Team game results -- 2021 Detroit Tigers
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/1/2021 | | | Cle | W | 5-3 | | Giolito | R | Soria | Iglesias,R | Eflin | R |
| 4/3/2021 | | | Cle | W | 3-2 | | Buehler | R | Iglesias,R | | Keller,M | R |
| 4/4/2021 | | | Cle | W | 10-9 | | Berrios | R | Doolittle | | Weaver | R |
| 4/5/2021 | | | Min | W | 4-2 | | Hendricks | R | Hendricks | Spitzbarth | Pineda,M | R |
| 4/6/2021 | | | Min | W | 13-1 | | Castillo,D | R | Castillo,D | | Civale | R |
| 4/7/2021 | | | Min | W | 2-1 | | Giolito | R | Iglesias,R | | Arrieta | R |
| 4/9/2021 | | @ | Cle | L | 0-1 | 10 | Buehler | R | Iglesias,R | | Kuhl | R |
| 4/10/2021 | | @ | Cle | W | 12-7 | | Berrios | R | Berrios | | Brault | L |
| 4/11/2021 | | @ | Cle | L | 2-4 | | Hendricks | R | Hendricks | | Eflin | R |
| 4/12/2021 | | @ | Hou | L | 0-6 | | Castillo,D | R | Castillo,D | | Matz | L |
| 4/13/2021 | | @ | Hou | W | 5-4 | | Giolito | R | Giolito | Iglesias,R | Gant | R |
| 4/14/2021 | | @ | Hou | W | 9-0 | | Buehler | R | Buehler | Rodriguez,Rich | Brubaker | R |
| 4/15/2021 | | @ | Oak | W | 6-3 | | Berrios | R | Berrios | Iglesias,R | Gray,Jon | R |
| 4/16/2021 | | @ | Oak | W | 9-4 | | Hendricks | R | Hendricks | | Peterson,Da | L |
| 4/17/2021 | | @ | Oak | W | 3-0 | | Castillo,D | R | Castillo,D | Sherfy | Webb,L | R |
| 4/18/2021 | | @ | Oak | L | 2-7 | | Giolito | R | Giolito | | Cole,G | R |
| 4/20/2021 | | | Pit | W | 9-2 | | Buehler | R | Buehler | | Odorizzi | R |
| 4/21/2021 | | | Pit | L | 4-8 | | Berrios | R | Berrios | | Velasquez | R |
| 4/22/2021 | | | Pit | W | 11-2 | | Hendricks | R | Hendricks | | Martinez,C | R |
| 4/23/2021 | | | KC | W | 11-7 | | Castillo,D | R | Castillo,D | Loup | Kershaw | L |
| 4/24/2021 | | | KC | W | 6-1 | | Giolito | R | Giolito | | Thompson,J | R |
| 4/25/2021 | | | KC | W | 8-0 | | Buehler | R | Buehler | | Boyd | L |
| 4/26/2021 | | | KC | W | 8-4 | | Berrios | R | Berrios | | Stroman | R |
| 4/27/2021 | | @ | ChA | W | 5-3 | | Hendricks | R | Hendricks | Iglesias,R | Flores,B | L |
| 4/28/2021 | | @ | ChA | W | 2-0 | | Castillo,D | R | Castillo,D | Iglesias,R | de la Cruz,J | R |
| 4/29/2021 | | @ | ChA | W | 7-2 | | Giolito | R | Giolito | | Keller,Bra | R |
| 4/30/2021 | | @ | NYA | W | 5-0 | | Buehler | R | Buehler | | Strasburg | R |
| 5/1/2021 | | @ | NYA | L | 0-5 | | Berrios | R | Berrios | | Scherzer | R |
| 5/2/2021 | | @ | NYA | W | 3-1 | | Hendricks | R | Hendricks | Iglesias,R | Darvish | R |
| 5/4/2021 | | @ | Bos | L | 4-10 | | Springs | L | Springs | | Castillo,L | R |
| 5/5/2021 | | @ | Bos | L | 7-8 | | Giolito | R | Loup | | Marquez,G | R |
| 5/6/2021 | | @ | Bos | W | 4-1 | | Buehler | R | Buehler | | Kluber | R |
| 5/7/2021 | | | Min | L | 4-11 | | Berrios | R | Berrios | | Gray,S | R |
| 5/8/2021 | | | Min | L | 8-11 | | Hendricks | R | Soria | | Arrieta | R |
| 5/9/2021 | | | Min | W | 9-8 | 10 | Springs | L | Spitzbarth | | Pineda,M | R |
| 5/11/2021 | | | KC | L | 3-6 | | Giolito | R | Giolito | | Boyd | L |
| 5/12/2021 | | | KC | L | 0-3 | | Buehler | R | Buehler | | Stroman | R |
| 5/13/2021 | | | KC | W | 4-3 | | Berrios | R | Berrios | Iglesias,R | Thompson,J | R |
| 5/14/2021 | | | ChN | W | 2-1 | | Hendricks | R | Iglesias,R | | Minor | L |
| 5/15/2021 | | | ChN | L | 4-7 | 10 | Springs | L | Iglesias,R | | Green,C | R |
| 5/16/2021 | | | ChN | W | 3-2 | | Giolito | R | Loup | | Keuchel | L |
| 5/17/2021 | | @ | Sea | W | 4-3 | | Buehler | R | Buehler | Cahill | Ynoa,H | R |
| 5/18/2021 | | @ | Sea | W | 8-3 | | Berrios | R | Berrios | | Garcia,LuisH | R |
| 5/19/2021 | | @ | Sea | W | 8-3 | | Hendricks | R | Hendricks | Sherfy | Alzolay | R |
| 5/21/2021 | | @ | KC | W | 3-2 | 11 | Castillo,D | R | Iglesias,R | | Lopez,Jo | R |
| 5/22/2021 | | @ | KC | W | 4-3 | | Giolito | R | Giolito | Loup | Boyd | L |
| 5/23/2021 | | @ | KC | L | 4-11 | | Buehler | R | Buehler | | Kershaw | L |
| 5/24/2021 | | | Cle | L | 2-5 | | Berrios | R | Berrios | | Eflin | R |
| 5/25/2021 | | | Cle | L | 1-2 | | Hendricks | R | Hendricks | | Montgomery,J | L |
| 5/26/2021 | | | Cle | W | 6-0 | | Castillo,D | R | Castillo,D | | Wacha | R |
| 5/27/2021 | | | Cle | L | 2-3 | | Giolito | R | Iglesias,R | | Weaver | R |
| 5/28/2021 | | | NYA | W | 9-8 | 10 | Buehler | R | Iglesias,R | | Crismatt | R |
| 5/29/2021 | | | NYA | W | 6-1 | | Berrios | R | Berrios | | Scherzer | R |
| 5/30/2021 | | | NYA | L | 1-11 | | Hendricks | R | Hendricks | | Strasburg | R |
| 5/31/2021 | | @ | Mil | W | 4-1 | | Castillo,D | R | Castillo,D | Iglesias,R | Lindblom | R |
| 6/1/2021 | | @ | Mil | W | 10-6 | 10 | Giolito | R | Iglesias,R | | Woods Richardsn | R |
| 6/3/2021 | | @ | ChA | L | 5-6 | 11 | Buehler | R | Springs | | de la Cruz,J | R |
| 6/4/2021 | | @ | ChA | W | 12-9 | | Berrios | R | Loup | Cahill | King,J | L |
| 6/5/2021 | | @ | ChA | L | 2-8 | | Hendricks | R | Hendricks | | Duplantier | R |
| 6/6/2021 | | @ | ChA | L | 2-5 | | Castillo,D | R | Castillo,D | | Seabold | R |
| 6/8/2021 | | | Sea | W | 11-6 | | Giolito | R | Giolito | Cahill | Glasnow | R |
| 6/9/2021 | | | Sea | L | 5-7 | | Buehler | R | Stammen | | Mejia,J | R |
| 6/10/2021 | | | Sea | W | 6-3 | | Berrios | R | Berrios | Iglesias,R | Garcia,LuisH | R |
| 6/11/2021 | | | ChA | L | 4-6 | | Hendricks | R | Hendricks | | Duplantier | R |
| 6/12/2021 | | | ChA | W | 2-1 | 10 | Castillo,D | R | Iglesias,R | | Seabold | R |
| 6/13/2021 | | | ChA | W | 3-2 | | Giolito | R | Kolarek | Iglesias,R | Flores,B | L |
| 6/14/2021 | | @ | KC | W | 9-6 | | Buehler | R | Kolarek | Suero | Boyd | L |
| 6/15/2021 | | @ | KC | L | 1-2 | 10 | Berrios | R | Iglesias,R | | Wheeler | R |
| 6/16/2021 | | @ | KC | W | 2-1 | | Hendricks | R | Stammen | | Yarbrough | L |
| 6/17/2021 | | @ | LAA | W | 5-3 | | Castillo,D | R | Doolittle | Iglesias,R | Banda | L |
| 6/18/2021 | | @ | LAA | W | 6-1 | | Giolito | R | Giolito | | Montgomery,M | L |
| 6/19/2021 | | @ | LAA | L | 2-3 | | Buehler | R | Iglesias,R | | Hoffman | R |
| 6/20/2021 | | @ | LAA | W | 7-5 | 11 | Berrios | R | Iglesias,R | | Rondon,A | R |
| 6/22/2021 | | | StL | L | 2-3 | | Hendricks | R | Hendricks | | Chavez,J | R |
| 6/23/2021 | | | StL | L | 2-5 | | Castillo,D | R | Cahill | | Ponce de Leon | R |
| 6/24/2021 | | | Hou | W | 5-2 | | Giolito | R | Giolito | Cahill | Gant | R |
| 6/25/2021 | | | Hou | L | 8-11 | | Buehler | R | Buehler | | Ray,R | L |
| 6/26/2021 | | | Hou | W | 4-1 | | Berrios | R | Berrios | Iglesias,R | Pineda,M | R |
| 6/27/2021 | | | Hou | L | 2-3 | | Buehler | R | Kolarek | | Bauer | R |
| 6/28/2021 | | @ | Cle | L | 8-10 | | Hendricks | R | Hendricks | | Montgomery,J | L |
| 6/29/2021 | | @ | Cle | L | 2-5 | | Castillo,D | R | Suero | | Wacha | R |
| 6/30/2021 | | @ | Cle | L | 6-7 | | Giolito | R | Giolito | | Weaver | R |
| 7/2/2021 | | | ChA | W | 5-2 | | Buehler | R | Buehler | Iglesias,R | King,J | L |
| 7/3/2021 | | | ChA | L | 2-9 | | Berrios | R | Kolarek | | Seabold | R |
| 7/4/2021 | | | ChA | W | 6-1 | | Hendricks | R | Hendricks | | White,Mit | R |
| 7/5/2021 | | @ | Tex | W | 2-1 | 10 | Castillo,D | R | Stammen | | Stashak | R |
| 7/6/2021 | | @ | Tex | L | 3-6 | | Giolito | R | Giolito | | Lopez,P | R |
| 7/7/2021 | | @ | Tex | W | 9-3 | | Buehler | R | Iglesias,R | | Ohtani | R |
| 7/8/2021 | | @ | Min | L | 5-7 | | Berrios | R | Suero | | Civale | R |
| 7/9/2021 | | @ | Min | W | 7-3 | 10 | Hendricks | R | Kolarek | | Ober | R |
| 7/10/2021 | | @ | Min | L | 9-10 | | Castillo,D | R | Loup | | Arrieta | R |
| 7/11/2021 | | @ | Min | W | 8-3 | | Giolito | R | Giolito | | Manning | R |
| 7/16/2021 | | | Min | L | 6-9 | 10 | Hendricks | R | Hand | | Gutierrez,V | R |
| 7/17/2021 | | | Min | W | 8-2 | | Berrios | R | Berrios | | Civale | R |
| 7/18/2021 | | | Min | W | 5-2 | | Castillo,D | R | Castillo,D | Rodriguez,Rich | Ober | R |
| 7/19/2021 | | | Tex | L | 1-5 | | Buehler | R | Buehler | | Toussaint | R |
| 7/20/2021 | | | Tex | W | 10-7 | | Giolito | R | Iglesias,R | Suero | Patino | R |
| 7/21/2021 | | | Tex | W | 10-5 | | Hendricks | R | Stammen | | McCullers Jr. | R |
| 7/22/2021 | | | Tex | L | 2-9 | | Berrios | R | Berrios | | Gonsolin | R |
| 7/23/2021 | | @ | KC | W | 4-3 | 11 | Castillo,D | R | Rodriguez,Rich | | Turnbull | R |
| 7/24/2021 | | @ | KC | L | 3-12 | | Buehler | R | Buehler | | Wheeler | R |
| 7/25/2021 | | @ | KC | W | 9-6 | | Giolito | R | Giolito | Loup | Stroman | R |
| 7/26/2021 | | @ | Min | W | 7-3 | 10 | Springs | L | Loup | | Gutierrez,V | R |
| 7/27/2021 | | @ | Min | W | 5-4 | | Berrios | R | Berrios | Hand | Thornton | R |
| 7/28/2021 | | @ | Min | W | 8-7 | | Castillo,D | R | Hand | Rodriguez,Rich | Ober | R |
| 7/29/2021 | | | Bal | W | 4-2 | | Buehler | R | Buehler | | Sanchez,Aa | R |
| 7/30/2021 | | | Bal | W | 11-3 | | Giolito | R | Giolito | | Alcala | R |
| 7/31/2021 | | | Bal | W | 9-1 | | Springs | L | Springs | | Snell | L |
| 8/1/2021 | | | Bal | W | 4-3 | | Berrios | R | Loup | | Taillon | R |
| 8/3/2021 | | | Bos | W | 6-4 | | Garrett,B | L | Stammen | Kolarek | Castillo,L | R |
| 8/4/2021 | | | Bos | W | 8-2 | | Buehler | R | Buehler | | Marquez,G | R |
| 8/5/2021 | | | Bos | W | 2-1 | 11 | Giolito | R | Loup | | Alcantara,Sa | R |
| 8/6/2021 | | @ | Cle | L | 2-6 | | Springs | L | Springs | | Valdez,F | L |
| 8/7/2021 | | @ | Cle | L | 4-7 | | Berrios | R | Berrios | | Wacha | R |
| 8/8/2021 | | @ | Cle | W | 10-6 | | Garrett,B | L | Garrett,B | | Brault | L |
| 8/10/2021 | | @ | Bal | L | 5-6 | | Buehler | R | Buehler | | Snell | L |
| 8/11/2021 | | @ | Bal | W | 3-0 | | Giolito | R | Giolito | Castillo,D | Taillon | R |
| 8/12/2021 | | @ | Bal | L | 1-2 | | Springs | L | Springs | | Sanchez,Aa | R |
| 8/13/2021 | | | Cle | W | 6-2 | | Berrios | R | Berrios | | Wacha | R |
| 8/14/2021 | | | Cle | L | 3-4 | | Gonzales | L | Gonzales | | Brault | L |
| 8/15/2021 | | | Cle | W | 6-3 | | Buehler | R | Buehler | Castillo,D | Kuhl | R |
| 8/17/2021 | | | LAA | W | 13-1 | | Giolito | R | Giolito | Garrett,B | Rondon,A | R |
| 8/18/2021 | | | LAA | W | 7-1 | | Springs | L | Springs | | Howard,Sp | R |
| 8/19/2021 | | | LAA | W | 6-4 | | Garrett,B | L | Robertson,Dav | | Banda | L |
| 8/20/2021 | | @ | Tor | L | 4-5 | | Berrios | R | Berrios | | Corbin | L |
| 8/21/2021 | | @ | Tor | L | 8-9 | 10 | Gonzales | L | Kolarek | | Abbott | R |
| 8/22/2021 | | @ | Tor | W | 3-2 | | Buehler | R | Robertson,Dav | Iglesias,R | Richards,G | R |
| 8/24/2021 | | @ | StL | L | 2-5 | | Giolito | R | Giolito | | Wilson,Bry | R |
| 8/25/2021 | | @ | StL | L | 4-5 | | Acevedo | R | Acevedo | | Fernandez,J | R |
| 8/27/2021 | | | Tor | W | 5-1 | | Berrios | R | Berrios | | Richards,G | R |
| 8/28/2021 | | | Tor | W | 6-5 | | Gonzales | L | Knebel | | Cashner | R |
| 8/29/2021 | | | Tor | W | 9-2 | | Buehler | R | Buehler | | Harvey,H | R |
| 8/31/2021 | | | Oak | L | 4-5 | | Giolito | R | Giolito | | Cole,G | R |
| 9/1/2021 | | | Oak | L | 6-9 | | Greinke | R | Greinke | | Webb,L | R |
| 9/2/2021 | | | Oak | L | 1-3 | | Berrios | R | Berrios | | Gray,Jon | R |
| 9/3/2021 | | @ | Cin | W | 8-3 | | Gonzales | L | Gonzales | | Lorenzen | R |
| 9/4/2021 | | @ | Cin | L | 4-7 | | Buehler | R | Buehler | | Davies | R |
| 9/5/2021 | | @ | Cin | L | 5-6 | 11 | Giolito | R | Iglesias,R | | Snell | L |
| 9/6/2021 | | @ | Pit | W | 15-0 | | Greinke | R | Greinke | | Taillon | R |
| 9/7/2021 | | @ | Pit | L | 2-4 | | Berrios | R | Iglesias,R | | Archer | R |
| 9/8/2021 | | @ | Pit | W | 4-2 | | Gonzales | L | Yardley | Karinchak | Boyd | L |
| 9/10/2021 | | | Tam | W | 4-2 | | Buehler | R | Buehler | Karinchak | Skubal | L |
| 9/11/2021 | | | Tam | W | 3-1 | | Castillo,D | R | Castillo,D | Karinchak | Green,J | R |
| 9/12/2021 | | | Tam | W | 5-2 | | Greinke | R | Greinke | Iglesias,R | Sheffield,Ju | L |
| 9/14/2021 | | | Mil | W | 2-0 | | Berrios | R | Berrios | Karinchak | Mejia,H | R |
| 9/15/2021 | | | Mil | W | 7-2 | | Gonzales | L | Gonzales | | Moss | L |
| 9/16/2021 | | @ | Tam | W | 8-5 | | Buehler | R | Robertson,Dav | Karinchak | Green,J | R |
| 9/17/2021 | | @ | Tam | W | 7-1 | | Castillo,D | R | Castillo,D | | Sheffield,Ju | L |
| 9/18/2021 | | @ | Tam | W | 6-4 | 11 | Greinke | R | Stammen | Hill,T | Lynch | L |
| 9/19/2021 | | @ | Tam | L | 8-9 | | Berrios | R | Hill,T | | Anderson,I | R |
| 9/20/2021 | | | ChA | W | 4-3 | | Gonzales | L | Kolarek | Karinchak | Mize | R |
| 9/21/2021 | | | ChA | W | 6-3 | | Buehler | R | Buehler | Robertson,Dav | Seabold | R |
| 9/22/2021 | | | ChA | W | 7-2 | | Castillo,D | R | Castillo,D | | White,Mit | R |
| 9/24/2021 | | | KC | W | 4-3 | 10 | Greinke | R | Iglesias,R | | Wheeler | R |
| 9/25/2021 | | | KC | W | 5-1 | | Berrios | R | Berrios | | Stroman | R |
| 9/26/2021 | | | KC | L | 4-6 | | Gonzales | L | Gonzales | | Lopez,Jo | R |
| 9/28/2021 | | @ | Min | W | 2-1 | | Buehler | R | Buehler | Karinchak | Quantrill | R |
| 9/29/2021 | | @ | Min | W | 3-1 | | Castillo,D | R | Castillo,D | Karinchak | Manning | R |
| 9/30/2021 | | @ | Min | W | 5-1 | | Giolito | R | Giolito | | Thornton | R |
| 10/1/2021 | | @ | ChA | W | 6-1 | | Berrios | R | Berrios | Iglesias,R | Megill | R |
| 10/2/2021 | | @ | ChA | W | 8-0 | | Gonzales | L | Gonzales | | Mize | R |
| 10/3/2021 | | @ | ChA | W | 11-5 | | Garrett,B | L | Hill,T | Karinchak | Seabold | R |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/1/2021 | | | Cle | W | Pham | 5 | 3 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/3/2021 | | | Cle | W | Barnhart | 3 | 2 | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 4/4/2021 | | | Cle | W | | 10 | 9 | 3 | 0 | 1.000 | 3-0 | W3 | 3 |
| 4/5/2021 | | | Min | W | Seager,C | 4 | 2 | 4 | 0 | 1.000 | 4-0 | W4 | 4 |
| 4/6/2021 | | | Min | W | | 13 | 1 | 5 | 0 | 1.000 | 5-0 | W5 | 5 |
| 4/7/2021 | | | Min | W | Devers,R | 2 | 1 | 6 | 0 | 1.000 | 6-0 | W6 | 6 |
| 4/9/2021 | | @ | Cle | L | | 0 | 1 | 6 | 1 | .857 | 6-1 | L1 | 7 |
| 4/10/2021 | | @ | Cle | W | Pham | 12 | 7 | 7 | 1 | .875 | 7-1 | W1 | 8 |
| 4/11/2021 | | @ | Cle | L | | 2 | 4 | 7 | 2 | .778 | 7-2 | L1 | 9 |
| 4/12/2021 | | @ | Hou | L | | 0 | 6 | 7 | 3 | .700 | 7-3 | L2 | 10 |
| 4/13/2021 | | @ | Hou | W | Escobar,E | 5 | 4 | 8 | 3 | .727 | 7-3 | W1 | 11 |
| 4/14/2021 | | @ | Hou | W | Astudillo | 9 | 0 | 9 | 3 | .750 | 7-3 | W2 | 12 |
| 4/15/2021 | | @ | Oak | W | Santana,C | 6 | 3 | 10 | 3 | .769 | 7-3 | W3 | 13 |
| 4/16/2021 | | @ | Oak | W | Seager,C | 9 | 4 | 11 | 3 | .786 | 7-3 | W4 | 14 |
| 4/17/2021 | | @ | Oak | W | Seager,C | 3 | 0 | 12 | 3 | .800 | 7-3 | W5 | 15 |
| 4/18/2021 | | @ | Oak | L | | 2 | 7 | 12 | 4 | .750 | 6-4 | L1 | 16 |
| 4/20/2021 | | | Pit | W | Astudillo | 9 | 2 | 13 | 4 | .765 | 7-3 | W1 | 17 |
| 4/21/2021 | | | Pit | L | | 4 | 8 | 13 | 5 | .722 | 6-4 | L1 | 18 |
| 4/22/2021 | | | Pit | W | Santana,C | 11 | 2 | 14 | 5 | .737 | 7-3 | W1 | 19 |
| 4/23/2021 | | | KC | W | Pham | 11 | 7 | 15 | 5 | .750 | 8-2 | W2 | 20 |
| 4/24/2021 | | | KC | W | Santana,C | 6 | 1 | 16 | 5 | .762 | 8-2 | W3 | 21 |
| 4/25/2021 | | | KC | W | Daza | 8 | 0 | 17 | 5 | .773 | 8-2 | W4 | 22 |
| 4/26/2021 | | | KC | W | Martinez,JD | 8 | 4 | 18 | 5 | .783 | 8-2 | W5 | 23 |
| 4/27/2021 | | @ | ChA | W | Betts | 5 | 3 | 19 | 5 | .792 | 8-2 | W6 | 24 |
| 4/28/2021 | | @ | ChA | W | Escobar,E | 2 | 0 | 20 | 5 | .800 | 8-2 | W7 | 25 |
| 4/29/2021 | | @ | ChA | W | Escobar,E | 7 | 2 | 21 | 5 | .808 | 9-1 | W8 | 26 |
| 4/30/2021 | | @ | NYA | W | Devers,R | 5 | 0 | 22 | 5 | .815 | 9-1 | W9 | 27 |
| 5/1/2021 | | @ | NYA | L | | 0 | 5 | 22 | 6 | .786 | 9-1 | L1 | 28 |
| 5/2/2021 | | @ | NYA | W | Tucker,K | 3 | 1 | 23 | 6 | .793 | 9-1 | W1 | 29 |
| 5/4/2021 | | @ | Bos | L | | 4 | 10 | 23 | 7 | .767 | 8-2 | L1 | 30 |
| 5/5/2021 | | @ | Bos | L | | 7 | 8 | 23 | 8 | .742 | 7-3 | L2 | 31 |
| 5/6/2021 | | @ | Bos | W | Astudillo | 4 | 1 | 24 | 8 | .750 | 7-3 | W1 | 32 |
| 5/7/2021 | | | Min | L | | 4 | 11 | 24 | 9 | .727 | 6-4 | L1 | 33 |
| 5/8/2021 | | | Min | L | | 8 | 11 | 24 | 10 | .706 | 5-5 | L2 | 34 |
| 5/9/2021 | | | Min | W | Pham | 9 | 8 | 25 | 10 | .714 | 5-5 | W1 | 35 |
| 5/11/2021 | | | KC | L | | 3 | 6 | 25 | 11 | .694 | 4-6 | L1 | 36 |
| 5/12/2021 | | | KC | L | | 0 | 3 | 25 | 12 | .676 | 3-7 | L2 | 37 |
| 5/13/2021 | | | KC | W | Seager,C | 4 | 3 | 26 | 12 | .684 | 4-6 | W1 | 38 |
| 5/14/2021 | | | ChN | W | Astudillo | 2 | 1 | 27 | 12 | .692 | 4-6 | W2 | 39 |
| 5/15/2021 | | | ChN | L | | 4 | 7 | 27 | 13 | .675 | 4-6 | L1 | 40 |
| 5/16/2021 | | | ChN | W | Martinez,JD | 3 | 2 | 28 | 13 | .683 | 5-5 | W1 | 41 |
| 5/17/2021 | | @ | Sea | W | | 4 | 3 | 29 | 13 | .690 | 5-5 | W2 | 42 |
| 5/18/2021 | | @ | Sea | W | | 8 | 3 | 30 | 13 | .698 | 6-4 | W3 | 43 |
| 5/19/2021 | | @ | Sea | W | Astudillo | 8 | 3 | 31 | 13 | .705 | 7-3 | W4 | 44 |
| 5/21/2021 | | @ | KC | W | Daza | 3 | 2 | 32 | 13 | .711 | 7-3 | W5 | 45 |
| 5/22/2021 | | @ | KC | W | Escobar,E | 4 | 3 | 33 | 13 | .717 | 8-2 | W6 | 46 |
| 5/23/2021 | | @ | KC | L | | 4 | 11 | 33 | 14 | .702 | 8-2 | L1 | 47 |
| 5/24/2021 | | | Cle | L | | 2 | 5 | 33 | 15 | .688 | 7-3 | L2 | 48 |
| 5/25/2021 | | | Cle | L | | 1 | 2 | 33 | 16 | .673 | 6-4 | L3 | 49 |
| 5/26/2021 | | | Cle | W | Bote | 6 | 0 | 34 | 16 | .680 | 7-3 | W1 | 50 |
| 5/27/2021 | | | Cle | L | | 2 | 3 | 34 | 17 | .667 | 6-4 | L1 | 51 |
| 5/28/2021 | | | NYA | W | Astudillo | 9 | 8 | 35 | 17 | .673 | 6-4 | W1 | 52 |
| 5/29/2021 | | | NYA | W | Pham | 6 | 1 | 36 | 17 | .679 | 6-4 | W2 | 53 |
| 5/30/2021 | | | NYA | L | | 1 | 11 | 36 | 18 | .667 | 5-5 | L1 | 54 |
| 5/31/2021 | | @ | Mil | W | Escobar,E | 4 | 1 | 37 | 18 | .673 | 5-5 | W1 | 55 |
| 6/1/2021 | | @ | Mil | W | Betts | 10 | 6 | 38 | 18 | .679 | 5-5 | W2 | 56 |
| 6/3/2021 | | @ | ChA | L | | 5 | 6 | 38 | 19 | .667 | 5-5 | L1 | 57 |
| 6/4/2021 | | @ | ChA | W | Pham | 12 | 9 | 39 | 19 | .672 | 6-4 | W1 | 58 |
| 6/5/2021 | | @ | ChA | L | | 2 | 8 | 39 | 20 | .661 | 6-4 | L1 | 59 |
| 6/6/2021 | | @ | ChA | L | | 2 | 5 | 39 | 21 | .650 | 5-5 | L2 | 60 |
| 6/8/2021 | | | Sea | W | Astudillo | 11 | 6 | 40 | 21 | .656 | 6-4 | W1 | 61 |
| 6/9/2021 | | | Sea | L | | 5 | 7 | 40 | 22 | .645 | 5-5 | L1 | 62 |
| 6/10/2021 | | | Sea | W | Tucker,K | 6 | 3 | 41 | 22 | .651 | 5-5 | W1 | 63 |
| 6/11/2021 | | | ChA | L | | 4 | 6 | 41 | 23 | .641 | 5-5 | L1 | 64 |
| 6/12/2021 | | | ChA | W | Escobar,E | 2 | 1 | 42 | 23 | .646 | 5-5 | W1 | 65 |
| 6/13/2021 | | | ChA | W | Tucker,K | 3 | 2 | 43 | 23 | .652 | 5-5 | W2 | 66 |
| 6/14/2021 | | @ | KC | W | Santana,C | 9 | 6 | 44 | 23 | .657 | 6-4 | W3 | 67 |
| 6/15/2021 | | @ | KC | L | | 1 | 2 | 44 | 24 | .647 | 5-5 | L1 | 68 |
| 6/16/2021 | | @ | KC | W | Escobar,E | 2 | 1 | 45 | 24 | .652 | 6-4 | W1 | 69 |
| 6/17/2021 | | @ | LAA | W | Escobar,E | 5 | 3 | 46 | 24 | .657 | 7-3 | W2 | 70 |
| 6/18/2021 | | @ | LAA | W | Devers,R | 6 | 1 | 47 | 24 | .662 | 7-3 | W3 | 71 |
| 6/19/2021 | | @ | LAA | L | | 2 | 3 | 47 | 25 | .653 | 7-3 | L1 | 72 |
| 6/20/2021 | | @ | LAA | W | Devers,R | 7 | 5 | 48 | 25 | .658 | 7-3 | W1 | 73 |
| 6/22/2021 | | | StL | L | | 2 | 3 | 48 | 26 | .649 | 7-3 | L1 | 74 |
| 6/23/2021 | | | StL | L | | 2 | 5 | 48 | 27 | .640 | 6-4 | L2 | 75 |
| 6/24/2021 | | | Hou | W | Escobar,E | 5 | 2 | 49 | 27 | .645 | 6-4 | W1 | 76 |
| 6/25/2021 | | | Hou | L | | 8 | 11 | 49 | 28 | .636 | 5-5 | L1 | 77 |
| 6/26/2021 | | | Hou | W | Devers,R | 4 | 1 | 50 | 28 | .641 | 6-4 | W1 | 78 |
| 6/27/2021 | | | Hou | L | | 2 | 3 | 50 | 29 | .633 | 5-5 | L1 | 79 |
| 6/28/2021 | | @ | Cle | L | | 8 | 10 | 50 | 30 | .625 | 4-6 | L2 | 80 |
| 6/29/2021 | | @ | Cle | L | | 2 | 5 | 50 | 31 | .617 | 3-7 | L3 | 81 |
| 6/30/2021 | | @ | Cle | L | | 6 | 7 | 50 | 32 | .610 | 3-7 | L4 | 82 |
| 7/2/2021 | | | ChA | W | Astudillo | 5 | 2 | 51 | 32 | .614 | 3-7 | W1 | 83 |
| 7/3/2021 | | | ChA | L | | 2 | 9 | 51 | 33 | .607 | 3-7 | L1 | 84 |
| 7/4/2021 | | | ChA | W | Devers,R | 6 | 1 | 52 | 33 | .612 | 4-6 | W1 | 85 |
| 7/5/2021 | | @ | Tex | W | Astudillo | 2 | 1 | 53 | 33 | .616 | 4-6 | W2 | 86 |
| 7/6/2021 | | @ | Tex | L | | 3 | 6 | 53 | 34 | .609 | 4-6 | L1 | 87 |
| 7/7/2021 | | @ | Tex | W | Jones,No | 9 | 3 | 54 | 34 | .614 | 4-6 | W1 | 88 |
| 7/8/2021 | | @ | Min | L | | 5 | 7 | 54 | 35 | .607 | 4-6 | L1 | 89 |
| 7/9/2021 | | @ | Min | W | Santana,C | 7 | 3 | 55 | 35 | .611 | 5-5 | W1 | 90 |
| 7/10/2021 | | @ | Min | L | | 9 | 10 | 55 | 36 | .604 | 5-5 | L1 | 91 |
| 7/11/2021 | | @ | Min | W | Jones,No | 8 | 3 | 56 | 36 | .609 | 6-4 | W1 | 92 |
| 7/16/2021 | | | Min | L | | 6 | 9 | 56 | 37 | .602 | 5-5 | L1 | 93 |
| 7/17/2021 | | | Min | W | Betts | 8 | 2 | 57 | 37 | .606 | 6-4 | W1 | 94 |
| 7/18/2021 | | | Min | W | Astudillo | 5 | 2 | 58 | 37 | .611 | 6-4 | W2 | 95 |
| 7/19/2021 | | | Tex | L | | 1 | 5 | 58 | 38 | .604 | 5-5 | L1 | 96 |
| 7/20/2021 | | | Tex | W | | 10 | 7 | 59 | 38 | .608 | 6-4 | W1 | 97 |
| 7/21/2021 | | | Tex | W | Jones,No | 10 | 5 | 60 | 38 | .612 | 6-4 | W2 | 98 |
| 7/22/2021 | | | Tex | L | | 2 | 9 | 60 | 39 | .606 | 6-4 | L1 | 99 |
| 7/23/2021 | | @ | KC | W | Jones,No | 4 | 3 | 61 | 39 | .610 | 6-4 | W1 | 100 |
| 7/24/2021 | | @ | KC | L | | 3 | 12 | 61 | 40 | .604 | 6-4 | L1 | 101 |
| 7/25/2021 | | @ | KC | W | Martinez,JD | 9 | 6 | 62 | 40 | .608 | 6-4 | W1 | 102 |
| 7/26/2021 | | @ | Min | W | Devers,R | 7 | 3 | 63 | 40 | .612 | 7-3 | W2 | 103 |
| 7/27/2021 | | @ | Min | W | Devers,R | 5 | 4 | 64 | 40 | .615 | 7-3 | W3 | 104 |
| 7/28/2021 | | @ | Min | W | Devers,R | 8 | 7 | 65 | 40 | .619 | 7-3 | W4 | 105 |
| 7/29/2021 | | | Bal | W | Martinez,JD | 4 | 2 | 66 | 40 | .623 | 8-2 | W5 | 106 |
| 7/30/2021 | | | Bal | W | Fletcher,D | 11 | 3 | 67 | 40 | .626 | 8-2 | W6 | 107 |
| 7/31/2021 | | | Bal | W | Betts | 9 | 1 | 68 | 40 | .630 | 8-2 | W7 | 108 |
| 8/1/2021 | | | Bal | W | Escobar,E | 4 | 3 | 69 | 40 | .633 | 9-1 | W8 | 109 |
| 8/3/2021 | | | Bos | W | Seager,C | 6 | 4 | 70 | 40 | .636 | 9-1 | W9 | 110 |
| 8/4/2021 | | | Bos | W | Tucker,K | 8 | 2 | 71 | 40 | .640 | 10-0 | W10 | 111 |
| 8/5/2021 | | | Bos | W | Devers,R | 2 | 1 | 72 | 40 | .643 | 10-0 | W11 | 112 |
| 8/6/2021 | | @ | Cle | L | | 2 | 6 | 72 | 41 | .637 | 9-1 | L1 | 113 |
| 8/7/2021 | | @ | Cle | L | | 4 | 7 | 72 | 42 | .632 | 8-2 | L2 | 114 |
| 8/8/2021 | | @ | Cle | W | Devers,R | 10 | 6 | 73 | 42 | .635 | 8-2 | W1 | 115 |
| 8/10/2021 | | @ | Bal | L | | 5 | 6 | 73 | 43 | .629 | 7-3 | L1 | 116 |
| 8/11/2021 | | @ | Bal | W | Astudillo | 3 | 0 | 74 | 43 | .632 | 7-3 | W1 | 117 |
| 8/12/2021 | | @ | Bal | L | | 1 | 2 | 74 | 44 | .627 | 6-4 | L1 | 118 |
| 8/13/2021 | | | Cle | W | Tucker,K | 6 | 2 | 75 | 44 | .630 | 6-4 | W1 | 119 |
| 8/14/2021 | | | Cle | L | | 3 | 4 | 75 | 45 | .625 | 5-5 | L1 | 120 |
| 8/15/2021 | | | Cle | W | Seager,C | 6 | 3 | 76 | 45 | .628 | 5-5 | W1 | 121 |
| 8/17/2021 | | | LAA | W | Devers,R | 13 | 1 | 77 | 45 | .631 | 5-5 | W2 | 122 |
| 8/18/2021 | | | LAA | W | Martinez,JD | 7 | 1 | 78 | 45 | .634 | 6-4 | W3 | 123 |
| 8/19/2021 | | | LAA | W | Astudillo | 6 | 4 | 79 | 45 | .637 | 7-3 | W4 | 124 |
| 8/20/2021 | | @ | Tor | L | | 4 | 5 | 79 | 46 | .632 | 6-4 | L1 | 125 |
| 8/21/2021 | | @ | Tor | L | | 8 | 9 | 79 | 47 | .627 | 6-4 | L2 | 126 |
| 8/22/2021 | | @ | Tor | W | Fletcher,D | 3 | 2 | 80 | 47 | .630 | 6-4 | W1 | 127 |
| 8/24/2021 | | @ | StL | L | | 2 | 5 | 80 | 48 | .625 | 6-4 | L1 | 128 |
| 8/25/2021 | | @ | StL | L | | 4 | 5 | 80 | 49 | .620 | 5-5 | L2 | 129 |
| 8/27/2021 | | | Tor | W | Garcia,Le | 5 | 1 | 81 | 49 | .623 | 6-4 | W1 | 130 |
| 8/28/2021 | | | Tor | W | Garcia,Ad | 6 | 5 | 82 | 49 | .626 | 6-4 | W2 | 131 |
| 8/29/2021 | | | Tor | W | Jones,No | 9 | 2 | 83 | 49 | .629 | 6-4 | W3 | 132 |
| 8/31/2021 | | | Oak | L | | 4 | 5 | 83 | 50 | .624 | 5-5 | L1 | 133 |
| 9/1/2021 | | | Oak | L | | 6 | 9 | 83 | 51 | .619 | 4-6 | L2 | 134 |
| 9/2/2021 | | | Oak | L | | 1 | 3 | 83 | 52 | .615 | 4-6 | L3 | 135 |
| 9/3/2021 | | @ | Cin | W | Astudillo | 8 | 3 | 84 | 52 | .618 | 5-5 | W1 | 136 |
| 9/4/2021 | | @ | Cin | L | | 4 | 7 | 84 | 53 | .613 | 4-6 | L1 | 137 |
| 9/5/2021 | | @ | Cin | L | | 5 | 6 | 84 | 54 | .609 | 4-6 | L2 | 138 |
| 9/6/2021 | | @ | Pit | W | Betts | 15 | 0 | 85 | 54 | .612 | 5-5 | W1 | 139 |
| 9/7/2021 | | @ | Pit | L | | 2 | 4 | 85 | 55 | .607 | 4-6 | L1 | 140 |
| 9/8/2021 | | @ | Pit | W | Tucker,K | 4 | 2 | 86 | 55 | .610 | 4-6 | W1 | 141 |
| 9/10/2021 | | | Tam | W | Betts | 4 | 2 | 87 | 55 | .613 | 4-6 | W2 | 142 |
| 9/11/2021 | | | Tam | W | Seager,C | 3 | 1 | 88 | 55 | .615 | 5-5 | W3 | 143 |
| 9/12/2021 | | | Tam | W | Turner,J | 5 | 2 | 89 | 55 | .618 | 6-4 | W4 | 144 |
| 9/14/2021 | | | Mil | W | Duran,Ja | 2 | 0 | 90 | 55 | .621 | 7-3 | W5 | 145 |
| 9/15/2021 | | | Mil | W | Turner,J | 7 | 2 | 91 | 55 | .623 | 7-3 | W6 | 146 |
| 9/16/2021 | | @ | Tam | W | Seager,C | 8 | 5 | 92 | 55 | .626 | 8-2 | W7 | 147 |
| 9/17/2021 | | @ | Tam | W | Betts | 7 | 1 | 93 | 55 | .628 | 9-1 | W8 | 148 |
| 9/18/2021 | | @ | Tam | W | Astudillo | 6 | 4 | 94 | 55 | .631 | 9-1 | W9 | 149 |
| 9/19/2021 | | @ | Tam | L | | 8 | 9 | 94 | 56 | .627 | 9-1 | L1 | 150 |
| 9/20/2021 | | | ChA | W | Betts | 4 | 3 | 95 | 56 | .629 | 9-1 | W1 | 151 |
| 9/21/2021 | | | ChA | W | Castellanos,N | 6 | 3 | 96 | 56 | .632 | 9-1 | W2 | 152 |
| 9/22/2021 | | | ChA | W | Tucker,K | 7 | 2 | 97 | 56 | .634 | 9-1 | W3 | 153 |
| 9/24/2021 | | | KC | W | Crawford,J | 4 | 3 | 98 | 56 | .636 | 9-1 | W4 | 154 |
| 9/25/2021 | | | KC | W | Castellanos,N | 5 | 1 | 99 | 56 | .639 | 9-1 | W5 | 155 |
| 9/26/2021 | | | KC | L | | 4 | 6 | 99 | 57 | .635 | 8-2 | L1 | 156 |
| 9/28/2021 | | @ | Min | W | Seager,C | 2 | 1 | 100 | 57 | .637 | 8-2 | W1 | 157 |
| 9/29/2021 | | @ | Min | W | Tucker,K | 3 | 1 | 101 | 57 | .639 | 8-2 | W2 | 158 |
| 9/30/2021 | | @ | Min | W | Turner,J | 5 | 1 | 102 | 57 | .642 | 8-2 | W3 | 159 |
| 10/1/2021 | | @ | ChA | W | Betts | 6 | 1 | 103 | 57 | .644 | 9-1 | W4 | 160 |
| 10/2/2021 | | @ | ChA | W | Betts | 8 | 0 | 104 | 57 | .646 | 9-1 | W5 | 161 |
| 10/3/2021 | | @ | ChA | W | Santana,C | 11 | 5 | 105 | 57 | .648 | 9-1 | W6 | 162 |
