| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/5/2019 | Bos | Diehl | Signed | | | Before |
| 4/5/2019 | Cle | Gordon,N | Demoted to reserve roster | | | Before |
| 4/5/2019 | Cle | Tucker,C | Promoted to active roster | | | Before |
| 4/5/2019 | Hou | Alvarez,Ya | Signed | | | Before |
| 4/5/2019 | Hou | Flexen | Released | | | Before |
| 4/5/2019 | Oak | Pivetta | Promoted to active roster | | | Before |
| 4/5/2019 | Oak | Turner,T | Demoted to reserve roster | | | Before |
| 4/5/2019 | Tor | Escobar,L | Released | | | Before |
| 4/5/2019 | Tor | Santana,Da | Signed | | | Before |
| 4/8/2019 | Bos | Wacha | Demoted to reserve roster | | | Before |
| 4/8/2019 | KC | McMahon | Demoted to reserve roster | | | Before |
| 4/8/2019 | KC | Ward,T | Promoted to active roster | | | Before |
| 4/8/2019 | LAA | Colon,C | Demoted to reserve roster | | | Before |
| 4/8/2019 | LAA | Pedroia | Promoted to active roster | | | Before |
| 4/8/2019 | Min | Austin | Promoted to active roster | | | Before |
| 4/8/2019 | Min | Flowers | Promoted to active roster | | | Before |
| 4/8/2019 | Min | McCann,B | Demoted to reserve roster | | | Before |
| 4/8/2019 | Min | Murphy,D | Demoted to reserve roster | | | Before |
| 4/11/2019 | Tex | Edwards,C | Acquired via trade | Pit | | After |
| 4/12/2019 | Bos | Barrera,T | Released | | | Before |
| 4/12/2019 | Bos | Gaviglio | Signed | | | Before |
| 4/12/2019 | ChA | Cessa | Signed | | | Before |
| 4/12/2019 | ChA | Jones,Na | Released | | | Before |
| 4/12/2019 | KC | Cole,T | Released | | | Before |
| 4/12/2019 | LAA | Wingenter | Signed | | | Before |
| 4/12/2019 | Tex | Edwards,C | Demoted to reserve roster | | | Before |
| 4/15/2019 | KC | Gonsalves | Demoted to reserve roster | | | Before |
| 4/15/2019 | KC | Reid-Foley | Promoted to active roster | | | Before |
| 4/15/2019 | Min | Lester,Jon | Demoted to reserve roster | | | Before |
| 4/15/2019 | Min | Mejia,Ad | Promoted to active roster | | | Before |
| 4/15/2019 | Oak | Grullon | Signed | | | Before |
| 4/15/2019 | Oak | Sanchez,G | Demoted to reserve roster | | | Before |
| 4/15/2019 | Oak | Smith,Cal | Promoted to active roster | | | Before |
| 4/15/2019 | Oak | Urias,J | Demoted to reserve roster | | | Before |
| 4/15/2019 | Tex | Edwards,C | Demoted to reserve roster | | | Before |
| 4/15/2019 | Tor | deGrom | Demoted to reserve roster | | | Before |
| 4/15/2019 | Tor | Rodriguez,Je | Promoted to active roster | | | Before |
| 4/15/2019 | Tor | Snell | Demoted to reserve roster | | | Before |
| 4/15/2019 | Tor | Stratton | Promoted to active roster | | | Before |
| 4/19/2019 | Bos | Anderson,Ty | Demoted to reserve roster | | | Before |
| 4/19/2019 | Bos | Clevinger | Demoted to reserve roster | | | Before |
| 4/19/2019 | Bos | Lopez,Re | Promoted to active roster | | | Before |
| 4/19/2019 | Bos | Wacha | Promoted to active roster | | | Before |
| 4/19/2019 | NYA | Kershaw | Promoted to active roster | | | Before |
| 4/19/2019 | NYA | Yamamoto | Demoted to reserve roster | | | Before |
| 4/19/2019 | Oak | Peralta,F | Demoted to reserve roster | | | Before |
| 4/19/2019 | Oak | Urias,J | Promoted to active roster | | | Before |
| 4/22/2019 | LAA | Colon,C | Promoted to active roster | | | Before |
| 4/22/2019 | LAA | Eovaldi | Demoted to reserve roster | | | Before |
| 4/22/2019 | LAA | Pedroia | Demoted to reserve roster | | | Before |
| 4/22/2019 | LAA | Pena,Fe | Promoted to active roster | | | Before |
| 4/22/2019 | Min | Galvis | Demoted to reserve roster | | | Before |
| 4/22/2019 | Min | Lindor | Promoted to active roster | | | Before |
| 4/22/2019 | Tam | Bader | Demoted to reserve roster | | | Before |
| 4/22/2019 | Tam | Fernandez,V | Promoted to active roster | | | Before |
| 4/22/2019 | Tam | Helsley | Promoted to active roster | | | Before |
| 4/22/2019 | Tam | Wisler | Demoted to reserve roster | | | Before |
| 4/26/2019 | Hou | Davis,C | Signed | | | Before |
| 4/26/2019 | Min | Austin | Demoted to reserve roster | | | Before |
| 4/26/2019 | Min | Davis,C | Released | | | Before |
| 4/26/2019 | Min | Davis,C | Promoted to active roster | | | Before |
| 4/26/2019 | Min | Gutierrez,K | Signed | | | Before |
| 4/26/2019 | Min | Murphy,D | Promoted to active roster | | | Before |
| 4/26/2019 | Oak | Cron,K | Signed | | | Before |
| 4/26/2019 | Oak | Grullon | Demoted to reserve roster | | | Before |
| 4/26/2019 | Oak | Rengifo | Promoted to active roster | | | Before |
| 4/26/2019 | Oak | Riddle | Released | | | Before |
| 4/26/2019 | Oak | Sanchez,G | Promoted to active roster | | | Before |
| 4/26/2019 | Oak | Severino,P | Signed | | | Before |
| 4/26/2019 | Oak | Severino,P | Promoted to active roster | | | Before |
| 4/26/2019 | Oak | Stallings | Released | | | Before |
| 4/26/2019 | Tex | Arano | Demoted to reserve roster | | | Before |
| 4/26/2019 | Tex | Edwards,C | Promoted to active roster | | | Before |
| 4/26/2019 | Tex | Jimenez,El | Demoted to reserve roster | | | Before |
| 4/26/2019 | Tex | Perdomo,L | Signed | | | Before |
| 4/26/2019 | Tex | Perdomo,L | Promoted to active roster | | | Before |
| 4/29/2019 | KC | Bichette | Demoted to reserve roster | | | Before |
| 4/29/2019 | KC | Kingery | Demoted to reserve roster | | | Before |
| 4/29/2019 | KC | McMahon | Promoted to active roster | | | Before |
| 4/29/2019 | KC | Moya | Promoted to active roster | | | Before |
| 4/29/2019 | KC | Neuse | Promoted to active roster | | | Before |
| 4/29/2019 | KC | Reid-Foley | Demoted to reserve roster | | | Before |
| 4/29/2019 | KC | Stewart,CG | Demoted to reserve roster | | | Before |
| 4/29/2019 | Min | Lester,Jon | Promoted to active roster | | | Before |
| 4/29/2019 | Min | Mejia,Ad | Demoted to reserve roster | | | Before |
| 4/29/2019 | Tor | deGrom | Promoted to active roster | | | Before |
| 4/29/2019 | Tor | Rodriguez,Je | Demoted to reserve roster | | | Before |
| 4/29/2019 | Tor | Snell | Promoted to active roster | | | Before |
| 4/29/2019 | Tor | Stratton | Demoted to reserve roster | | | Before |
| 5/3/2019 | Tex | Reyes,A | Demoted to reserve roster | | | Before |
| 5/3/2019 | Tex | Russell | Promoted to active roster | | | Before |
| 5/5/2019 | Det | Difo | Acquired via trade | Oak | | After |
| 5/5/2019 | Det | Hamilton,B | Acquired via trade | Oak | | After |
| 5/5/2019 | Det | Rodriguez,Ro | Traded away | Oak | | After |
| 5/5/2019 | Oak | Difo | Traded away | Det | | After |
| 5/5/2019 | Oak | Hamilton,B | Traded away | Det | | After |
| 5/5/2019 | Oak | Rodriguez,Ro | Acquired via trade | Det | | After |
| 5/6/2019 | Bos | Anderson,Ty | Promoted to active roster | | | Before |
| 5/6/2019 | Bos | Lopez,Re | Demoted to reserve roster | | | Before |
| 5/6/2019 | Det | Clement | Released | | | Before |
| 5/6/2019 | Det | Difo | Demoted to reserve roster | | | Before |
| 5/6/2019 | Det | Solarte | Released | | | Before |
| 5/6/2019 | KC | Kratz | Demoted to reserve roster | | | Before |
| 5/6/2019 | KC | Reid-Foley | Promoted to active roster | | | Before |
| 5/6/2019 | KC | Solarte | Signed | | | Before |
| 5/6/2019 | KC | Solarte | Promoted to active roster | | | Before |
| 5/6/2019 | KC | Stephenson,T | Demoted to reserve roster | | | Before |
| 5/6/2019 | KC | Stephenson,T | Promoted to active roster | | | Before |
| 5/6/2019 | KC | Wilkerson,A | Demoted to reserve roster | | | Before |
| 5/6/2019 | LAA | Bummer | Demoted to reserve roster | | | Before |
| 5/6/2019 | LAA | Bummer | Promoted to active roster | | | Before |
| 5/6/2019 | LAA | Canha | Demoted to reserve roster | | | Before |
| 5/6/2019 | LAA | Kirilloff | Promoted to active roster | | | Before |
| 5/6/2019 | Min | Frazier,T | Promoted to active roster | | | Before |
| 5/6/2019 | Min | Zimmerman | Demoted to reserve roster | | | Before |
| 5/6/2019 | NYA | Judge | Demoted to reserve roster | | | Before |
| 5/6/2019 | NYA | Lopes,C | Promoted to active roster | | | Before |
| 5/6/2019 | NYA | Maldonado | Promoted to active roster | | | Before |
| 5/6/2019 | NYA | Tatis | Demoted to reserve roster | | | Before |
| 5/6/2019 | Oak | Cron,K | Released | | | Before |
| 5/6/2019 | Oak | de los Santos | Promoted to active roster | | | Before |
| 5/6/2019 | Oak | Johnson,Da | Promoted to active roster | | | Before |
| 5/6/2019 | Oak | Peralta,F | Promoted to active roster | | | Before |
| 5/6/2019 | Oak | Pivetta | Demoted to reserve roster | | | Before |
| 5/6/2019 | Oak | Pivetta | Promoted to active roster | | | Before |
| 5/6/2019 | Oak | Pivetta | Demoted to reserve roster | | | Before |
| 5/6/2019 | Oak | Smith,Cal | Demoted to reserve roster | | | Before |
| 5/6/2019 | Oak | Whitlock | Released | | | Before |
| 5/6/2019 | Tex | Bolt | Signed | | | Before |
| 5/6/2019 | Tex | Bolt | Promoted to active roster | | | Before |
| 5/6/2019 | Tex | Perdomo,L | Released | | | Before |
| 5/6/2019 | Tor | McGee,J | Demoted to reserve roster | | | Before |
| 5/6/2019 | Tor | Stratton | Promoted to active roster | | | Before |
| 5/10/2019 | ChA | Beltre,M | Promoted to active roster | | | Before |
| 5/10/2019 | ChA | Palka | Released | | | Before |
| 5/10/2019 | Cle | Clouse | Demoted to reserve roster | | | Before |
| 5/10/2019 | Cle | Gordon,N | Promoted to active roster | | | Before |
| 5/10/2019 | Cle | Tucker,C | Demoted to reserve roster | | | Before |
| 5/10/2019 | Cle | VerHagen | Promoted to active roster | | | Before |
| 5/10/2019 | Det | Diaz,A | Promoted to active roster | | | Before |
| 5/10/2019 | Det | Wilson,Ju | Demoted to reserve roster | | | Before |
| 5/10/2019 | Det | Wood,H | Released | | | Before |
| 5/10/2019 | NYA | Mills,W | Released | | | Before |
| 5/10/2019 | Oak | Johnson,Da | Released | | | Before |
| 5/10/2019 | Tex | Johnson,Da | Signed | | | Before |
| 5/10/2019 | Tex | Paulino,Da | Released | | | Before |
| 5/10/2019 | Tor | Fernandez,JosMi | Released | | | Before |
| 5/10/2019 | Tor | Moran,B | Signed | | | Before |
| 5/13/2019 | ChA | Lin | Demoted to reserve roster | | | Before |
| 5/13/2019 | ChA | Stokes | Promoted to active roster | | | Before |
| 5/13/2019 | Hou | Jackson,Au | Released | | | Before |
| 5/13/2019 | Hou | Paredes,Edw | Released | | | Before |
| 5/13/2019 | NYA | Maldonado | Demoted to reserve roster | | | Before |
| 5/13/2019 | NYA | Olson,M | Promoted to active roster | | | Before |
| 5/13/2019 | NYA | Steckenrider | Demoted to reserve roster | | | Before |
| 5/13/2019 | NYA | Yamamoto | Promoted to active roster | | | Before |
| 5/13/2019 | Oak | Fowler,Du | Promoted to active roster | | | Before |
| 5/13/2019 | Oak | Glasnow | Demoted to reserve roster | | | Before |
| 5/13/2019 | Oak | Grullon | Released | | | Before |
| 5/13/2019 | Oak | Kela | Demoted to reserve roster | | | Before |
| 5/13/2019 | Oak | Mendick | Signed | | | Before |
| 5/13/2019 | Oak | Mendick | Promoted to active roster | | | Before |
| 5/13/2019 | Oak | Pivetta | Promoted to active roster | | | Before |
| 5/13/2019 | Oak | Rengifo | Demoted to reserve roster | | | Before |
| 5/13/2019 | Oak | Smith,Cal | Promoted to active roster | | | Before |
| 5/13/2019 | Sea | Armenteros | Promoted to active roster | | | Before |
| 5/13/2019 | Sea | Dahl | Promoted to active roster | | | Before |
| 5/13/2019 | Sea | Dickerson,C | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Gamel | Promoted to active roster | | | Before |
| 5/13/2019 | Sea | Gohara | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Martinez,C | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Paxton | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Perez,F | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Prado | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Upton | Demoted to reserve roster | | | Before |
| 5/13/2019 | Sea | Wahl | Demoted to reserve roster | | | Before |
| 5/13/2019 | Tam | Bader | Promoted to active roster | | | Before |
| 5/13/2019 | Tam | Fernandez,V | Demoted to reserve roster | | | Before |
| 5/13/2019 | Tam | Shawaryn | Promoted to active roster | | | Before |
| 5/13/2019 | Tam | Suarez,J | Demoted to reserve roster | | | Before |
| 5/13/2019 | Tex | de la Cruz | Signed | | | Before |
| 5/13/2019 | Tex | Johnson,Da | Released | | | Before |
| 5/13/2019 | Tex | Ohtani | Promoted to active roster | | | Before |
| 5/17/2019 | ChA | Lin | Released | | | Before |
| 5/17/2019 | Cle | Cuevas,N | Released | | | Before |
| 5/17/2019 | Cle | Nunez,D | Signed | | | Before |
| 5/17/2019 | Cle | Pagan | Signed | | | Before |
| 5/17/2019 | Det | Altuve | Demoted to reserve roster | | | Before |
| 5/17/2019 | Det | Difo | Promoted to active roster | | | Before |
| 5/17/2019 | Det | Inciarte | Demoted to reserve roster | | | Before |
| 5/17/2019 | Det | Phillips,Bre | Promoted to active roster | | | Before |
| 5/17/2019 | Oak | Johnson,Da | Signed | | | Before |
| 5/17/2019 | Tam | Dyson,S | Demoted to reserve roster | | | Before |
| 5/17/2019 | Tam | Hamilton,I | Promoted to active roster | | | Before |
| 5/17/2019 | Tex | Anderson,J | Signed | | | Before |
| 5/17/2019 | Tex | Bolt | Released | | | Before |
| 5/17/2019 | Tex | de la Cruz | Released | | | Before |
| 5/17/2019 | Tex | Swihart | Signed | | | Before |
| 5/17/2019 | Tor | Hernandez,F | Demoted to reserve roster | | | Before |
| 5/17/2019 | Tor | Moran,B | Promoted to active roster | | | Before |
| 5/17/2019 | Tor | Price | Demoted to reserve roster | | | Before |
| 5/17/2019 | Tor | Rodriguez,Je | Promoted to active roster | | | Before |
| 5/20/2019 | Bos | Cruz,N | Demoted to reserve roster | | | Before |
| 5/20/2019 | Bos | Ray,C | Promoted to active roster | | | Before |
| 5/20/2019 | Cle | Crick | Promoted to active roster | | | Before |
| 5/20/2019 | Cle | Gordon,N | Demoted to reserve roster | | | Before |
| 5/20/2019 | Cle | Mejia,F | Demoted to reserve roster | | | Before |
| 5/20/2019 | Cle | Nunez,D | Promoted to active roster | | | Before |
| 5/20/2019 | Det | Jackson,Al | Signed | | | Before |
| 5/20/2019 | Det | Pereda | Released | | | Before |
| 5/20/2019 | Oak | Fowler,Du | Demoted to reserve roster | | | Before |
| 5/20/2019 | Oak | Johnson,Da | Promoted to active roster | | | Before |
| 5/20/2019 | Oak | Turner,T | Promoted to active roster | | | Before |
| 5/20/2019 | Oak | Urias,J | Demoted to reserve roster | | | Before |
| 5/20/2019 | Tam | Shawaryn | Demoted to reserve roster | | | Before |
| 5/20/2019 | Tam | Suarez,J | Promoted to active roster | | | Before |
| 5/20/2019 | Tex | Anderson,J | Promoted to active roster | | | Before |
| 5/20/2019 | Tex | Garver | Demoted to reserve roster | | | Before |
| 5/20/2019 | Tex | Jimenez,El | Promoted to active roster | | | Before |
| 5/20/2019 | Tex | Karinchak | Demoted to reserve roster | | | Before |
| 5/20/2019 | Tex | Swihart | Promoted to active roster | | | Before |
| 5/23/2019 | Det | Shaw,T | Demoted to reserve roster | | | Before |
| 5/23/2019 | NYA | Bauer | Traded away | Mia | | After |
| 5/23/2019 | NYA | Hedges,A | Traded away | Mia | | After |
| 5/23/2019 | NYA | Realmuto | Acquired via trade | Mia | | After |
| 5/23/2019 | NYA | Rogers,Ja | Acquired via trade | Mia | | After |
| 5/23/2019 | NYA | Ruiz,K | Traded away | Mia | | After |
| 5/23/2019 | NYA | Verlander | Acquired via trade | Mia | | After |
| 5/24/2019 | ChA | Descalso | Signed | | | Before |
| 5/24/2019 | Cle | Brewer | Released | | | Before |
| 5/24/2019 | Cle | Floro | Signed | | | Before |
| 5/24/2019 | Cle | Gordon,N | Promoted to active roster | | | Before |
| 5/24/2019 | Cle | Mountcastle | Demoted to reserve roster | | | Before |
| 5/24/2019 | Cle | Pagan | Demoted to reserve roster | | | Before |
| 5/24/2019 | Cle | Pagan | Promoted to active roster | | | Before |
| 5/24/2019 | Cle | Pagan | Promoted to active roster | | | Before |
| 5/24/2019 | Det | Davis,W | Demoted to reserve roster | | | Before |
| 5/24/2019 | Det | Kay | Promoted to active roster | | | Before |
| 5/24/2019 | Det | Narvaez | Promoted to active roster | | | Before |
| 5/24/2019 | KC | Kratz | Released | | | Before |
| 5/24/2019 | NYA | Haase | Signed | | | Before |
| 5/24/2019 | NYA | Maldonado | Released | | | Before |
| 5/24/2019 | Oak | Bowden | Signed | | | Before |
| 5/24/2019 | Oak | Hill,D | Signed | | | Before |
| 5/24/2019 | Tam | Helsley | Demoted to reserve roster | | | Before |
| 5/24/2019 | Tam | Scholtens | Released | | | Before |
| 5/24/2019 | Tam | Shawaryn | Promoted to active roster | | | Before |
| 5/24/2019 | Tam | Williams,Tr | Demoted to reserve roster | | | Before |
| 5/24/2019 | Tam | Wisler | Promoted to active roster | | | Before |
| 5/27/2019 | Bos | Anderson,Ty | Demoted to reserve roster | | | Before |
| 5/27/2019 | Bos | Lopez,Re | Promoted to active roster | | | Before |
| 5/27/2019 | Bos | Ray,C | Demoted to reserve roster | | | Before |
| 5/27/2019 | Bos | Smith,Kevi | Promoted to active roster | | | Before |
| 5/27/2019 | Bos | Springer | Demoted to reserve roster | | | Before |
| 5/27/2019 | Bos | Tejeda | Promoted to active roster | | | Before |
| 5/27/2019 | ChA | Beltre,M | Demoted to reserve roster | | | Before |
| 5/27/2019 | ChA | Descalso | Promoted to active roster | | | Before |
| 5/27/2019 | Det | Cron,K | Signed | | | Before |
| 5/27/2019 | Det | Flores,W | Demoted to reserve roster | | | Before |
| 5/27/2019 | Det | Narvaez | Demoted to reserve roster | | | Before |
| 5/27/2019 | LAA | Gallagher | Released | | | Before |
| 5/27/2019 | LAA | Tilson | Signed | | | Before |
| 5/27/2019 | Min | Hechavarria | Released | | | Before |
| 5/27/2019 | NYA | Haase | Demoted to reserve roster | | | Before |
| 5/27/2019 | NYA | Haase | Promoted to active roster | | | Before |
| 5/27/2019 | NYA | Kang | Demoted to reserve roster | | | Before |
| 5/27/2019 | Oak | Bowden | Promoted to active roster | | | Before |
| 5/27/2019 | Oak | Fowler,Du | Promoted to active roster | | | Before |
| 5/27/2019 | Oak | Gordon,D | Demoted to reserve roster | | | Before |
| 5/27/2019 | Oak | Hernandez,Elies | Signed | | | Before |
| 5/27/2019 | Oak | Hill,D | Released | | | Before |
| 5/27/2019 | Oak | Mendick | Released | | | Before |
| 5/27/2019 | Oak | Urshela | Signed | | | Before |
| 5/27/2019 | Tor | Cano | Demoted to reserve roster | | | Before |
| 5/27/2019 | Tor | Price | Promoted to active roster | | | Before |
| 5/27/2019 | Tor | Rodriguez,Je | Demoted to reserve roster | | | Before |
| 5/27/2019 | Tor | Santana,Da | Promoted to active roster | | | Before |
| 5/28/2019 | Bal | Kemp,M | Demoted to reserve roster | | | Before |
| 5/28/2019 | Det | Cron,K | Signed | | | Before |
| 5/31/2019 | Bos | Gaviglio | Released | | | Before |
| 5/31/2019 | Bos | O'Grady,B | Signed | | | Before |
| 5/31/2019 | ChA | Cabrera,Me | Signed | | | Before |
| 5/31/2019 | ChA | Cabrera,Me | Promoted to active roster | | | Before |
| 5/31/2019 | ChA | Chisenhall | Released | | | Before |
| 5/31/2019 | ChA | Stokes | Demoted to reserve roster | | | Before |
| 5/31/2019 | Det | Phillips,Bre | Released | | | Before |
| 5/31/2019 | KC | Rodney | Released | | | Before |
| 5/31/2019 | Tam | Crawford,J | Demoted to reserve roster | | | Before |
| 5/31/2019 | Tam | Daza | Demoted to reserve roster | | | Before |
| 5/31/2019 | Tam | Dyson,S | Promoted to active roster | | | Before |
| 5/31/2019 | Tam | Gattis | Released | | | Before |
| 5/31/2019 | Tam | Hays | Promoted to active roster | | | Before |
| 5/31/2019 | Tam | Newman | Promoted to active roster | | | Before |
| 5/31/2019 | Tam | Wisler | Demoted to reserve roster | | | Before |
| 5/31/2019 | Tex | Anderson,J | Released | | | Before |
| 5/31/2019 | Tex | Kline | Signed | | | Before |
| 5/31/2019 | Tex | Swihart | Released | | | Before |
| 5/31/2019 | Tor | Hernandez,F | Demoted to reserve roster | | | Before |
| 5/31/2019 | Tor | Moran,B | Promoted to active roster | | | Before |
| 5/31/2019 | Tor | Price | Demoted to reserve roster | | | Before |
| 5/31/2019 | Tor | Rodriguez,Je | Promoted to active roster | | | Before |
| 6/2/2019 | Det | Grichuk | Acquired via trade | Phi | | After |
| 6/3/2019 | Det | Diaz,A | Demoted to reserve roster | | | Before |
| 6/3/2019 | Det | Herrera,O | Signed | | | Before |
| 6/3/2019 | Det | Olivares | Promoted to active roster | | | Before |
| 6/3/2019 | Oak | Bowden | Demoted to reserve roster | | | Before |
| 6/3/2019 | Oak | Urias,J | Promoted to active roster | | | Before |
| 6/3/2019 | Tam | Velazquez,A | Signed | | | Before |
| 6/3/2019 | Tex | Adell | Promoted to active roster | | | Before |
| 6/3/2019 | Tex | Baez,M | Promoted to active roster | | | Before |
| 6/3/2019 | Tex | Garver | Demoted to reserve roster | | | Before |
| 6/3/2019 | Tex | Garver | Promoted to active roster | | | Before |
| 6/3/2019 | Tex | Garver | Promoted to active roster | | | Before |
| 6/3/2019 | Tex | Kline | Demoted to reserve roster | | | Before |
| 6/3/2019 | Tex | Kline | Promoted to active roster | | | Before |
| 6/3/2019 | Tex | Reyes,A | Promoted to active roster | | | Before |
| 6/3/2019 | Tex | Valdez,F | Released | | | Before |
| 6/3/2019 | Tex | White,El | Released | | | Before |
| 6/5/2019 | Min | Zobrist | Demoted to reserve roster | | | Before |
| 6/7/2019 | ChA | Johnson,DJ | Released | | | Before |
| 6/7/2019 | ChA | Valdez,F | Signed | | | Before |
| 6/7/2019 | Cle | Floro | Promoted to active roster | | | Before |
| 6/7/2019 | Cle | Healy,R | Demoted to reserve roster | | | Before |
| 6/7/2019 | Cle | Mejia,F | Promoted to active roster | | | Before |
| 6/7/2019 | Cle | Weaver | Demoted to reserve roster | | | Before |
| 6/7/2019 | Det | Jackson,Al | Released | | | Before |
| 6/7/2019 | Hou | Alvarez,Ya | Promoted to active roster | | | Before |
| 6/7/2019 | Hou | Cingrani | Promoted to active roster | | | Before |
| 6/7/2019 | Hou | Fulmer,C | Released | | | Before |
| 6/7/2019 | Hou | Lail | Promoted to active roster | | | Before |
| 6/7/2019 | KC | Solarte | Demoted to reserve roster | | | Before |
| 6/7/2019 | LAA | Peterson,Da | Promoted to active roster | | | Before |
| 6/7/2019 | LAA | Strahm | Demoted to reserve roster | | | Before |
| 6/7/2019 | Min | Austin | Promoted to active roster | | | Before |
| 6/7/2019 | Min | Grisham | Signed | | | Before |
| 6/7/2019 | Min | Grisham | Promoted to active roster | | | Before |
| 6/7/2019 | Min | McCutchen | Demoted to reserve roster | | | Before |
| 6/7/2019 | Min | Wade,L | Released | | | Before |
| 6/7/2019 | Tam | Candelario | Demoted to reserve roster | | | Before |
| 6/7/2019 | Tam | Velazquez,A | Promoted to active roster | | | Before |
| 6/7/2019 | Tex | Diaz,M | Signed | | | Before |
| 6/7/2019 | Tex | Kline | Released | | | Before |
| 6/9/2019 | Bos | Castillo,L | Acquired via trade | Phi | | After |
| 6/9/2019 | Bos | Peralta,D | Acquired via trade | Phi | | After |
| 6/9/2019 | Bos | Springer | Traded away | Phi | | After |
| 6/9/2019 | Bos | Tejeda | Traded away | Phi | | After |
| 6/10/2019 | Bos | Cruz,N | Promoted to active roster | | | Before |
| 6/10/2019 | Bos | Lopez,Re | Demoted to reserve roster | | | Before |
| 6/10/2019 | Bos | Smith,Kevi | Demoted to reserve roster | | | Before |
| 6/10/2019 | ChA | Cessa | Promoted to active roster | | | Before |
| 6/10/2019 | ChA | Freeland | Demoted to reserve roster | | | Before |
| 6/10/2019 | ChA | Valdez,F | Promoted to active roster | | | Before |
| 6/10/2019 | Cle | Alberto | Signed | | | Before |
| 6/10/2019 | Cle | Eveld | Released | | | Before |
| 6/10/2019 | Det | Leon,S | Released | | | Before |
| 6/10/2019 | Det | Perez,R | Signed | | | Before |
| 6/10/2019 | KC | Gonsalves | Promoted to active roster | | | Before |
| 6/10/2019 | KC | Kingery | Promoted to active roster | | | Before |
| 6/10/2019 | KC | Stewart,CG | Promoted to active roster | | | Before |
| 6/10/2019 | LAA | Gagnon | Promoted to active roster | | | Before |
| 6/10/2019 | LAA | Parker,B | Demoted to reserve roster | | | Before |
| 6/10/2019 | Oak | Bowden | Promoted to active roster | | | Before |
| 6/10/2019 | Oak | Haniger | Demoted to reserve roster | | | Before |
| 6/10/2019 | Oak | Rengifo | Promoted to active roster | | | Before |
| 6/10/2019 | Oak | Smith,Cal | Demoted to reserve roster | | | Before |
| 6/10/2019 | Tam | Shreve | Released | | | Before |
| 6/10/2019 | Tex | Diaz,M | Promoted to active roster | | | Before |
| 6/10/2019 | Tex | Gimenez,A | Demoted to reserve roster | | | Before |
| 6/12/2019 | LAA | Bruce | Promoted to active roster | | | Before |
| 6/12/2019 | LAA | Kirilloff | Demoted to reserve roster | | | Before |
| 6/13/2019 | Hou | Barreto | Traded away | Was | | After |
| 6/13/2019 | Hou | Marte,S | Acquired via trade | Was | | After |
| 6/13/2019 | Hou | Neidert | Traded away | Was | | After |
| 6/14/2019 | Bos | Alcantara,Sa | Demoted to reserve roster | | | Before |
| 6/14/2019 | Bos | Luzardo | Promoted to active roster | | | Before |
| 6/14/2019 | ChA | Bergen | Demoted to reserve roster | | | Before |
| 6/14/2019 | ChA | Freeland | Promoted to active roster | | | Before |
| 6/14/2019 | ChA | Sampson,A | Signed | | | Before |
| 6/14/2019 | Det | Chacin,J | Demoted to reserve roster | | | Before |
| 6/14/2019 | Det | Davis,W | Promoted to active roster | | | Before |
| 6/14/2019 | Det | Olivares | Demoted to reserve roster | | | Before |
| 6/14/2019 | Det | Romero,Jo | Promoted to active roster | | | Before |
| 6/14/2019 | Det | Shaw,T | Promoted to active roster | | | Before |
| 6/14/2019 | Tam | Faria | Promoted to active roster | | | Before |
| 6/14/2019 | Tam | Helsley | Demoted to reserve roster | | | Before |
| 6/14/2019 | Tam | Helsley | Promoted to active roster | | | Before |
| 6/14/2019 | Tam | Meyer,A | Released | | | Before |
| 6/14/2019 | Tam | Shawaryn | Demoted to reserve roster | | | Before |
| 6/14/2019 | Tam | Shawaryn | Promoted to active roster | | | Before |
| 6/14/2019 | Tam | Urena,Jo | Demoted to reserve roster | | | Before |
| 6/16/2019 | ChA | Olivares | Acquired via trade | Det | | After |
| 6/16/2019 | ChA | Santana,Ca | Traded away | Det | | After |
| 6/16/2019 | Det | Armstrong | Acquired via trade | Cin | | After |
| 6/16/2019 | Det | Olivares | Traded away | ChA | | After |
| 6/16/2019 | Det | Romero,Jo | Traded away | Cin | | After |
| 6/16/2019 | Det | Santana,Ca | Acquired via trade | ChA | | After |
| 6/16/2019 | Oak | Gordon,D | Traded away | Pit | | After |
| 6/16/2019 | Oak | Leyba | Acquired via trade | Pit | | After |
| 6/16/2019 | Oak | Pazos | Traded away | Pit | | After |
| 6/16/2019 | Oak | Pinder,Chad | Traded away | Pit | | After |
| 6/16/2019 | Tam | Thomas | Traded away | Was | | After |
| 6/16/2019 | Tam | Villar | Acquired via trade | Was | | After |
| 6/17/2019 | Bos | O'Day | Released | | | Before |
| 6/17/2019 | Bos | O'Grady,B | Released | | | Before |
| 6/17/2019 | ChA | Banuelos | Released | | | Before |
| 6/17/2019 | ChA | Cessa | Demoted to reserve roster | | | Before |
| 6/17/2019 | ChA | Holland,G | Promoted to active roster | | | Before |
| 6/17/2019 | ChA | Mullins | Demoted to reserve roster | | | Before |
| 6/17/2019 | ChA | Newberry | Released | | | Before |
| 6/17/2019 | ChA | Nogowski | Signed | | | Before |
| 6/17/2019 | ChA | Nogowski | Promoted to active roster | | | Before |
| 6/17/2019 | ChA | Reyes,P | Demoted to reserve roster | | | Before |
| 6/17/2019 | ChA | Tilson | Signed | | | Before |
| 6/17/2019 | ChA | Tilson | Promoted to active roster | | | Before |
| 6/17/2019 | ChA | Wendle | Promoted to active roster | | | Before |
| 6/17/2019 | ChA | Woodruff | Promoted to active roster | | | Before |
| 6/17/2019 | Det | Armstrong | Promoted to active roster | | | Before |
| 6/17/2019 | Det | Perez,R | Demoted to reserve roster | | | Before |
| 6/17/2019 | Det | Perez,R | Promoted to active roster | | | Before |
| 6/17/2019 | Det | Seager,C | Demoted to reserve roster | | | Before |
| 6/17/2019 | Hou | Alvarez,Ya | Demoted to reserve roster | | | Before |
| 6/17/2019 | Hou | Cingrani | Demoted to reserve roster | | | Before |
| 6/17/2019 | LAA | Alexander,S | Demoted to reserve roster | | | Before |
| 6/17/2019 | LAA | Eickhoff | Demoted to reserve roster | | | Before |
| 6/17/2019 | LAA | Lopes,T | Signed | | | Before |
| 6/17/2019 | LAA | Strahm | Promoted to active roster | | | Before |
| 6/17/2019 | LAA | Tilson | Released | | | Before |
| 6/17/2019 | Oak | Hernandez,Elies | Promoted to active roster | | | Before |
| 6/17/2019 | Tam | Crawford,J | Promoted to active roster | | | Before |
| 6/17/2019 | Tam | Daza | Demoted to reserve roster | | | Before |
| 6/17/2019 | Tam | Daza | Promoted to active roster | | | Before |
| 6/17/2019 | Tam | Newman | Demoted to reserve roster | | | Before |
| 6/17/2019 | Tam | Newman | Promoted to active roster | | | Before |
| 6/17/2019 | Tam | Velazquez,A | Released | | | Before |
| 6/17/2019 | Tex | Edwards,C | Demoted to reserve roster | | | Before |
| 6/17/2019 | Tex | Gimenez,A | Promoted to active roster | | | Before |
| 6/17/2019 | Tor | Cano | Promoted to active roster | | | Before |
| 6/17/2019 | Tor | Kimbrel | Promoted to active roster | | | Before |
| 6/17/2019 | Tor | Santana,Da | Demoted to reserve roster | | | Before |
| 6/17/2019 | Tor | Stratton | Demoted to reserve roster | | | Before |
| 6/20/2019 | KC | Barreto | Acquired via trade | Was | | After |
| 6/20/2019 | KC | Bichette | Traded away | Was | | After |
| 6/20/2019 | KC | Hudson,Dak | Traded away | Was | | After |
| 6/20/2019 | KC | Trammell | Acquired via trade | Was | | After |
| 6/21/2019 | Bos | Anderson,Ty | Released | | | Before |
| 6/21/2019 | Bos | Clevinger | Promoted to active roster | | | Before |
| 6/21/2019 | Bos | Kelly,M | Demoted to reserve roster | | | Before |
| 6/21/2019 | Cle | Alberto | Promoted to active roster | | | Before |
| 6/21/2019 | Cle | Healy,R | Released | | | Before |
| 6/21/2019 | Cle | Marshall | Signed | | | Before |
| 6/21/2019 | Cle | Marshall | Demoted to reserve roster | | | Before |
| 6/21/2019 | Cle | Marshall | Promoted to active roster | | | Before |
| 6/21/2019 | Det | Altuve | Promoted to active roster | | | Before |
| 6/21/2019 | Det | Cron,K | Demoted to reserve roster | | | Before |
| 6/21/2019 | Det | Kay | Demoted to reserve roster | | | Before |
| 6/21/2019 | Det | Paulino,Da | Signed | | | Before |
| 6/21/2019 | Det | Paulino,Da | Promoted to active roster | | | Before |
| 6/21/2019 | Hou | Cecchini | Released | | | Before |
| 6/21/2019 | Hou | Stankiewicz | Signed | | | Before |
| 6/21/2019 | Hou | Wall | Promoted to active roster | | | Before |
| 6/21/2019 | Hou | Walton | Signed | | | Before |
| 6/21/2019 | KC | Funkhouser | Promoted to active roster | | | Before |
| 6/21/2019 | KC | Gonsalves | Demoted to reserve roster | | | Before |
| 6/21/2019 | KC | Neuse | Demoted to reserve roster | | | Before |
| 6/21/2019 | KC | Schrock | Demoted to reserve roster | | | Before |
| 6/21/2019 | KC | Wilkerson,A | Promoted to active roster | | | Before |
| 6/21/2019 | LAA | Acevedo | Released | | | Before |
| 6/21/2019 | Oak | Villines | Released | | | Before |
| 6/21/2019 | Tex | Diaz,M | Released | | | Before |
| 6/21/2019 | Tex | Reyes,V | Signed | | | Before |
| 6/23/2019 | Det | Kela | Acquired via trade | Oak | | After |
| 6/23/2019 | Det | Rodriguez,Ro | Acquired via trade | Oak | | After |
| 6/23/2019 | NYA | Alzolay | Traded away | Oak | | After |
| 6/23/2019 | NYA | Chapman,A | Acquired via trade | Oak | | After |
| 6/23/2019 | NYA | Kiermaier | Acquired via trade | Was | | After |
| 6/23/2019 | NYA | Leyba | Acquired via trade | Oak | | After |
| 6/23/2019 | NYA | Mata | Traded away | Oak | | After |
| 6/23/2019 | NYA | Pearce | Acquired via trade | Was | | After |
| 6/23/2019 | NYA | Trivino | Acquired via trade | Was | | After |
| 6/23/2019 | Oak | Alzolay | Acquired via trade | NYA | | After |
| 6/23/2019 | Oak | Chapman,A | Traded away | NYA | | After |
| 6/23/2019 | Oak | Kela | Traded away | Det | | After |
| 6/23/2019 | Oak | Leyba | Traded away | NYA | | After |
| 6/23/2019 | Oak | Mata | Acquired via trade | NYA | | After |
| 6/23/2019 | Oak | Rodriguez,Ro | Traded away | Det | | After |
| 6/24/2019 | Bos | Clevinger | Demoted to reserve roster | | | Before |
| 6/24/2019 | Bos | Demeritte | Released | | | Before |
| 6/24/2019 | Bos | Demeritte | Signed | | | Before |
| 6/24/2019 | Bos | Smith,Kevi | Promoted to active roster | | | Before |
| 6/24/2019 | ChA | Beltre,M | Released | | | Before |
| 6/24/2019 | ChA | Urshela | Signed | | | Before |
| 6/24/2019 | Det | Chacin,J | Promoted to active roster | | | Before |
| 6/24/2019 | Det | Difo | Demoted to reserve roster | | | Before |
| 6/24/2019 | Det | Difo | Promoted to active roster | | | Before |
| 6/24/2019 | Det | Herrera,O | Released | | | Before |
| 6/24/2019 | Det | Kolarek | Demoted to reserve roster | | | Before |
| 6/24/2019 | Det | Paulino,Da | Demoted to reserve roster | | | Before |
| 6/24/2019 | Det | Paulino,Da | Promoted to active roster | | | Before |
| 6/24/2019 | Det | Syndergaard | Demoted to reserve roster | | | Before |
| 6/24/2019 | LAA | Gordon,A | Promoted to active roster | | | Before |
| 6/24/2019 | LAA | Kirilloff | Promoted to active roster | | | Before |
| 6/24/2019 | LAA | Lopes,T | Promoted to active roster | | | Before |
| 6/24/2019 | LAA | Martin,L | Demoted to reserve roster | | | Before |
| 6/24/2019 | LAA | Story | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Guerrero,T | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Guerrero,T | Promoted to active roster | | | Before |
| 6/24/2019 | NYA | Guerrero,T | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Judge | Promoted to active roster | | | Before |
| 6/24/2019 | NYA | Kang | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Kang | Promoted to active roster | | | Before |
| 6/24/2019 | NYA | Kang | Promoted to active roster | | | Before |
| 6/24/2019 | NYA | Layne | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Leyba | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Lopes,C | Released | | | Before |
| 6/24/2019 | NYA | Pillar | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Tatis | Demoted to reserve roster | | | Before |
| 6/24/2019 | NYA | Tatis | Promoted to active roster | | | Before |
| 6/24/2019 | NYA | Yamamoto | Demoted to reserve roster | | | Before |
| 6/24/2019 | Oak | Alzolay | Promoted to active roster | | | Before |
| 6/24/2019 | Oak | Feliz,M | Signed | | | Before |
| 6/24/2019 | Oak | Feliz,M | Promoted to active roster | | | Before |
| 6/24/2019 | Oak | Lee,K | Promoted to active roster | | | Before |
| 6/24/2019 | Oak | Mata | Promoted to active roster | | | Before |
| 6/24/2019 | Oak | Newcomb | Demoted to reserve roster | | | Before |
| 6/24/2019 | Oak | Nogosek | Signed | | | Before |
| 6/24/2019 | Oak | Nogosek | Promoted to active roster | | | Before |
| 6/24/2019 | Oak | Urshela | Released | | | Before |
| 6/24/2019 | Tam | Faria | Demoted to reserve roster | | | Before |
| 6/24/2019 | Tam | Fernandez,V | Released | | | Before |
| 6/24/2019 | Tam | Williams,Tr | Promoted to active roster | | | Before |
| 6/24/2019 | Tex | Brosseau | Signed | | | Before |
| 6/24/2019 | Tex | Buxton | Demoted to reserve roster | | | Before |
| 6/24/2019 | Tex | Reyes,V | Promoted to active roster | | | Before |
| 6/24/2019 | Tor | Matijevic | Released | | | Before |
| 6/27/2019 | Min | Soler | Acquired via trade | StL | | After |
| 6/28/2019 | Bos | Lopez,Re | Released | | | Before |
| 6/28/2019 | Cle | Lopez,Re | Signed | | | Before |
| 6/28/2019 | Cle | Nunez,D | Released | | | Before |
| 6/28/2019 | Hou | Cecchini | Signed | | | Before |
| 6/28/2019 | KC | Heim | Signed | | | Before |
| 6/28/2019 | KC | McGuire,R | Released | | | Before |
| 6/28/2019 | KC | Schrock | Released | | | Before |
| 6/28/2019 | KC | Solarte | Released | | | Before |
| 6/28/2019 | Min | Gutierrez,K | Released | | | Before |
| 6/28/2019 | Oak | Feliz,M | Released | | | Before |
| 6/28/2019 | Tex | Harvey,H | Signed | | | Before |
| 6/28/2019 | Tex | Harvey,H | Promoted to active roster | | | Before |
| 6/28/2019 | Tex | Lopez,P | Demoted to reserve roster | | | Before |
| 6/28/2019 | Tex | Reyes,A | Demoted to reserve roster | | | Before |
| 6/28/2019 | Tex | Selman | Signed | | | Before |
| 6/28/2019 | Tex | Selman | Promoted to active roster | | | Before |
| 6/30/2019 | Bos | Bote | Traded away | Was | | After |
| 6/30/2019 | Bos | Cabrera,A | Acquired via trade | Was | | After |
| 7/1/2019 | ChA | Anderson,Ti | Demoted to reserve roster | | | Before |
| 7/1/2019 | ChA | Cabrera,Me | Released | | | Before |
| 7/1/2019 | ChA | Mendick | Signed | | | Before |
| 7/1/2019 | ChA | Palka | Signed | | | Before |
| 7/1/2019 | ChA | Palka | Promoted to active roster | | | Before |
| 7/1/2019 | ChA | Peters,DJ | Promoted to active roster | | | Before |
| 7/1/2019 | ChA | Stokes | Released | | | Before |
| 7/1/2019 | Cle | Lopez,Re | Demoted to reserve roster | | | Before |
| 7/1/2019 | Cle | Lopez,Re | Promoted to active roster | | | Before |
| 7/1/2019 | Cle | Marshall | Promoted to active roster | | | Before |
| 7/1/2019 | LAA | Agrazal | Signed | | | Before |
| 7/1/2019 | LAA | Agrazal | Promoted to active roster | | | Before |
| 7/1/2019 | LAA | Gennett | Promoted to active roster | | | Before |
| 7/1/2019 | LAA | Lopes,T | Demoted to reserve roster | | | Before |
| 7/1/2019 | LAA | Parker,B | Released | | | Before |
| 7/1/2019 | LAA | Pena,Fe | Demoted to reserve roster | | | Before |
| 7/1/2019 | Oak | Demeritte | Signed | | | Before |
| 7/1/2019 | Oak | Newcomb | Promoted to active roster | | | Before |
| 7/1/2019 | Oak | Rosario,Ed | Demoted to reserve roster | | | Before |
| 7/1/2019 | Tam | Candelario | Promoted to active roster | | | Before |
| 7/1/2019 | Tam | Daza | Promoted to active roster | | | Before |
| 7/1/2019 | Tam | Hamilton,I | Demoted to reserve roster | | | Before |
| 7/1/2019 | Tam | Hays | Demoted to reserve roster | | | Before |
| 7/1/2019 | Tam | Littell | Promoted to active roster | | | Before |
| 7/1/2019 | Tam | Perez,Her | Demoted to reserve roster | | | Before |
| 7/1/2019 | Tor | Quijada | Signed | | | Before |
| 7/5/2019 | Cle | Floro | Released | | | Before |
| 7/5/2019 | Cle | Holmes,G | Signed | | | Before |
| 7/5/2019 | Cle | Marshall | Released | | | Before |
| 7/5/2019 | Cle | Mountcastle | Promoted to active roster | | | Before |
| 7/5/2019 | Cle | Telis | Signed | | | Before |
| 7/5/2019 | Cle | Telis | Promoted to active roster | | | Before |
| 7/5/2019 | Det | Paulino,Da | Released | | | Before |
| 7/5/2019 | Det | Syndergaard | Promoted to active roster | | | Before |
| 7/5/2019 | Det | Wilson,Ju | Promoted to active roster | | | Before |
| 7/5/2019 | NYA | Herrera,O | Signed | | | Before |
| 7/5/2019 | NYA | Madson | Released | | | Before |
| 7/5/2019 | Oak | Nogosek | Released | | | Before |
| 7/5/2019 | Oak | Sanchez,Al | Signed | | | Before |
| 7/5/2019 | Tam | Dugger | Signed | | | Before |
| 7/5/2019 | Tam | Ramos,R | Signed | | | Before |
| 7/5/2019 | Tam | Urena,Jo | Released | | | Before |
| 7/5/2019 | Tor | Stratton | Released | | | Before |
| 7/7/2019 | ChA | Bote | Acquired via trade | Was | | After |
| 7/7/2019 | ChA | Bradley,B | Traded away | Was | | After |
| 7/7/2019 | ChA | Hudson,Dak | Acquired via trade | Was | | After |
| 7/7/2019 | ChA | Kepler | Acquired via trade | Was | | After |
| 7/7/2019 | ChA | Welker | Traded away | Was | | After |
| 7/7/2019 | ChA | Wright,K | Traded away | Was | | After |
| 7/7/2019 | Hou | Giolito | Acquired via trade | Was | | After |
| 7/7/2019 | LAA | Jennings | Acquired via trade | Was | | After |
| 7/7/2019 | Min | Estevez,O | Acquired via trade | Pit | | After |
| 7/7/2019 | Min | McCutchen | Traded away | Pit | | After |
| 7/7/2019 | Min | Thornton | Acquired via trade | Pit | | After |
| 7/7/2019 | Tex | Erlin | Traded away | Mia | | After |
| 7/7/2019 | Tex | McCullers | Acquired via trade | Was | | After |
| 7/7/2019 | Tex | Sanchez,J | Traded away | Was | | After |
| 7/11/2019 | Bos | Clevinger | Promoted to active roster | | | Before |
| 7/11/2019 | Bos | Diaz,I | Promoted to active roster | | | Before |
| 7/11/2019 | Bos | Fernandez,X | Demoted to reserve roster | | | Before |
| 7/11/2019 | Bos | Luzardo | Demoted to reserve roster | | | Before |
| 7/11/2019 | Bos | Peralta,D | Demoted to reserve roster | | | Before |
| 7/11/2019 | Bos | Ray,C | Promoted to active roster | | | Before |
| 7/11/2019 | ChA | Bleier | Promoted to active roster | | | Before |
| 7/11/2019 | ChA | Cabrera,Me | Signed | | | Before |
| 7/11/2019 | ChA | Cabrera,Me | Promoted to active roster | | | Before |
| 7/11/2019 | ChA | Davies | Demoted to reserve roster | | | Before |
| 7/11/2019 | ChA | Engel | Released | | | Before |
| 7/11/2019 | ChA | Hernandez,M | Signed | | | Before |
| 7/11/2019 | ChA | Lambert,J | Released | | | Before |
| 7/11/2019 | ChA | Marshall | Signed | | | Before |
| 7/11/2019 | ChA | Marshall | Promoted to active roster | | | Before |
| 7/11/2019 | ChA | Mendick | Promoted to active roster | | | Before |
| 7/11/2019 | ChA | Palka | Released | | | Before |
| 7/11/2019 | ChA | Perdomo,L | Signed | | | Before |
| 7/11/2019 | ChA | Rivera,L | Released | | | Before |
| 7/11/2019 | ChA | Roe | Released | | | Before |
| 7/11/2019 | ChA | Swanson,E | Released | | | Before |
| 7/11/2019 | ChA | Valdez,F | Demoted to reserve roster | | | Before |
| 7/11/2019 | ChA | Zavala | Released | | | Before |
| 7/11/2019 | Cle | Brault | Signed | | | Before |
| 7/11/2019 | Cle | VerHagen | Released | | | Before |
| 7/11/2019 | Det | Difo | Released | | | Before |
| 7/11/2019 | Det | Miller,Ju | Demoted to reserve roster | | | Before |
| 7/11/2019 | Det | Seager,C | Promoted to active roster | | | Before |
| 7/11/2019 | Det | Steele | Signed | | | Before |
| 7/11/2019 | Hou | Urena,R | Released | | | Before |
| 7/11/2019 | LAA | Castillo,We | Demoted to reserve roster | | | Before |
| 7/11/2019 | LAA | Colon,C | Demoted to reserve roster | | | Before |
| 7/11/2019 | LAA | Lucroy | Released | | | Before |
| 7/11/2019 | LAA | Otero | Demoted to reserve roster | | | Before |
| 7/11/2019 | LAA | Pena,Fe | Released | | | Before |
| 7/11/2019 | LAA | Stallings | Signed | | | Before |
| 7/11/2019 | LAA | Stallings | Promoted to active roster | | | Before |
| 7/11/2019 | LAA | Story | Promoted to active roster | | | Before |
| 7/11/2019 | Min | Stewart,K | Released | | | Before |
| 7/11/2019 | Oak | Smith,Cal | Promoted to active roster | | | Before |
| 7/11/2019 | Tex | Buxton | Promoted to active roster | | | Before |
| 7/11/2019 | Tex | Garrett,A | Demoted to reserve roster | | | Before |
| 7/11/2019 | Tex | Goody | Signed | | | Before |
| 7/11/2019 | Tex | Goody | Promoted to active roster | | | Before |
| 7/11/2019 | Tex | Harvey,H | Released | | | Before |
| 7/11/2019 | Tex | Reyes,G | Signed | | | Before |
| 7/11/2019 | Tex | Reyes,V | Released | | | Before |
| 7/11/2019 | Tex | Reyes,V | Signed | | | Before |
| 7/11/2019 | Tex | Salow | Released | | | Before |
| 7/11/2019 | Tex | Salow | Signed | | | Before |
| 7/11/2019 | Tex | Taylor,J | Signed | | | Before |
| 7/11/2019 | Tex | Taylor,J | Promoted to active roster | | | Before |
| 7/14/2019 | KC | Andujar | Acquired via trade | Was | | After |
| 7/14/2019 | KC | Medina | Traded away | Was | | After |
| 7/14/2019 | Min | McCann,J | Acquired via trade | Was | | After |
| 7/14/2019 | Oak | Happ,I | Acquired via trade | Phi | | After |
| 7/14/2019 | Oak | Pivetta | Traded away | Phi | | After |
| 7/15/2019 | Bos | Alcantara,Sa | Promoted to active roster | | | Before |
| 7/15/2019 | Bos | Cron,C | Demoted to reserve roster | | | Before |
| 7/15/2019 | Det | Wood,H | Signed | | | Before |
| 7/15/2019 | KC | Adams,C | Promoted to active roster | | | Before |
| 7/15/2019 | KC | Dayton | Demoted to reserve roster | | | Before |
| 7/15/2019 | KC | Lamet | Promoted to active roster | | | Before |
| 7/15/2019 | KC | Stephenson,T | Promoted to active roster | | | Before |
| 7/15/2019 | KC | Wilkerson,A | Demoted to reserve roster | | | Before |
| 7/15/2019 | LAA | Bettis | Promoted to active roster | | | Before |
| 7/15/2019 | LAA | Bundy | Demoted to reserve roster | | | Before |
| 7/15/2019 | LAA | Menez | Demoted to reserve roster | | | Before |
| 7/15/2019 | LAA | Menez | Promoted to active roster | | | Before |
| 7/15/2019 | Min | Mejia,Ad | Released | | | Before |
| 7/15/2019 | Tex | Pena,Fe | Signed | | | Before |
| 7/15/2019 | Tex | Reyes,G | Released | | | Before |
| 7/15/2019 | Tex | Reyes,V | Released | | | Before |
| 7/15/2019 | Tex | Reyes,V | Signed | | | Before |
| 7/15/2019 | Tex | Reyes,V | Promoted to active roster | | | Before |
| 7/18/2019 | Cle | Melendez | Promoted to active roster | | | Before |
| 7/18/2019 | Cle | Yamamoto | Promoted to active roster | | | Before |
| 7/18/2019 | Cle | Frazier,C | Acquired via trade | Was | | After |
| 7/18/2019 | Cle | Haseley | Traded away | Was | | After |
| 7/18/2019 | Cle | Thomas | Acquired via trade | Was | | After |
| 7/18/2019 | Hou | Diaz,El | Traded away | Pit | | After |
| 7/19/2019 | Det | Choo | Demoted to reserve roster | | | Before |
| 7/19/2019 | Det | Flores,W | Promoted to active roster | | | Before |
| 7/19/2019 | Det | Inciarte | Promoted to active roster | | | Before |
| 7/19/2019 | Det | Rodriguez,Ro | Demoted to reserve roster | | | Before |
| 7/19/2019 | KC | Wilkerson,A | Released | | | Before |
| 7/19/2019 | LAA | Brice | Signed | | | Before |
| 7/19/2019 | LAA | Pedroia | Released | | | Before |
| 7/19/2019 | Oak | Sanchez,Al | Released | | | Before |
| 7/19/2019 | Tam | Daza | Demoted to reserve roster | | | Before |
| 7/19/2019 | Tam | Ramos,R | Promoted to active roster | | | Before |
| 7/21/2019 | Det | Cron,K | Traded away | Atl | | After |
| 7/21/2019 | Det | Jeffress | Acquired via trade | Atl | | After |
| 7/21/2019 | Det | Kay | Traded away | Atl | | After |
| 7/21/2019 | Det | Sano | Acquired via trade | Atl | | After |
| 7/21/2019 | KC | Davis,A | Traded away | Mia | | After |
| 7/21/2019 | KC | Kingery | Traded away | Mia | | After |
| 7/21/2019 | KC | Oliva | Acquired via trade | Mia | | After |
| 7/21/2019 | NYA | Rogers,Ja | Traded away | Was | | After |
| 7/22/2019 | Bos | Casali | Demoted to reserve roster | | | Before |
| 7/22/2019 | Bos | Cron,C | Promoted to active roster | | | Before |
| 7/22/2019 | Bos | Diaz,I | Demoted to reserve roster | | | Before |
| 7/22/2019 | Bos | Fernandez,X | Promoted to active roster | | | Before |
| 7/22/2019 | ChA | Engel | Signed | | | Before |
| 7/22/2019 | ChA | Mullins | Released | | | Before |
| 7/22/2019 | ChA | Santander | Signed | | | Before |
| 7/22/2019 | ChA | Tilson | Released | | | Before |
| 7/22/2019 | Hou | Lavarnway | Signed | | | Before |
| 7/22/2019 | LAA | Bettis | Demoted to reserve roster | | | Before |
| 7/22/2019 | LAA | Bundy | Promoted to active roster | | | Before |
| 7/22/2019 | LAA | Eovaldi | Promoted to active roster | | | Before |
| 7/22/2019 | LAA | Gagnon | Demoted to reserve roster | | | Before |
| 7/22/2019 | Oak | Alzolay | Demoted to reserve roster | | | Before |
| 7/22/2019 | Oak | Rosario,Ed | Promoted to active roster | | | Before |
| 7/22/2019 | Oak | Stanek | Demoted to reserve roster | | | Before |
| 7/22/2019 | Tex | Buxton | Demoted to reserve roster | | | Before |
| 7/22/2019 | Tex | Edwards,C | Promoted to active roster | | | Before |
| 7/22/2019 | Tex | Garrett,A | Promoted to active roster | | | Before |
| 7/22/2019 | Tex | Hultzen | Signed | | | Before |
| 7/22/2019 | Tex | Hultzen | Promoted to active roster | | | Before |
| 7/22/2019 | Tex | Jimenez,El | Demoted to reserve roster | | | Before |
| 7/22/2019 | Tex | Pena,Fe | Released | | | Before |
| 7/22/2019 | Tor | Escobar,L | Signed | | | Before |
| 7/22/2019 | Tor | Moran,B | Released | | | Before |
| 7/22/2019 | Tor | Quijada | Promoted to active roster | | | Before |
| 7/22/2019 | Tor | Wilson,M | Signed | | | Before |
| 7/24/2019 | NYA | Maldonado | Released | | | Before |
| 7/24/2019 | NYA | Maldonado | Signed | | | Before |
| 7/24/2019 | NYA | Maldonado | Promoted to active roster | | | Before |
| 7/25/2019 | Cle | Castellanos | Acquired via trade | Ari | | After |
| 7/25/2019 | Cle | Chisholm | Traded away | Was | | After |
| 7/25/2019 | Cle | Dunn,J | Traded away | Ari | | After |
| 7/26/2019 | ChA | Flores,B | Signed | | | Before |
| 7/26/2019 | ChA | Sampson,A | Released | | | Before |
| 7/26/2019 | Cle | Elias | Released | | | Before |
| 7/26/2019 | Cle | Wong,Ke | Signed | | | Before |
| 7/26/2019 | Cle | Young,Al | Signed | | | Before |
| 7/26/2019 | Det | Barnes,M | Demoted to reserve roster | | | Before |
| 7/26/2019 | Det | Devenski | Demoted to reserve roster | | | Before |
| 7/26/2019 | Det | Flores,W | Demoted to reserve roster | | | Before |
| 7/26/2019 | Det | Kela | Promoted to active roster | | | Before |
| 7/26/2019 | LAA | Bettis | Released | | | Before |
| 7/26/2019 | LAA | Bundy | Promoted to active roster | | | Before |
| 7/26/2019 | LAA | Castillo,We | Promoted to active roster | | | Before |
| 7/26/2019 | LAA | Eovaldi | Promoted to active roster | | | Before |
| 7/26/2019 | LAA | Gagnon | Demoted to reserve roster | | | Before |
| 7/26/2019 | LAA | Gordon,A | Demoted to reserve roster | | | Before |
| 7/26/2019 | LAA | Viloria | Signed | | | Before |
| 7/26/2019 | NYA | Maldonado | Signed | | | Before |
| 7/26/2019 | Tam | Perez,Her | Released | | | Before |
| 7/26/2019 | Tam | Sosa | Signed | | | Before |
| 7/26/2019 | Tex | Buxton | Demoted to reserve roster | | | Before |
| 7/26/2019 | Tex | Buxton | Promoted to active roster | | | Before |
| 7/26/2019 | Tex | Karinchak | Promoted to active roster | | | Before |
| 7/26/2019 | Tex | Reyes,V | Released | | | Before |
| 7/29/2019 | Bos | Cron,C | Demoted to reserve roster | | | Before |
| 7/29/2019 | Bos | Peralta,D | Promoted to active roster | | | Before |
| 7/29/2019 | ChA | Cessa | Promoted to active roster | | | Before |
| 7/29/2019 | ChA | Descalso | Released | | | Before |
| 7/29/2019 | ChA | Engel | Promoted to active roster | | | Before |
| 7/29/2019 | ChA | Urshela | Promoted to active roster | | | Before |
| 7/29/2019 | ChA | Vargas,E | Released | | | Before |
| 7/29/2019 | ChA | Woodruff | Demoted to reserve roster | | | Before |
| 7/29/2019 | Cle | Adams,AL | Demoted to reserve roster | | | Before |
| 7/29/2019 | Cle | Clouse | Promoted to active roster | | | Before |
| 7/29/2019 | Cle | Friedl | Demoted to reserve roster | | | Before |
| 7/29/2019 | Cle | Suarez,R | Promoted to active roster | | | Before |
| 7/29/2019 | Cle | Telis | Promoted to active roster | | | Before |
| 7/29/2019 | Cle | Thomas | Demoted to reserve roster | | | Before |
| 7/29/2019 | Cle | Thomas | Promoted to active roster | | | Before |
| 7/29/2019 | KC | Duke | Released | | | Before |
| 7/29/2019 | KC | Elias | Signed | | | Before |
| 7/29/2019 | Min | Austin | Demoted to reserve roster | | | Before |
| 7/29/2019 | Min | Burrows,T | Demoted to reserve roster | | | Before |
| 7/29/2019 | Min | Burrows,T | Promoted to active roster | | | Before |
| 7/29/2019 | Min | Gsellman | Promoted to active roster | | | Before |
| 7/29/2019 | Min | Hicks,Jor | Demoted to reserve roster | | | Before |
| 7/29/2019 | Min | Thornton | Demoted to reserve roster | | | Before |
| 7/29/2019 | Oak | Sanchez,G | Demoted to reserve roster | | | Before |
| 7/29/2019 | Tex | Hultzen | Released | | | Before |
| 7/29/2019 | Tex | Wojciechowski | Signed | | | Before |
| 7/29/2019 | Tor | Rodriguez,Je | Promoted to active roster | | | Before |
| 7/29/2019 | Tor | Snell | Demoted to reserve roster | | | Before |
| 7/30/2019 | NYA | Kiermaier | Demoted to reserve roster | | | Before |
| 7/30/2019 | NYA | Pillar | Promoted to active roster | | | Before |
| 8/1/2019 | Bos | Dyson,J | Acquired via trade | SF | | After |
| 8/1/2019 | Bos | Kluber | Acquired via trade | SF | | After |
| 8/1/2019 | Bos | Luzardo | Traded away | SF | | After |
| 8/1/2019 | Bos | Posey | Acquired via trade | SF | | After |
| 8/1/2019 | LAA | Diekman | Acquired via trade | SF | | After |
| 8/1/2019 | Tex | Anderson,Bri | Traded away | Pit | | After |
| 8/1/2019 | Tex | Bird,G | Acquired via trade | Pit | | After |
| 8/1/2019 | Tex | Lopez,Y | Traded away | Pit | | After |
| 8/1/2019 | Tex | Means | Acquired via trade | Pit | | After |
| 8/2/2019 | Bal | Hoover | Released | | | Before |
| 8/2/2019 | Bos | Alcantara,Sa | Demoted to reserve roster | | | Before |
| 8/2/2019 | Bos | Posey | Promoted to active roster | | | Before |
| 8/2/2019 | Bos | Ray,C | Demoted to reserve roster | | | Before |
| 8/2/2019 | Cle | Holmes,G | Promoted to active roster | | | Before |
| 8/2/2019 | Cle | Richards,T | Released | | | Before |
| 8/2/2019 | LAA | Bruce | Demoted to reserve roster | | | Before |
| 8/2/2019 | LAA | Colon,C | Promoted to active roster | | | Before |
| 8/2/2019 | LAA | Elledge | Promoted to active roster | | | Before |
| 8/2/2019 | LAA | Gagnon | Released | | | Before |
| 8/2/2019 | LAA | Kelly,Car | Demoted to reserve roster | | | Before |
| 8/2/2019 | LAA | Peterson,Da | Demoted to reserve roster | | | Before |
| 8/2/2019 | Min | Austin | Released | | | Before |
| 8/2/2019 | NYA | Maldonado | Released | | | Before |
| 8/2/2019 | NYA | Trevino | Signed | | | Before |
| 8/4/2019 | Det | Arenado | Acquired via trade | Hou | | After |
| 8/4/2019 | Det | Lauer | Acquired via trade | Hou | | After |
| 8/4/2019 | Det | Sano | Traded away | Hou | | After |
| 8/4/2019 | Det | Syndergaard | Traded away | Hou | | After |
| 8/4/2019 | Hou | Arenado | Traded away | Det | | After |
| 8/4/2019 | Hou | Lauer | Traded away | Det | | After |
| 8/4/2019 | Hou | Marte,S | Traded away | LAA | | After |
| 8/4/2019 | Hou | Puig | Acquired via trade | LAA | | After |
| 8/4/2019 | Hou | Sano | Acquired via trade | Det | | After |
| 8/4/2019 | Hou | Syndergaard | Acquired via trade | Det | | After |
| 8/4/2019 | LAA | Marte,S | Acquired via trade | Hou | | After |
| 8/4/2019 | LAA | Puig | Traded away | Hou | | After |
| 8/4/2019 | Tex | Brosseau | Traded away | Was | | After |
| 8/5/2019 | ChA | Anderson,Ti | Promoted to active roster | | | Before |
| 8/5/2019 | ChA | Mendick | Demoted to reserve roster | | | Before |
| 8/5/2019 | Cle | Alexander,T | Signed | | | Before |
| 8/5/2019 | Det | Chacin,J | Demoted to reserve roster | | | Before |
| 8/5/2019 | Det | Devenski | Promoted to active roster | | | Before |
| 8/5/2019 | Det | Lauer | Demoted to reserve roster | | | Before |
| 8/5/2019 | Det | Lauer | Promoted to active roster | | | Before |
| 8/5/2019 | Det | Scherzer | Demoted to reserve roster | | | Before |
| 8/5/2019 | Det | Wood,H | Promoted to active roster | | | Before |
| 8/5/2019 | Hou | Lavarnway | Released | | | Before |
| 8/5/2019 | KC | Elias | Released | | | Before |
| 8/5/2019 | KC | Florial | Promoted to active roster | | | Before |
| 8/5/2019 | KC | Hansen | Promoted to active roster | | | Before |
| 8/5/2019 | KC | Laureano | Demoted to reserve roster | | | Before |
| 8/5/2019 | KC | Neuse | Promoted to active roster | | | Before |
| 8/5/2019 | LAA | Canha | Promoted to active roster | | | Before |
| 8/5/2019 | LAA | Jennings | Demoted to reserve roster | | | Before |
| 8/5/2019 | LAA | Martin,L | Released | | | Before |
| 8/5/2019 | Min | Stashak | Signed | | | Before |
| 8/5/2019 | Oak | Alzolay | Promoted to active roster | | | Before |
| 8/5/2019 | Oak | Montero,E | Promoted to active roster | | | Before |
| 8/5/2019 | Tam | Bauers | Demoted to reserve roster | | | Before |
| 8/5/2019 | Tam | Canning | Demoted to reserve roster | | | Before |
| 8/5/2019 | Tam | Cortes | Demoted to reserve roster | | | Before |
| 8/5/2019 | Tam | Daza | Promoted to active roster | | | Before |
| 8/5/2019 | Tam | Dugger | Promoted to active roster | | | Before |
| 8/5/2019 | Tam | Dyson,S | Demoted to reserve roster | | | Before |
| 8/5/2019 | Tam | Faria | Promoted to active roster | | | Before |
| 8/5/2019 | Tam | Helsley | Demoted to reserve roster | | | Before |
| 8/5/2019 | Tam | Helsley | Promoted to active roster | | | Before |
| 8/5/2019 | Tam | Wisler | Promoted to active roster | | | Before |
| 8/5/2019 | Tex | Jimenez,El | Promoted to active roster | | | Before |
| 8/5/2019 | Tex | Keller,Bri | Signed | | | Before |
| 8/5/2019 | Tex | Keller,Bri | Promoted to active roster | | | Before |
| 8/5/2019 | Tex | King | Promoted to active roster | | | Before |
| 8/5/2019 | Tex | Nola,Au | Signed | | | Before |
| 8/5/2019 | Tex | Nola,Au | Promoted to active roster | | | Before |
| 8/5/2019 | Tex | Wojciechowski | Released | | | Before |
| 8/8/2019 | Bos | Moreland | Signed | | | Before |
| 8/8/2019 | KC | Cave | Acquired via trade | Was | | After |
| 8/8/2019 | KC | Senzatela | Acquired via trade | Was | | After |
| 8/8/2019 | NYA | Abreu,A | Traded away | Was | | After |
| 8/8/2019 | NYA | Chisholm | Acquired via trade | Was | | After |
| 8/8/2019 | NYA | Hoyt | Acquired via trade | Cin | | After |
| 8/8/2019 | NYA | Leyba | Traded away | Cin | | After |
| 8/8/2019 | NYA | Urias,L | Traded away | Was | | After |
| 8/8/2019 | NYA | Yamamoto | Traded away | Was | | After |
| 8/9/2019 | Bos | Cron,C | Promoted to active roster | | | Before |
| 8/9/2019 | Bos | Moreland | Promoted to active roster | | | Before |
| 8/9/2019 | Bos | Smith,Kevi | Demoted to reserve roster | | | Before |
| 8/9/2019 | Bos | Wacha | Demoted to reserve roster | | | Before |
| 8/9/2019 | Cle | Crick | Released | | | Before |
| 8/9/2019 | Cle | Rojas,M | Signed | | | Before |
| 8/9/2019 | Det | Ibanez | Signed | | | Before |
| 8/9/2019 | Det | Wood,H | Released | | | Before |
| 8/9/2019 | Hou | Davis,C | Released | | | Before |
| 8/9/2019 | KC | Adams,C | Released | | | Before |
| 8/9/2019 | KC | Kendall | Demoted to reserve roster | | | Before |
| 8/9/2019 | KC | Kendall | Promoted to active roster | | | Before |
| 8/9/2019 | KC | Nola,Au | Signed | | | Before |
| 8/9/2019 | KC | Nola,Au | Promoted to active roster | | | Before |
| 8/9/2019 | KC | Stephenson,T | Demoted to reserve roster | | | Before |
| 8/9/2019 | KC | Stewart,CG | Demoted to reserve roster | | | Before |
| 8/9/2019 | Min | Stashak | Released | | | Before |
| 8/9/2019 | Oak | Hernandez,Elies | Released | | | Before |
| 8/9/2019 | Tam | Cortes | Promoted to active roster | | | Before |
| 8/9/2019 | Tam | Scheetz | Demoted to reserve roster | | | Before |
| 8/9/2019 | Tex | Duffey | Signed | | | Before |
| 8/9/2019 | Tex | Duffey | Promoted to active roster | | | Before |
| 8/9/2019 | Tex | Keller,Bri | Released | | | Before |
| 8/9/2019 | Tex | Means | Promoted to active roster | | | Before |
| 8/9/2019 | Tex | Nola,Au | Released | | | Before |
| 8/9/2019 | Tex | Selman | Released | | | Before |
| 8/9/2019 | Tex | Underwood | Signed | | | Before |
| 8/9/2019 | Tex | Underwood | Promoted to active roster | | | Before |
| 8/11/2019 | ChA | Johnson,T | Released | | | Before |
| 8/11/2019 | ChA | Perdomo,L | Released | | | Before |
| 8/11/2019 | Min | Soler | Traded away | Pit | | After |
| 8/12/2019 | Bos | Cruz,N | Demoted to reserve roster | | | Before |
| 8/12/2019 | Bos | Hernandez,Elies | Signed | | | Before |
| 8/12/2019 | Bos | Smith,Kevi | Demoted to reserve roster | | | Before |
| 8/12/2019 | Bos | Smith,Kevi | Promoted to active roster | | | Before |
| 8/12/2019 | Bos | Wacha | Promoted to active roster | | | Before |
| 8/12/2019 | Cle | Brault | Promoted to active roster | | | Before |
| 8/12/2019 | Cle | Lopez,Re | Demoted to reserve roster | | | Before |
| 8/12/2019 | Cle | Lopez,Re | Promoted to active roster | | | Before |
| 8/12/2019 | Det | Cahill | Signed | | | Before |
| 8/12/2019 | Det | Cahill | Promoted to active roster | | | Before |
| 8/12/2019 | KC | Gonsalves | Promoted to active roster | | | Before |
| 8/12/2019 | KC | Kendall | Demoted to reserve roster | | | Before |
| 8/12/2019 | LAA | Elledge | Demoted to reserve roster | | | Before |
| 8/12/2019 | LAA | Kelly,Car | Promoted to active roster | | | Before |
| 8/12/2019 | LAA | Peterson,Da | Promoted to active roster | | | Before |
| 8/12/2019 | LAA | Stallings | Demoted to reserve roster | | | Before |
| 8/12/2019 | Min | Garcia,Ad | Promoted to active roster | | | Before |
| 8/12/2019 | Oak | Montero,E | Demoted to reserve roster | | | Before |
| 8/12/2019 | Oak | Sanchez,G | Promoted to active roster | | | Before |
| 8/12/2019 | Oak | Stanek | Promoted to active roster | | | Before |
| 8/12/2019 | Tam | Candelario | Demoted to reserve roster | | | Before |
| 8/12/2019 | Tam | Fuentes,J | Promoted to active roster | | | Before |
| 8/12/2019 | Tam | Hays | Promoted to active roster | | | Before |
| 8/12/2019 | Tam | Luplow | Demoted to reserve roster | | | Before |
| 8/12/2019 | Tex | Garrett,A | Demoted to reserve roster | | | Before |
| 8/12/2019 | Tex | Houser | Signed | | | Before |
| 8/12/2019 | Tex | Houser | Promoted to active roster | | | Before |
| 8/13/2019 | Cle | Friedl | Released | | | Before |
| 8/15/2019 | Det | Diaz,A | Traded away | Cin | | After |
| 8/15/2019 | Det | Gonzalez,G | Acquired via trade | Cin | | After |
| 8/15/2019 | Hou | Kennedy,I | Traded away | Pit | | After |
| 8/15/2019 | Hou | Puig | Traded away | Pit | | After |
| 8/15/2019 | Hou | Soler | Acquired via trade | Pit | | After |
| 8/15/2019 | Min | Cain | Traded away | Pit | | After |
| 8/15/2019 | Min | Morton | Traded away | Pit | | After |
| 8/15/2019 | Min | Pinder,Chad | Acquired via trade | Pit | | After |
| 8/15/2019 | Min | Puig | Acquired via trade | Pit | | After |
| 8/16/2019 | Bos | Hernandez,Elies | Released | | | Before |
| 8/16/2019 | ChA | Chavis | Demoted to reserve roster | | | Before |
| 8/16/2019 | ChA | Hernandez,M | Promoted to active roster | | | Before |
| 8/16/2019 | ChA | Holland,G | Released | | | Before |
| 8/16/2019 | ChA | Johnson,T | Signed | | | Before |
| 8/16/2019 | ChA | Lambert,P | Promoted to active roster | | | Before |
| 8/16/2019 | ChA | Mendick | Promoted to active roster | | | Before |
| 8/16/2019 | ChA | Wendle | Demoted to reserve roster | | | Before |
| 8/16/2019 | Cle | Alexander,T | Released | | | Before |
| 8/16/2019 | Cle | Clouse | Demoted to reserve roster | | | Before |
| 8/16/2019 | Cle | Garcia,Jar | Signed | | | Before |
| 8/16/2019 | Cle | Garcia,Jar | Promoted to active roster | | | Before |
| 8/16/2019 | Cle | Gordon,N | Demoted to reserve roster | | | Before |
| 8/16/2019 | Cle | Wong,Ke | Promoted to active roster | | | Before |
| 8/16/2019 | Det | Barnes,M | Promoted to active roster | | | Before |
| 8/16/2019 | Det | Cahill | Demoted to reserve roster | | | Before |
| 8/16/2019 | Det | Gonzalez,G | Promoted to active roster | | | Before |
| 8/16/2019 | Hou | Crick | Signed | | | Before |
| 8/16/2019 | Hou | Giolito | Promoted to active roster | | | Before |
| 8/16/2019 | KC | Moran,B | Signed | | | Before |
| 8/16/2019 | KC | Moya | Released | | | Before |
| 8/16/2019 | LAA | Agrazal | Released | | | Before |
| 8/16/2019 | LAA | Berti | Signed | | | Before |
| 8/16/2019 | Min | Burrows,T | Released | | | Before |
| 8/16/2019 | Min | Hildenberger | Released | | | Before |
| 8/16/2019 | Min | Thornton | Promoted to active roster | | | Before |
| 8/16/2019 | Min | Valera | Released | | | Before |
| 8/16/2019 | Tam | Bauers | Promoted to active roster | | | Before |
| 8/16/2019 | Tam | Martinez,Jo | Demoted to reserve roster | | | Before |
| 8/16/2019 | Tex | Duffey | Released | | | Before |
| 8/16/2019 | Tex | Heineman,S | Signed | | | Before |
| 8/16/2019 | Tex | Heineman,S | Promoted to active roster | | | Before |
| 8/18/2019 | Det | Lester,Jon | Acquired via trade | Min | | After |
| 8/18/2019 | Min | Lester,Jon | Traded away | Det | | After |
| 8/19/2019 | Bal | Polanco,G | Demoted to reserve roster | | | Before |
| 8/19/2019 | ChA | Garcia,Av | Demoted to reserve roster | | | Before |
| 8/19/2019 | ChA | Johnson,T | Promoted to active roster | | | Before |
| 8/19/2019 | ChA | Martin,Ri | Demoted to reserve roster | | | Before |
| 8/19/2019 | ChA | Oberg | Demoted to reserve roster | | | Before |
| 8/19/2019 | ChA | Reyes,P | Promoted to active roster | | | Before |
| 8/19/2019 | ChA | Santander | Promoted to active roster | | | Before |
| 8/19/2019 | Det | Barnes,M | Demoted to reserve roster | | | Before |
| 8/19/2019 | Det | Cahill | Released | | | Before |
| 8/19/2019 | Det | Flores,W | Promoted to active roster | | | Before |
| 8/19/2019 | Det | Hill,D | Signed | | | Before |
| 8/19/2019 | Det | Inciarte | Demoted to reserve roster | | | Before |
| 8/19/2019 | Det | Miller,Ju | Promoted to active roster | | | Before |
| 8/19/2019 | Det | Sale | Demoted to reserve roster | | | Before |
| 8/19/2019 | Det | Shaw,T | Demoted to reserve roster | | | Before |
| 8/19/2019 | LAA | Brice | Released | | | Before |
| 8/19/2019 | LAA | Menez | Promoted to active roster | | | Before |
| 8/19/2019 | LAA | Votto | Demoted to reserve roster | | | Before |
| 8/19/2019 | Min | Arrieta | Demoted to reserve roster | | | Before |
| 8/19/2019 | Min | Estevez,C | Promoted to active roster | | | Before |
| 8/19/2019 | Min | Galvis | Promoted to active roster | | | Before |
| 8/19/2019 | Min | Garcia,Ad | Demoted to reserve roster | | | Before |
| 8/19/2019 | Min | Gonsolin | Promoted to active roster | | | Before |
| 8/19/2019 | Min | Gsellman | Demoted to reserve roster | | | Before |
| 8/19/2019 | Min | Robinson,Du | Released | | | Before |
| 8/19/2019 | Min | Sborz | Promoted to active roster | | | Before |
| 8/19/2019 | Oak | Franco,Ma | Demoted to reserve roster | | | Before |
| 8/19/2019 | Oak | Montero,E | Promoted to active roster | | | Before |
| 8/19/2019 | Oak | Ray,R | Demoted to reserve roster | | | Before |
| 8/19/2019 | Oak | Urias,J | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Dahl | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Dickerson,C | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Dietrich | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | La Stella | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Lowe,B | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Martinez,C | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Montgomery,Mi | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Morales,K | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Naylor | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Paxton | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Peter | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Prado | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Smith,Car | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Taylor,Chr | Demoted to reserve roster | | | Before |
| 8/19/2019 | Sea | Upton | Promoted to active roster | | | Before |
| 8/19/2019 | Sea | Warren,Ad | Demoted to reserve roster | | | Before |
| 8/19/2019 | Tex | Edwards,C | Demoted to reserve roster | | | Before |
| 8/19/2019 | Tex | Garrett,A | Promoted to active roster | | | Before |
| 8/21/2019 | Bal | Moustakas | Promoted to active roster | | | Before |
| 8/22/2019 | Min | Howard,B | Acquired via trade | Was | | After |
| 8/22/2019 | NYA | Tejeda | Acquired via trade | Was | | After |
| 8/23/2019 | ChA | Bergen | Released | | | Before |
| 8/23/2019 | ChA | Brown,S | Signed | | | Before |
| 8/23/2019 | ChA | Martin,Ri | Released | | | Before |
| 8/23/2019 | Det | Hill,D | Released | | | Before |
| 8/23/2019 | Det | Phillips,Bre | Signed | | | Before |
| 8/23/2019 | Det | Waguespack | Signed | | | Before |
| 8/23/2019 | LAA | Eickhoff | Promoted to active roster | | | Before |
| 8/23/2019 | LAA | Menez | Demoted to reserve roster | | | Before |
| 8/23/2019 | LAA | Webb,L | Promoted to active roster | | | Before |
| 8/23/2019 | NYA | Makita | Released | | | Before |
| 8/23/2019 | Tex | Reyes,V | Signed | | | Before |
| 8/23/2019 | Tex | Underwood | Released | | | Before |
| 8/25/2019 | Bal | Anderson,Bri | Acquired via trade | Pit | | After |
| 8/25/2019 | Bal | Carrasco | Acquired via trade | Pit | | After |
| 8/25/2019 | Bal | Greinke | Traded away | Pit | | After |
| 8/25/2019 | Bal | Moustakas | Traded away | Pit | | After |
| 8/25/2019 | Bos | Diaz,I | Traded away | Mia | | After |
| 8/25/2019 | Bos | Gausman | Acquired via trade | Mia | | After |
| 8/25/2019 | Bos | Gregorius | Acquired via trade | Mia | | After |
| 8/25/2019 | Bos | Rodriguez,E | Traded away | Mia | | After |
| 8/25/2019 | Det | Astudillo | Acquired via trade | SF | | After |
| 8/25/2019 | Det | Shaw,T | Traded away | SF | | After |
| 8/25/2019 | Min | Medina | Acquired via trade | Was | | After |
| 8/25/2019 | Min | Vogelbach | Traded away | Was | | After |
| 8/25/2019 | NYA | Duffy,M | Acquired via trade | SF | | After |
| 8/26/2019 | Bal | Cordell | Released | | | Before |
| 8/26/2019 | Bal | Greene,S | Promoted to active roster | | | Before |
| 8/26/2019 | Bal | Kaminsky | Promoted to active roster | | | Before |
| 8/26/2019 | Bal | Kemp,M | Released | | | Before |
| 8/26/2019 | Bal | Oaks | Promoted to active roster | | | Before |
| 8/26/2019 | Bal | Solis | Released | | | Before |
| 8/26/2019 | Bal | Starling | Promoted to active roster | | | Before |
| 8/26/2019 | Bos | Cruz,N | Promoted to active roster | | | Before |
| 8/26/2019 | Bos | Moreland | Demoted to reserve roster | | | Before |
| 8/26/2019 | Bos | Peralta,D | Demoted to reserve roster | | | Before |
| 8/26/2019 | ChA | Cabrera,Me | Released | | | Before |
| 8/26/2019 | ChA | Newberry | Signed | | | Before |
| 8/26/2019 | ChA | Underwood | Signed | | | Before |
| 8/26/2019 | ChA | Valdez,F | Released | | | Before |
| 8/26/2019 | Cle | Brown,Z | Released | | | Before |
| 8/26/2019 | Cle | Eflin | Demoted to reserve roster | | | Before |
| 8/26/2019 | Cle | Valdez,F | Signed | | | Before |
| 8/26/2019 | Cle | Valdez,F | Promoted to active roster | | | Before |
| 8/26/2019 | Det | Armstrong | Demoted to reserve roster | | | Before |
| 8/26/2019 | Det | Astudillo | Demoted to reserve roster | | | Before |
| 8/26/2019 | Det | Flores,W | Demoted to reserve roster | | | Before |
| 8/26/2019 | Det | Kolarek | Promoted to active roster | | | Before |
| 8/26/2019 | Det | Narvaez | Demoted to reserve roster | | | Before |
| 8/26/2019 | Det | Narvaez | Promoted to active roster | | | Before |
| 8/26/2019 | Det | Rodriguez,Ro | Promoted to active roster | | | Before |
| 8/26/2019 | Det | Scherzer | Promoted to active roster | | | Before |
| 8/26/2019 | Det | Steele | Released | | | Before |
| 8/26/2019 | Det | Steele | Released | | | Before |
| 8/26/2019 | Det | Waguespack | Demoted to reserve roster | | | Before |
| 8/26/2019 | Det | Waguespack | Promoted to active roster | | | Before |
| 8/26/2019 | Det | Wilson,Ju | Demoted to reserve roster | | | Before |
| 8/26/2019 | NYA | Duffy,M | Promoted to active roster | | | Before |
| 8/26/2019 | Tex | Reyes,V | Promoted to active roster | | | Before |
| 8/26/2019 | Tor | Cano | Demoted to reserve roster | | | Before |
| 8/29/2019 | Cle | Clouse | Released | | | Before |
| 8/30/2019 | Bos | Moreland | Released | | | Before |
| 8/30/2019 | ChA | Engel | Released | | | Before |
| 8/30/2019 | Cle | Goodrum | Demoted to reserve roster | | | Before |
| 8/30/2019 | Cle | Goody | Signed | | | Before |
| 8/30/2019 | Cle | Goody | Promoted to active roster | | | Before |
| 8/30/2019 | Det | Banda | Promoted to active roster | | | Before |
| 8/30/2019 | Det | Chacin,J | Demoted to reserve roster | | | Before |
| 8/30/2019 | Det | Chacin,J | Promoted to active roster | | | Before |
| 8/30/2019 | Det | Lauer | Demoted to reserve roster | | | Before |
| 8/30/2019 | Min | Dozier,H | Promoted to active roster | | | Before |
| 8/30/2019 | Min | Flowers | Demoted to reserve roster | | | Before |
| 8/30/2019 | Min | McCann,J | Promoted to active roster | | | Before |
| 8/30/2019 | Min | Medina | Demoted to reserve roster | | | Before |
| 8/30/2019 | Min | Medina | Promoted to active roster | | | Before |
| 8/30/2019 | Min | Pressly | Demoted to reserve roster | | | Before |
| 8/30/2019 | Tex | Baez,M | Demoted to reserve roster | | | Before |
| 8/30/2019 | Tex | Cordoba | Signed | | | Before |
| 8/30/2019 | Tex | Cordoba | Promoted to active roster | | | Before |
| 8/30/2019 | Tex | Goody | Released | | | Before |
| 8/30/2019 | Tex | O'Hearn | Signed | | | Before |
| 8/30/2019 | Tex | O'Hearn | Promoted to active roster | | | Before |
| 9/1/2019 | Cle | Boyd,M | Traded away | Was | | After |
| 9/1/2019 | Cle | Solak | Acquired via trade | Was | | After |
| 9/1/2019 | Min | Murphy,D | Traded away | NYA | | After |
| 9/1/2019 | NYA | Murphy,D | Acquired via trade | Min | | After |
| 9/1/2019 | Tam | Allard | Acquired via trade | Was | | After |
| 9/1/2019 | Tam | Canning | Traded away | Was | | After |
| 9/2/2019 | Bos | Casali | Promoted to active roster | | | Before |
| 9/2/2019 | Bos | Ray,C | Promoted to active roster | | | Before |
| 9/2/2019 | Bos | Smith,Kevi | Promoted to active roster | | | Before |
| 9/2/2019 | ChA | Reyes,P | Released | | | Before |
| 9/2/2019 | ChA | White,El | Signed | | | Before |
| 9/2/2019 | Cle | Adams,AL | Promoted to active roster | | | Before |
| 9/2/2019 | Cle | Burrows,B | Released | | | Before |
| 9/2/2019 | Cle | Eflin | Promoted to active roster | | | Before |
| 9/2/2019 | Cle | Fedde | Demoted to reserve roster | | | Before |
| 9/2/2019 | Cle | Mejia,F | Demoted to reserve roster | | | Before |
| 9/2/2019 | Cle | Mountcastle | Promoted to active roster | | | Before |
| 9/2/2019 | Cle | Rojas,M | Promoted to active roster | | | Before |
| 9/2/2019 | Cle | Solak | Demoted to reserve roster | | | Before |
| 9/2/2019 | Cle | Thomas | Demoted to reserve roster | | | Before |
| 9/2/2019 | Cle | Wong,Ke | Demoted to reserve roster | | | Before |
| 9/2/2019 | Cle | Wong,Ke | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Berti | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Gordon,A | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Lopes,T | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Menez | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Otero | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Stallings | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Votto | Promoted to active roster | | | Before |
| 9/2/2019 | LAA | Zeuch | Released | | | Before |
| 9/2/2019 | Min | Duffey | Signed | | | Before |
| 9/2/2019 | Min | Duffey | Promoted to active roster | | | Before |
| 9/2/2019 | Min | Estevez,C | Released | | | Before |
| 9/2/2019 | Min | Flowers | Promoted to active roster | | | Before |
| 9/2/2019 | Min | McCann,B | Promoted to active roster | | | Before |
| 9/2/2019 | Min | Medina | Promoted to active roster | | | Before |
| 9/2/2019 | Min | Young,An | Promoted to active roster | | | Before |
| 9/2/2019 | Min | Zimmerman | Promoted to active roster | | | Before |
| 9/2/2019 | Min | Zobrist | Promoted to active roster | | | Before |
| 9/2/2019 | Oak | Demeritte | Released | | | Before |
| 9/2/2019 | Oak | Kasowski | Signed | | | Before |
| 9/2/2019 | Sea | Taylor,Chr | Promoted to active roster | | | Before |
| 9/2/2019 | Tam | Bedrosian | Demoted to reserve roster | | | Before |
| 9/2/2019 | Tam | Crawford,J | Demoted to reserve roster | | | Before |
| 9/2/2019 | Tam | Sosa | Promoted to active roster | | | Before |
| 9/6/2019 | ChA | Choi | Signed | | | Before |
| 9/6/2019 | Det | Armstrong | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Astudillo | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Barnes,M | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Chacin,J | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Choo | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Flores,W | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Ibanez | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Lauer | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Perez,R | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Waguespack | Promoted to active roster | | | Before |
| 9/6/2019 | Det | Wilson,Ju | Promoted to active roster | | | Before |
| 9/6/2019 | NYA | Pearce | Released | | | Before |
| 9/9/2019 | Bos | Alcantara,Sa | Promoted to active roster | | | Before |
| 9/9/2019 | Bos | O'Day | Signed | | | Before |
| 9/9/2019 | Bos | O'Day | Promoted to active roster | | | Before |
| 9/9/2019 | Bos | Wacha | Demoted to reserve roster | | | Before |
| 9/9/2019 | Det | Miller,Ju | Released | | | Before |
| 9/9/2019 | Det | Sanchez,Y | Signed | | | Before |
| 9/9/2019 | LAA | Bruce | Promoted to active roster | | | Before |
| 9/9/2019 | LAA | Eickhoff | Demoted to reserve roster | | | Before |
| 9/9/2019 | LAA | Gennett | Demoted to reserve roster | | | Before |
| 9/9/2019 | LAA | Heller | Promoted to active roster | | | Before |
| 9/9/2019 | LAA | Tauchman | Demoted to reserve roster | | | Before |
| 9/9/2019 | NYA | Baez,Ja | Demoted to reserve roster | | | Before |
| 9/9/2019 | Oak | Franco,Ma | Promoted to active roster | | | Before |
| 9/9/2019 | Oak | Ray,R | Promoted to active roster | | | Before |
| 9/13/2019 | ChA | Castro,H | Signed | | | Before |
| 9/13/2019 | ChA | Listi | Released | | | Before |
| 9/13/2019 | ChA | White,El | Released | | | Before |
| 9/13/2019 | Cle | Montgomery,J | Promoted to active roster | | | Before |
| 9/13/2019 | Cle | Mountcastle | Demoted to reserve roster | | | Before |
| 9/13/2019 | Cle | Rojas,M | Demoted to reserve roster | | | Before |
| 9/13/2019 | Cle | Rojas,M | Promoted to active roster | | | Before |
| 9/13/2019 | NYA | Montero,R | Signed | | | Before |
| 9/16/2019 | ChA | Adrianza | Signed | | | Before |
| 9/16/2019 | ChA | Mendick | Released | | | Before |
| 9/16/2019 | Tex | Baez,M | Promoted to active roster | | | Before |
| 9/16/2019 | Tex | Ohtani | Demoted to reserve roster | | | Before |
| 9/16/2019 | Tor | Arozarena | Promoted to active roster | | | Before |
| 9/16/2019 | Tor | Cano | Promoted to active roster | | | Before |
| 9/16/2019 | Tor | Hernandez,Dar | Promoted to active roster | | | Before |
| 9/16/2019 | Tor | Kimbrel | Demoted to reserve roster | | | Before |
| 9/16/2019 | Tor | McGee,J | Promoted to active roster | | | Before |
| 9/16/2019 | Tor | Nunez,E | Demoted to reserve roster | | | Before |
| 9/16/2019 | Tor | Ramos,E | Demoted to reserve roster | | | Before |
| 9/16/2019 | Tor | Ramos,E | Promoted to active roster | | | Before |
| 9/16/2019 | Tor | Sanchez,Aa | Demoted to reserve roster | | | Before |
| 9/18/2019 | NYA | Yelich | Demoted to reserve roster | | | Before |
| 9/20/2019 | Bos | Bailey,H | Signed | | | Before |
| 9/20/2019 | Bos | Wacha | Released | | | Before |
| 9/20/2019 | ChA | Castro,M | Signed | | | Before |
| 9/20/2019 | Cle | McGuire,R | Signed | | | Before |
| 9/20/2019 | Cle | McGuire,R | Promoted to active roster | | | Before |
| 9/20/2019 | Cle | Mejia,F | Promoted to active roster | | | Before |
| 9/20/2019 | Cle | Telis | Released | | | Before |
| 9/20/2019 | Cle | Wong,Ke | Demoted to reserve roster | | | Before |
| 9/20/2019 | Det | Jeffress | Demoted to reserve roster | | | Before |
| 9/23/2019 | Bos | Allen,L | Promoted to active roster | | | Before |
| 9/23/2019 | Bos | Bailey,H | Promoted to active roster | | | Before |
| 9/23/2019 | Bos | Kelly,M | Promoted to active roster | | | Before |
| 9/23/2019 | Bos | Marquez | Demoted to reserve roster | | | Before |
| 9/23/2019 | Bos | May,D | Promoted to active roster | | | Before |
| 9/23/2019 | Bos | Peralta,D | Demoted to reserve roster | | | Before |
| 9/23/2019 | Bos | Peralta,D | Promoted to active roster | | | Before |
| 9/23/2019 | ChA | Castro,M | Released | | | Before |
| 9/23/2019 | Cle | Adams,AL | Demoted to reserve roster | | | Before |
| 9/23/2019 | Cle | Brault | Released | | | Before |
| 9/23/2019 | Cle | Mountcastle | Promoted to active roster | | | Before |
| 9/23/2019 | Cle | Wacha | Signed | | | Before |
| 9/23/2019 | Cle | Weaver | Promoted to active roster | | | Before |
| 9/23/2019 | Det | Phillips,Bre | Released | | | Before |
| 9/23/2019 | NYA | Beede | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Chapman,A | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Guerrero,T | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Guzman,J | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Haase | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Harper,Bryc | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Judge | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Kang | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Kershaw | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Kiermaier | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Layne | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Montero,R | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Moronta | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Realmuto | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Strasburg | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Tejeda | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | ThompsnWilliams | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Trevino | Promoted to active roster | | | Before |
| 9/23/2019 | NYA | Vazquez,F | Demoted to reserve roster | | | Before |
| 9/23/2019 | NYA | Verlander | Demoted to reserve roster | | | Before |
| 9/23/2019 | Tor | Castro,W | Promoted to active roster | | | Before |
| 9/23/2019 | Tor | Santana,Da | Promoted to active roster | | | Before |
| 9/23/2019 | Tor | Snell | Promoted to active roster | | | Before |
| 9/23/2019 | Tor | Vogt | Promoted to active roster | | | Before |
| 9/27/2019 | Bos | Allen,L | Demoted to reserve roster | | | Before |
| 9/27/2019 | Bos | Bailey,H | Demoted to reserve roster | | | Before |
| 9/27/2019 | Bos | Fernandez,X | Demoted to reserve roster | | | Before |
| 9/27/2019 | Bos | Kelly,M | Demoted to reserve roster | | | Before |
| 9/27/2019 | Bos | Smith,Kevi | Demoted to reserve roster | | | Before |
| 9/27/2019 | LAA | Jennings | Released | | | Before |
| 9/27/2019 | LAA | Rogers,Ty | Signed | | | Before |
| 9/27/2019 | Oak | Glasnow | Promoted to active roster | | | Before |
| 9/27/2019 | Oak | Rengifo | Demoted to reserve roster | | | Before |
| 9/27/2019 | Oak | Urias,J | Promoted to active roster | | | Before |
