| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/2/2016 | Det | Fielder | Traded away | Tex | | After |
| 4/2/2016 | Det | Fielder | Acquired via trade | Tex | | After |
| 4/2/2016 | Det | Fielder | Acquired via trade | Tex | | After |
| 4/2/2016 | Det | Margot | Traded away | Tex | | After |
| 4/2/2016 | Det | Margot | Traded away | Tex | | After |
| 4/2/2016 | Det | Margot | Acquired via trade | Tex | | After |
| 4/2/2016 | Det | Markakis | Traded away | Tex | | After |
| 4/2/2016 | Det | Markakis | Acquired via trade | Tex | | After |
| 4/2/2016 | Det | Markakis | Acquired via trade | Tex | | After |
| 4/2/2016 | Det | Young,CB | Traded away | Tex | | After |
| 4/2/2016 | Det | Young,CB | Acquired via trade | Tex | | After |
| 4/2/2016 | Det | Young,CB | Acquired via trade | Tex | | After |
| 4/2/2016 | Oak | Lawrie | Traded away | Pit | | After |
| 4/2/2016 | Oak | Lawrie | Traded away | Pit | | After |
| 4/2/2016 | Oak | Lawrie | Acquired via trade | Pit | | After |
| 4/2/2016 | Oak | Wieters | Traded away | Pit | | After |
| 4/2/2016 | Oak | Wieters | Acquired via trade | Pit | | After |
| 4/2/2016 | Oak | Wieters | Acquired via trade | Pit | | After |
| 4/2/2016 | Tex | Cabrera,Mi | Traded away | Pit | | After |
| 4/2/2016 | Tex | Caminero | Traded away | Pit | | After |
| 4/2/2016 | Tex | Carter | Acquired via trade | Pit | | After |
| 4/2/2016 | Tex | Cingrani | Traded away | Pit | | After |
| 4/2/2016 | Tex | Fielder | Traded away | Det | | After |
| 4/2/2016 | Tex | Fielder | Traded away | Det | | After |
| 4/2/2016 | Tex | Fielder | Acquired via trade | Det | | After |
| 4/2/2016 | Tex | Frazier,C | Acquired via trade | Pit | | After |
| 4/2/2016 | Tex | Gordon,A | Traded away | Pit | | After |
| 4/2/2016 | Tex | Margot | Traded away | Det | | After |
| 4/2/2016 | Tex | Margot | Acquired via trade | Det | | After |
| 4/2/2016 | Tex | Margot | Acquired via trade | Det | | After |
| 4/2/2016 | Tex | Markakis | Traded away | Det | | After |
| 4/2/2016 | Tex | Markakis | Traded away | Det | | After |
| 4/2/2016 | Tex | Markakis | Acquired via trade | Det | | After |
| 4/2/2016 | Tex | Reyes,Al | Acquired via trade | Pit | | After |
| 4/2/2016 | Tex | Wieters | Traded away | Pit | | After |
| 4/2/2016 | Tex | Winker | Acquired via trade | Pit | | After |
| 4/2/2016 | Tex | Young,CB | Traded away | Det | | After |
| 4/2/2016 | Tex | Young,CB | Traded away | Det | | After |
| 4/2/2016 | Tex | Young,CB | Acquired via trade | Det | | After |
| 4/6/2016 | LAA | Chisenhall | Demoted to reserve roster | | | Before |
| 4/6/2016 | Tor | Affeldt | Demoted to reserve roster | | | Before |
| 4/11/2016 | Bos | Paulino,D | Promoted to active roster | | | Before |
| 4/11/2016 | Bos | Ross,T | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Alvarez,Darie | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Broadway | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Cabrera,Me | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Cabrera,Me | Promoted to active roster | | | Before |
| 4/11/2016 | Det | Cabrera,Me | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Cabrera,Me | Promoted to active roster | | | Before |
| 4/11/2016 | Det | Markakis | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Markakis | Promoted to active roster | | | Before |
| 4/11/2016 | Det | Markakis | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Young,CB | Demoted to reserve roster | | | Before |
| 4/11/2016 | Det | Young,CB | Promoted to active roster | | | Before |
| 4/11/2016 | KC | Cecchini,Gar | Promoted to active roster | | | Before |
| 4/11/2016 | KC | Crawford,C | Demoted to reserve roster | | | Before |
| 4/11/2016 | LAA | Eickhoff | Promoted to active roster | | | Before |
| 4/11/2016 | LAA | Jackson,L | Demoted to reserve roster | | | Before |
| 4/11/2016 | LAA | Pham | Demoted to reserve roster | | | Before |
| 4/12/2016 | Bos | Blackburn | Acquired via trade | KC | | After |
| 4/12/2016 | Bos | Ege | Traded away | Cin | | After |
| 4/12/2016 | Bos | Freese | Traded away | StL | | After |
| 4/12/2016 | Bos | Hernandez,M | Acquired via trade | KC | | After |
| 4/12/2016 | Bos | Kingham | Traded away | KC | | After |
| 4/12/2016 | Bos | McHugh | Traded away | Cin | | After |
| 4/12/2016 | Bos | Mills,A | Acquired via trade | Cin | | After |
| 4/12/2016 | Bos | Ortiz,Dav | Traded away | KC | | After |
| 4/12/2016 | Bos | Ozuna | Traded away | KC | | After |
| 4/12/2016 | Bos | Rodriguez,Al | Traded away | SD | | After |
| 4/12/2016 | Bos | Ross,T | Traded away | KC | | After |
| 4/12/2016 | Bos | Smith,Mal | Acquired via trade | Cin | | After |
| 4/12/2016 | Bos | Uribe | Traded away | Pit | | After |
| 4/12/2016 | Hou | Jones,A | Traded away | SD | | After |
| 4/12/2016 | KC | Blackburn | Traded away | Bos | | After |
| 4/12/2016 | KC | Gattis | Acquired via trade | NYA | | After |
| 4/12/2016 | KC | Hernandez,M | Traded away | Bos | | After |
| 4/12/2016 | KC | Kingham | Acquired via trade | Bos | | After |
| 4/12/2016 | KC | Ortiz,Dav | Acquired via trade | Bos | | After |
| 4/12/2016 | KC | Ozuna | Acquired via trade | Bos | | After |
| 4/12/2016 | KC | Ross,T | Acquired via trade | Bos | | After |
| 4/12/2016 | NYA | Gattis | Traded away | KC | | After |
| 4/12/2016 | Tex | Buchholz | Traded away | Cin | | After |
| 4/13/2016 | Bos | Ortega,R | Released | | | Before |
| 4/13/2016 | Hou | Rosario,W | Released | | | Before |
| 4/13/2016 | KC | Arcia,Os | Demoted to reserve roster | | | Before |
| 4/13/2016 | KC | Cecchini,Gar | Demoted to reserve roster | | | Before |
| 4/13/2016 | KC | Cecchini,Gar | Promoted to active roster | | | Before |
| 4/13/2016 | KC | Dickey | Released | | | Before |
| 4/13/2016 | KC | Gattis | Promoted to active roster | | | Before |
| 4/13/2016 | KC | Vogelbach | Demoted to reserve roster | | | Before |
| 4/13/2016 | NYA | Howell | Signed | | | Before |
| 4/13/2016 | Oak | Avilan | Released | | | Before |
| 4/13/2016 | Oak | Wright,M | Released | | | Before |
| 4/13/2016 | Tex | Givens | Traded away | Cin | | After |
| 4/13/2016 | Tor | Affeldt | Released | | | Before |
| 4/18/2016 | Hou | Chatwood | Promoted to active roster | | | Before |
| 4/18/2016 | Hou | Gutierrez,F | Promoted to active roster | | | Before |
| 4/18/2016 | Hou | Kontos | Demoted to reserve roster | | | Before |
| 4/18/2016 | Hou | Rollins,J | Promoted to active roster | | | Before |
| 4/18/2016 | Hou | Solarte | Demoted to reserve roster | | | Before |
| 4/18/2016 | KC | Cecchini,Gar | Demoted to reserve roster | | | Before |
| 4/18/2016 | KC | Grandal | Promoted to active roster | | | Before |
| 4/18/2016 | KC | Hardy,J | Demoted to reserve roster | | | Before |
| 4/18/2016 | KC | Tropeano | Promoted to active roster | | | Before |
| 4/18/2016 | Tex | Vargas,C | Signed | | | Before |
| 4/18/2016 | Tex | Vargas,C | Promoted to active roster | | | Before |
| 4/19/2016 | Bos | Cosart | Traded away | Tor | | After |
| 4/19/2016 | Bos | Martin,Ra | Traded away | Tor | | After |
| 4/19/2016 | Bos | Olson,M | Acquired via trade | Tor | | After |
| 4/19/2016 | NYA | Nicasio | Acquired via trade | Pit | | After |
| 4/19/2016 | NYA | Rondon,Jos | Traded away | Pit | | After |
| 4/19/2016 | Tor | Cosart | Acquired via trade | Bos | | After |
| 4/19/2016 | Tor | Martin,Ra | Acquired via trade | Bos | | After |
| 4/19/2016 | Tor | Olson,M | Traded away | Bos | | After |
| 4/20/2016 | Bos | Hernandez,M | Promoted to active roster | | | Before |
| 4/20/2016 | Bos | Karns | Promoted to active roster | | | Before |
| 4/20/2016 | Bos | Mills,A | Promoted to active roster | | | Before |
| 4/20/2016 | Bos | Smith,Mal | Promoted to active roster | | | Before |
| 4/20/2016 | Bos | Williamson | Promoted to active roster | | | Before |
| 4/20/2016 | ChA | Conley | Promoted to active roster | | | Before |
| 4/20/2016 | ChA | Davies,Z | Demoted to reserve roster | | | Before |
| 4/20/2016 | Det | Broadway | Promoted to active roster | | | Before |
| 4/20/2016 | Det | Garneau | Demoted to reserve roster | | | Before |
| 4/20/2016 | Det | Markakis | Promoted to active roster | | | Before |
| 4/20/2016 | Det | Prado | Demoted to reserve roster | | | Before |
| 4/20/2016 | Det | Strop | Demoted to reserve roster | | | Before |
| 4/20/2016 | Det | Strop | Promoted to active roster | | | Before |
| 4/20/2016 | Det | Vazquez | Promoted to active roster | | | Before |
| 4/20/2016 | Det | Young,CB | Demoted to reserve roster | | | Before |
| 4/20/2016 | KC | Crawford,C | Demoted to reserve roster | | | Before |
| 4/20/2016 | KC | Crawford,C | Promoted to active roster | | | Before |
| 4/20/2016 | KC | Hicks,A | Demoted to reserve roster | | | Before |
| 4/20/2016 | KC | Hicks,A | Promoted to active roster | | | Before |
| 4/20/2016 | Min | Berrios | Promoted to active roster | | | Before |
| 4/20/2016 | Min | Gibson,K | Demoted to reserve roster | | | Before |
| 4/20/2016 | Oak | Alfaro | Demoted to reserve roster | | | Before |
| 4/20/2016 | Oak | Brinson | Demoted to reserve roster | | | Before |
| 4/20/2016 | Oak | Gallo | Demoted to reserve roster | | | Before |
| 4/20/2016 | Oak | Rondon,B | Promoted to active roster | | | Before |
| 4/20/2016 | Sea | Anderson,Bre | Demoted to reserve roster | | | Before |
| 4/20/2016 | Sea | Chapman,K | Promoted to active roster | | | Before |
| 4/20/2016 | Sea | Heaney | Demoted to reserve roster | | | Before |
| 4/20/2016 | Sea | Rivero,A | Promoted to active roster | | | Before |
| 4/20/2016 | Sea | Smith,Car | Demoted to reserve roster | | | Before |
| 4/20/2016 | Sea | Wahl | Promoted to active roster | | | Before |
| 4/25/2016 | Cle | Lazo | Promoted to active roster | | | Before |
| 4/25/2016 | Cle | Nunez,R | Demoted to reserve roster | | | Before |
| 4/25/2016 | LAA | Chisenhall | Promoted to active roster | | | Before |
| 4/25/2016 | LAA | Jackson,L | Promoted to active roster | | | Before |
| 4/25/2016 | LAA | Meadows | Promoted to active roster | | | Before |
| 4/25/2016 | LAA | Plouffe | Demoted to reserve roster | | | Before |
| 4/25/2016 | NYA | Baez,J | Promoted to active roster | | | Before |
| 4/25/2016 | NYA | Foltynewicz | Demoted to reserve roster | | | Before |
| 4/25/2016 | NYA | Howell | Promoted to active roster | | | Before |
| 4/25/2016 | NYA | Nicasio | Demoted to reserve roster | | | Before |
| 4/25/2016 | NYA | Sweeney | Demoted to reserve roster | | | Before |
| 4/28/2016 | Det | Gomes,Y | Traded away | Mia | | After |
| 4/28/2016 | Det | Murphy,Dan | Acquired via trade | Cin | | After |
| 4/28/2016 | Det | Perez,S | Acquired via trade | Mia | | After |
| 4/28/2016 | Det | Strop | Traded away | Cin | | After |
| 4/28/2016 | Det | Volquez | Acquired via trade | Mia | | After |
| 4/28/2016 | Det | Wood,A | Traded away | Mia | | After |
| 4/28/2016 | Hou | Adames,C | Traded away | Phi | | After |
| 4/28/2016 | Hou | Cecchini,Gav | Acquired via trade | Phi | | After |
| 4/28/2016 | Hou | Madson | Traded away | Phi | | After |
| 4/28/2016 | Hou | Neris | Acquired via trade | Phi | | After |
| 4/28/2016 | Hou | Sipp | Traded away | Phi | | After |
| 4/28/2016 | Hou | Tomlin | Acquired via trade | Phi | | After |
| 4/28/2016 | Hou | Wainwright | Traded away | Phi | | After |
| 4/28/2016 | Hou | Zimmermann | Acquired via trade | Phi | | After |
| 4/28/2016 | NYA | Gonzalez,Ad | Acquired via trade | Mia | | After |
| 4/28/2016 | NYA | Shaw,B | Traded away | Mia | | After |
| 4/28/2016 | Tex | Davis,Ro | Acquired via trade | Cin | | After |
| 4/29/2016 | Bal | Avila | Demoted to reserve roster | | | Before |
| 4/29/2016 | Bal | Carrasco | Demoted to reserve roster | | | Before |
| 4/29/2016 | Bal | Jenkins,T | Promoted to active roster | | | Before |
| 4/29/2016 | Bal | Mahtook | Promoted to active roster | | | Before |
| 4/29/2016 | Bos | Healy,R | Signed | | | Before |
| 4/29/2016 | ChA | Butler,B | Demoted to reserve roster | | | Before |
| 4/29/2016 | ChA | Drake | Released | | | Before |
| 4/29/2016 | ChA | Goody | Signed | | | Before |
| 4/29/2016 | ChA | Guerrero,A | Signed | | | Before |
| 4/29/2016 | ChA | Ramos,E | Signed | | | Before |
| 4/29/2016 | ChA | Rodriguez,Y | Released | | | Before |
| 4/29/2016 | ChA | Walker,C | Promoted to active roster | | | Before |
| 4/29/2016 | Cle | Alvarez,Darie | Signed | | | Before |
| 4/29/2016 | Cle | Kivlehan | Released | | | Before |
| 4/29/2016 | Cle | Kivlehan | Demoted to reserve roster | | | Before |
| 4/29/2016 | Det | Alvarez,Darie | Released | | | Before |
| 4/29/2016 | Min | McCullers | Demoted to reserve roster | | | Before |
| 4/29/2016 | Min | Winkler | Promoted to active roster | | | Before |
| 5/2/2016 | Bos | Clevinger | Promoted to active roster | | | Before |
| 5/2/2016 | Bos | Hoyt | Demoted to reserve roster | | | Before |
| 5/2/2016 | LAA | Gennett | Demoted to reserve roster | | | Before |
| 5/6/2016 | Cle | Bautista,R | Signed | | | Before |
| 5/6/2016 | Min | May,T | Promoted to active roster | | | Before |
| 5/6/2016 | Min | Richards | Demoted to reserve roster | | | Before |
| 5/6/2016 | NYA | Elias | Demoted to reserve roster | | | Before |
| 5/6/2016 | NYA | Gausman | Promoted to active roster | | | Before |
| 5/6/2016 | NYA | Hedges | Demoted to reserve roster | | | Before |
| 5/6/2016 | NYA | Nicasio | Promoted to active roster | | | Before |
| 5/6/2016 | NYA | Sweeney | Promoted to active roster | | | Before |
| 5/6/2016 | NYA | Wilkins | Demoted to reserve roster | | | Before |
| 5/9/2016 | Bal | Diaz,Y | Promoted to active roster | | | Before |
| 5/9/2016 | Bal | Moustakas | Demoted to reserve roster | | | Before |
| 5/9/2016 | LAA | Perez,C | Promoted to active roster | | | Before |
| 5/9/2016 | LAA | Perez,Rob | Demoted to reserve roster | | | Before |
| 5/9/2016 | LAA | Plouffe | Promoted to active roster | | | Before |
| 5/9/2016 | NYA | de Leon,Jos | Promoted to active roster | | | Before |
| 5/9/2016 | NYA | Nicasio | Demoted to reserve roster | | | Before |
| 5/13/2016 | Bos | Johnson,Cha | Released | | | Before |
| 5/13/2016 | ChA | Goody | Promoted to active roster | | | Before |
| 5/13/2016 | ChA | Gott | Demoted to reserve roster | | | Before |
| 5/13/2016 | ChA | Martinez,N | Demoted to reserve roster | | | Before |
| 5/13/2016 | ChA | Ramos,E | Promoted to active roster | | | Before |
| 5/13/2016 | Oak | Alfaro | Promoted to active roster | | | Before |
| 5/13/2016 | Oak | Alford | Promoted to active roster | | | Before |
| 5/13/2016 | Oak | Brinson | Promoted to active roster | | | Before |
| 5/13/2016 | Oak | Coulombe | Released | | | Before |
| 5/13/2016 | Oak | Coulombe | Signed | | | Before |
| 5/13/2016 | Oak | Williams,T | Released | | | Before |
| 5/13/2016 | Tex | Vargas,C | Released | | | Before |
| 5/16/2016 | Bal | Avila | Promoted to active roster | | | Before |
| 5/16/2016 | Bal | Cashner | Demoted to reserve roster | | | Before |
| 5/16/2016 | Det | Rijo | Released | | | Before |
| 5/16/2016 | Det | Vargas,K | Signed | | | Before |
| 5/16/2016 | LAA | Canha | Demoted to reserve roster | | | Before |
| 5/16/2016 | LAA | Gennett | Promoted to active roster | | | Before |
| 5/16/2016 | NYA | Elias | Released | | | Before |
| 5/16/2016 | NYA | Nicasio | Promoted to active roster | | | Before |
| 5/16/2016 | NYA | Severino,L | Demoted to reserve roster | | | Before |
| 5/16/2016 | Sea | Montgomery,Mi | Signed | | | Before |
| 5/16/2016 | Sea | Vargas,K | Released | | | Before |
| 5/16/2016 | Tor | Benoit | Demoted to reserve roster | | | Before |
| 5/16/2016 | Tor | Flores,W | Demoted to reserve roster | | | Before |
| 5/20/2016 | Bos | Campos,V | Signed | | | Before |
| 5/20/2016 | Bos | Pirela | Released | | | Before |
| 5/20/2016 | LAA | Johnson,Sh | Signed | | | Before |
| 5/20/2016 | Tex | Campos,V | Released | | | Before |
| 5/20/2016 | Tex | Vargas,C | Signed | | | Before |
| 5/20/2016 | Tor | Nunez,E | Signed | | | Before |
| 5/20/2016 | Tor | Nunez,E | Demoted to reserve roster | | | Before |
| 5/20/2016 | Tor | Nunez,E | Promoted to active roster | | | Before |
| 5/20/2016 | Tor | Ramirez,Al | Released | | | Before |
| 5/20/2016 | Tor | Rodney | Promoted to active roster | | | Before |
| 5/23/2016 | Bal | Gomez,C | Demoted to reserve roster | | | Before |
| 5/23/2016 | Bal | Moustakas | Promoted to active roster | | | Before |
| 5/23/2016 | ChA | Davies,Z | Promoted to active roster | | | Before |
| 5/23/2016 | ChA | Johnson,Er | Released | | | Before |
| 5/23/2016 | ChA | Jordan | Demoted to reserve roster | | | Before |
| 5/23/2016 | ChA | Mariot | Promoted to active roster | | | Before |
| 5/23/2016 | ChA | May,J | Demoted to reserve roster | | | Before |
| 5/23/2016 | ChA | Ortega,R | Signed | | | Before |
| 5/23/2016 | ChA | Ortega,R | Promoted to active roster | | | Before |
| 5/23/2016 | ChA | Ramos,E | Demoted to reserve roster | | | Before |
| 5/23/2016 | Det | Cecil | Demoted to reserve roster | | | Before |
| 5/23/2016 | Det | Lopez,Ja | Promoted to active roster | | | Before |
| 5/23/2016 | LAA | Jackson,L | Demoted to reserve roster | | | Before |
| 5/23/2016 | LAA | Pham | Promoted to active roster | | | Before |
| 5/23/2016 | Min | Lowrie | Demoted to reserve roster | | | Before |
| 5/23/2016 | Min | McCullers | Promoted to active roster | | | Before |
| 5/23/2016 | Min | Moroff | Promoted to active roster | | | Before |
| 5/23/2016 | Oak | Gallo | Promoted to active roster | | | Before |
| 5/23/2016 | Oak | Rondon,B | Demoted to reserve roster | | | Before |
| 5/23/2016 | Tam | Gallardo | Demoted to reserve roster | | | Before |
| 5/23/2016 | Tam | Hahn | Promoted to active roster | | | Before |
| 5/23/2016 | Tor | McMahon | Promoted to active roster | | | Before |
| 5/23/2016 | Tor | Peralta,D | Demoted to reserve roster | | | Before |
| 5/26/2016 | Det | Cabrera,Me | Traded away | Pit | | After |
| 5/26/2016 | Det | Jankowski,T | Acquired via trade | Pit | | After |
| 5/26/2016 | Det | Ruiz,R | Acquired via trade | Pit | | After |
| 5/26/2016 | Det | Young,CB | Traded away | Pit | | After |
| 5/26/2016 | KC | Gordon,A | Acquired via trade | Pit | | After |
| 5/26/2016 | KC | Gray,S | Traded away | Pit | | After |
| 5/26/2016 | KC | Kazmir | Traded away | Pit | | After |
| 5/26/2016 | KC | Phelps,D | Acquired via trade | Pit | | After |
| 5/26/2016 | KC | Valera | Traded away | Pit | | After |
| 5/26/2016 | KC | Wacha | Acquired via trade | Pit | | After |
| 5/26/2016 | KC | Wong,K | Acquired via trade | Pit | | After |
| 5/27/2016 | Det | Cecil | Demoted to reserve roster | | | Before |
| 5/27/2016 | Det | Hunter,Tom | Promoted to active roster | | | Before |
| 5/27/2016 | Det | Lopez,Ja | Promoted to active roster | | | Before |
| 5/27/2016 | Det | Markakis | Demoted to reserve roster | | | Before |
| 5/27/2016 | Det | Prado | Promoted to active roster | | | Before |
| 5/27/2016 | Hou | Kontos | Promoted to active roster | | | Before |
| 5/27/2016 | Hou | Solarte | Promoted to active roster | | | Before |
| 5/27/2016 | KC | Gordon,A | Demoted to reserve roster | | | Before |
| 5/27/2016 | KC | Gordon,A | Promoted to active roster | | | Before |
| 5/27/2016 | KC | Ozuna | Demoted to reserve roster | | | Before |
| 5/27/2016 | KC | Phelps,D | Promoted to active roster | | | Before |
| 5/27/2016 | KC | Ross,T | Demoted to reserve roster | | | Before |
| 5/27/2016 | KC | Ross,T | Promoted to active roster | | | Before |
| 5/27/2016 | Oak | Szczur | Signed | | | Before |
| 5/27/2016 | Oak | Turner,Ja | Released | | | Before |
| 5/27/2016 | Tor | Benoit | Promoted to active roster | | | Before |
| 5/27/2016 | Tor | Flores,W | Promoted to active roster | | | Before |
| 5/27/2016 | Tor | Rodney | Demoted to reserve roster | | | Before |
| 5/27/2016 | Tor | Tulowitzki | Demoted to reserve roster | | | Before |
| 5/30/2016 | Bal | Cashner | Promoted to active roster | | | Before |
| 5/30/2016 | Bal | Diaz,Y | Demoted to reserve roster | | | Before |
| 5/30/2016 | Bal | Moustakas | Demoted to reserve roster | | | Before |
| 5/30/2016 | Bal | Travis,D | Promoted to active roster | | | Before |
| 5/30/2016 | Cle | Barrett,J | Signed | | | Before |
| 5/30/2016 | Cle | Barrett,J | Promoted to active roster | | | Before |
| 5/30/2016 | Cle | Bautista,R | Promoted to active roster | | | Before |
| 5/30/2016 | Cle | Johnson,B | Demoted to reserve roster | | | Before |
| 5/30/2016 | Cle | Nunez,R | Promoted to active roster | | | Before |
| 5/30/2016 | Cle | Urshela | Demoted to reserve roster | | | Before |
| 5/30/2016 | Cle | Williams,R | Demoted to reserve roster | | | Before |
| 5/30/2016 | KC | Crawford,C | Promoted to active roster | | | Before |
| 5/30/2016 | KC | Gordon,A | Demoted to reserve roster | | | Before |
| 5/30/2016 | Sea | La Stella | Promoted to active roster | | | Before |
| 5/30/2016 | Sea | Marte,K | Demoted to reserve roster | | | Before |
| 6/3/2016 | Tor | Byrd | Released | | | Before |
| 6/6/2016 | Bal | Carrasco | Promoted to active roster | | | Before |
| 6/6/2016 | Bal | Gomez,C | Promoted to active roster | | | Before |
| 6/6/2016 | Bal | Jenkins,T | Demoted to reserve roster | | | Before |
| 6/6/2016 | Bal | Mahtook | Demoted to reserve roster | | | Before |
| 6/6/2016 | Bos | Holaday | Signed | | | Before |
| 6/6/2016 | Bos | Joseph,Ca | Released | | | Before |
| 6/6/2016 | Cle | Lee,Ch | Demoted to reserve roster | | | Before |
| 6/6/2016 | Cle | Nunez,R | Demoted to reserve roster | | | Before |
| 6/6/2016 | Cle | Nunez,R | Promoted to active roster | | | Before |
| 6/6/2016 | Cle | Urshela | Promoted to active roster | | | Before |
| 6/6/2016 | KC | Dunn | Promoted to active roster | | | Before |
| 6/6/2016 | KC | Tropeano | Demoted to reserve roster | | | Before |
| 6/6/2016 | NYA | Garcia,Av | Promoted to active roster | | | Before |
| 6/6/2016 | NYA | Howell | Demoted to reserve roster | | | Before |
| 6/6/2016 | NYA | Howell | Promoted to active roster | | | Before |
| 6/6/2016 | NYA | Howell | Demoted to reserve roster | | | Before |
| 6/6/2016 | NYA | Puig | Demoted to reserve roster | | | Before |
| 6/6/2016 | NYA | Severino,L | Promoted to active roster | | | Before |
| 6/6/2016 | NYA | Wilkins | Released | | | Before |
| 6/6/2016 | Oak | Meyer | Demoted to reserve roster | | | Before |
| 6/6/2016 | Oak | Rodriguez,E | Promoted to active roster | | | Before |
| 6/6/2016 | Oak | Szczur | Promoted to active roster | | | Before |
| 6/6/2016 | Oak | Tocci | Demoted to reserve roster | | | Before |
| 6/6/2016 | Tex | Cervelli | Demoted to reserve roster | | | Before |
| 6/6/2016 | Tex | Darvish | Promoted to active roster | | | Before |
| 6/6/2016 | Tex | Davis,Ro | Promoted to active roster | | | Before |
| 6/6/2016 | Tex | Edwards,C | Demoted to reserve roster | | | Before |
| 6/6/2016 | Tex | Odor | Demoted to reserve roster | | | Before |
| 6/6/2016 | Tex | Reyes,Al | Promoted to active roster | | | Before |
| 6/6/2016 | Tex | Vargas,C | Demoted to reserve roster | | | Before |
| 6/6/2016 | Tor | Hernandez,F | Demoted to reserve roster | | | Before |
| 6/6/2016 | Tor | Merrifield | Signed | | | Before |
| 6/6/2016 | Tor | Merrifield | Promoted to active roster | | | Before |
| 6/6/2016 | Tor | Snell | Promoted to active roster | | | Before |
| 6/9/2016 | Oak | Feliz,N | Traded away | Sea | | After |
| 6/9/2016 | Oak | Leathersich | Acquired via trade | Sea | | After |
| 6/9/2016 | Oak | Swihart | Acquired via trade | Sea | | After |
| 6/9/2016 | Oak | Wieters | Traded away | Sea | | After |
| 6/9/2016 | Sea | Feliz,N | Acquired via trade | Oak | | After |
| 6/9/2016 | Sea | Leathersich | Traded away | Oak | | After |
| 6/9/2016 | Sea | Swihart | Traded away | Oak | | After |
| 6/9/2016 | Sea | Wieters | Acquired via trade | Oak | | After |
| 6/10/2016 | Bos | Bellinger | Promoted to active roster | | | Before |
| 6/10/2016 | Bos | Holaday | Promoted to active roster | | | Before |
| 6/10/2016 | Cle | Gosselin | Released | | | Before |
| 6/10/2016 | Det | Hunter,Tom | Demoted to reserve roster | | | Before |
| 6/10/2016 | Det | Markakis | Promoted to active roster | | | Before |
| 6/10/2016 | Hou | Harper,Brya | Signed | | | Before |
| 6/10/2016 | Hou | Varvaro | Released | | | Before |
| 6/10/2016 | Hou | Wright,D | Demoted to reserve roster | | | Before |
| 6/10/2016 | Tex | Sardinas | Released | | | Before |
| 6/10/2016 | Tex | Vargas,C | Released | | | Before |
| 6/12/2016 | ChA | Drury | Traded away | Cin | | After |
| 6/12/2016 | ChA | Finnegan | Traded away | Cin | | After |
| 6/12/2016 | ChA | Frazier,T | Acquired via trade | Cin | | After |
| 6/12/2016 | ChA | Schebler | Traded away | Cin | | After |
| 6/13/2016 | Bal | Cashner | Demoted to reserve roster | | | Before |
| 6/13/2016 | Bal | Jenkins,T | Promoted to active roster | | | Before |
| 6/13/2016 | Bos | Guyer | Demoted to reserve roster | | | Before |
| 6/13/2016 | Bos | Olson,M | Promoted to active roster | | | Before |
| 6/13/2016 | ChA | Butler,B | Released | | | Before |
| 6/13/2016 | ChA | Coats | Signed | | | Before |
| 6/13/2016 | ChA | Coats | Promoted to active roster | | | Before |
| 6/13/2016 | ChA | Goody | Demoted to reserve roster | | | Before |
| 6/13/2016 | ChA | Gott | Promoted to active roster | | | Before |
| 6/13/2016 | ChA | Jordan | Promoted to active roster | | | Before |
| 6/13/2016 | ChA | Mariot | Demoted to reserve roster | | | Before |
| 6/13/2016 | ChA | Ramos,E | Promoted to active roster | | | Before |
| 6/13/2016 | ChA | Tomlinson | Demoted to reserve roster | | | Before |
| 6/13/2016 | ChA | Torreyes | Signed | | | Before |
| 6/13/2016 | ChA | Torreyes | Promoted to active roster | | | Before |
| 6/13/2016 | ChA | Yates | Signed | | | Before |
| 6/13/2016 | LAA | Jackson,L | Released | | | Before |
| 6/13/2016 | Min | Asche | Promoted to active roster | | | Before |
| 6/13/2016 | Min | Butler,R | Demoted to reserve roster | | | Before |
| 6/13/2016 | Min | Castro,J | Promoted to active roster | | | Before |
| 6/13/2016 | Min | Gibson,K | Promoted to active roster | | | Before |
| 6/13/2016 | Min | Hanigan | Demoted to reserve roster | | | Before |
| 6/13/2016 | Min | Lowrie | Promoted to active roster | | | Before |
| 6/13/2016 | Min | Pence | Demoted to reserve roster | | | Before |
| 6/13/2016 | Min | Soler | Demoted to reserve roster | | | Before |
| 6/13/2016 | Min | Tillman,C | Demoted to reserve roster | | | Before |
| 6/13/2016 | Oak | Cotham | Demoted to reserve roster | | | Before |
| 6/13/2016 | Oak | Law | Demoted to reserve roster | | | Before |
| 6/13/2016 | Oak | Peterson,J | Released | | | Before |
| 6/13/2016 | Oak | Romero,E | Promoted to active roster | | | Before |
| 6/13/2016 | Oak | Rondon,B | Promoted to active roster | | | Before |
| 6/13/2016 | Oak | Sims | Promoted to active roster | | | Before |
| 6/13/2016 | Oak | Swihart | Demoted to reserve roster | | | Before |
| 6/13/2016 | Oak | Tocci | Promoted to active roster | | | Before |
| 6/13/2016 | Sea | La Stella | Demoted to reserve roster | | | Before |
| 6/13/2016 | Tex | Chirinos | Promoted to active roster | | | Before |
| 6/13/2016 | Tex | Darvish | Demoted to reserve roster | | | Before |
| 6/13/2016 | Tex | Edwards,C | Promoted to active roster | | | Before |
| 6/13/2016 | Tor | McGee,J | Demoted to reserve roster | | | Before |
| 6/13/2016 | Tor | McMahon | Demoted to reserve roster | | | Before |
| 6/13/2016 | Tor | Peralta,D | Promoted to active roster | | | Before |
| 6/13/2016 | Tor | Rodney | Promoted to active roster | | | Before |
| 6/16/2016 | NYA | Almora | Traded away | Cin | | After |
| 6/16/2016 | NYA | Ellsbury | Acquired via trade | Cin | | After |
| 6/16/2016 | NYA | Encarnacion | Acquired via trade | Cin | | After |
| 6/16/2016 | NYA | Hosmer | Traded away | Cin | | After |
| 6/16/2016 | Oak | Law | Traded away | Was | | After |
| 6/17/2016 | ChA | Cotts | Released | | | Before |
| 6/17/2016 | ChA | Loup | Signed | | | Before |
| 6/17/2016 | Cle | Alvarez,Darie | Released | | | Before |
| 6/17/2016 | Cle | Dean,P | Signed | | | Before |
| 6/17/2016 | Cle | Dean,P | Promoted to active roster | | | Before |
| 6/17/2016 | Cle | Friedrich | Signed | | | Before |
| 6/17/2016 | Cle | Friedrich | Promoted to active roster | | | Before |
| 6/17/2016 | Cle | Garcia,Jar | Demoted to reserve roster | | | Before |
| 6/17/2016 | Cle | Merritt | Signed | | | Before |
| 6/17/2016 | Cle | Merritt | Promoted to active roster | | | Before |
| 6/17/2016 | Cle | Perez,H | Signed | | | Before |
| 6/17/2016 | Cle | Perez,H | Promoted to active roster | | | Before |
| 6/17/2016 | Cle | Stripling | Demoted to reserve roster | | | Before |
| 6/17/2016 | Cle | Williams,R | Released | | | Before |
| 6/20/2016 | ChA | Okert | Signed | | | Before |
| 6/20/2016 | Cle | Quinn | Demoted to reserve roster | | | Before |
| 6/20/2016 | Cle | Sewald | Released | | | Before |
| 6/20/2016 | Cle | Ynoa,M | Signed | | | Before |
| 6/20/2016 | Cle | Ynoa,M | Promoted to active roster | | | Before |
| 6/20/2016 | LAA | Cole,G | Demoted to reserve roster | | | Before |
| 6/20/2016 | Oak | Alford | Demoted to reserve roster | | | Before |
| 6/20/2016 | Sea | Gray,J | Promoted to active roster | | | Before |
| 6/20/2016 | Sea | Marte,K | Promoted to active roster | | | Before |
| 6/20/2016 | Sea | Robinson,Dr | Demoted to reserve roster | | | Before |
| 6/20/2016 | Sea | Wahl | Demoted to reserve roster | | | Before |
| 6/24/2016 | Bos | Duffy,MM | Demoted to reserve roster | | | Before |
| 6/24/2016 | Bos | Healy,R | Promoted to active roster | | | Before |
| 6/24/2016 | Bos | Smith,Mal | Demoted to reserve roster | | | Before |
| 6/24/2016 | Bos | Tellez | Promoted to active roster | | | Before |
| 6/24/2016 | ChA | Yates | Released | | | Before |
| 6/24/2016 | Cle | Dean,P | Released | | | Before |
| 6/24/2016 | Cle | Stratton | Signed | | | Before |
| 6/24/2016 | Hou | Leon,S | Signed | | | Before |
| 6/24/2016 | Tor | Nunez,E | Demoted to reserve roster | | | Before |
| 6/24/2016 | Tor | Tulowitzki | Promoted to active roster | | | Before |
| 6/27/2016 | ChA | Almonte,A | Signed | | | Before |
| 6/27/2016 | ChA | Coats | Released | | | Before |
| 6/27/2016 | Cle | Brito | Demoted to reserve roster | | | Before |
| 6/27/2016 | Cle | Lorenzen | Promoted to active roster | | | Before |
| 6/27/2016 | Cle | Stratton | Promoted to active roster | | | Before |
| 6/27/2016 | KC | Crawford,C | Demoted to reserve roster | | | Before |
| 6/27/2016 | KC | Gordon,A | Promoted to active roster | | | Before |
| 6/27/2016 | KC | Maurer | Demoted to reserve roster | | | Before |
| 6/27/2016 | KC | Tropeano | Promoted to active roster | | | Before |
| 6/27/2016 | NYA | Garcia,Av | Demoted to reserve roster | | | Before |
| 6/27/2016 | NYA | Puig | Promoted to active roster | | | Before |
| 6/27/2016 | Tor | McMahon | Promoted to active roster | | | Before |
| 6/27/2016 | Tor | Peralta,D | Demoted to reserve roster | | | Before |
| 6/30/2016 | Bal | Phillips,Bra | Traded away | NYA | | After |
| 6/30/2016 | Det | Harris,W | Acquired via trade | Cin | | After |
| 6/30/2016 | NYA | Phillips,Bra | Acquired via trade | Bal | | After |
| 7/1/2016 | Cle | Stripling | Promoted to active roster | | | Before |
| 7/1/2016 | Det | Hunter,Tom | Released | | | Before |
| 7/1/2016 | Oak | Peterson,J | Signed | | | Before |
| 7/1/2016 | Tor | Labourt | Released | | | Before |
| 7/4/2016 | Bal | Cashner | Promoted to active roster | | | Before |
| 7/4/2016 | Det | Hess | Released | | | Before |
| 7/4/2016 | KC | Cain,L | Demoted to reserve roster | | | Before |
| 7/4/2016 | KC | Reyes,Jos | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Butler,R | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Carpenter,M | Demoted to reserve roster | | | Before |
| 7/4/2016 | Min | Flowers | Demoted to reserve roster | | | Before |
| 7/4/2016 | Min | Hanigan | Demoted to reserve roster | | | Before |
| 7/4/2016 | Min | Hanigan | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Hanigan | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Kepler | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Panik | Demoted to reserve roster | | | Before |
| 7/4/2016 | Min | Rickard | Demoted to reserve roster | | | Before |
| 7/4/2016 | Min | Rickard | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Smith Jr. | Promoted to active roster | | | Before |
| 7/4/2016 | Min | Winkler | Demoted to reserve roster | | | Before |
| 7/4/2016 | NYA | Pederson | Demoted to reserve roster | | | Before |
| 7/4/2016 | NYA | Strasburg | Demoted to reserve roster | | | Before |
| 7/4/2016 | Tex | Colome | Demoted to reserve roster | | | Before |
| 7/4/2016 | Tex | Lincecum | Promoted to active roster | | | Before |
| 7/4/2016 | Tex | Ross,J | Demoted to reserve roster | | | Before |
| 7/4/2016 | Tor | McGee,J | Promoted to active roster | | | Before |
| 7/4/2016 | Tor | Snell | Demoted to reserve roster | | | Before |
| 7/5/2016 | Hou | Rollins,J | Demoted to reserve roster | | | Before |
| 7/5/2016 | Min | Panik | Demoted to reserve roster | | | Before |
| 7/8/2016 | Bal | Avila | Demoted to reserve roster | | | Before |
| 7/8/2016 | Bal | Diaz,Y | Promoted to active roster | | | Before |
| 7/8/2016 | Bal | Greinke | Demoted to reserve roster | | | Before |
| 7/8/2016 | Bal | Kaminsky | Promoted to active roster | | | Before |
| 7/8/2016 | Bal | Mahtook | Promoted to active roster | | | Before |
| 7/8/2016 | Bal | Miller,Ju | Demoted to reserve roster | | | Before |
| 7/8/2016 | ChA | Goody | Promoted to active roster | | | Before |
| 7/8/2016 | ChA | Loup | Promoted to active roster | | | Before |
| 7/8/2016 | ChA | Martinez,N | Promoted to active roster | | | Before |
| 7/8/2016 | ChA | May,J | Demoted to reserve roster | | | Before |
| 7/8/2016 | ChA | May,J | Promoted to active roster | | | Before |
| 7/8/2016 | ChA | Ramos,E | Demoted to reserve roster | | | Before |
| 7/8/2016 | Cle | Crockett | Released | | | Before |
| 7/8/2016 | Cle | Friedrich | Released | | | Before |
| 7/8/2016 | Cle | Leclerc | Signed | | | Before |
| 7/8/2016 | Cle | Leclerc | Promoted to active roster | | | Before |
| 7/8/2016 | Cle | Morimando | Signed | | | Before |
| 7/8/2016 | Cle | Morimando | Promoted to active roster | | | Before |
| 7/8/2016 | Cle | Ryan,K | Signed | | | Before |
| 7/8/2016 | Cle | Ryan,K | Promoted to active roster | | | Before |
| 7/8/2016 | Cle | Stratton | Released | | | Before |
| 7/8/2016 | Det | Volquez | Demoted to reserve roster | | | Before |
| 7/8/2016 | Min | Jennings,De | Demoted to reserve roster | | | Before |
| 7/8/2016 | Min | Jennings,De | Demoted to reserve roster | | | Before |
| 7/8/2016 | Min | Rickard | Promoted to active roster | | | Before |
| 7/8/2016 | Min | Rickard | Promoted to active roster | | | Before |
| 7/8/2016 | Oak | Romero,E | Released | | | Before |
| 7/10/2016 | ChA | Almonte,A | Traded away | ChN | | After |
| 7/10/2016 | Cle | Alcantara,A | Traded away | Oak | | After |
| 7/10/2016 | Oak | Alcantara,A | Acquired via trade | Cle | | After |
| 7/10/2016 | Tor | Cosart | Demoted to reserve roster | | | Before |
| 7/15/2016 | Bos | Candelario | Promoted to active roster | | | Before |
| 7/15/2016 | Bos | Cron | Demoted to reserve roster | | | Before |
| 7/15/2016 | Bos | Heineman | Signed | | | Before |
| 7/15/2016 | Bos | Heineman | Promoted to active roster | | | Before |
| 7/15/2016 | Bos | Holaday | Released | | | Before |
| 7/15/2016 | Cle | Flynn | Signed | | | Before |
| 7/15/2016 | Cle | Flynn | Promoted to active roster | | | Before |
| 7/15/2016 | Cle | Lazo | Released | | | Before |
| 7/15/2016 | Cle | Merrifield | Signed | | | Before |
| 7/15/2016 | Cle | Merrifield | Promoted to active roster | | | Before |
| 7/15/2016 | Cle | Merritt | Released | | | Before |
| 7/15/2016 | Cle | Morimando | Released | | | Before |
| 7/15/2016 | Cle | Perez,H | Released | | | Before |
| 7/15/2016 | Cle | Rogers,T | Signed | | | Before |
| 7/15/2016 | Cle | Rogers,T | Promoted to active roster | | | Before |
| 7/15/2016 | Det | Broadway | Demoted to reserve roster | | | Before |
| 7/15/2016 | Det | Cecil | Promoted to active roster | | | Before |
| 7/15/2016 | Hou | Estrada | Demoted to reserve roster | | | Before |
| 7/15/2016 | Hou | Gant | Promoted to active roster | | | Before |
| 7/15/2016 | Hou | Lail | Promoted to active roster | | | Before |
| 7/15/2016 | Hou | Tomlin | Promoted to active roster | | | Before |
| 7/15/2016 | Hou | Zimmermann | Demoted to reserve roster | | | Before |
| 7/15/2016 | LAA | Johnson,Sh | Promoted to active roster | | | Before |
| 7/15/2016 | LAA | Plouffe | Demoted to reserve roster | | | Before |
| 7/15/2016 | Min | Flowers | Released | | | Before |
| 7/15/2016 | Tor | Bauers | Promoted to active roster | | | Before |
| 7/15/2016 | Tor | Bour | Demoted to reserve roster | | | Before |
| 7/15/2016 | Tor | Butler,E | Released | | | Before |
| 7/15/2016 | Tor | Merrifield | Released | | | Before |
| 7/15/2016 | Tor | Nunez,E | Promoted to active roster | | | Before |
| 7/15/2016 | Tor | Snell | Promoted to active roster | | | Before |
| 7/17/2016 | Cle | Rupp | Traded away | Phi | | After |
| 7/17/2016 | Det | Castro,J | Acquired via trade | Min | | After |
| 7/17/2016 | Det | Fielder | Traded away | Min | | After |
| 7/17/2016 | Det | Garneau | Traded away | Min | | After |
| 7/17/2016 | Det | Pence | Acquired via trade | Min | | After |
| 7/17/2016 | Det | Pillar | Acquired via trade | StL | | After |
| 7/17/2016 | Det | Prado | Traded away | Min | | After |
| 7/17/2016 | Min | Castro,J | Traded away | Det | | After |
| 7/17/2016 | Min | Fielder | Acquired via trade | Det | | After |
| 7/17/2016 | Min | Garneau | Acquired via trade | Det | | After |
| 7/17/2016 | Min | Pence | Traded away | Det | | After |
| 7/17/2016 | Min | Prado | Acquired via trade | Det | | After |
| 7/18/2016 | ChA | Baumann | Signed | | | Before |
| 7/18/2016 | ChA | Guerrero,A | Released | | | Before |
| 7/18/2016 | ChA | Martinez,N | Released | | | Before |
| 7/18/2016 | Cle | Bandy | Signed | | | Before |
| 7/18/2016 | Cle | Bandy | Promoted to active roster | | | Before |
| 7/18/2016 | Cle | Reinheimer | Signed | | | Before |
| 7/18/2016 | Det | Burns,B | Demoted to reserve roster | | | Before |
| 7/18/2016 | Det | Goodwin | Signed | | | Before |
| 7/18/2016 | Det | Volquez | Promoted to active roster | | | Before |
| 7/18/2016 | Min | Moroff | Demoted to reserve roster | | | Before |
| 7/18/2016 | Min | Stammen | Released | | | Before |
| 7/18/2016 | NYA | Hedges | Promoted to active roster | | | Before |
| 7/18/2016 | NYA | Howell | Promoted to active roster | | | Before |
| 7/18/2016 | NYA | Nicasio | Demoted to reserve roster | | | Before |
| 7/18/2016 | NYA | Strasburg | Promoted to active roster | | | Before |
| 7/18/2016 | NYA | Sweeney | Demoted to reserve roster | | | Before |
| 7/21/2016 | Det | Harvey,H | Traded away | Oak | | After |
| 7/21/2016 | Det | McGuire,R | Acquired via trade | Oak | | After |
| 7/21/2016 | Det | Vazquez | Traded away | Oak | | After |
| 7/21/2016 | Min | Hendricks | Traded away | Was | | After |
| 7/21/2016 | Min | Inciarte | Acquired via trade | Was | | After |
| 7/21/2016 | NYA | Gray,S | Acquired via trade | Pit | | After |
| 7/21/2016 | NYA | Tanaka | Traded away | Pit | | After |
| 7/21/2016 | Oak | Harvey,H | Acquired via trade | Det | | After |
| 7/21/2016 | Oak | Law | Acquired via trade | Was | | After |
| 7/21/2016 | Oak | McGuire,R | Traded away | Det | | After |
| 7/21/2016 | Oak | Smoak | Traded away | Was | | After |
| 7/21/2016 | Oak | Szczur | Traded away | Was | | After |
| 7/21/2016 | Oak | Vazquez | Acquired via trade | Det | | After |
| 7/22/2016 | ChA | Loup | Demoted to reserve roster | | | Before |
| 7/22/2016 | ChA | May,J | Promoted to active roster | | | Before |
| 7/22/2016 | ChA | Okert | Promoted to active roster | | | Before |
| 7/22/2016 | ChA | Ortega,R | Released | | | Before |
| 7/22/2016 | ChA | Tomlinson | Promoted to active roster | | | Before |
| 7/22/2016 | Cle | Waldrop | Signed | | | Before |
| 7/22/2016 | Min | Barnes,M | Promoted to active roster | | | Before |
| 7/22/2016 | Min | Fielder | Demoted to reserve roster | | | Before |
| 7/22/2016 | Min | Moroff | Demoted to reserve roster | | | Before |
| 7/22/2016 | NYA | Garcia,Av | Released | | | Before |
| 7/22/2016 | Oak | Peterson,J | Released | | | Before |
| 7/22/2016 | Sea | Harvey,M | Demoted to reserve roster | | | Before |
| 7/22/2016 | Sea | McAllister | Demoted to reserve roster | | | Before |
| 7/24/2016 | KC | Colon,B | Acquired via trade | Pit | | After |
| 7/24/2016 | KC | Kingham | Traded away | Pit | | After |
| 7/24/2016 | NYA | Gregerson | Traded away | StL | | After |
| 7/24/2016 | Tex | Romo | Traded away | Pit | | After |
| 7/25/2016 | ChA | Almonte,A | Signed | | | Before |
| 7/25/2016 | ChA | Almonte,A | Promoted to active roster | | | Before |
| 7/25/2016 | ChA | Baumann | Released | | | Before |
| 7/25/2016 | ChA | Gott | Demoted to reserve roster | | | Before |
| 7/25/2016 | ChA | Mariot | Released | | | Before |
| 7/25/2016 | ChA | May,J | Demoted to reserve roster | | | Before |
| 7/25/2016 | ChA | Ramos,E | Promoted to active roster | | | Before |
| 7/25/2016 | ChA | Williams,T | Signed | | | Before |
| 7/25/2016 | Cle | Johnson,B | Promoted to active roster | | | Before |
| 7/25/2016 | Cle | Reinheimer | Promoted to active roster | | | Before |
| 7/25/2016 | Cle | Waldrop | Demoted to reserve roster | | | Before |
| 7/25/2016 | Cle | Waldrop | Promoted to active roster | | | Before |
| 7/25/2016 | KC | Tropeano | Demoted to reserve roster | | | Before |
| 7/25/2016 | LAA | Cole,G | Promoted to active roster | | | Before |
| 7/25/2016 | LAA | Taillon | Demoted to reserve roster | | | Before |
| 7/25/2016 | LAA | Taillon | Promoted to active roster | | | Before |
| 7/25/2016 | Min | Maxwell,B | Signed | | | Before |
| 7/25/2016 | NYA | Judge | Demoted to reserve roster | | | Before |
| 7/25/2016 | NYA | Nicasio | Promoted to active roster | | | Before |
| 7/25/2016 | NYA | Pederson | Promoted to active roster | | | Before |
| 7/25/2016 | Tor | Higashioka | Signed | | | Before |
| 7/28/2016 | Hou | Cingrani | Acquired via trade | Pit | | After |
| 7/28/2016 | Hou | Lind | Traded away | Pit | | After |
| 7/28/2016 | Hou | Napoli | Acquired via trade | Pit | | After |
| 7/28/2016 | NYA | Howell | Traded away | Cin | | After |
| 7/28/2016 | NYA | O'Day | Acquired via trade | Cin | | After |
| 7/28/2016 | NYA | Plawecki | Traded away | Cin | | After |
| 7/28/2016 | NYA | Strop | Acquired via trade | Cin | | After |
| 7/28/2016 | Tex | Lincecum | Traded away | Pit | | After |
| 7/29/2016 | ChA | Loup | Released | | | Before |
| 7/29/2016 | Cle | Haniger | Signed | | | Before |
| 7/29/2016 | Cle | Waldrop | Released | | | Before |
| 7/29/2016 | Hou | Rollins,J | Released | | | Before |
| 7/29/2016 | Min | Panik | Promoted to active roster | | | Before |
| 7/29/2016 | Min | Rickard | Demoted to reserve roster | | | Before |
| 7/29/2016 | NYA | Judge | Promoted to active roster | | | Before |
| 7/29/2016 | NYA | O'Day | Demoted to reserve roster | | | Before |
| 7/29/2016 | NYA | O'Day | Promoted to active roster | | | Before |
| 7/29/2016 | Tex | Dickerson,A | Signed | | | Before |
| 7/30/2016 | Min | Winkler | Released | | | Before |
| 7/31/2016 | Cle | Frazier,C | Acquired via trade | Tex | | After |
| 7/31/2016 | Det | Chen,W | Acquired via trade | ChN | | After |
| 7/31/2016 | Det | Jankowski,T | Traded away | ChN | | After |
| 7/31/2016 | Det | Uehara | Acquired via trade | ChN | | After |
| 7/31/2016 | KC | Bailey,H | Acquired via trade | Col | | After |
| 7/31/2016 | KC | Cervelli | Acquired via trade | Tex | | After |
| 7/31/2016 | KC | Cozart | Acquired via trade | Col | | After |
| 7/31/2016 | KC | Estevez | Acquired via trade | Col | | After |
| 7/31/2016 | KC | Gattis | Traded away | Col | | After |
| 7/31/2016 | KC | Hardy,J | Traded away | Col | | After |
| 7/31/2016 | Oak | Hosmer | Acquired via trade | Cin | | After |
| 7/31/2016 | Oak | Swihart | Traded away | Cin | | After |
| 7/31/2016 | Tex | Cervelli | Traded away | KC | | After |
| 7/31/2016 | Tex | Frazier,C | Traded away | Cle | | After |
| 7/31/2016 | Tex | Sadzeck | Traded away | Col | | After |
| 7/31/2016 | Tex | Winker | Traded away | Col | | After |
| 8/1/2016 | Bos | Heineman | Released | | | Before |
| 8/1/2016 | Bos | Higashioka | Signed | | | Before |
| 8/1/2016 | ChA | Altherr | Promoted to active roster | | | Before |
| 8/1/2016 | ChA | Ellington | Signed | | | Before |
| 8/1/2016 | ChA | Ellington | Promoted to active roster | | | Before |
| 8/1/2016 | ChA | Farquhar | Demoted to reserve roster | | | Before |
| 8/1/2016 | ChA | Jordan | Demoted to reserve roster | | | Before |
| 8/1/2016 | ChA | Sabathia | Signed | | | Before |
| 8/1/2016 | ChA | Severino,P | Demoted to reserve roster | | | Before |
| 8/1/2016 | Det | Chen,W | Demoted to reserve roster | | | Before |
| 8/1/2016 | Det | McGuire,R | Demoted to reserve roster | | | Before |
| 8/1/2016 | Det | Pence | Promoted to active roster | | | Before |
| 8/1/2016 | Hou | Kennedy | Signed | | | Before |
| 8/1/2016 | KC | Conger | Released | | | Before |
| 8/1/2016 | KC | Crawford,C | Released | | | Before |
| 8/1/2016 | Min | Fien | Released | | | Before |
| 8/1/2016 | Min | Hultzen | Signed | | | Before |
| 8/1/2016 | Tex | Colome | Promoted to active roster | | | Before |
| 8/1/2016 | Tex | Darvish | Promoted to active roster | | | Before |
| 8/1/2016 | Tex | Dickerson,A | Promoted to active roster | | | Before |
| 8/1/2016 | Tex | Odor | Promoted to active roster | | | Before |
| 8/1/2016 | Tex | Pressly | Signed | | | Before |
| 8/1/2016 | Tex | Pressly | Promoted to active roster | | | Before |
| 8/1/2016 | Tor | Bauers | Demoted to reserve roster | | | Before |
| 8/1/2016 | Tor | Hernandez,F | Promoted to active roster | | | Before |
| 8/1/2016 | Tor | Higashioka | Released | | | Before |
| 8/1/2016 | Tor | Peralta,D | Promoted to active roster | | | Before |
| 8/1/2016 | Tor | Snell | Demoted to reserve roster | | | Before |
| 8/2/2016 | ChA | Sabathia | Signed | | | Before |
| 8/2/2016 | KC | Reyes,Jos | Demoted to reserve roster | | | Before |
| 8/2/2016 | NYA | O'Day | Promoted to active roster | | | Before |
| 8/2/2016 | NYA | Rosenthal | Demoted to reserve roster | | | Before |
| 8/5/2016 | Bos | Garrett | Promoted to active roster | | | Before |
| 8/5/2016 | Bos | Higashioka | Promoted to active roster | | | Before |
| 8/5/2016 | Bos | Karns | Demoted to reserve roster | | | Before |
| 8/5/2016 | Min | Carpenter,M | Promoted to active roster | | | Before |
| 8/5/2016 | Min | Garneau | Promoted to active roster | | | Before |
| 8/5/2016 | Min | Hanigan | Demoted to reserve roster | | | Before |
| 8/5/2016 | Min | Lowrie | Demoted to reserve roster | | | Before |
| 8/5/2016 | Min | McCullers | Demoted to reserve roster | | | Before |
| 8/5/2016 | Min | Soler | Promoted to active roster | | | Before |
| 8/5/2016 | Oak | Light | Signed | | | Before |
| 8/5/2016 | Oak | Peterson,J | Signed | | | Before |
| 8/5/2016 | Tex | Olivera | Released | | | Before |
| 8/7/2016 | Oak | Gonzalez,Ch | Acquired via trade | Col | | After |
| 8/8/2016 | Cle | Brito | Demoted to reserve roster | | | Before |
| 8/8/2016 | Cle | Brito | Promoted to active roster | | | Before |
| 8/8/2016 | Cle | Gilmartin | Demoted to reserve roster | | | Before |
| 8/8/2016 | Cle | Leclerc | Demoted to reserve roster | | | Before |
| 8/8/2016 | Cle | Leclerc | Promoted to active roster | | | Before |
| 8/8/2016 | Cle | Nunez,R | Demoted to reserve roster | | | Before |
| 8/8/2016 | Cle | Quinn | Promoted to active roster | | | Before |
| 8/8/2016 | KC | Bailey,H | Promoted to active roster | | | Before |
| 8/8/2016 | KC | Boxberger | Promoted to active roster | | | Before |
| 8/8/2016 | KC | Cain,L | Promoted to active roster | | | Before |
| 8/8/2016 | KC | Cervelli | Promoted to active roster | | | Before |
| 8/8/2016 | KC | Estevez | Demoted to reserve roster | | | Before |
| 8/8/2016 | KC | Milone | Demoted to reserve roster | | | Before |
| 8/8/2016 | KC | Montero,R | Demoted to reserve roster | | | Before |
| 8/8/2016 | KC | Montero,R | Promoted to active roster | | | Before |
| 8/8/2016 | KC | Montero,R | Demoted to reserve roster | | | Before |
| 8/8/2016 | LAA | Osich | Demoted to reserve roster | | | Before |
| 8/8/2016 | LAA | Perez,Rob | Demoted to reserve roster | | | Before |
| 8/8/2016 | LAA | Perez,Rob | Promoted to active roster | | | Before |
| 8/8/2016 | LAA | Plouffe | Promoted to active roster | | | Before |
| 8/8/2016 | LAA | Story | Demoted to reserve roster | | | Before |
| 8/8/2016 | LAA | Taillon | Promoted to active roster | | | Before |
| 8/8/2016 | Oak | Hand,B | Signed | | | Before |
| 8/8/2016 | Sea | La Stella | Promoted to active roster | | | Before |
| 8/8/2016 | Sea | Marte,K | Demoted to reserve roster | | | Before |
| 8/8/2016 | Sea | McAllister | Promoted to active roster | | | Before |
| 8/8/2016 | Tex | Pressly | Released | | | Before |
| 8/8/2016 | Tex | Torres,J | Signed | | | Before |
| 8/8/2016 | Tor | Bauers | Promoted to active roster | | | Before |
| 8/8/2016 | Tor | Cosart | Promoted to active roster | | | Before |
| 8/8/2016 | Tor | Peralta,D | Demoted to reserve roster | | | Before |
| 8/8/2016 | Tor | Salazar | Demoted to reserve roster | | | Before |
| 8/11/2016 | KC | Beede | Acquired via trade | NYA | | After |
| 8/11/2016 | KC | Ortiz,Dav | Traded away | NYA | | After |
| 8/11/2016 | KC | Werth | Traded away | Phi | | After |
| 8/11/2016 | NYA | Beede | Traded away | KC | | After |
| 8/11/2016 | NYA | Ortiz,Dav | Acquired via trade | KC | | After |
| 8/12/2016 | ChA | Pressly | Signed | | | Before |
| 8/12/2016 | LAA | Albers,M | Released | | | Before |
| 8/12/2016 | NYA | Judge | Demoted to reserve roster | | | Before |
| 8/12/2016 | Oak | Garcia,Av | Signed | | | Before |
| 8/14/2016 | Bos | Blackburn | Traded away | Cin | | After |
| 8/14/2016 | Bos | Hoyt | Traded away | Cin | | After |
| 8/14/2016 | Min | Mejia,A | Acquired via trade | Oak | | After |
| 8/14/2016 | Min | Soler | Traded away | Oak | | After |
| 8/14/2016 | Oak | Mejia,A | Traded away | Min | | After |
| 8/14/2016 | Oak | Soler | Acquired via trade | Min | | After |
| 8/14/2016 | Tor | Bauers | Traded away | Cin | | After |
| 8/14/2016 | Tor | Flores,W | Traded away | Cin | | After |
| 8/14/2016 | Tor | Kemp,T | Acquired via trade | Cin | | After |
| 8/14/2016 | Tor | Kimbrel | Acquired via trade | Cin | | After |
| 8/14/2016 | Tor | Martinez,JD | Acquired via trade | Cin | | After |
| 8/14/2016 | Tor | Myers | Traded away | Cin | | After |
| 8/15/2016 | Bal | Greinke | Promoted to active roster | | | Before |
| 8/15/2016 | Bal | Jenkins,T | Demoted to reserve roster | | | Before |
| 8/15/2016 | ChA | Conley | Demoted to reserve roster | | | Before |
| 8/15/2016 | ChA | Ellington | Demoted to reserve roster | | | Before |
| 8/15/2016 | ChA | Gott | Promoted to active roster | | | Before |
| 8/15/2016 | ChA | Jordan | Promoted to active roster | | | Before |
| 8/15/2016 | ChA | Sabathia | Released | | | Before |
| 8/15/2016 | ChA | Williams,T | Promoted to active roster | | | Before |
| 8/15/2016 | Cle | Nunez,R | Promoted to active roster | | | Before |
| 8/15/2016 | Cle | Reinheimer | Released | | | Before |
| 8/15/2016 | Det | Burns,B | Promoted to active roster | | | Before |
| 8/15/2016 | Det | Pillar | Demoted to reserve roster | | | Before |
| 8/15/2016 | KC | Montero,R | Promoted to active roster | | | Before |
| 8/15/2016 | KC | Ozuna | Promoted to active roster | | | Before |
| 8/15/2016 | KC | Reyes,Jos | Promoted to active roster | | | Before |
| 8/15/2016 | KC | Wacha | Demoted to reserve roster | | | Before |
| 8/15/2016 | Min | Fielder | Released | | | Before |
| 8/15/2016 | NYA | Foltynewicz | Promoted to active roster | | | Before |
| 8/15/2016 | NYA | Gray,S | Demoted to reserve roster | | | Before |
| 8/15/2016 | NYA | Judge | Promoted to active roster | | | Before |
| 8/15/2016 | NYA | O'Day | Demoted to reserve roster | | | Before |
| 8/15/2016 | NYA | Strop | Demoted to reserve roster | | | Before |
| 8/15/2016 | NYA | Sweeney | Promoted to active roster | | | Before |
| 8/15/2016 | Oak | Alford | Promoted to active roster | | | Before |
| 8/15/2016 | Oak | Gonzalez,Ch | Demoted to reserve roster | | | Before |
| 8/15/2016 | Oak | Hand,B | Promoted to active roster | | | Before |
| 8/15/2016 | Oak | Law | Promoted to active roster | | | Before |
| 8/15/2016 | Oak | Leathersich | Promoted to active roster | | | Before |
| 8/15/2016 | Oak | Peterson,J | Promoted to active roster | | | Before |
| 8/15/2016 | Oak | Sims | Demoted to reserve roster | | | Before |
| 8/15/2016 | Oak | Tocci | Demoted to reserve roster | | | Before |
| 8/15/2016 | Tam | Detwiler | Signed | | | Before |
| 8/15/2016 | Tor | Hatcher | Demoted to reserve roster | | | Before |
| 8/15/2016 | Tor | Hatcher | Promoted to active roster | | | Before |
| 8/15/2016 | Tor | Kemp,T | Promoted to active roster | | | Before |
| 8/15/2016 | Tor | Orlando | Signed | | | Before |
| 8/15/2016 | Tor | Orlando | Promoted to active roster | | | Before |
| 8/15/2016 | Tor | Rodney | Demoted to reserve roster | | | Before |
| 8/16/2016 | ChA | Farquhar | Released | | | Before |
| 8/18/2016 | Bos | Duffy,MM | Traded away | Det | | After |
| 8/18/2016 | Det | Duffy,MM | Acquired via trade | Bos | | After |
| 8/18/2016 | KC | Smith,W | Acquired via trade | Ari | | After |
| 8/18/2016 | Oak | Robles | Acquired via trade | Ari | | After |
| 8/19/2016 | Bos | Campos,V | Promoted to active roster | | | Before |
| 8/19/2016 | Bos | Guyer | Promoted to active roster | | | Before |
| 8/19/2016 | Bos | Hader | Demoted to reserve roster | | | Before |
| 8/19/2016 | Bos | Williamson | Demoted to reserve roster | | | Before |
| 8/19/2016 | Oak | Peterson,J | Released | | | Before |
| 8/22/2016 | Bal | Jenkins,T | Promoted to active roster | | | Before |
| 8/22/2016 | Bal | Solis,S | Demoted to reserve roster | | | Before |
| 8/22/2016 | ChA | Chacin | Demoted to reserve roster | | | Before |
| 8/22/2016 | ChA | Cole,A | Promoted to active roster | | | Before |
| 8/22/2016 | Det | Broadway | Released | | | Before |
| 8/22/2016 | Det | Duffy,MM | Promoted to active roster | | | Before |
| 8/22/2016 | Det | Stanton | Demoted to reserve roster | | | Before |
| 8/22/2016 | Det | Stanton | Demoted to reserve roster | | | Before |
| 8/22/2016 | KC | Arcia,Os | Released | | | Before |
| 8/22/2016 | KC | Coulter | Signed | | | Before |
| 8/22/2016 | KC | Phelps,D | Demoted to reserve roster | | | Before |
| 8/22/2016 | Min | Alburquerque | Demoted to reserve roster | | | Before |
| 8/22/2016 | Min | Hultzen | Released | | | Before |
| 8/22/2016 | Min | Matzek | Signed | | | Before |
| 8/22/2016 | Min | Matzek | Promoted to active roster | | | Before |
| 8/22/2016 | NYA | Lackey | Demoted to reserve roster | | | Before |
| 8/22/2016 | Tor | Smolinski | Signed | | | Before |
| 8/26/2016 | ChA | Chacin | Released | | | Before |
| 8/26/2016 | ChA | Dean,P | Signed | | | Before |
| 8/26/2016 | ChA | Dean,P | Promoted to active roster | | | Before |
| 8/26/2016 | ChA | Jordan | Released | | | Before |
| 8/26/2016 | ChA | Pressly | Promoted to active roster | | | Before |
| 8/26/2016 | ChA | Ramos,E | Demoted to reserve roster | | | Before |
| 8/26/2016 | Cle | Locke | Released | | | Before |
| 8/26/2016 | Cle | Lugo | Signed | | | Before |
| 8/26/2016 | Cle | Lugo | Promoted to active roster | | | Before |
| 8/26/2016 | Det | Broadway | Released | | | Before |
| 8/26/2016 | Min | Maxwell,B | Released | | | Before |
| 8/26/2016 | Min | Orf | Signed | | | Before |
| 8/26/2016 | Tor | Arcia,Os | Signed | | | Before |
| 8/26/2016 | Tor | Hatcher | Released | | | Before |
| 8/29/2016 | ChA | May,J | Released | | | Before |
| 8/29/2016 | ChA | Pressly | Demoted to reserve roster | | | Before |
| 8/29/2016 | ChA | Ramos,E | Promoted to active roster | | | Before |
| 8/29/2016 | Cle | Gilmartin | Released | | | Before |
| 8/29/2016 | Cle | Haniger | Promoted to active roster | | | Before |
| 8/29/2016 | Cle | Quinn | Demoted to reserve roster | | | Before |
| 8/29/2016 | Cle | Wolters | Signed | | | Before |
| 8/29/2016 | Det | Burns,B | Demoted to reserve roster | | | Before |
| 8/29/2016 | Det | Duffy,MM | Promoted to active roster | | | Before |
| 8/29/2016 | Det | Goodwin | Released | | | Before |
| 8/29/2016 | Det | Murphy,Dan | Demoted to reserve roster | | | Before |
| 8/29/2016 | Det | Murphy,Dan | Promoted to active roster | | | Before |
| 8/29/2016 | Det | Pillar | Promoted to active roster | | | Before |
| 8/29/2016 | Det | Pollock | Promoted to active roster | | | Before |
| 8/29/2016 | Det | Storen | Demoted to reserve roster | | | Before |
| 8/29/2016 | Min | Matzek | Promoted to active roster | | | Before |
| 8/29/2016 | Min | May,T | Demoted to reserve roster | | | Before |
| 8/29/2016 | NYA | Alcantara,R | Promoted to active roster | | | Before |
| 8/29/2016 | NYA | Newcomb | Promoted to active roster | | | Before |
| 8/29/2016 | NYA | Strasburg | Demoted to reserve roster | | | Before |
| 8/29/2016 | Sea | Dietrich | Demoted to reserve roster | | | Before |
| 8/29/2016 | Sea | Marte,K | Promoted to active roster | | | Before |
| 8/29/2016 | Sea | Montgomery,Mi | Promoted to active roster | | | Before |
| 8/29/2016 | Sea | Paxton | Demoted to reserve roster | | | Before |
| 8/29/2016 | Tex | Sardinas | Signed | | | Before |
| 8/29/2016 | Tor | Arcia,Os | Promoted to active roster | | | Before |
| 8/29/2016 | Tor | McMahon | Demoted to reserve roster | | | Before |
| 9/1/2016 | ChA | Duke | Traded away | Phi | | After |
| 9/1/2016 | Hou | Carter | Acquired via trade | Tex | | After |
| 9/1/2016 | Hou | Jackson,A | Acquired via trade | Pit | | After |
| 9/1/2016 | Hou | Jimenez,U | Traded away | Pit | | After |
| 9/1/2016 | NYA | Grimm | Acquired via trade | Pit | | After |
| 9/1/2016 | NYA | Phillips,Bra | Traded away | Pit | | After |
| 9/1/2016 | Tex | Carter | Traded away | Hou | | After |
| 9/1/2016 | Tor | Morneau | Acquired via trade | Col | | After |
| 9/2/2016 | Bos | Cron | Promoted to active roster | | | Before |
| 9/2/2016 | ChA | Kiekhefer | Signed | | | Before |
| 9/2/2016 | ChA | Okert | Released | | | Before |
| 9/2/2016 | ChA | Tovar | Signed | | | Before |
| 9/2/2016 | Cle | Brito | Promoted to active roster | | | Before |
| 9/2/2016 | Cle | Garcia,Av | Signed | | | Before |
| 9/2/2016 | Cle | Garcia,Av | Promoted to active roster | | | Before |
| 9/2/2016 | Cle | Garcia,Jar | Promoted to active roster | | | Before |
| 9/2/2016 | Cle | Haniger | Released | | | Before |
| 9/2/2016 | Cle | Wolters | Promoted to active roster | | | Before |
| 9/2/2016 | Hou | Flores,Ra | Released | | | Before |
| 9/2/2016 | Hou | Harper,Brya | Released | | | Before |
| 9/2/2016 | Oak | Garcia,Av | Released | | | Before |
| 9/2/2016 | Tor | Kemp,T | Demoted to reserve roster | | | Before |
| 9/2/2016 | Tor | Kemp,T | Promoted to active roster | | | Before |
| 9/2/2016 | Tor | McMahon | Promoted to active roster | | | Before |
| 9/2/2016 | Tor | Rodney | Promoted to active roster | | | Before |
| 9/5/2016 | Det | Burns,B | Promoted to active roster | | | Before |
| 9/5/2016 | Det | Cobb | Promoted to active roster | | | Before |
| 9/5/2016 | Det | Patterson | Promoted to active roster | | | Before |
| 9/5/2016 | LAA | Cole,G | Demoted to reserve roster | | | Before |
| 9/5/2016 | Tex | Black,R | Demoted to reserve roster | | | Before |
| 9/5/2016 | Tex | Torres,J | Promoted to active roster | | | Before |
| 9/8/2016 | ChA | Ellington | Promoted to active roster | | | Before |
| 9/8/2016 | ChA | Kiekhefer | Promoted to active roster | | | Before |
| 9/8/2016 | ChA | Pressly | Promoted to active roster | | | Before |
| 9/8/2016 | ChA | Severino,P | Promoted to active roster | | | Before |
| 9/8/2016 | ChA | Tovar | Promoted to active roster | | | Before |
| 9/8/2016 | Det | Hill,R | Promoted to active roster | | | Before |
| 9/8/2016 | Det | Vargas,K | Promoted to active roster | | | Before |
| 9/12/2016 | ChA | Dean,P | Released | | | Before |
| 9/12/2016 | ChA | Haniger | Signed | | | Before |
| 9/12/2016 | ChA | Haniger | Promoted to active roster | | | Before |
| 9/12/2016 | ChA | Paulsen | Released | | | Before |
| 9/12/2016 | ChA | Richard | Signed | | | Before |
| 9/12/2016 | ChA | Richard | Promoted to active roster | | | Before |
| 9/12/2016 | Det | Duffy,MM | Demoted to reserve roster | | | Before |
| 9/12/2016 | Det | Stanton | Promoted to active roster | | | Before |
| 9/12/2016 | Det | Storen | Promoted to active roster | | | Before |
| 9/12/2016 | Det | Uehara | Promoted to active roster | | | Before |
| 9/12/2016 | KC | Cain,L | Demoted to reserve roster | | | Before |
| 9/12/2016 | KC | Cecchini,Gar | Promoted to active roster | | | Before |
| 9/12/2016 | KC | Coulter | Promoted to active roster | | | Before |
| 9/12/2016 | KC | Dozier,H | Promoted to active roster | | | Before |
| 9/12/2016 | KC | Hazelbaker | Promoted to active roster | | | Before |
| 9/12/2016 | KC | Hicks,A | Demoted to reserve roster | | | Before |
| 9/12/2016 | KC | Vogelbach | Promoted to active roster | | | Before |
| 9/12/2016 | Min | Barnes,M | Demoted to reserve roster | | | Before |
| 9/12/2016 | Min | Barnes,M | Promoted to active roster | | | Before |
| 9/12/2016 | Min | Hanigan | Promoted to active roster | | | Before |
| 9/12/2016 | Min | Jennings,De | Promoted to active roster | | | Before |
| 9/12/2016 | Min | May,T | Promoted to active roster | | | Before |
| 9/12/2016 | NYA | Lackey | Promoted to active roster | | | Before |
| 9/16/2016 | ChA | Merritt | Signed | | | Before |
| 9/16/2016 | ChA | Tovar | Released | | | Before |
| 9/16/2016 | Oak | Okert | Signed | | | Before |
| 9/16/2016 | Tex | Scheppers | Signed | | | Before |
| 9/19/2016 | Bal | Avila | Promoted to active roster | | | Before |
| 9/19/2016 | Bal | Carrasco | Demoted to reserve roster | | | Before |
| 9/19/2016 | Bal | Miller,Ju | Promoted to active roster | | | Before |
| 9/19/2016 | Bos | Cron | Promoted to active roster | | | Before |
| 9/19/2016 | Bos | deGrom | Demoted to reserve roster | | | Before |
| 9/19/2016 | Bos | Hader | Promoted to active roster | | | Before |
| 9/19/2016 | Bos | Harrison,J | Demoted to reserve roster | | | Before |
| 9/19/2016 | Bos | Smith,Mal | Demoted to reserve roster | | | Before |
| 9/19/2016 | Bos | Smith,Mal | Promoted to active roster | | | Before |
| 9/19/2016 | Bos | Williamson | Promoted to active roster | | | Before |
| 9/19/2016 | Cle | Quinn | Promoted to active roster | | | Before |
| 9/19/2016 | KC | Wacha | Promoted to active roster | | | Before |
| 9/19/2016 | LAA | Anderson,Ti | Promoted to active roster | | | Before |
| 9/19/2016 | LAA | Bregman | Signed | | | Before |
| 9/19/2016 | LAA | Hernandez,T | Promoted to active roster | | | Before |
| 9/19/2016 | LAA | Osich | Promoted to active roster | | | Before |
| 9/19/2016 | LAA | Perez,Rob | Promoted to active roster | | | Before |
| 9/19/2016 | LAA | Plouffe | Demoted to reserve roster | | | Before |
| 9/19/2016 | LAA | Williams,N | Promoted to active roster | | | Before |
| 9/19/2016 | NYA | Judge | Demoted to reserve roster | | | Before |
| 9/19/2016 | NYA | Rosenthal | Promoted to active roster | | | Before |
| 9/19/2016 | Tor | Bour | Promoted to active roster | | | Before |
| 9/23/2016 | LAA | Perdomo | Signed | | | Before |
| 9/26/2016 | KC | Hicks,A | Promoted to active roster | | | Before |
| 9/26/2016 | Oak | Light | Released | | | Before |
| 9/26/2016 | Tex | Ross,J | Promoted to active roster | | | Before |
| 9/26/2016 | Tex | Sardinas | Promoted to active roster | | | Before |
| 9/26/2016 | Tor | Arcia,Os | Released | | | Before |
| 9/27/2016 | NYA | O'Day | Promoted to active roster | | | Before |
| 9/27/2016 | NYA | Strop | Promoted to active roster | | | Before |
| 9/30/2016 | Bos | Fields,J | Released | | | Before |
| 9/30/2016 | ChA | Castro,D | Released | | | Before |
| 9/30/2016 | ChA | Kiekhefer | Released | | | Before |
| 9/30/2016 | ChA | Merritt | Promoted to active roster | | | Before |
| 9/30/2016 | Cle | Urshela | Released | | | Before |
| 9/30/2016 | Min | Hanigan | Released | | | Before |
| 9/30/2016 | Min | Maxwell,B | Signed | | | Before |
| 10/1/2016 | Tor | Salazar | Demoted to reserve roster | | | Before |
| 10/1/2016 | Tor | Snell | Promoted to active roster | | | Before |
| 10/2/2016 | Bal | Fernandez | Demoted to reserve roster | | | Before |
