| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/3/2020 | LAA | Berti | Demoted to reserve roster | | | Before |
| 4/3/2020 | LAA | Burdi,N | Promoted to active roster | | | Before |
| 4/9/2020 | Det | Feliz,M | Traded away | Hou | | After |
| 4/9/2020 | Hou | Feliz,M | Acquired via trade | Det | | After |
| 4/10/2020 | Hou | Feliz,M | Promoted to active roster | | | Before |
| 4/10/2020 | Hou | Lail | Demoted to reserve roster | | | Before |
| 4/10/2020 | KC | Siri,J | Released | | | Before |
| 4/10/2020 | Oak | Mata | Demoted to reserve roster | | | Before |
| 4/10/2020 | Oak | Williams,D | Signed | | | Before |
| 4/10/2020 | Oak | Williams,D | Promoted to active roster | | | Before |
| 4/10/2020 | Tam | Hamilton,I | Promoted to active roster | | | Before |
| 4/10/2020 | Tam | Waguespack | Demoted to reserve roster | | | Before |
| 4/10/2020 | Tam | Whitley,K | Promoted to active roster | | | Before |
| 4/10/2020 | Tam | Wisler | Demoted to reserve roster | | | Before |
| 4/10/2020 | Tex | Nelson,J | Signed | | | Before |
| 4/10/2020 | Tex | Reyes,G | Released | | | Before |
| 4/13/2020 | Tam | Castro,J | Signed | | | Before |
| 4/19/2020 | Det | Mazara | Traded away | Mia | | After |
| 4/19/2020 | Det | McKenzie | Traded away | Mia | | After |
| 4/19/2020 | Det | Walden | Acquired via trade | Mia | | After |
| 4/20/2020 | Hou | Lail | Released | | | Before |
| 4/24/2020 | Hou | Vizcaino,A | Demoted to reserve roster | | | Before |
| 4/24/2020 | Tam | Castro,J | Promoted to active roster | | | Before |
| 4/24/2020 | Tam | Sosa,E | Demoted to reserve roster | | | Before |
| 4/27/2020 | KC | Peralta,F | Promoted to active roster | | | Before |
| 4/27/2020 | KC | Thorpe | Demoted to reserve roster | | | Before |
| 5/1/2020 | Det | Anderson,Ty | Demoted to reserve roster | | | Before |
| 5/1/2020 | Det | Dolis | Demoted to reserve roster | | | Before |
| 5/1/2020 | Det | Honeywell | Promoted to active roster | | | Before |
| 5/1/2020 | Det | Walden | Demoted to reserve roster | | | Before |
| 5/1/2020 | KC | Peralta,F | Demoted to reserve roster | | | Before |
| 5/1/2020 | KC | Thorpe | Promoted to active roster | | | Before |
| 5/3/2020 | Hou | Faedo | Traded away | Pit | | After |
| 5/3/2020 | Hou | Gray,Jos | Traded away | Oak | | After |
| 5/3/2020 | Hou | Kennedy,I | Acquired via trade | Pit | | After |
| 5/3/2020 | Hou | Kuhnel | Acquired via trade | Oak | | After |
| 5/3/2020 | Hou | McClanahan | Traded away | Oak | | After |
| 5/3/2020 | Hou | Porcello | Acquired via trade | Pit | | After |
| 5/3/2020 | Hou | Ray,R | Acquired via trade | Oak | | After |
| 5/3/2020 | Oak | Gray,Jos | Acquired via trade | Hou | | After |
| 5/3/2020 | Oak | Kuhnel | Traded away | Hou | | After |
| 5/3/2020 | Oak | McClanahan | Acquired via trade | Hou | | After |
| 5/3/2020 | Oak | Ray,R | Traded away | Hou | | After |
| 5/4/2020 | Hou | Bain | Demoted to reserve roster | | | Before |
| 5/4/2020 | Hou | Cecchini | Released | | | Before |
| 5/4/2020 | Hou | Garrett,B | Demoted to reserve roster | | | Before |
| 5/4/2020 | Hou | Porcello | Promoted to active roster | | | Before |
| 5/4/2020 | Hou | Stankiewicz | Released | | | Before |
| 5/4/2020 | Hou | Tomlin | Demoted to reserve roster | | | Before |
| 5/4/2020 | Hou | Trevino | Signed | | | Before |
| 5/4/2020 | Hou | Trevino | Promoted to active roster | | | Before |
| 5/4/2020 | Hou | Venditte | Signed | | | Before |
| 5/4/2020 | Hou | Venditte | Promoted to active roster | | | Before |
| 5/4/2020 | Hou | Walton | Demoted to reserve roster | | | Before |
| 5/4/2020 | KC | Peralta,F | Promoted to active roster | | | Before |
| 5/4/2020 | KC | Thorpe | Demoted to reserve roster | | | Before |
| 5/4/2020 | Oak | Gray,Jos | Promoted to active roster | | | Before |
| 5/4/2020 | Oak | Mata | Promoted to active roster | | | Before |
| 5/4/2020 | Oak | Rodriguez,Ju | Demoted to reserve roster | | | Before |
| 5/11/2020 | ChA | Johnson,T | Promoted to active roster | | | Before |
| 5/11/2020 | ChA | Wick | Demoted to reserve roster | | | Before |
| 5/15/2020 | ChA | Fletcher,A | Signed | | | Before |
| 5/15/2020 | ChA | Wick | Released | | | Before |
| 5/15/2020 | Hou | Chatwood | Signed | | | Before |
| 5/15/2020 | Oak | Colina | Signed | | | Before |
| 5/15/2020 | Oak | Colina | Promoted to active roster | | | Before |
| 5/15/2020 | Oak | Fletcher,A | Released | | | Before |
| 5/15/2020 | Oak | Henry | Signed | | | Before |
| 5/15/2020 | Oak | Henry | Promoted to active roster | | | Before |
| 5/15/2020 | Oak | Holloway | Signed | | | Before |
| 5/15/2020 | Oak | Holloway | Promoted to active roster | | | Before |
| 5/15/2020 | Oak | Montero,E | Demoted to reserve roster | | | Before |
| 5/15/2020 | Oak | White,Mit | Released | | | Before |
| 5/25/2020 | Hou | Chatwood | Promoted to active roster | | | Before |
| 5/25/2020 | Hou | Evans,D | Demoted to reserve roster | | | Before |
| 5/25/2020 | Hou | McKinney,B | Promoted to active roster | | | Before |
| 5/25/2020 | Hou | Sims,L | Demoted to reserve roster | | | Before |
| 5/28/2020 | KC | Davidson,T | Traded away | Cin | | After |
| 5/28/2020 | KC | Diaz,A | Acquired via trade | Cin | | After |
| 5/28/2020 | KC | Selman | Acquired via trade | Cin | | After |
| 5/29/2020 | Bos | Anderson,Ja | Signed | | | Before |
| 5/29/2020 | KC | Barreto | Demoted to reserve roster | | | Before |
| 5/29/2020 | KC | Diaz,A | Promoted to active roster | | | Before |
| 5/29/2020 | KC | Nelson,K | Demoted to reserve roster | | | Before |
| 5/29/2020 | KC | Selman | Promoted to active roster | | | Before |
| 5/31/2020 | Bos | Chafin | Traded away | Phi | | After |
| 5/31/2020 | Bos | Crawford,B | Traded away | Phi | | After |
| 5/31/2020 | Bos | Smith,WillM | Acquired via trade | Phi | | After |
| 6/1/2020 | Bos | Abreu,B | Demoted to reserve roster | | | Before |
| 6/1/2020 | Bos | Anderson,Ja | Promoted to active roster | | | Before |
| 6/1/2020 | Bos | Dyson,J | Demoted to reserve roster | | | Before |
| 6/1/2020 | Bos | Dyson,J | Promoted to active roster | | | Before |
| 6/1/2020 | Bos | Shewmake | Promoted to active roster | | | Before |
| 6/1/2020 | Oak | Rodriguez,Ju | Released | | | Before |
| 6/4/2020 | Hou | Bettencourt | Promoted to active roster | | | Before |
| 6/4/2020 | Hou | Chatwood | Demoted to reserve roster | | | Before |
| 6/4/2020 | Hou | Chatwood | Promoted to active roster | | | Before |
| 6/4/2020 | Hou | Westbrook | Demoted to reserve roster | | | Before |
| 6/4/2020 | Hou | Bettencourt | Acquired via trade | Mia | | After |
| 6/4/2020 | Oak | Henry | Demoted to reserve roster | | | Before |
| 6/4/2020 | Oak | Montero,E | Promoted to active roster | | | Before |
| 6/7/2020 | Min | Lutz | Traded away | Mia | | After |
| 6/7/2020 | Min | Schoop | Acquired via trade | Mia | | After |
| 6/7/2020 | NYA | Montero,R | Traded away | Cin | | After |
| 6/7/2020 | NYA | Ottavino | Acquired via trade | Cin | | After |
| 6/8/2020 | Min | Kieboom | Demoted to reserve roster | | | Before |
| 6/12/2020 | Oak | Holloway | Released | | | Before |
| 6/26/2020 | ChA | Engel | Signed | | | Before |
| 7/6/2020 | Oak | Clase | Promoted to active roster | | | Before |
| 7/6/2020 | Oak | Haniger | Demoted to reserve roster | | | Before |
| 7/10/2020 | Tex | Nelson,J | Released | | | Before |
| 7/12/2020 | Hou | Puig | Acquired via trade | Mia | | After |
| 7/12/2020 | LAA | Gurriel | Acquired via trade | Cin | | After |
| 7/12/2020 | LAA | Votto | Traded away | Cin | | After |
| 7/20/2020 | ChA | Engel | Released | | | Before |
| 7/20/2020 | ChA | Hernandez,Ya | Signed | | | Before |
| 7/20/2020 | ChA | Hernandez,Ya | Promoted to active roster | | | Before |
| 7/20/2020 | ChA | Urshela | Demoted to reserve roster | | | Before |
| 7/20/2020 | Tam | Suarez,J | Demoted to reserve roster | | | Before |
| 7/20/2020 | Tam | Wisler | Promoted to active roster | | | Before |
| 7/22/2020 | ChA | Fletcher,A | Released | | | Before |
| 7/23/2020 | ChA | Urshela | Traded away | Pit | | After |
| 7/24/2020 | ChA | Bumgarner | Demoted to reserve roster | | | Before |
| 7/24/2020 | ChA | Davies | Promoted to active roster | | | Before |
| 7/24/2020 | ChA | Engel | Signed | | | Before |
| 7/26/2020 | ChA | Bumgarner | Traded away | Min | | After |
| 7/26/2020 | ChA | de la Cruz,J | Acquired via trade | Min | | After |
| 7/26/2020 | ChA | McCann,J | Acquired via trade | Min | | After |
| 7/26/2020 | Det | Anderson,Ty | Traded away | SD | | After |
| 7/26/2020 | Det | Boyd | Acquired via trade | SD | | After |
| 7/26/2020 | Det | Gallo | Traded away | SD | | After |
| 7/26/2020 | Det | Honeywell | Traded away | SD | | After |
| 7/26/2020 | Det | Nimmo | Acquired via trade | SD | | After |
| 7/26/2020 | Min | Bumgarner | Acquired via trade | ChA | | After |
| 7/26/2020 | Min | de la Cruz,J | Traded away | ChA | | After |
| 7/26/2020 | Min | McCann,J | Traded away | ChA | | After |
| 7/27/2020 | ChA | Lambert,J | Signed | | | Before |
| 7/27/2020 | ChA | McCann,J | Promoted to active roster | | | Before |
| 7/27/2020 | ChA | Mercedes | Demoted to reserve roster | | | Before |
| 7/27/2020 | Det | Narvaez | Demoted to reserve roster | | | Before |
| 7/27/2020 | Det | Perez,R | Promoted to active roster | | | Before |
| 7/27/2020 | Det | Walden | Promoted to active roster | | | Before |
| 7/27/2020 | LAA | Alexander,S | Demoted to reserve roster | | | Before |
| 7/27/2020 | LAA | Eovaldi | Demoted to reserve roster | | | Before |
| 7/27/2020 | LAA | Eovaldi | Promoted to active roster | | | Before |
| 7/27/2020 | LAA | Heller | Promoted to active roster | | | Before |
| 7/27/2020 | LAA | Strahm | Demoted to reserve roster | | | Before |
| 7/27/2020 | LAA | Wingenter | Promoted to active roster | | | Before |
| 7/28/2020 | ChA | Parkinson | Released | | | Before |
| 7/28/2020 | Min | Bumgarner | Promoted to active roster | | | Before |
| 7/28/2020 | Min | Roark | Demoted to reserve roster | | | Before |
| 7/30/2020 | Tor | Kimbrel | Traded away | Col | | After |
| 7/30/2020 | Tor | Martinez,J.D. | Traded away | Col | | After |
| 7/30/2020 | Tor | Taillon | Acquired via trade | Col | | After |
| 7/31/2020 | ChA | Bleier | Promoted to active roster | | | Before |
| 7/31/2020 | ChA | Diehl | Demoted to reserve roster | | | Before |
| 7/31/2020 | ChA | Heuer | Promoted to active roster | | | Before |
| 7/31/2020 | ChA | Oberg | Demoted to reserve roster | | | Before |
| 7/31/2020 | Tex | Bird,G | Released | | | Before |
| 7/31/2020 | Tex | Cobb | Signed | | | Before |
| 7/31/2020 | Tex | Urena,Jo | Released | | | Before |
| 8/3/2020 | ChA | Anderson,Ti | Demoted to reserve roster | | | Before |
| 8/3/2020 | ChA | Engel | Promoted to active roster | | | Before |
| 8/3/2020 | ChA | Mercedes | Demoted to reserve roster | | | Before |
| 8/3/2020 | ChA | Mercedes | Promoted to active roster | | | Before |
| 8/3/2020 | Det | Devenski | Demoted to reserve roster | | | Before |
| 8/3/2020 | Det | Dolis | Promoted to active roster | | | Before |
| 8/3/2020 | LAA | Alexander,S | Promoted to active roster | | | Before |
| 8/3/2020 | LAA | Cimber | Promoted to active roster | | | Before |
| 8/3/2020 | LAA | Kahnle | Demoted to reserve roster | | | Before |
| 8/3/2020 | LAA | Wingenter | Demoted to reserve roster | | | Before |
| 8/3/2020 | NYA | Rodriguez,De | Promoted to active roster | | | Before |
| 8/3/2020 | NYA | Verlander | Demoted to reserve roster | | | Before |
| 8/3/2020 | Oak | Hosmer | Demoted to reserve roster | | | Before |
| 8/3/2020 | Oak | Miranda | Signed | | | Before |
| 8/3/2020 | Oak | Miranda | Promoted to active roster | | | Before |
| 8/3/2020 | Tex | Hatch | Released | | | Before |
| 8/3/2020 | Tex | Hatch | Signed | | | Before |
| 8/3/2020 | Tex | Zimmer,K | Released | | | Before |
| 8/3/2020 | Tex | Zimmer,K | Signed | | | Before |
| 8/6/2020 | Det | Narvaez | Promoted to active roster | | | Before |
| 8/6/2020 | Det | Perez,R | Demoted to reserve roster | | | Before |
| 8/6/2020 | Hou | Crick | Demoted to reserve roster | | | Before |
| 8/6/2020 | Hou | Ramos,W | Acquired via trade | Tor | | After |
| 8/6/2020 | Tor | Ramos,W | Traded away | Hou | | After |
| 8/7/2020 | Hou | Raleigh | Demoted to reserve roster | | | Before |
| 8/7/2020 | LAA | Burdi,N | Demoted to reserve roster | | | Before |
| 8/7/2020 | LAA | Colon | Demoted to reserve roster | | | Before |
| 8/7/2020 | LAA | Kirilloff | Promoted to active roster | | | Before |
| 8/7/2020 | LAA | Strahm | Promoted to active roster | | | Before |
| 8/7/2020 | NYA | Alexander,TyJe | Signed | | | Before |
| 8/7/2020 | NYA | Alexander,TyJe | Demoted to reserve roster | | | Before |
| 8/7/2020 | Oak | Henry | Released | | | Before |
| 8/7/2020 | Oak | Miranda | Released | | | Before |
| 8/7/2020 | Oak | Moore,D | Signed | | | Before |
| 8/7/2020 | Oak | Moore,D | Promoted to active roster | | | Before |
| 8/7/2020 | Tam | Bauers | Demoted to reserve roster | | | Before |
| 8/7/2020 | Tam | Bedrosian | Demoted to reserve roster | | | Before |
| 8/7/2020 | Tam | Chang | Promoted to active roster | | | Before |
| 8/7/2020 | Tam | Waguespack | Promoted to active roster | | | Before |
| 8/7/2020 | Tex | Brubaker | Signed | | | Before |
| 8/7/2020 | Tex | Castro,M | Signed | | | Before |
| 8/7/2020 | Tex | Cobb | Released | | | Before |
| 8/7/2020 | Tex | O'Brien,R | Released | | | Before |
| 8/9/2020 | Det | Dolis | Traded away | NYN | | After |
| 8/9/2020 | Det | Inciarte | Traded away | NYN | | After |
| 8/9/2020 | KC | Kingery | Acquired via trade | Mia | | After |
| 8/9/2020 | KC | Madrigal | Traded away | Mia | | After |
| 8/9/2020 | KC | Sanchez,S | Traded away | Mia | | After |
| 8/9/2020 | KC | Urquidy | Acquired via trade | Mia | | After |
| 8/9/2020 | Min | Civale | Acquired via trade | SD | | After |
| 8/9/2020 | Min | Turner,J | Traded away | SD | | After |
| 8/9/2020 | Tor | Brantley | Traded away | Phi | | After |
| 8/9/2020 | Tor | DeJong | Traded away | Phi | | After |
| 8/9/2020 | Tor | Donaldson | Traded away | Phi | | After |
| 8/9/2020 | Tor | Hoskins | Acquired via trade | Phi | | After |
| 8/9/2020 | Tor | Springer | Acquired via trade | Phi | | After |
| 8/10/2020 | Det | Brigham | Signed | | | Before |
| 8/10/2020 | Det | Brigham | Promoted to active roster | | | Before |
| 8/10/2020 | Det | Hamilton,B | Demoted to reserve roster | | | Before |
| 8/10/2020 | Det | Hamilton,B | Promoted to active roster | | | Before |
| 8/10/2020 | Det | Kasowski | Demoted to reserve roster | | | Before |
| 8/10/2020 | Det | Kasowski | Promoted to active roster | | | Before |
| 8/10/2020 | Det | Kasowski | Promoted to active roster | | | Before |
| 8/10/2020 | Det | Osuna,R | Demoted to reserve roster | | | Before |
| 8/10/2020 | Det | Perez,O | Demoted to reserve roster | | | Before |
| 8/10/2020 | Det | Solano | Signed | | | Before |
| 8/10/2020 | Det | Solano | Promoted to active roster | | | Before |
| 8/10/2020 | Hou | Garrett,B | Promoted to active roster | | | Before |
| 8/10/2020 | Hou | Samardzija | Demoted to reserve roster | | | Before |
| 8/10/2020 | LAA | Berti | Promoted to active roster | | | Before |
| 8/10/2020 | LAA | Bummer | Demoted to reserve roster | | | Before |
| 8/10/2020 | LAA | Hartlieb | Promoted to active roster | | | Before |
| 8/10/2020 | LAA | Kirilloff | Demoted to reserve roster | | | Before |
| 8/10/2020 | LAA | Menez | Demoted to reserve roster | | | Before |
| 8/10/2020 | LAA | Menez | Promoted to active roster | | | Before |
| 8/10/2020 | Tex | Castro,M | Promoted to active roster | | | Before |
| 8/10/2020 | Tex | Gonsolin | Promoted to active roster | | | Before |
| 8/10/2020 | Tex | King | Promoted to active roster | | | Before |
| 8/10/2020 | Tor | Arozarena | Promoted to active roster | | | Before |
| 8/10/2020 | Tor | Castro,W | Promoted to active roster | | | Before |
| 8/10/2020 | Tor | Ramos,E | Promoted to active roster | | | Before |
| 8/10/2020 | Tor | Vogt | Promoted to active roster | | | Before |
| 8/13/2020 | Det | Barnhart | Acquired via trade | StL | | After |
| 8/13/2020 | Det | Narvaez | Traded away | StL | | After |
| 8/13/2020 | Det | Wittgren | Acquired via trade | StL | | After |
| 8/14/2020 | ChA | Adrianza | Demoted to reserve roster | | | Before |
| 8/14/2020 | ChA | Adrianza | Promoted to active roster | | | Before |
| 8/14/2020 | ChA | Anderson,Ti | Promoted to active roster | | | Before |
| 8/14/2020 | ChA | Olivares | Demoted to reserve roster | | | Before |
| 8/14/2020 | Oak | Hosmer | Promoted to active roster | | | Before |
| 8/14/2020 | Oak | Ruiz,R | Released | | | Before |
| 8/14/2020 | Oak | Ruiz,R | Signed | | | Before |
| 8/14/2020 | Tam | Foster | Signed | | | Before |
| 8/14/2020 | Tam | Fuentes,J | Released | | | Before |
| 8/16/2020 | ChA | Haseley | Acquired via trade | Mia | | After |
| 8/16/2020 | ChA | Kepler | Traded away | Mia | | After |
| 8/16/2020 | ChA | Madrigal | Acquired via trade | Mia | | After |
| 8/16/2020 | ChA | Mazara | Acquired via trade | Mia | | After |
| 8/16/2020 | ChA | Vesia | Traded away | Mia | | After |
| 8/17/2020 | ChA | Diehl | Promoted to active roster | | | Before |
| 8/17/2020 | ChA | Haseley | Demoted to reserve roster | | | Before |
| 8/17/2020 | ChA | Johnson,T | Demoted to reserve roster | | | Before |
| 8/17/2020 | ChA | Olivares | Promoted to active roster | | | Before |
| 8/17/2020 | Det | Doolittle | Demoted to reserve roster | | | Before |
| 8/17/2020 | Det | Perez,O | Promoted to active roster | | | Before |
| 8/17/2020 | Hou | Castro,S | Demoted to reserve roster | | | Before |
| 8/17/2020 | LAA | Colon | Released | | | Before |
| 8/17/2020 | LAA | Cyr | Signed | | | Before |
| 8/17/2020 | LAA | Cyr | Promoted to active roster | | | Before |
| 8/17/2020 | LAA | Leclerc | Demoted to reserve roster | | | Before |
| 8/17/2020 | LAA | Pena,Fe | Signed | | | Before |
| 8/17/2020 | LAA | Pena,Fe | Demoted to reserve roster | | | Before |
| 8/17/2020 | LAA | Pena,Fe | Promoted to active roster | | | Before |
| 8/17/2020 | LAA | Pena,Fe | Promoted to active roster | | | Before |
| 8/17/2020 | LAA | Strahm | Demoted to reserve roster | | | Before |
| 8/17/2020 | LAA | Wingenter | Released | | | Before |
| 8/17/2020 | Min | Bumgarner | Demoted to reserve roster | | | Before |
| 8/17/2020 | Min | Civale | Promoted to active roster | | | Before |
| 8/17/2020 | Min | Kieboom | Promoted to active roster | | | Before |
| 8/17/2020 | Min | Stanton | Demoted to reserve roster | | | Before |
| 8/17/2020 | Min | Young,An | Promoted to active roster | | | Before |
| 8/17/2020 | NYA | Judge | Demoted to reserve roster | | | Before |
| 8/17/2020 | NYA | Morejon | Promoted to active roster | | | Before |
| 8/17/2020 | NYA | Strasburg | Demoted to reserve roster | | | Before |
| 8/17/2020 | Oak | Castellani | Signed | | | Before |
| 8/17/2020 | Oak | Castellani | Promoted to active roster | | | Before |
| 8/17/2020 | Oak | Colina | Demoted to reserve roster | | | Before |
| 8/17/2020 | Oak | Montero,E | Demoted to reserve roster | | | Before |
| 8/17/2020 | Oak | Ruiz,R | Signed | | | Before |
| 8/17/2020 | Oak | Ruiz,R | Promoted to active roster | | | Before |
| 8/17/2020 | Tam | Bauers | Promoted to active roster | | | Before |
| 8/17/2020 | Tam | Foster | Promoted to active roster | | | Before |
| 8/17/2020 | Tam | Hamilton,I | Demoted to reserve roster | | | Before |
| 8/17/2020 | Tam | Hays | Demoted to reserve roster | | | Before |
| 8/17/2020 | Tex | Brubaker | Released | | | Before |
| 8/17/2020 | Tex | Lakins | Signed | | | Before |
| 8/19/2020 | Bos | Acuna Jr. | Demoted to reserve roster | | | Before |
| 8/19/2020 | Bos | Albies | Demoted to reserve roster | | | Before |
| 8/19/2020 | Bos | Yates | Demoted to reserve roster | | | Before |
| 8/20/2020 | Bos | Kluber | Demoted to reserve roster | | | Before |
| 8/20/2020 | Oak | Franco,Ma | Traded away | Pit | | After |
| 8/20/2020 | Oak | Hosmer | Traded away | Pit | | After |
| 8/20/2020 | Oak | Long,S | Traded away | Pit | | After |
| 8/21/2020 | Det | Cabrera,Mi | Signed | | | Before |
| 8/21/2020 | Det | Lucroy | Released | | | Before |
| 8/21/2020 | Hou | Brubaker | Signed | | | Before |
| 8/21/2020 | Hou | Chatwood | Released | | | Before |
| 8/21/2020 | Hou | Cingrani | Released | | | Before |
| 8/21/2020 | Hou | Sanchez,R | Signed | | | Before |
| 8/21/2020 | Oak | Colina | Promoted to active roster | | | Before |
| 8/21/2020 | Oak | Guillorme | Signed | | | Before |
| 8/21/2020 | Oak | Guillorme | Promoted to active roster | | | Before |
| 8/21/2020 | Oak | Montero,E | Promoted to active roster | | | Before |
| 8/21/2020 | Oak | O'Hearn | Released | | | Before |
| 8/21/2020 | Oak | O'Hearn | Signed | | | Before |
| 8/21/2020 | Tam | Bauers | Demoted to reserve roster | | | Before |
| 8/21/2020 | Tam | Smith Jr. | Signed | | | Before |
| 8/21/2020 | Tam | Smith Jr. | Promoted to active roster | | | Before |
| 8/21/2020 | Tex | Garcia,Dei | Promoted to active roster | | | Before |
| 8/21/2020 | Tex | Stashak | Demoted to reserve roster | | | Before |
| 8/21/2020 | Tor | Almonte,Y | Signed | | | Before |
| 8/21/2020 | Tor | Feigl | Released | | | Before |
| 8/23/2020 | Det | Bauer | Traded away | Hou | | After |
| 8/23/2020 | Det | Flores,W | Acquired via trade | Atl | | After |
| 8/23/2020 | Det | Giolito | Acquired via trade | Hou | | After |
| 8/23/2020 | Det | Loup | Acquired via trade | Atl | | After |
| 8/23/2020 | Det | Porcello | Acquired via trade | Hou | | After |
| 8/23/2020 | Det | Tejeda | Traded away | Atl | | After |
| 8/23/2020 | Det | Yajure | Traded away | Atl | | After |
| 8/23/2020 | Det | Zamora | Acquired via trade | Hou | | After |
| 8/23/2020 | Hou | Bauer | Acquired via trade | Det | | After |
| 8/23/2020 | Hou | Giolito | Traded away | Det | | After |
| 8/23/2020 | Hou | Porcello | Traded away | Det | | After |
| 8/23/2020 | Hou | Zamora | Traded away | Det | | After |
| 8/24/2020 | Bos | Alcantara,Sa | Promoted to active roster | | | Before |
| 8/24/2020 | Bos | Dyson,J | Promoted to active roster | | | Before |
| 8/24/2020 | Bos | Gibson,K | Promoted to active roster | | | Before |
| 8/24/2020 | Bos | Ray,C | Promoted to active roster | | | Before |
| 8/24/2020 | ChA | Basabe | Released | | | Before |
| 8/24/2020 | ChA | Gonzalez,L | Released | | | Before |
| 8/24/2020 | ChA | Sulser,C | Signed | | | Before |
| 8/24/2020 | Det | Brigham | Released | | | Before |
| 8/24/2020 | Det | Cabrera,Mi | Released | | | Before |
| 8/24/2020 | Det | Crichton | Released | | | Before |
| 8/24/2020 | Det | Crichton | Signed | | | Before |
| 8/24/2020 | Det | Guillorme | Signed | | | Before |
| 8/24/2020 | Det | Kasowski | Released | | | Before |
| 8/24/2020 | Det | Knebel | Demoted to reserve roster | | | Before |
| 8/24/2020 | Det | Loup | Promoted to active roster | | | Before |
| 8/24/2020 | Det | Porcello | Demoted to reserve roster | | | Before |
| 8/24/2020 | Det | Solano | Demoted to reserve roster | | | Before |
| 8/24/2020 | Det | Stratton | Signed | | | Before |
| 8/24/2020 | Det | Stratton | Demoted to reserve roster | | | Before |
| 8/24/2020 | Det | Stratton | Promoted to active roster | | | Before |
| 8/24/2020 | Det | Wright,K | Promoted to active roster | | | Before |
| 8/24/2020 | Hou | Dohy | Promoted to active roster | | | Before |
| 8/24/2020 | Hou | Sanchez,R | Promoted to active roster | | | Before |
| 8/24/2020 | KC | Barreto | Promoted to active roster | | | Before |
| 8/24/2020 | KC | Cave | Demoted to reserve roster | | | Before |
| 8/24/2020 | KC | Diaz,A | Demoted to reserve roster | | | Before |
| 8/24/2020 | KC | Heineman,T | Demoted to reserve roster | | | Before |
| 8/24/2020 | KC | Paredes,En | Promoted to active roster | | | Before |
| 8/24/2020 | KC | Pearson | Demoted to reserve roster | | | Before |
| 8/24/2020 | KC | Reid-Foley | Promoted to active roster | | | Before |
| 8/24/2020 | KC | Stephenson,T | Demoted to reserve roster | | | Before |
| 8/24/2020 | KC | Stephenson,T | Promoted to active roster | | | Before |
| 8/24/2020 | KC | Urquidy | Demoted to reserve roster | | | Before |
| 8/24/2020 | KC | Wong,C | Promoted to active roster | | | Before |
| 8/24/2020 | LAA | Bregman | Demoted to reserve roster | | | Before |
| 8/24/2020 | LAA | Kirilloff | Promoted to active roster | | | Before |
| 8/24/2020 | LAA | Peterson,Da | Demoted to reserve roster | | | Before |
| 8/24/2020 | LAA | Strahm | Promoted to active roster | | | Before |
| 8/24/2020 | NYA | Bohm | Promoted to active roster | | | Before |
| 8/24/2020 | NYA | LeMahieu | Demoted to reserve roster | | | Before |
| 8/24/2020 | Oak | Fletcher,A | Signed | | | Before |
| 8/24/2020 | Oak | Guillorme | Released | | | Before |
| 8/24/2020 | Tam | Littell | Demoted to reserve roster | | | Before |
| 8/24/2020 | Tam | Suarez,J | Promoted to active roster | | | Before |
| 8/24/2020 | Tex | Alvarez,Yo | Demoted to reserve roster | | | Before |
| 8/24/2020 | Tex | Bichette | Demoted to reserve roster | | | Before |
| 8/24/2020 | Tex | Buxton | Demoted to reserve roster | | | Before |
| 8/24/2020 | Tex | Contreras,WJ | Promoted to active roster | | | Before |
| 8/24/2020 | Tex | Feliciano | Demoted to reserve roster | | | Before |
| 8/24/2020 | Tex | Feliciano | Promoted to active roster | | | Before |
| 8/24/2020 | Tex | Gimenez | Promoted to active roster | | | Before |
| 8/24/2020 | Tex | Gonzalez,L | Signed | | | Before |
| 8/24/2020 | Tex | Gonzalez,L | Promoted to active roster | | | Before |
| 8/24/2020 | Tex | Lakins | Released | | | Before |
| 8/24/2020 | Tex | Taveras | Promoted to active roster | | | Before |
| 8/24/2020 | Tex | Torres,G | Demoted to reserve roster | | | Before |
| 8/27/2020 | KC | Andujar | Traded away | NYA | | After |
| 8/27/2020 | KC | Baez,Ja | Acquired via trade | NYA | | After |
| 8/27/2020 | KC | Bohm | Acquired via trade | NYA | | After |
| 8/27/2020 | KC | German,D | Acquired via trade | NYA | | After |
| 8/27/2020 | KC | Paddack | Traded away | NYA | | After |
| 8/27/2020 | NYA | Andujar | Acquired via trade | KC | | After |
| 8/27/2020 | NYA | Baez,Ja | Traded away | KC | | After |
| 8/27/2020 | NYA | Bohm | Traded away | KC | | After |
| 8/27/2020 | NYA | German,D | Traded away | KC | | After |
| 8/27/2020 | NYA | Paddack | Acquired via trade | KC | | After |
| 8/27/2020 | Oak | Fletcher,A | Promoted to active roster | | | Before |
| 8/27/2020 | Oak | Moore,D | Demoted to reserve roster | | | Before |
| 8/28/2020 | ChA | Adrianza | Demoted to reserve roster | | | Before |
| 8/28/2020 | ChA | Haseley | Promoted to active roster | | | Before |
| 8/28/2020 | ChA | Heuer | Demoted to reserve roster | | | Before |
| 8/28/2020 | ChA | Heuer | Promoted to active roster | | | Before |
| 8/28/2020 | ChA | Johnson,T | Demoted to reserve roster | | | Before |
| 8/28/2020 | ChA | Johnson,T | Promoted to active roster | | | Before |
| 8/28/2020 | ChA | Madrigal | Promoted to active roster | | | Before |
| 8/28/2020 | ChA | Olivares | Demoted to reserve roster | | | Before |
| 8/28/2020 | KC | Bohm | Demoted to reserve roster | | | Before |
| 8/28/2020 | KC | Cave | Promoted to active roster | | | Before |
| 8/28/2020 | KC | Heineman,T | Promoted to active roster | | | Before |
| 8/28/2020 | KC | Kingery | Demoted to reserve roster | | | Before |
| 8/28/2020 | KC | Reid-Foley | Demoted to reserve roster | | | Before |
| 8/28/2020 | KC | Thorpe | Promoted to active roster | | | Before |
| 8/28/2020 | Tor | Fry,P | Signed | | | Before |
| 8/28/2020 | Tor | Shaw,C | Released | | | Before |
| 8/28/2020 | Tor | Valdez,P | Signed | | | Before |
| 8/28/2020 | Tor | Wilson,M | Released | | | Before |
| 8/30/2020 | NYA | Gordon,D | Acquired via trade | Cin | | After |
| 8/30/2020 | Oak | Newcomb | Traded away | NYN | | After |
| 8/31/2020 | ChA | Castellani | Signed | | | Before |
| 8/31/2020 | ChA | Lambert,P | Released | | | Before |
| 8/31/2020 | LAA | Peterson,Da | Promoted to active roster | | | Before |
| 8/31/2020 | LAA | Strahm | Demoted to reserve roster | | | Before |
| 8/31/2020 | Min | Erlin | Signed | | | Before |
| 8/31/2020 | NYA | Alexander,TyJe | Released | | | Before |
| 8/31/2020 | NYA | Betances | Demoted to reserve roster | | | Before |
| 8/31/2020 | NYA | Britton | Demoted to reserve roster | | | Before |
| 8/31/2020 | NYA | Gordon,D | Promoted to active roster | | | Before |
| 8/31/2020 | NYA | LeMahieu | Promoted to active roster | | | Before |
| 8/31/2020 | NYA | Rodriguez,Joe | Promoted to active roster | | | Before |
| 8/31/2020 | NYA | Steckenrider | Demoted to reserve roster | | | Before |
| 8/31/2020 | Oak | Castellani | Released | | | Before |
| 8/31/2020 | Oak | Estevez,O | Signed | | | Before |
| 8/31/2020 | Oak | Estevez,O | Promoted to active roster | | | Before |
| 8/31/2020 | Oak | Hatch | Released | | | Before |
| 8/31/2020 | Oak | Hatch | Signed | | | Before |
| 8/31/2020 | Oak | Mullins | Released | | | Before |
| 8/31/2020 | Oak | Mullins | Signed | | | Before |
| 8/31/2020 | Oak | Pop | Signed | | | Before |
| 8/31/2020 | Oak | Pop | Promoted to active roster | | | Before |
| 8/31/2020 | Oak | Rosario,Eg | Signed | | | Before |
| 8/31/2020 | Oak | Rosario,Eg | Promoted to active roster | | | Before |
| 8/31/2020 | Oak | Ruiz,R | Released | | | Before |
| 8/31/2020 | Oak | Widener | Released | | | Before |
| 8/31/2020 | Oak | Widener | Signed | | | Before |
| 8/31/2020 | Tam | Bauers | Promoted to active roster | | | Before |
| 8/31/2020 | Tam | Chang | Demoted to reserve roster | | | Before |
| 8/31/2020 | Tam | Foster | Demoted to reserve roster | | | Before |
| 8/31/2020 | Tam | Hamilton,I | Promoted to active roster | | | Before |
| 8/31/2020 | Tam | Smith Jr. | Released | | | Before |
| 8/31/2020 | Tam | Sosa,E | Promoted to active roster | | | Before |
| 8/31/2020 | Tex | Anderson,N | Demoted to reserve roster | | | Before |
| 8/31/2020 | Tex | Edwards Jr. | Demoted to reserve roster | | | Before |
| 8/31/2020 | Tex | Feliciano | Demoted to reserve roster | | | Before |
| 8/31/2020 | Tex | Feliciano | Promoted to active roster | | | Before |
| 8/31/2020 | Tex | Gimenez | Demoted to reserve roster | | | Before |
| 8/31/2020 | Tex | Gimenez | Promoted to active roster | | | Before |
| 8/31/2020 | Tex | Ross,J | Promoted to active roster | | | Before |
| 8/31/2020 | Tex | Weigel | Promoted to active roster | | | Before |
| 9/3/2020 | ChA | Cain | Traded away | Det | | After |
| 9/3/2020 | ChA | Guillorme | Acquired via trade | Det | | After |
| 9/3/2020 | Det | Cain | Acquired via trade | ChA | | After |
| 9/3/2020 | Det | Castillo,D | Acquired via trade | LAN | | After |
| 9/3/2020 | Det | Duffy,M | Acquired via trade | NYA | | After |
| 9/3/2020 | Det | Guillorme | Traded away | ChA | | After |
| 9/3/2020 | Det | Perez,O | Traded away | NYA | | After |
| 9/3/2020 | Det | Soria | Acquired via trade | Phi | | After |
| 9/3/2020 | Det | Stratton | Traded away | Phi | | After |
| 9/3/2020 | KC | Diaz,A | Traded away | NYN | | After |
| 9/3/2020 | KC | Honeywell | Acquired via trade | Mia | | After |
| 9/3/2020 | KC | Jimenez,J | Traded away | NYN | | After |
| 9/3/2020 | KC | Mancini | Acquired via trade | NYN | | After |
| 9/3/2020 | KC | Riley | Traded away | Mia | | After |
| 9/3/2020 | Min | Bradley Jr. | Traded away | Pit | | After |
| 9/3/2020 | Min | Carpenter,M | Traded away | NYN | | After |
| 9/3/2020 | Min | Greinke | Traded away | NYN | | After |
| 9/3/2020 | Min | Jones,No | Acquired via trade | NYN | | After |
| 9/3/2020 | Min | Moreland | Acquired via trade | Pit | | After |
| 9/3/2020 | Min | Puk | Acquired via trade | NYN | | After |
| 9/3/2020 | NYA | Duffy,M | Traded away | Det | | After |
| 9/3/2020 | NYA | Familia | Acquired via trade | Tam | | After |
| 9/3/2020 | NYA | Perez,O | Acquired via trade | Det | | After |
| 9/3/2020 | NYA | Rodriguez,De | Traded away | Tam | | After |
| 9/3/2020 | NYA | Stripling | Acquired via trade | Cin | | After |
| 9/3/2020 | Oak | Gerber,J | Acquired via trade | Atl | | After |
| 9/3/2020 | Oak | Jones,Jah | Acquired via trade | Atl | | After |
| 9/3/2020 | Tam | Familia | Traded away | NYA | | After |
| 9/3/2020 | Tam | Rodriguez,De | Acquired via trade | NYA | | After |
| 9/3/2020 | Tex | Mize | Traded away | Mia | | After |
| 9/3/2020 | Tex | Sanchez,S | Acquired via trade | Mia | | After |
| 9/3/2020 | Tor | Encarnacion | Traded away | Pit | | After |
| 9/3/2020 | Tor | Paxton | Acquired via trade | Pit | | After |
| 9/3/2020 | Tor | Price | Traded away | Pit | | After |
| 9/3/2020 | Tor | Reyes,V | Acquired via trade | Pit | | After |
| 9/4/2020 | ChA | Adrianza | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Castellani | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | de la Cruz,J | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Dunning | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Flores,B | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Gonzalez,G | Demoted to reserve roster | | | Before |
| 9/4/2020 | ChA | Guillorme | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Holland,D | Signed | | | Before |
| 9/4/2020 | ChA | Johnson,T | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Mercedes | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Olivares | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Peters,DJ | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Sousa | Promoted to active roster | | | Before |
| 9/4/2020 | ChA | Sulser,C | Released | | | Before |
| 9/4/2020 | Det | Buehler | Demoted to reserve roster | | | Before |
| 9/4/2020 | Det | Choo | Demoted to reserve roster | | | Before |
| 9/4/2020 | Det | Doolittle | Promoted to active roster | | | Before |
| 9/4/2020 | Det | Fuentes,S | Released | | | Before |
| 9/4/2020 | Det | Porcello | Promoted to active roster | | | Before |
| 9/4/2020 | Det | Wittgren | Demoted to reserve roster | | | Before |
| 9/4/2020 | Det | Wright,K | Demoted to reserve roster | | | Before |
| 9/4/2020 | LAA | Cimber | Released | | | Before |
| 9/4/2020 | LAA | Gennett | Released | | | Before |
| 9/4/2020 | LAA | Goudeau | Released | | | Before |
| 9/4/2020 | LAA | Haggerty | Signed | | | Before |
| 9/4/2020 | LAA | Howard,Sa | Signed | | | Before |
| 9/4/2020 | LAA | Marmolejos | Signed | | | Before |
| 9/4/2020 | LAA | Misiewicz | Signed | | | Before |
| 9/4/2020 | LAA | Sharp | Released | | | Before |
| 9/4/2020 | Min | Barrera,L | Promoted to active roster | | | Before |
| 9/4/2020 | Min | Roark | Promoted to active roster | | | Before |
| 9/4/2020 | NYA | Casali | Signed | | | Before |
| 9/4/2020 | NYA | Perdomo,A | Released | | | Before |
| 9/4/2020 | Oak | Adolfo | Released | | | Before |
| 9/4/2020 | Oak | Adolfo | Signed | | | Before |
| 9/4/2020 | Oak | Barria | Released | | | Before |
| 9/4/2020 | Oak | Barria | Signed | | | Before |
| 9/4/2020 | Oak | Coonrod | Signed | | | Before |
| 9/4/2020 | Oak | Coonrod | Promoted to active roster | | | Before |
| 9/4/2020 | Oak | Estevez,O | Released | | | Before |
| 9/4/2020 | Oak | Fletcher,A | Released | | | Before |
| 9/4/2020 | Oak | Gerber,J | Released | | | Before |
| 9/4/2020 | Oak | Hatch | Signed | | | Before |
| 9/4/2020 | Oak | Hatch | Promoted to active roster | | | Before |
| 9/4/2020 | Oak | Hentges | Signed | | | Before |
| 9/4/2020 | Oak | Hentges | Promoted to active roster | | | Before |
| 9/4/2020 | Oak | Jones,Jah | Promoted to active roster | | | Before |
| 9/4/2020 | Oak | Pop | Demoted to reserve roster | | | Before |
| 9/4/2020 | Oak | Quijada | Released | | | Before |
| 9/4/2020 | Oak | Quijada | Signed | | | Before |
| 9/4/2020 | Oak | Rosario,Eg | Released | | | Before |
| 9/4/2020 | Oak | Santana,De | Released | | | Before |
| 9/4/2020 | Oak | Santana,De | Signed | | | Before |
| 9/4/2020 | Tam | Alexander,TyJe | Signed | | | Before |
| 9/4/2020 | Tam | Alexander,TyJe | Promoted to active roster | | | Before |
| 9/4/2020 | Tam | Bedrosian | Promoted to active roster | | | Before |
| 9/4/2020 | Tam | Chang | Promoted to active roster | | | Before |
| 9/4/2020 | Tam | Littell | Released | | | Before |
| 9/4/2020 | Tam | Odor | Demoted to reserve roster | | | Before |
| 9/4/2020 | Tor | Rodriguez,Je | Released | | | Before |
| 9/7/2020 | Det | Chavis | Demoted to reserve roster | | | Before |
| 9/7/2020 | Det | Devenski | Promoted to active roster | | | Before |
| 9/7/2020 | Det | Walden | Demoted to reserve roster | | | Before |
| 9/7/2020 | LAA | Bruce | Demoted to reserve roster | | | Before |
| 9/7/2020 | LAA | Gray,Jon | Demoted to reserve roster | | | Before |
| 9/7/2020 | LAA | Menez | Promoted to active roster | | | Before |
| 9/7/2020 | Min | Bumgarner | Promoted to active roster | | | Before |
| 9/7/2020 | Min | Roark | Demoted to reserve roster | | | Before |
| 9/7/2020 | Oak | Moore,D | Promoted to active roster | | | Before |
| 9/7/2020 | Tex | Anderson,N | Promoted to active roster | | | Before |
| 9/7/2020 | Tex | Buxton | Promoted to active roster | | | Before |
| 9/7/2020 | Tex | Contreras,WJ | Demoted to reserve roster | | | Before |
| 9/7/2020 | Tex | Gonzalez,L | Demoted to reserve roster | | | Before |
| 9/7/2020 | Tex | Torres,G | Promoted to active roster | | | Before |
| 9/7/2020 | Tex | Weigel | Demoted to reserve roster | | | Before |
| 9/11/2020 | ChA | Lambert,J | Released | | | Before |
| 9/11/2020 | ChA | Mills,A | Signed | | | Before |
| 9/11/2020 | Cle | Altuve | Demoted to reserve roster | | | Before |
| 9/11/2020 | Det | Buehler | Promoted to active roster | | | Before |
| 9/11/2020 | Det | Knebel | Promoted to active roster | | | Before |
| 9/11/2020 | Det | Porcello | Demoted to reserve roster | | | Before |
| 9/11/2020 | Det | Soria | Demoted to reserve roster | | | Before |
| 9/11/2020 | KC | Barreto | Demoted to reserve roster | | | Before |
| 9/11/2020 | KC | Neuse | Promoted to active roster | | | Before |
| 9/11/2020 | KC | Urquidy | Promoted to active roster | | | Before |
| 9/11/2020 | LAA | Bregman | Promoted to active roster | | | Before |
| 9/11/2020 | NYA | Britton | Promoted to active roster | | | Before |
| 9/11/2020 | NYA | Stripling | Promoted to active roster | | | Before |
| 9/11/2020 | Oak | Alcantara,Se | Signed | | | Before |
| 9/11/2020 | Oak | Alcantara,Se | Promoted to active roster | | | Before |
| 9/11/2020 | Oak | Barria | Signed | | | Before |
| 9/11/2020 | Oak | Barria | Promoted to active roster | | | Before |
| 9/11/2020 | Oak | Coonrod | Demoted to reserve roster | | | Before |
| 9/11/2020 | Oak | Mata | Demoted to reserve roster | | | Before |
| 9/11/2020 | Oak | Mata | Promoted to active roster | | | Before |
| 9/11/2020 | Oak | Pop | Released | | | Before |
| 9/14/2020 | Det | Buehler | Demoted to reserve roster | | | Before |
| 9/14/2020 | Det | Devenski | Demoted to reserve roster | | | Before |
| 9/14/2020 | Det | Doolittle | Demoted to reserve roster | | | Before |
| 9/14/2020 | Det | Porcello | Demoted to reserve roster | | | Before |
| 9/14/2020 | Det | Porcello | Promoted to active roster | | | Before |
| 9/14/2020 | Det | Porcello | Promoted to active roster | | | Before |
| 9/14/2020 | Det | Soria | Demoted to reserve roster | | | Before |
| 9/14/2020 | Det | Soria | Promoted to active roster | | | Before |
| 9/14/2020 | Det | Wittgren | Promoted to active roster | | | Before |
| 9/14/2020 | Det | Wright,K | Promoted to active roster | | | Before |
| 9/14/2020 | Tex | Bichette | Promoted to active roster | | | Before |
| 9/14/2020 | Tex | Gimenez | Demoted to reserve roster | | | Before |
| 9/14/2020 | Tex | Gimenez | Promoted to active roster | | | Before |
| 9/14/2020 | Tex | Gimenez | Demoted to reserve roster | | | Before |
| 9/14/2020 | Tex | McCullers Jr. | Demoted to reserve roster | | | Before |
| 9/14/2020 | Tex | Stashak | Promoted to active roster | | | Before |
| 9/18/2020 | Det | Duffy,D | Promoted to active roster | | | Before |
| 9/18/2020 | Det | Porcello | Demoted to reserve roster | | | Before |
| 9/18/2020 | Min | Erlin | Released | | | Before |
| 9/18/2020 | Min | Gsellman | Released | | | Before |
| 9/18/2020 | Min | Thielbar | Signed | | | Before |
| 9/18/2020 | Min | Voth | Released | | | Before |
| 9/18/2020 | Min | Wade,L | Signed | | | Before |
| 9/21/2020 | ChA | Choi | Demoted to reserve roster | | | Before |
| 9/21/2020 | ChA | Holland,D | Promoted to active roster | | | Before |
| 9/21/2020 | ChA | Hudson,Dak | Demoted to reserve roster | | | Before |
| 9/21/2020 | ChA | Kikuchi | Promoted to active roster | | | Before |
| 9/21/2020 | ChA | Mills,A | Promoted to active roster | | | Before |
| 9/21/2020 | Det | Brault | Signed | | | Before |
| 9/21/2020 | Det | Devenski | Released | | | Before |
| 9/21/2020 | Det | Duffy,D | Demoted to reserve roster | | | Before |
| 9/21/2020 | Det | Soria | Promoted to active roster | | | Before |
| 9/21/2020 | LAA | Bruce | Promoted to active roster | | | Before |
| 9/21/2020 | Min | Arrieta | Demoted to reserve roster | | | Before |
| 9/21/2020 | Min | Barrera,L | Demoted to reserve roster | | | Before |
| 9/21/2020 | Min | Roark | Promoted to active roster | | | Before |
| 9/21/2020 | Min | Stanton | Promoted to active roster | | | Before |
| 9/21/2020 | Min | Wade,L | Promoted to active roster | | | Before |
| 9/21/2020 | NYA | Judge | Promoted to active roster | | | Before |
| 9/21/2020 | Oak | Alcantara,Se | Released | | | Before |
| 9/25/2020 | NYA | Abreu,A | Promoted to active roster | | | Before |
| 9/25/2020 | NYA | Britton | Demoted to reserve roster | | | Before |
| 9/25/2020 | NYA | Casali | Promoted to active roster | | | Before |
| 9/25/2020 | NYA | Chapman,A | Demoted to reserve roster | | | Before |
| 9/25/2020 | NYA | Chisholm | Promoted to active roster | | | Before |
| 9/25/2020 | NYA | Darvish | Demoted to reserve roster | | | Before |
| 9/25/2020 | NYA | Nevin | Promoted to active roster | | | Before |
| 9/25/2020 | NYA | Paddack | Demoted to reserve roster | | | Before |
| 9/25/2020 | NYA | Realmuto | Demoted to reserve roster | | | Before |
| 9/25/2020 | NYA | Scherzer | Demoted to reserve roster | | | Before |
| 9/25/2020 | Tam | Newman | Demoted to reserve roster | | | Before |
| 9/25/2020 | Tam | Odor | Promoted to active roster | | | Before |
| 9/25/2020 | Tam | Robertson,Dan | Signed | | | Before |
| 9/25/2020 | Tam | Robertson,Dan | Promoted to active roster | | | Before |
| 9/25/2020 | Tam | Waguespack | Released | | | Before |
| 9/26/2020 | LAA | Heller | Demoted to reserve roster | | | Before |
| 9/27/2020 | Tor | Hernandez,F | Released | | | Before |
| 9/29/2020 | Bos | Acuna Jr. | Promoted to active roster | | | Before |
| 9/29/2020 | Bos | Albies | Promoted to active roster | | | Before |
| 9/29/2020 | Bos | Alcantara,Sa | Demoted to reserve roster | | | Before |
| 9/29/2020 | Bos | Gibson,K | Demoted to reserve roster | | | Before |
| 9/29/2020 | Bos | Ray,C | Demoted to reserve roster | | | Before |
| 9/29/2020 | Tex | Cordero,F | Promoted to active roster | | | Before |
| 9/29/2020 | Tex | King | Demoted to reserve roster | | | Before |
| 9/29/2020 | Tex | McCullers Jr. | Promoted to active roster | | | Before |
