Team game results -- 2021 Cleveland Indians
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/1/2021 | | @ | Det | L | 3-5 | | Eflin | R | Brault | | Giolito | R |
| 4/3/2021 | | @ | Det | L | 2-3 | | Keller,M | R | Bass | | Buehler | R |
| 4/4/2021 | | @ | Det | L | 9-10 | | Weaver | R | Pagan | | Berrios | R |
| 4/5/2021 | | | KC | W | 6-3 | | Wacha | R | Wacha | | Yarbrough | L |
| 4/7/2021 | | | KC | L | 3-5 | 11 | Montgomery,J | L | Bedrosian | | Thompson,J | R |
| 4/9/2021 | | | Det | W | 1-0 | 10 | Kuhl | R | Bass | | Buehler | R |
| 4/10/2021 | | | Det | L | 7-12 | | Brault | L | Brault | | Berrios | R |
| 4/11/2021 | | | Det | W | 4-2 | | Eflin | R | Eflin | Suarez,R | Hendricks | R |
| 4/12/2021 | | @ | ChA | L | 8-9 | | Keller,M | R | Bedrosian | | Keller,Bra | R |
| 4/13/2021 | | @ | ChA | W | 9-3 | | Weaver | R | Weaver | | Kikuchi | L |
| 4/14/2021 | | @ | ChA | L | 5-8 | | Suarez,R | L | Suarez,R | | Duplantier | R |
| 4/15/2021 | | @ | ChA | W | 5-2 | | Wacha | R | Wacha | Pagan | Flores,B | L |
| 4/16/2021 | | @ | Cin | L | 2-3 | | Montgomery,J | L | Pagan | | Gallen | R |
| 4/17/2021 | | @ | Cin | L | 2-4 | | Kuhl | R | Kuhl | | Nelson,Ji | R |
| 4/18/2021 | | @ | Cin | L | 2-5 | | Eflin | R | Eflin | | Davies | R |
| 4/20/2021 | | | ChA | W | 8-4 | | Brault | L | Brault | | Flores,B | L |
| 4/21/2021 | | | ChA | L | 0-5 | | Keller,M | R | Keller,M | | de la Cruz,J | R |
| 4/22/2021 | | | NYA | L | 6-10 | | Weaver | R | Suarez,R | | Darvish | R |
| 4/23/2021 | | | NYA | L | 7-10 | | Eflin | R | Eflin | | Paddack | R |
| 4/24/2021 | | | NYA | W | 11-3 | | Wacha | R | Wacha | | Urena,J | R |
| 4/25/2021 | | | NYA | W | 5-2 | | Kuhl | R | Kuhl | Suarez,R | Strasburg | R |
| 4/26/2021 | | | Min | L | 1-4 | | Montgomery,J | L | Montgomery,J | | Gray,S | R |
| 4/27/2021 | | | Min | W | 9-8 | | Keller,M | R | Keller,M | Pagan | Arrieta | R |
| 4/28/2021 | | | Min | W | 3-2 | | Weaver | R | Suarez,R | | Pineda,M | R |
| 4/30/2021 | | @ | ChA | W | 6-5 | 11 | Suarez,R | L | Bedrosian | | Kikuchi | L |
| 5/1/2021 | | @ | ChA | L | 5-7 | | Brault | L | Brault | | Duplantier | R |
| 5/2/2021 | | @ | ChA | W | 11-7 | 10 | Eflin | R | Pagan | | Flores,B | L |
| 5/3/2021 | | @ | KC | L | 1-4 | | Wacha | R | Wacha | | Thompson,J | R |
| 5/4/2021 | | @ | KC | L | 2-5 | | Keller,M | R | Keller,M | | Yarbrough | L |
| 5/5/2021 | | @ | KC | W | 7-1 | | Weaver | R | Weaver | | Stroman | R |
| 5/6/2021 | | @ | KC | W | 6-2 | | Montgomery,J | L | Montgomery,J | | Boyd | L |
| 5/7/2021 | | | Cin | W | 5-3 | | Kuhl | R | Kuhl | | Gallen | R |
| 5/8/2021 | | | Cin | W | 6-2 | | Eflin | R | Bass | | Nelson,Ji | R |
| 5/9/2021 | | | Cin | L | 3-5 | | Brault | L | Brault | | Davies | R |
| 5/11/2021 | | | ChN | W | 4-3 | | Keller,M | R | Keller,M | Bedrosian | Keuchel | L |
| 5/12/2021 | | | ChN | W | 4-3 | | Wacha | R | Wacha | Pagan | Wood,A | L |
| 5/13/2021 | | @ | Sea | L | 3-4 | | Weaver | R | Pagan | | McClanahan | L |
| 5/14/2021 | | @ | Sea | W | 6-5 | | Suarez,R | L | Garrett,A | Pagan | Duran,Jh | R |
| 5/15/2021 | | @ | Sea | W | 7-4 | | Eflin | R | Eflin | Brault | Marquez,B | L |
| 5/16/2021 | | @ | Sea | W | 6-5 | | Montgomery,J | L | Bedrosian | | Glasnow | R |
| 5/17/2021 | | @ | LAA | L | 2-5 | | Kuhl | R | Kuhl | | Hoffman | R |
| 5/18/2021 | | @ | LAA | L | 8-9 | 10 | Eflin | R | Pagan | | Rondon,A | R |
| 5/19/2021 | | @ | LAA | L | 0-1 | | Montgomery,J | L | Suarez,R | | Howard,Sp | R |
| 5/21/2021 | | | Min | W | 8-2 | | Wacha | R | Wacha | | Pineda,M | R |
| 5/22/2021 | | | Min | W | 3-2 | | Weaver | R | Keller,M | | Rodriguez,E | L |
| 5/23/2021 | | | Min | L | 7-9 | | Kuhl | R | Pagan | | Maeda | R |
| 5/24/2021 | | @ | Det | W | 5-2 | | Eflin | R | Eflin | Suarez,R | Berrios | R |
| 5/25/2021 | | @ | Det | W | 2-1 | | Montgomery,J | L | Montgomery,J | Pagan | Hendricks | R |
| 5/26/2021 | | @ | Det | L | 0-6 | | Wacha | R | Wacha | | Castillo,D | R |
| 5/27/2021 | | @ | Det | W | 3-2 | | Weaver | R | Keller,M | | Giolito | R |
| 5/28/2021 | | | Tor | L | 1-7 | | Kuhl | R | Kuhl | | Flaherty | R |
| 5/29/2021 | | | Tor | W | 3-2 | | Valdez,F | L | Valdez,F | Pagan | Corbin | L |
| 5/30/2021 | | | Tor | W | 8-5 | 10 | Montgomery,J | L | Irvin,C | | Abbott | R |
| 5/31/2021 | | | ChA | W | 10-5 | | Wacha | R | Wacha | | Duplantier | R |
| 6/1/2021 | | | ChA | L | 0-6 | | Weaver | R | Weaver | | Seabold | R |
| 6/2/2021 | | | ChA | W | 5-4 | | Kuhl | R | Bass | Pagan | Flores,B | L |
| 6/4/2021 | | @ | Bal | L | 4-6 | | Valdez,F | L | Valdez,F | | Taillon | R |
| 6/5/2021 | | @ | Bal | L | 1-9 | | Montgomery,J | L | Montgomery,J | | Sanchez,Aa | R |
| 6/6/2021 | | @ | Bal | L | 1-5 | | Wacha | R | Wacha | | deGrom | R |
| 6/8/2021 | | @ | StL | W | 7-4 | | Weaver | R | Weaver | | Martin,Co | R |
| 6/9/2021 | | @ | StL | W | 2-1 | | Kuhl | R | Kuhl | Pagan | Chavez,J | R |
| 6/11/2021 | | | Sea | W | 12-1 | | Valdez,F | L | Valdez,F | | McClanahan | L |
| 6/12/2021 | | | Sea | W | 6-0 | | Montgomery,J | L | Montgomery,J | | Hernandez,Ca | R |
| 6/13/2021 | | | Sea | W | 8-1 | | Wacha | R | Wacha | Bass | Glasnow | R |
| 6/14/2021 | | | Bal | L | 4-8 | | Weaver | R | Weaver | | Taillon | R |
| 6/15/2021 | | | Bal | W | 4-3 | | Kuhl | R | Pagan | | Sanchez,Aa | R |
| 6/16/2021 | | | Bal | L | 2-5 | | Valdez,F | L | Valdez,F | | deGrom | R |
| 6/17/2021 | | | Bal | W | 5-2 | | Montgomery,J | L | Montgomery,J | Pagan | Snell | L |
| 6/18/2021 | | @ | Pit | L | 2-6 | | Wacha | R | Bass | | Odorizzi | R |
| 6/19/2021 | | @ | Pit | L | 2-4 | | Weaver | R | Weaver | | Velasquez | R |
| 6/20/2021 | | @ | Pit | L | 4-8 | | Kuhl | R | Kuhl | | Gore,M | L |
| 6/21/2021 | | @ | ChN | L | 3-10 | | Valdez,F | L | Valdez,F | | Minor | L |
| 6/22/2021 | | @ | ChN | W | 6-5 | | Montgomery,J | L | Montgomery,J | Garrett,A | Keuchel | L |
| 6/24/2021 | | @ | Min | L | 2-3 | | Wacha | R | Wacha | | Ober | R |
| 6/25/2021 | | @ | Min | L | 5-8 | | Weaver | R | Weaver | | Arrieta | R |
| 6/26/2021 | | @ | Min | L | 4-6 | | Kuhl | R | Kuhl | | Manning | R |
| 6/27/2021 | | @ | Min | L | 1-7 | | Valdez,F | L | Valdez,F | | Gutierrez,V | R |
| 6/28/2021 | | | Det | W | 10-8 | | Montgomery,J | L | Brault | Pagan | Hendricks | R |
| 6/29/2021 | | | Det | W | 5-2 | | Wacha | R | Pagan | | Castillo,D | R |
| 6/30/2021 | | | Det | W | 7-6 | | Weaver | R | Weaver | Eflin | Giolito | R |
| 7/1/2021 | | | Hou | L | 0-4 | | Kuhl | R | Kuhl | | Brubaker | R |
| 7/2/2021 | | | Hou | W | 6-4 | | Valdez,F | L | Valdez,F | Brault | Bauer | R |
| 7/3/2021 | | | Hou | L | 2-7 | | Montgomery,J | L | Montgomery,J | | Rogers,Tr | L |
| 7/4/2021 | | | Hou | W | 6-5 | 10 | Wacha | R | Pagan | | Gant | R |
| 7/5/2021 | | @ | Tam | L | 2-3 | | Weaver | R | Bass | | Skubal | L |
| 7/6/2021 | | @ | Tam | W | 7-6 | | Kuhl | R | Pagan | Bedrosian | Keller,Bra | R |
| 7/7/2021 | | @ | Tam | W | 7-5 | | Valdez,F | L | Valdez,F | Irvin,C | Duffy,D | L |
| 7/8/2021 | | | KC | L | 3-9 | 10 | Montgomery,J | L | Irvin,C | | Yarbrough | L |
| 7/9/2021 | | | KC | W | 12-5 | | Wacha | R | Irvin,C | | Stroman | R |
| 7/10/2021 | | | KC | W | 4-1 | | Weaver | R | Weaver | Garrett,A | Kershaw | L |
| 7/11/2021 | | | KC | W | 5-4 | | Kuhl | R | Pagan | | Turnbull | R |
| 7/16/2021 | | @ | Oak | L | 1-3 | | Valdez,F | L | Valdez,F | | Cole,G | R |
| 7/17/2021 | | @ | Oak | W | 8-3 | | Montgomery,J | L | Montgomery,J | Bass | Webb,L | R |
| 7/18/2021 | | @ | Oak | W | 6-2 | | Wacha | R | Wacha | | Gray,Jon | R |
| 7/19/2021 | | @ | Hou | L | 3-4 | 10 | Weaver | R | Pagan | | Pineda,M | R |
| 7/20/2021 | | @ | Hou | L | 3-6 | | Kuhl | R | Eflin | | Ray,R | L |
| 7/21/2021 | | @ | Hou | W | 9-6 | | Valdez,F | L | Valdez,F | Brault | Brubaker | R |
| 7/22/2021 | | | Tam | W | 9-6 | 10 | Montgomery,J | L | Bass | | Skubal | L |
| 7/23/2021 | | | Tam | L | 1-4 | | Wacha | R | Garrett,A | | Keller,Bra | R |
| 7/24/2021 | | | Tam | W | 7-2 | | Weaver | R | Weaver | | Lynch | L |
| 7/25/2021 | | | Tam | L | 3-6 | | Kuhl | R | Kuhl | | Allard | L |
| 7/27/2021 | | | StL | W | 5-4 | | Wacha | R | Eflin | Irvin,C | Martin,Co | R |
| 7/28/2021 | | | StL | L | 4-5 | | Weaver | R | Weaver | | Chavez,J | R |
| 7/30/2021 | | @ | ChA | W | 2-1 | | Kuhl | R | Brault | Pagan | Mize | R |
| 7/31/2021 | | @ | ChA | L | 2-4 | | Senzatela | R | Suarez,R | | Seabold | R |
| 8/1/2021 | | @ | ChA | L | 1-2 | 10 | Valdez,F | L | Pagan | | White,Mit | R |
| 8/2/2021 | | @ | Tor | L | 2-11 | | Wacha | R | Wacha | | Corbin | L |
| 8/3/2021 | | @ | Tor | L | 7-8 | | Brault | L | Brault | | Abbott | R |
| 8/4/2021 | | @ | Tor | L | 4-10 | | Kuhl | R | Rodriguez,Rich | | Richards,G | R |
| 8/5/2021 | | @ | Tor | W | 6-2 | | Senzatela | R | Senzatela | Irvin,C | Cashner | R |
| 8/6/2021 | | | Det | W | 6-2 | | Valdez,F | L | Valdez,F | | Springs | L |
| 8/7/2021 | | | Det | W | 7-4 | | Wacha | R | Wacha | Eflin | Berrios | R |
| 8/8/2021 | | | Det | L | 6-10 | | Brault | L | Brault | | Garrett,B | L |
| 8/10/2021 | | | Oak | L | 1-4 | | Kuhl | R | Kuhl | | Webb,L | R |
| 8/11/2021 | | | Oak | L | 1-12 | | Senzatela | R | Senzatela | | Gray,Jon | R |
| 8/12/2021 | | | Oak | W | 5-0 | | Valdez,F | L | Valdez,F | | Eovaldi | R |
| 8/13/2021 | | @ | Det | L | 2-6 | | Wacha | R | Wacha | | Berrios | R |
| 8/14/2021 | | @ | Det | W | 4-3 | | Brault | L | Irvin,C | Rodriguez,Rich | Gonzales | L |
| 8/15/2021 | | @ | Det | L | 3-6 | | Kuhl | R | Kuhl | | Buehler | R |
| 8/16/2021 | | @ | Min | L | 3-8 | | Senzatela | R | Senzatela | | Quantrill | R |
| 8/17/2021 | | @ | Min | L | 2-5 | | Valdez,F | L | Valdez,F | | Manning | R |
| 8/18/2021 | | @ | Min | W | 5-3 | | Wacha | R | Wacha | Rodriguez,Rich | Gutierrez,V | R |
| 8/20/2021 | | | LAA | L | 1-5 | | Brault | L | Brault | | Naughton,P | L |
| 8/21/2021 | | | LAA | W | 9-8 | 10 | Kuhl | R | Pagan | | Anderson,Bre | L |
| 8/22/2021 | | | LAA | W | 11-4 | | Senzatela | R | Senzatela | | Rondon,A | R |
| 8/24/2021 | | | Tex | W | 16-1 | | Valdez,F | L | Valdez,F | | Medina,L | R |
| 8/25/2021 | | | Tex | W | 10-8 | | Wacha | R | Wacha | Rodriguez,Rich | Ohtani | R |
| 8/26/2021 | | | Tex | W | 8-3 | | Brault | L | Brault | | McCullers Jr. | R |
| 8/27/2021 | | | Bos | L | 6-7 | | Kuhl | R | Kuhl | | Castillo,L | R |
| 8/28/2021 | | | Bos | L | 2-4 | | Senzatela | R | Irvin,C | | Marquez,G | R |
| 8/29/2021 | | | Bos | L | 2-3 | | Valdez,F | L | Valdez,F | | Alcantara,Sa | R |
| 8/31/2021 | | @ | KC | W | 2-0 | | Wacha | R | Wacha | Rodriguez,Rich | Velazquez,H | R |
| 9/1/2021 | | @ | KC | L | 4-10 | | Brault | L | Brault | | Wheeler | R |
| 9/2/2021 | | @ | KC | L | 3-4 | | Kuhl | R | Bass | | Stroman | R |
| 9/3/2021 | | @ | Bos | L | 3-7 | | Senzatela | R | Senzatela | | Woodruff | R |
| 9/4/2021 | | @ | Bos | L | 4-8 | | Valdez,F | L | Valdez,F | | Castillo,L | R |
| 9/5/2021 | | @ | Bos | L | 0-11 | | Wacha | R | Wacha | | Marquez,G | R |
| 9/6/2021 | | | Min | W | 8-5 | | Brault | L | Brault | Rodriguez,Rich | Thornton | R |
| 9/7/2021 | | | Min | L | 4-5 | | Kuhl | R | Rodriguez,Rich | | Ober | R |
| 9/8/2021 | | | Min | W | 6-4 | | Senzatela | R | Irvin,C | | Quantrill | R |
| 9/9/2021 | | | Min | W | 2-1 | 10 | Valdez,F | L | Lopez,R | | Manning | R |
| 9/10/2021 | | | Mil | W | 9-4 | | Wacha | R | Wacha | Lopez,R | Woods Richardsn | R |
| 9/11/2021 | | | Mil | W | 5-1 | | Brault | L | Brault | | Manaea | L |
| 9/12/2021 | | | Mil | L | 1-2 | 12 | Kuhl | R | Pagan | | Clarke | R |
| 9/14/2021 | | @ | Min | L | 3-4 | | Senzatela | R | Irvin,C | | Quantrill | R |
| 9/15/2021 | | @ | Min | W | 9-1 | | Valdez,F | L | Valdez,F | Irvin,C | Manning | R |
| 9/17/2021 | | @ | NYA | L | 2-5 | | Wacha | R | Wacha | | Urena,J | R |
| 9/18/2021 | | @ | NYA | L | 2-8 | | Brault | L | Brault | | Darvish | R |
| 9/19/2021 | | @ | NYA | L | 3-7 | | Kuhl | R | Kuhl | | Scherzer | R |
| 9/20/2021 | | | KC | L | 4-6 | | Senzatela | R | Senzatela | | Lopez,Jo | R |
| 9/21/2021 | | | KC | L | 2-5 | 10 | Valdez,F | L | Pagan | | Montgomery,J | L |
| 9/22/2021 | | | KC | L | 6-14 | | Wacha | R | Pagan | | DeSclafani | R |
| 9/23/2021 | | | ChA | L | 1-2 | | Brault | L | Brault | | de la Cruz,J | R |
| 9/24/2021 | | | ChA | W | 9-1 | | Kuhl | R | Kuhl | | Thorpe | L |
| 9/25/2021 | | | ChA | L | 6-9 | | Senzatela | R | Bass | | Mize | R |
| 9/26/2021 | | | ChA | W | 4-0 | | Valdez,F | L | Valdez,F | | Seabold | R |
| 9/28/2021 | | @ | KC | L | 5-7 | | Wacha | R | Lopez,R | | Montgomery,J | L |
| 9/29/2021 | | @ | KC | L | 1-7 | | Brault | L | Brault | | DeSclafani | R |
| 9/30/2021 | | @ | KC | W | 6-3 | | Kuhl | R | Kuhl | Rodriguez,Rich | Wheeler | R |
| 10/1/2021 | | @ | Tex | L | 1-2 | | Senzatela | R | Garrett,A | | Patino | R |
| 10/2/2021 | | @ | Tex | W | 10-9 | 10 | Valdez,F | L | Bass | Bedrosian | McCullers Jr. | R |
| 10/3/2021 | | @ | Tex | L | 2-4 | | Wacha | R | Wacha | | Means | L |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/1/2021 | | @ | Det | L | | 3 | 5 | 0 | 1 | .000 | 0-1 | L1 | 1 |
| 4/3/2021 | | @ | Det | L | | 2 | 3 | 0 | 2 | .000 | 0-2 | L2 | 2 |
| 4/4/2021 | | @ | Det | L | | 9 | 10 | 0 | 3 | .000 | 0-3 | L3 | 3 |
| 4/5/2021 | | | KC | W | Castellanos,N | 6 | 3 | 1 | 3 | .250 | 1-3 | W1 | 4 |
| 4/7/2021 | | | KC | L | | 3 | 5 | 1 | 4 | .200 | 1-4 | L1 | 5 |
| 4/9/2021 | | | Det | W | | 1 | 0 | 2 | 4 | .333 | 2-4 | W1 | 6 |
| 4/10/2021 | | | Det | L | | 7 | 12 | 2 | 5 | .286 | 2-5 | L1 | 7 |
| 4/11/2021 | | | Det | W | Altuve | 4 | 2 | 3 | 5 | .375 | 3-5 | W1 | 8 |
| 4/12/2021 | | @ | ChA | L | | 8 | 9 | 3 | 6 | .333 | 3-6 | L1 | 9 |
| 4/13/2021 | | @ | ChA | W | Bryant | 9 | 3 | 4 | 6 | .400 | 4-6 | W1 | 10 |
| 4/14/2021 | | @ | ChA | L | | 5 | 8 | 4 | 7 | .364 | 4-6 | L1 | 11 |
| 4/15/2021 | | @ | ChA | W | Peralta,D | 5 | 2 | 5 | 7 | .417 | 5-5 | W1 | 12 |
| 4/16/2021 | | @ | Cin | L | | 2 | 3 | 5 | 8 | .385 | 5-5 | L1 | 13 |
| 4/17/2021 | | @ | Cin | L | | 2 | 4 | 5 | 9 | .357 | 4-6 | L2 | 14 |
| 4/18/2021 | | @ | Cin | L | | 2 | 5 | 5 | 10 | .333 | 4-6 | L3 | 15 |
| 4/20/2021 | | | ChA | W | Altuve | 8 | 4 | 6 | 10 | .375 | 4-6 | W1 | 16 |
| 4/21/2021 | | | ChA | L | | 0 | 5 | 6 | 11 | .353 | 4-6 | L1 | 17 |
| 4/22/2021 | | | NYA | L | | 6 | 10 | 6 | 12 | .333 | 3-7 | L2 | 18 |
| 4/23/2021 | | | NYA | L | | 7 | 10 | 6 | 13 | .316 | 3-7 | L3 | 19 |
| 4/24/2021 | | | NYA | W | Mountcastle | 11 | 3 | 7 | 13 | .350 | 3-7 | W1 | 20 |
| 4/25/2021 | | | NYA | W | Bryant | 5 | 2 | 8 | 13 | .381 | 4-6 | W2 | 21 |
| 4/26/2021 | | | Min | L | | 1 | 4 | 8 | 14 | .364 | 3-7 | L1 | 22 |
| 4/27/2021 | | | Min | W | Altuve | 9 | 8 | 9 | 14 | .391 | 4-6 | W1 | 23 |
| 4/28/2021 | | | Min | W | Frazier,C | 3 | 2 | 10 | 14 | .417 | 5-5 | W2 | 24 |
| 4/30/2021 | | @ | ChA | W | Altuve | 6 | 5 | 11 | 14 | .440 | 6-4 | W3 | 25 |
| 5/1/2021 | | @ | ChA | L | | 5 | 7 | 11 | 15 | .423 | 5-5 | L1 | 26 |
| 5/2/2021 | | @ | ChA | W | Peralta,D | 11 | 7 | 12 | 15 | .444 | 6-4 | W1 | 27 |
| 5/3/2021 | | @ | KC | L | | 1 | 4 | 12 | 16 | .429 | 6-4 | L1 | 28 |
| 5/4/2021 | | @ | KC | L | | 2 | 5 | 12 | 17 | .414 | 6-4 | L2 | 29 |
| 5/5/2021 | | @ | KC | W | Mountcastle | 7 | 1 | 13 | 17 | .433 | 6-4 | W1 | 30 |
| 5/6/2021 | | @ | KC | W | Castellanos,N | 6 | 2 | 14 | 17 | .452 | 6-4 | W2 | 31 |
| 5/7/2021 | | | Cin | W | Bell | 5 | 3 | 15 | 17 | .469 | 7-3 | W3 | 32 |
| 5/8/2021 | | | Cin | W | Peralta,D | 6 | 2 | 16 | 17 | .485 | 7-3 | W4 | 33 |
| 5/9/2021 | | | Cin | L | | 3 | 5 | 16 | 18 | .471 | 6-4 | L1 | 34 |
| 5/11/2021 | | | ChN | W | Altuve | 4 | 3 | 17 | 18 | .486 | 6-4 | W1 | 35 |
| 5/12/2021 | | | ChN | W | Frazier,C | 4 | 3 | 18 | 18 | .500 | 7-3 | W2 | 36 |
| 5/13/2021 | | @ | Sea | L | | 3 | 4 | 18 | 19 | .486 | 6-4 | L1 | 37 |
| 5/14/2021 | | @ | Sea | W | | 6 | 5 | 19 | 19 | .500 | 7-3 | W1 | 38 |
| 5/15/2021 | | @ | Sea | W | Bell | 7 | 4 | 20 | 19 | .513 | 8-2 | W2 | 39 |
| 5/16/2021 | | @ | Sea | W | Bryant | 6 | 5 | 21 | 19 | .525 | 8-2 | W3 | 40 |
| 5/17/2021 | | @ | LAA | L | | 2 | 5 | 21 | 20 | .512 | 7-3 | L1 | 41 |
| 5/18/2021 | | @ | LAA | L | | 8 | 9 | 21 | 21 | .500 | 6-4 | L2 | 42 |
| 5/19/2021 | | @ | LAA | L | | 0 | 1 | 21 | 22 | .488 | 5-5 | L3 | 43 |
| 5/21/2021 | | | Min | W | Altuve | 8 | 2 | 22 | 22 | .500 | 6-4 | W1 | 44 |
| 5/22/2021 | | | Min | W | Bryant | 3 | 2 | 23 | 22 | .511 | 6-4 | W2 | 45 |
| 5/23/2021 | | | Min | L | | 7 | 9 | 23 | 23 | .500 | 5-5 | L1 | 46 |
| 5/24/2021 | | @ | Det | W | Castellanos,N | 5 | 2 | 24 | 23 | .511 | 6-4 | W1 | 47 |
| 5/25/2021 | | @ | Det | W | Bell | 2 | 1 | 25 | 23 | .521 | 6-4 | W2 | 48 |
| 5/26/2021 | | @ | Det | L | | 0 | 6 | 25 | 24 | .510 | 5-5 | L1 | 49 |
| 5/27/2021 | | @ | Det | W | Frazier,C | 3 | 2 | 26 | 24 | .520 | 5-5 | W1 | 50 |
| 5/28/2021 | | | Tor | L | | 1 | 7 | 26 | 25 | .510 | 5-5 | L1 | 51 |
| 5/29/2021 | | | Tor | W | Bell | 3 | 2 | 27 | 25 | .519 | 6-4 | W1 | 52 |
| 5/30/2021 | | | Tor | W | Bryant | 8 | 5 | 28 | 25 | .528 | 7-3 | W2 | 53 |
| 5/31/2021 | | | ChA | W | Peralta,D | 10 | 5 | 29 | 25 | .537 | 7-3 | W3 | 54 |
| 6/1/2021 | | | ChA | L | | 0 | 6 | 29 | 26 | .527 | 6-4 | L1 | 55 |
| 6/2/2021 | | | ChA | W | Altuve | 5 | 4 | 30 | 26 | .536 | 7-3 | W1 | 56 |
| 6/4/2021 | | @ | Bal | L | | 4 | 6 | 30 | 27 | .526 | 6-4 | L1 | 57 |
| 6/5/2021 | | @ | Bal | L | | 1 | 9 | 30 | 28 | .517 | 5-5 | L2 | 58 |
| 6/6/2021 | | @ | Bal | L | | 1 | 5 | 30 | 29 | .508 | 5-5 | L3 | 59 |
| 6/8/2021 | | @ | StL | W | Bryant | 7 | 4 | 31 | 29 | .517 | 5-5 | W1 | 60 |
| 6/9/2021 | | @ | StL | W | Castellanos,N | 2 | 1 | 32 | 29 | .525 | 6-4 | W2 | 61 |
| 6/11/2021 | | | Sea | W | Bell | 12 | 1 | 33 | 29 | .532 | 6-4 | W3 | 62 |
| 6/12/2021 | | | Sea | W | Mejia,F | 6 | 0 | 34 | 29 | .540 | 6-4 | W4 | 63 |
| 6/13/2021 | | | Sea | W | Castellanos,N | 8 | 1 | 35 | 29 | .547 | 6-4 | W5 | 64 |
| 6/14/2021 | | | Bal | L | | 4 | 8 | 35 | 30 | .538 | 6-4 | L1 | 65 |
| 6/15/2021 | | | Bal | W | Altuve | 4 | 3 | 36 | 30 | .545 | 6-4 | W1 | 66 |
| 6/16/2021 | | | Bal | L | | 2 | 5 | 36 | 31 | .537 | 6-4 | L1 | 67 |
| 6/17/2021 | | | Bal | W | Bryant | 5 | 2 | 37 | 31 | .544 | 7-3 | W1 | 68 |
| 6/18/2021 | | @ | Pit | L | | 2 | 6 | 37 | 32 | .536 | 7-3 | L1 | 69 |
| 6/19/2021 | | @ | Pit | L | | 2 | 4 | 37 | 33 | .529 | 6-4 | L2 | 70 |
| 6/20/2021 | | @ | Pit | L | | 4 | 8 | 37 | 34 | .521 | 5-5 | L3 | 71 |
| 6/21/2021 | | @ | ChN | L | | 3 | 10 | 37 | 35 | .514 | 4-6 | L4 | 72 |
| 6/22/2021 | | @ | ChN | W | Alberto | 6 | 5 | 38 | 35 | .521 | 4-6 | W1 | 73 |
| 6/24/2021 | | @ | Min | L | | 2 | 3 | 38 | 36 | .514 | 3-7 | L1 | 74 |
| 6/25/2021 | | @ | Min | L | | 5 | 8 | 38 | 37 | .507 | 3-7 | L2 | 75 |
| 6/26/2021 | | @ | Min | L | | 4 | 6 | 38 | 38 | .500 | 2-8 | L3 | 76 |
| 6/27/2021 | | @ | Min | L | | 1 | 7 | 38 | 39 | .494 | 2-8 | L4 | 77 |
| 6/28/2021 | | | Det | W | Peralta,D | 10 | 8 | 39 | 39 | .500 | 2-8 | W1 | 78 |
| 6/29/2021 | | | Det | W | Bell | 5 | 2 | 40 | 39 | .506 | 3-7 | W2 | 79 |
| 6/30/2021 | | | Det | W | Castellanos,N | 7 | 6 | 41 | 39 | .512 | 4-6 | W3 | 80 |
| 7/1/2021 | | | Hou | L | | 0 | 4 | 41 | 40 | .506 | 4-6 | L1 | 81 |
| 7/2/2021 | | | Hou | W | Bryant | 6 | 4 | 42 | 40 | .512 | 5-5 | W1 | 82 |
| 7/3/2021 | | | Hou | L | | 2 | 7 | 42 | 41 | .506 | 4-6 | L1 | 83 |
| 7/4/2021 | | | Hou | W | Bell | 6 | 5 | 43 | 41 | .512 | 5-5 | W1 | 84 |
| 7/5/2021 | | @ | Tam | L | | 2 | 3 | 43 | 42 | .506 | 5-5 | L1 | 85 |
| 7/6/2021 | | @ | Tam | W | Alberto | 7 | 6 | 44 | 42 | .512 | 6-4 | W1 | 86 |
| 7/7/2021 | | @ | Tam | W | Swanson,D | 7 | 5 | 45 | 42 | .517 | 7-3 | W2 | 87 |
| 7/8/2021 | | | KC | L | | 3 | 9 | 45 | 43 | .511 | 6-4 | L1 | 88 |
| 7/9/2021 | | | KC | W | Peralta,D | 12 | 5 | 46 | 43 | .517 | 6-4 | W1 | 89 |
| 7/10/2021 | | | KC | W | Castellanos,N | 4 | 1 | 47 | 43 | .522 | 6-4 | W2 | 90 |
| 7/11/2021 | | | KC | W | Mejia,F | 5 | 4 | 48 | 43 | .527 | 7-3 | W3 | 91 |
| 7/16/2021 | | @ | Oak | L | | 1 | 3 | 48 | 44 | .522 | 6-4 | L1 | 92 |
| 7/17/2021 | | @ | Oak | W | Castellanos,N | 8 | 3 | 49 | 44 | .527 | 7-3 | W1 | 93 |
| 7/18/2021 | | @ | Oak | W | Castellanos,N | 6 | 2 | 50 | 44 | .532 | 7-3 | W2 | 94 |
| 7/19/2021 | | @ | Hou | L | | 3 | 4 | 50 | 45 | .526 | 7-3 | L1 | 95 |
| 7/20/2021 | | @ | Hou | L | | 3 | 6 | 50 | 46 | .521 | 6-4 | L2 | 96 |
| 7/21/2021 | | @ | Hou | W | Altuve | 9 | 6 | 51 | 46 | .526 | 6-4 | W1 | 97 |
| 7/22/2021 | | | Tam | W | Frazier,C | 9 | 6 | 52 | 46 | .531 | 7-3 | W2 | 98 |
| 7/23/2021 | | | Tam | L | | 1 | 4 | 52 | 47 | .525 | 6-4 | L1 | 99 |
| 7/24/2021 | | | Tam | W | Abreu,J | 7 | 2 | 53 | 47 | .530 | 6-4 | W1 | 100 |
| 7/25/2021 | | | Tam | L | | 3 | 6 | 53 | 48 | .525 | 5-5 | L1 | 101 |
| 7/27/2021 | | | StL | W | Mountcastle | 5 | 4 | 54 | 48 | .529 | 6-4 | W1 | 102 |
| 7/28/2021 | | | StL | L | | 4 | 5 | 54 | 49 | .524 | 5-5 | L1 | 103 |
| 7/30/2021 | | @ | ChA | W | Jimenez,El | 2 | 1 | 55 | 49 | .529 | 5-5 | W1 | 104 |
| 7/31/2021 | | @ | ChA | L | | 2 | 4 | 55 | 50 | .524 | 5-5 | L1 | 105 |
| 8/1/2021 | | @ | ChA | L | | 1 | 2 | 55 | 51 | .519 | 5-5 | L2 | 106 |
| 8/2/2021 | | @ | Tor | L | | 2 | 11 | 55 | 52 | .514 | 4-6 | L3 | 107 |
| 8/3/2021 | | @ | Tor | L | | 7 | 8 | 55 | 53 | .509 | 3-7 | L4 | 108 |
| 8/4/2021 | | @ | Tor | L | | 4 | 10 | 55 | 54 | .505 | 3-7 | L5 | 109 |
| 8/5/2021 | | @ | Tor | W | | 6 | 2 | 56 | 54 | .509 | 3-7 | W1 | 110 |
| 8/6/2021 | | | Det | W | Mountcastle | 6 | 2 | 57 | 54 | .514 | 4-6 | W2 | 111 |
| 8/7/2021 | | | Det | W | Jimenez,El | 7 | 4 | 58 | 54 | .518 | 4-6 | W3 | 112 |
| 8/8/2021 | | | Det | L | | 6 | 10 | 58 | 55 | .513 | 4-6 | L1 | 113 |
| 8/10/2021 | | | Oak | L | | 1 | 4 | 58 | 56 | .509 | 3-7 | L2 | 114 |
| 8/11/2021 | | | Oak | L | | 1 | 12 | 58 | 57 | .504 | 3-7 | L3 | 115 |
| 8/12/2021 | | | Oak | W | | 5 | 0 | 59 | 57 | .509 | 4-6 | W1 | 116 |
| 8/13/2021 | | @ | Det | L | | 2 | 6 | 59 | 58 | .504 | 4-6 | L1 | 117 |
| 8/14/2021 | | @ | Det | W | Abreu,J | 4 | 3 | 60 | 58 | .508 | 5-5 | W1 | 118 |
| 8/15/2021 | | @ | Det | L | | 3 | 6 | 60 | 59 | .504 | 5-5 | L1 | 119 |
| 8/16/2021 | | @ | Min | L | | 3 | 8 | 60 | 60 | .500 | 4-6 | L2 | 120 |
| 8/17/2021 | | @ | Min | L | | 2 | 5 | 60 | 61 | .496 | 3-7 | L3 | 121 |
| 8/18/2021 | | @ | Min | W | Abreu,J | 5 | 3 | 61 | 61 | .500 | 3-7 | W1 | 122 |
| 8/20/2021 | | | LAA | L | | 1 | 5 | 61 | 62 | .496 | 3-7 | L1 | 123 |
| 8/21/2021 | | | LAA | W | Altuve | 9 | 8 | 62 | 62 | .500 | 4-6 | W1 | 124 |
| 8/22/2021 | | | LAA | W | Jimenez,El | 11 | 4 | 63 | 62 | .504 | 5-5 | W2 | 125 |
| 8/24/2021 | | | Tex | W | Altuve | 16 | 1 | 64 | 62 | .508 | 5-5 | W3 | 126 |
| 8/25/2021 | | | Tex | W | | 10 | 8 | 65 | 62 | .512 | 6-4 | W4 | 127 |
| 8/26/2021 | | | Tex | W | Altuve | 8 | 3 | 66 | 62 | .516 | 6-4 | W5 | 128 |
| 8/27/2021 | | | Bos | L | | 6 | 7 | 66 | 63 | .512 | 6-4 | L1 | 129 |
| 8/28/2021 | | | Bos | L | | 2 | 4 | 66 | 64 | .508 | 6-4 | L2 | 130 |
| 8/29/2021 | | | Bos | L | | 2 | 3 | 66 | 65 | .504 | 6-4 | L3 | 131 |
| 8/31/2021 | | @ | KC | W | Grichuk | 2 | 0 | 67 | 65 | .508 | 6-4 | W1 | 132 |
| 9/1/2021 | | @ | KC | L | | 4 | 10 | 67 | 66 | .504 | 6-4 | L1 | 133 |
| 9/2/2021 | | @ | KC | L | | 3 | 4 | 67 | 67 | .500 | 5-5 | L2 | 134 |
| 9/3/2021 | | @ | Bos | L | | 3 | 7 | 67 | 68 | .496 | 4-6 | L3 | 135 |
| 9/4/2021 | | @ | Bos | L | | 4 | 8 | 67 | 69 | .493 | 3-7 | L4 | 136 |
| 9/5/2021 | | @ | Bos | L | | 0 | 11 | 67 | 70 | .489 | 2-8 | L5 | 137 |
| 9/6/2021 | | | Min | W | Jimenez,El | 8 | 5 | 68 | 70 | .493 | 2-8 | W1 | 138 |
| 9/7/2021 | | | Min | L | | 4 | 5 | 68 | 71 | .489 | 2-8 | L1 | 139 |
| 9/8/2021 | | | Min | W | Jimenez,El | 6 | 4 | 69 | 71 | .493 | 3-7 | W1 | 140 |
| 9/9/2021 | | | Min | W | Nunez,R | 2 | 1 | 70 | 71 | .496 | 4-6 | W2 | 141 |
| 9/10/2021 | | | Mil | W | Grichuk | 9 | 4 | 71 | 71 | .500 | 4-6 | W3 | 142 |
| 9/11/2021 | | | Mil | W | Machado,M | 5 | 1 | 72 | 71 | .503 | 5-5 | W4 | 143 |
| 9/12/2021 | | | Mil | L | | 1 | 2 | 72 | 72 | .500 | 5-5 | L1 | 144 |
| 9/14/2021 | | @ | Min | L | | 3 | 4 | 72 | 73 | .497 | 5-5 | L2 | 145 |
| 9/15/2021 | | @ | Min | W | Machado,M | 9 | 1 | 73 | 73 | .500 | 6-4 | W1 | 146 |
| 9/17/2021 | | @ | NYA | L | | 2 | 5 | 73 | 74 | .497 | 6-4 | L1 | 147 |
| 9/18/2021 | | @ | NYA | L | | 2 | 8 | 73 | 75 | .493 | 5-5 | L2 | 148 |
| 9/19/2021 | | @ | NYA | L | | 3 | 7 | 73 | 76 | .490 | 5-5 | L3 | 149 |
| 9/20/2021 | | | KC | L | | 4 | 6 | 73 | 77 | .487 | 4-6 | L4 | 150 |
| 9/21/2021 | | | KC | L | | 2 | 5 | 73 | 78 | .483 | 3-7 | L5 | 151 |
| 9/22/2021 | | | KC | L | | 6 | 14 | 73 | 79 | .480 | 2-8 | L6 | 152 |
| 9/23/2021 | | | ChA | L | | 1 | 2 | 73 | 80 | .477 | 1-9 | L7 | 153 |
| 9/24/2021 | | | ChA | W | Altuve | 9 | 1 | 74 | 80 | .481 | 2-8 | W1 | 154 |
| 9/25/2021 | | | ChA | L | | 6 | 9 | 74 | 81 | .477 | 2-8 | L1 | 155 |
| 9/26/2021 | | | ChA | W | Jimenez,El | 4 | 0 | 75 | 81 | .481 | 2-8 | W1 | 156 |
| 9/28/2021 | | @ | KC | L | | 5 | 7 | 75 | 82 | .478 | 2-8 | L1 | 157 |
| 9/29/2021 | | @ | KC | L | | 1 | 7 | 75 | 83 | .475 | 2-8 | L2 | 158 |
| 9/30/2021 | | @ | KC | W | Altuve | 6 | 3 | 76 | 83 | .478 | 3-7 | W1 | 159 |
| 10/1/2021 | | @ | Tex | L | | 1 | 2 | 76 | 84 | .475 | 3-7 | L1 | 160 |
| 10/2/2021 | | @ | Tex | W | Grichuk | 10 | 9 | 77 | 84 | .478 | 4-6 | W1 | 161 |
| 10/3/2021 | | @ | Tex | L | | 2 | 4 | 77 | 85 | .475 | 4-6 | L1 | 162 |
