federowicz | 7 | 6 | 56 | 48 | .538 | 8-2 | W6 | 104 |
| 8/1/2021 | | @ | Tor | W | Rizzo,A | 9 | 6 | 57 | 48 | .543 | 8-2 | W7 | 105 |
| 8/3/2021 | | @ | ChA | W | Brantley | 5 | 2 | 58 | 48 | .547 | 9-1 | W8 | 106 |
| 8/4/2021 | | @ | ChA | W | Stassi | 7 | 2 | 59 | 48 | .551 | 9-1 | W9 | 107 |
| 8/5/2021 | | @ | ChA | L | | 8 | 9 | 59 | 49 | .546 | 9-1 | L1 | 108 |
| 8/6/2021 | | @ | StL | W | Bogaerts | 8 | 6 | 60 | 49 | .550 | 9-1 | W1 | 109 |
| 8/7/2021 | | @ | StL | W | Gonzalez,Ma | 9 | 8 | 61 | 49 | .555 | 9-1 | W2 | 110 |
| 8/8/2021 | | @ | StL | W | Ford | 9 | 0 | 62 | 49 | .559 | 9-1 | W3 | 111 |
| 8/9/2021 | | | NYA | W | Rizzo,A | 7 | 4 | 63 | 49 | .563 | 9-1 | W4 | 112 |
| 8/10/2021 | | | NYA | W | Flores,W | 3 | 2 | 64 | 49 | .566 | 9-1 | W5 | 113 |
| 8/11/2021 | | | NYA | W | Segura | 3 | 1 | 65 | 49 | .570 | 9-1 | W6 | 114 |
| 8/13/2021 | | | StL | W | Castellanos,N | 5 | 4 | 66 | 49 | .574 | 9-1 | W7 | 115 |
| 8/14/2021 | | | StL | L | | 1 | 3 | 66 | 50 | .569 | 8-2 | L1 | 116 |
| 8/15/2021 | | | StL | W | Castellanos,N | 7 | 1 | 67 | 50 | .573 | 8-2 | W1 | 117 |
| 8/16/2021 | | | Hou | L | | 9 | 11 | 67 | 51 | .568 | 8-2 | L1 | 118 |
| 8/17/2021 | | | Hou | L | | 3 | 6 | 67 | 52 | .563 | 7-3 | L2 | 119 |
| 8/18/2021 | | | Hou | W | Vazquez,C | 2 | 1 | 68 | 52 | .567 | 7-3 | W1 | 120 |
| 8/19/2021 | | | Hou | W | Castellanos,N | 5 | 4 | 69 | 52 | .570 | 7-3 | W2 | 121 |
| 8/20/2021 | | @ | ChN | L | | 3 | 4 | 69 | 53 | .566 | 6-4 | L1 | 122 |
| 8/21/2021 | | @ | ChN | W | Bogaerts | 2 | 1 | 70 | 53 | .569 | 6-4 | W1 | 123 |
| 8/22/2021 | | @ | ChN | L | | 5 | 6 | 70 | 54 | .565 | 5-5 | L1 | 124 |
| 8/23/2021 | | @ | Hou | W | Cain | 13 | 7 | 71 | 54 | .568 | 5-5 | W1 | 125 |
| 8/24/2021 | | @ | Hou | L | | 3 | 9 | 71 | 55 | .563 | 5-5 | L1 | 126 |
| 8/25/2021 | | @ | Hou | L | | 6 | 8 | 71 | 56 | .559 | 4-6 | L2 | 127 |
| 8/26/2021 | | @ | Sea | L | | 1 | 6 | 71 | 57 | .555 | 4-6 | L3 | 128 |
| 8/27/2021 | | @ | Sea | L | | 1 | 3 | 71 | 58 | .550 | 4-6 | L4 | 129 |
| 8/28/2021 | | @ | Sea | W | Rizzo,A | 6 | 0 | 72 | 58 | .554 | 4-6 | W1 | 130 |
| 8/29/2021 | | @ | Sea | W | Renfroe | 11 | 0 | 73 | 58 | .557 | 4-6 | W2 | 131 |
| 8/31/2021 | | | Cle | L | | 0 | 2 | 73 | 59 | .553 | 4-6 | L1 | 132 |
| 9/1/2021 | | | Cle | W | Rizzo,A | 10 | 4 | 74 | 59 | .556 | 4-6 | W1 | 133 |
| 9/2/2021 | | | Cle | W | Cain | 4 | 3 | 75 | 59 | .560 | 5-5 | W2 | 134 |
| 9/3/2021 | | | ChA | W | Bogaerts | 2 | 1 | 76 | 59 | .563 | 5-5 | W3 | 135 |
| 9/4/2021 | | | ChA | L | | 6 | 7 | 76 | 60 | .559 | 5-5 | L1 | 136 |
| 9/5/2021 | | | ChA | W | Rizzo,A | 4 | 2 | 77 | 60 | .562 | 6-4 | W1 | 137 |
| 9/6/2021 | | @ | Bal | L | | 6 | 17 | 77 | 61 | .558 | 6-4 | L1 | 138 |
| 9/7/2021 | | @ | Bal | W | Renfroe | 10 | 4 | 78 | 61 | .561 | 7-3 | W1 | 139 |
| 9/8/2021 | | @ | Bal | L | | 2 | 14 | 78 | 62 | .557 | 6-4 | L1 | 140 |
| 9/9/2021 | | @ | Bal | W | Escobar,E | 12 | 5 | 79 | 62 | .560 | 6-4 | W1 | 141 |
| 9/10/2021 | | @ | Min | L | | 4 | 9 | 79 | 63 | .556 | 6-4 | L1 | 142 |
| 9/11/2021 | | @ | Min | L | | 5 | 9 | 79 | 64 | .552 | 5-5 | L2 | 143 |
| 9/12/2021 | | @ | Min | L | | 3 | 8 | 79 | 65 | .549 | 4-6 | L3 | 144 |
| 9/14/2021 | | | Oak | W | Renfroe | 5 | 1 | 80 | 65 | .552 | 4-6 | W1 | 145 |
| 9/15/2021 | | | Oak | W | Brantley | 4 | 3 | 81 | 65 | .555 | 5-5 | W2 | 146 |
| 9/16/2021 | | | Oak | L | | 0 | 3 | 81 | 66 | .551 | 4-6 | L1 | 147 |
| 9/17/2021 | | | Sea | W | Brantley | 4 | 3 | 82 | 66 | .554 | 5-5 | W1 | 148 |
| 9/18/2021 | | | Sea | W | Daza | 6 | 2 | 83 | 66 | .557 | 5-5 | W2 | 149 |
| 9/19/2021 | | | Sea | W | Martinez,JD | 7 | 6 | 84 | 66 | .560 | 6-4 | W3 | 150 |
| 9/20/2021 | | @ | Cle | W | Vazquez,C | 6 | 4 | 85 | 66 | .563 | 6-4 | W4 | 151 |
| 9/21/2021 | | @ | Cle | W | Segura | 5 | 2 | 86 | 66 | .566 | 7-3 | W5 | 152 |
| 9/22/2021 | | @ | Cle | W | Bogaerts | 14 | 6 | 87 | 66 | .569 | 8-2 | W6 | 153 |
| 9/24/2021 | | @ | Det | L | | 3 | 4 | 87 | 67 | .565 | 8-2 | L1 | 154 |
| 9/25/2021 | | @ | Det | L | | 1 | 5 | 87 | 68 | .561 | 7-3 | L2 | 155 |
| 9/26/2021 | | @ | Det | W | Bogaerts | 6 | 4 | 88 | 68 | .564 | 7-3 | W1 | 156 |
| 9/28/2021 | | | Cle | W | Rizzo,A | 7 | 5 | 89 | 68 | .567 | 8-2 | W2 | 157 |
| 9/29/2021 | | | Cle | W | Rizzo,A | 7 | 1 | 90 | 68 | .570 | 8-2 | W3 | 158 |
| 9/30/2021 | | | Cle | L | | 3 | 6 | 90 | 69 | .566 | 7-3 | L1 | 159 |
| 10/1/2021 | | | Min | W | Renfroe | 10 | 3 | 91 | 69 | .569 | 7-3 | W1 | 160 |
| 10/2/2021 | | | Min | W | Escobar,E | 2 | 1 | 92 | 69 | .571 | 7-3 | W2 | 161 |
| 10/3/2021 | | | Min | W | Daza | 3 | 2 | 93 | 69 | .574 | 7-3 | W3 | 162 |
