| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/8/2015 | CHW | Dosch | Released | | | Before |
| 4/8/2015 | CHW | Dosch | Released | | | Before |
| 4/8/2015 | CHW | Dosch | Signed | | | Before |
| 4/8/2015 | CHW | Dosch | Signed | | | Before |
| 4/8/2015 | CHW | Lara | Released | | | Before |
| 4/8/2015 | CHW | Lara | Released | | | Before |
| 4/8/2015 | CHW | Lara | Signed | | | Before |
| 4/8/2015 | CHW | Lara | Signed | | | Before |
| 4/8/2015 | CHW | Morton | Released | | | Before |
| 4/8/2015 | CHW | Morton | Signed | | | Before |
| 4/8/2015 | CHW | O'Neill | Released | | | Before |
| 4/8/2015 | CHW | O'Neill | Signed | | | Before |
| 4/8/2015 | CHW | O'Neill | Demoted to reserve roster | | | Before |
| 4/8/2015 | CHW | Sisco | Released | | | Before |
| 4/8/2015 | CHW | Sisco | Signed | | | Before |
| 4/8/2015 | Det | Perez,A | Released | | | Before |
| 4/8/2015 | Det | Stanley | Released | | | Before |
| 4/8/2015 | Det | Stanley | Signed | | | Before |
| 4/8/2015 | Det | Stanley | Signed | | | Before |
| 4/8/2015 | Det | Valera | Released | | | Before |
| 4/8/2015 | Det | Valera | Signed | | | Before |
| 4/8/2015 | Hou | Aplin | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Chatwood | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Estrada | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Landazuri | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | League | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Loney | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Madson | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Olson,T | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Phelps,D | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Pries | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Socolovich | Demoted to reserve roster | | | Before |
| 4/8/2015 | Hou | Ziegler | Demoted to reserve roster | | | Before |
| 4/8/2015 | LAA | Streich | Released | | | Before |
| 4/8/2015 | Min | Austin | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Barnes,M | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Jansen | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Joseph,T | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | McCullers | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Moran | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Munson | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Pence | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Richards | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Rosario,E | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Smith Jr. | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Stauffer | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Stilson | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Turner,S | Demoted to reserve roster | | | Before |
| 4/8/2015 | Min | Windle | Demoted to reserve roster | | | Before |
| 4/8/2015 | NYY | Alcantara,R | Demoted to reserve roster | | | Before |
| 4/8/2015 | NYY | Cordier | Demoted to reserve roster | | | Before |
| 4/8/2015 | NYY | Diaz,Ja | Demoted to reserve roster | | | Before |
| 4/8/2015 | NYY | Dozier,H | Demoted to reserve roster | | | Before |
| 4/8/2015 | NYY | Judge | Demoted to reserve roster | | | Before |
| 4/8/2015 | NYY | Sherfy | Demoted to reserve roster | | | Before |
| 4/8/2015 | Oak | Cabrera,Ma | Signed | | | Before |
| 4/8/2015 | Tam | Dykstra,A | Released | | | Before |
| 4/8/2015 | Tam | Dykstra,A | Released | | | Before |
| 4/8/2015 | Tam | Dykstra,A | Signed | | | Before |
| 4/8/2015 | Tam | Dykstra,A | Signed | | | Before |
| 4/8/2015 | Tex | Colome | Demoted to reserve roster | | | Before |
| 4/8/2015 | Tor | Harrison,T | Signed | | | Before |
| 4/10/2015 | Tor | Binford | Promoted to active roster | | | Before |
| 4/10/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 4/13/2015 | Tam | Blach | Promoted to active roster | | | Before |
| 4/13/2015 | Tam | Duffey | Demoted to reserve roster | | | Before |
| 4/13/2015 | Tam | Flynn | Demoted to reserve roster | | | Before |
| 4/13/2015 | Tam | Jungmann | Promoted to active roster | | | Before |
| 4/13/2015 | Tam | Morris,B | Promoted to active roster | | | Before |
| 4/13/2015 | Tam | Wilhelmsen | Demoted to reserve roster | | | Before |
| 4/13/2015 | Tor | Binford | Demoted to reserve roster | | | Before |
| 4/13/2015 | Tor | Binford | Promoted to active roster | | | Before |
| 4/13/2015 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 4/13/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 4/16/2015 | Oak | Ackley | Traded away | Pit | | After |
| 4/16/2015 | Oak | Schoop,J | Acquired via trade | Pit | | After |
| 4/17/2015 | Bos | Howell | Promoted to active roster | | | Before |
| 4/17/2015 | Bos | Masterson | Demoted to reserve roster | | | Before |
| 4/17/2015 | Bos | Simms | Released | | | Before |
| 4/17/2015 | CHW | Webb,R | Signed | | | Before |
| 4/17/2015 | Oak | Francisco,J | Released | | | Before |
| 4/17/2015 | Oak | Orlando | Signed | | | Before |
| 4/17/2015 | Tam | Amarista | Released | | | Before |
| 4/17/2015 | Tam | Dykstra,A | Released | | | Before |
| 4/17/2015 | Tor | Chen,W | Promoted to active roster | | | Before |
| 4/17/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 4/20/2015 | Det | Gomes,Y | Demoted to reserve roster | | | Before |
| 4/20/2015 | Det | Kelly,J | Promoted to active roster | | | Before |
| 4/20/2015 | Det | Perez,A | Signed | | | Before |
| 4/20/2015 | Det | Ross,J | Demoted to reserve roster | | | Before |
| 4/20/2015 | Det | Stanley | Released | | | Before |
| 4/20/2015 | Det | Stanley | Promoted to active roster | | | Before |
| 4/20/2015 | Tor | Binford | Demoted to reserve roster | | | Before |
| 4/20/2015 | Tor | Uehara | Promoted to active roster | | | Before |
| 4/22/2015 | Det | Perez,A | Signed | | | Before |
| 4/22/2015 | Det | Stanley | Released | | | Before |
| 4/24/2015 | Det | Burns,B | Demoted to reserve roster | | | Before |
| 4/24/2015 | Det | Burns,B | Promoted to active roster | | | Before |
| 4/24/2015 | Det | Valera | Promoted to active roster | | | Before |
| 4/24/2015 | Det | Wright,W | Demoted to reserve roster | | | Before |
| 4/24/2015 | Min | Gibson,K | Demoted to reserve roster | | | Before |
| 4/24/2015 | Min | Richards | Promoted to active roster | | | Before |
| 4/24/2015 | Tex | Wieters | Demoted to reserve roster | | | Before |
| 4/24/2015 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 4/24/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 4/27/2015 | Bos | Fields,J | Promoted to active roster | | | Before |
| 4/27/2015 | Bos | Holdzkom | Demoted to reserve roster | | | Before |
| 4/27/2015 | Bos | Margot | Promoted to active roster | | | Before |
| 4/27/2015 | Bos | Treinen | Demoted to reserve roster | | | Before |
| 4/27/2015 | Bos | Victorino | Demoted to reserve roster | | | Before |
| 4/27/2015 | KC | Hicks,A | Promoted to active roster | | | Before |
| 4/27/2015 | KC | Iwakuma | Demoted to reserve roster | | | Before |
| 4/27/2015 | KC | Johnson,Ji | Promoted to active roster | | | Before |
| 4/27/2015 | KC | Zobrist | Demoted to reserve roster | | | Before |
| 4/27/2015 | LAA | Gennett | Demoted to reserve roster | | | Before |
| 4/27/2015 | LAA | Paredes | Promoted to active roster | | | Before |
| 4/27/2015 | Sea | Blevins | Demoted to reserve roster | | | Before |
| 4/27/2015 | Sea | La Stella | Demoted to reserve roster | | | Before |
| 4/27/2015 | Sea | Medina | Promoted to active roster | | | Before |
| 4/27/2015 | Sea | Taylor,C | Promoted to active roster | | | Before |
| 4/27/2015 | Tor | Fiers | Promoted to active roster | | | Before |
| 4/27/2015 | Tor | Jones,G | Demoted to reserve roster | | | Before |
| 4/27/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 4/27/2015 | Tor | Walters,Z | Promoted to active roster | | | Before |
| 5/1/2015 | Bal | Gomez,C | Demoted to reserve roster | | | Before |
| 5/1/2015 | Bal | Miller,S | Demoted to reserve roster | | | Before |
| 5/1/2015 | Bal | Saunders,M | Promoted to active roster | | | Before |
| 5/1/2015 | Bal | Solis,S | Promoted to active roster | | | Before |
| 5/1/2015 | Hou | Pierzynski | Signed | | | Before |
| 5/1/2015 | Oak | Beckham,G | Promoted to active roster | | | Before |
| 5/1/2015 | Oak | Schoop,J | Demoted to reserve roster | | | Before |
| 5/1/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 5/1/2015 | Tor | Jones,G | Promoted to active roster | | | Before |
| 5/1/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 5/1/2015 | Tor | Ruf | Demoted to reserve roster | | | Before |
| 5/3/2015 | Bal | Gomez,C | Demoted to reserve roster | | | Before |
| 5/4/2015 | Bos | Moore,T | Signed | | | Before |
| 5/4/2015 | Bos | Quentin | Released | | | Before |
| 5/4/2015 | Cle | Gallo | Promoted to active roster | | | Before |
| 5/4/2015 | Cle | Johnson,B | Promoted to active roster | | | Before |
| 5/4/2015 | Cle | Reed,AJ | Demoted to reserve roster | | | Before |
| 5/4/2015 | Cle | Webster | Demoted to reserve roster | | | Before |
| 5/4/2015 | Det | Mayers | Signed | | | Before |
| 5/4/2015 | Det | Mayers | Demoted to reserve roster | | | Before |
| 5/4/2015 | KC | Cecchini,Gar | Promoted to active roster | | | Before |
| 5/4/2015 | KC | Crawford,C | Demoted to reserve roster | | | Before |
| 5/4/2015 | LAA | Eickhoff | Signed | | | Before |
| 5/4/2015 | LAA | House,T | Demoted to reserve roster | | | Before |
| 5/4/2015 | Min | Barnes,M | Demoted to reserve roster | | | Before |
| 5/4/2015 | Min | Barnes,M | Promoted to active roster | | | Before |
| 5/4/2015 | Min | Fien | Demoted to reserve roster | | | Before |
| 5/4/2015 | Min | Hanigan | Demoted to reserve roster | | | Before |
| 5/4/2015 | Min | Joseph,T | Promoted to active roster | | | Before |
| 5/4/2015 | Min | Munson | Promoted to active roster | | | Before |
| 5/4/2015 | Sea | Crick | Promoted to active roster | | | Before |
| 5/4/2015 | Sea | Ottavino | Demoted to reserve roster | | | Before |
| 5/4/2015 | Tam | Flynn | Promoted to active roster | | | Before |
| 5/4/2015 | Tam | Spruill | Released | | | Before |
| 5/4/2015 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 5/4/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 5/4/2015 | Tor | Jones,G | Demoted to reserve roster | | | Before |
| 5/4/2015 | Tor | Ruf | Promoted to active roster | | | Before |
| 5/5/2015 | CHW | O'Neill | Released | | | Before |
| 5/5/2015 | Det | Mayers | Signed | | | Before |
| 5/5/2015 | Hou | Loney | Promoted to active roster | | | Before |
| 5/5/2015 | Hou | Puig | Demoted to reserve roster | | | Before |
| 5/5/2015 | Hou | Varvaro | Demoted to reserve roster | | | Before |
| 5/5/2015 | Hou | Ziegler | Promoted to active roster | | | Before |
| 5/5/2015 | NYY | Alcantara,R | Demoted to reserve roster | | | Before |
| 5/5/2015 | NYY | Alcantara,R | Promoted to active roster | | | Before |
| 5/5/2015 | NYY | Bradley,A | Demoted to reserve roster | | | Before |
| 5/5/2015 | NYY | Diaz,Ja | Promoted to active roster | | | Before |
| 5/5/2015 | NYY | Montero,R | Demoted to reserve roster | | | Before |
| 5/5/2015 | NYY | Tanaka,M | Demoted to reserve roster | | | Before |
| 5/6/2015 | CHW | Webb,R | Promoted to active roster | | | Before |
| 5/6/2015 | CHW | Yates | Demoted to reserve roster | | | Before |
| 5/7/2015 | Bal | Miller,S | Traded away | Det | | After |
| 5/7/2015 | Bal | Travis | Acquired via trade | Det | | After |
| 5/7/2015 | Bal | Valera | Acquired via trade | Det | | After |
| 5/7/2015 | Det | Miller,S | Acquired via trade | Bal | | After |
| 5/7/2015 | Det | Travis | Traded away | Bal | | After |
| 5/7/2015 | Det | Valera | Traded away | Bal | | After |
| 5/7/2015 | KC | Bourn | Acquired via trade | Cin | | After |
| 5/7/2015 | KC | Maurer | Traded away | Cin | | After |
| 5/7/2015 | NYY | Almora | Demoted to reserve roster | | | Before |
| 5/7/2015 | NYY | Jaime | Demoted to reserve roster | | | Before |
| 5/8/2015 | Bal | Anna | Released | | | Before |
| 5/8/2015 | Bos | Flores,K | Signed | | | Before |
| 5/8/2015 | Bos | Moore,T | Released | | | Before |
| 5/8/2015 | CHW | Cole,A | Demoted to reserve roster | | | Before |
| 5/8/2015 | CHW | Elias | Promoted to active roster | | | Before |
| 5/8/2015 | Cle | Nesbitt | Signed | | | Before |
| 5/8/2015 | Cle | Pettibone | Released | | | Before |
| 5/8/2015 | Cle | Yarbrough | Released | | | Before |
| 5/8/2015 | Det | Redman | Signed | | | Before |
| 5/8/2015 | LAA | Perez,Ca | Signed | | | Before |
| 5/8/2015 | LAA | Ryan,K | Released | | | Before |
| 5/8/2015 | Oak | Orlando | Released | | | Before |
| 5/8/2015 | Tor | Fiers | Promoted to active roster | | | Before |
| 5/8/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 5/8/2015 | Tor | Harrison,T | Released | | | Before |
| 5/10/2015 | NYY | Alcantara,A | Traded away | Oak | | After |
| 5/10/2015 | NYY | Almora | Traded away | Oak | | After |
| 5/10/2015 | NYY | Profar | Acquired via trade | Oak | | After |
| 5/10/2015 | Oak | Alcantara,A | Acquired via trade | NYY | | After |
| 5/10/2015 | Oak | Almora | Acquired via trade | NYY | | After |
| 5/10/2015 | Oak | Profar | Traded away | NYY | | After |
| 5/11/2015 | Bal | Cordell | Promoted to active roster | | | Before |
| 5/11/2015 | Bal | Saunders,M | Demoted to reserve roster | | | Before |
| 5/11/2015 | Bos | Springer | Demoted to reserve roster | | | Before |
| 5/11/2015 | CHW | Wagner,T | Signed | | | Before |
| 5/11/2015 | CHW | Wilson,T | Released | | | Before |
| 5/11/2015 | Cle | Guerrero,G | Demoted to reserve roster | | | Before |
| 5/11/2015 | Cle | Pirela | Promoted to active roster | | | Before |
| 5/11/2015 | Cle | Reed,AJ | Promoted to active roster | | | Before |
| 5/11/2015 | Det | Burns,B | Promoted to active roster | | | Before |
| 5/11/2015 | Det | Herrera,K | Demoted to reserve roster | | | Before |
| 5/11/2015 | Det | Jennings,De | Demoted to reserve roster | | | Before |
| 5/11/2015 | Det | Kelly,J | Demoted to reserve roster | | | Before |
| 5/11/2015 | Det | Kelly,J | Promoted to active roster | | | Before |
| 5/11/2015 | Det | Miller,S | Promoted to active roster | | | Before |
| 5/11/2015 | Det | Perez,W | Signed | | | Before |
| 5/11/2015 | Det | Redman | Promoted to active roster | | | Before |
| 5/11/2015 | KC | Arcia,Os | Demoted to reserve roster | | | Before |
| 5/11/2015 | KC | Billingsley | Promoted to active roster | | | Before |
| 5/11/2015 | KC | Gregerson | Demoted to reserve roster | | | Before |
| 5/11/2015 | Min | Jackson,A | Demoted to reserve roster | | | Before |
| 5/11/2015 | NYY | Gausman | Demoted to reserve roster | | | Before |
| 5/11/2015 | Oak | Axford | Signed | | | Before |
| 5/11/2015 | Oak | Beckham,G | Released | | | Before |
| 5/11/2015 | Oak | Brett | Demoted to reserve roster | | | Before |
| 5/11/2015 | Oak | Cabrera,Ev | Demoted to reserve roster | | | Before |
| 5/11/2015 | Oak | Davidson | Promoted to active roster | | | Before |
| 5/11/2015 | Oak | Gutierrez,J | Released | | | Before |
| 5/11/2015 | Oak | Peguero,C | Signed | | | Before |
| 5/11/2015 | Oak | Peguero,C | Promoted to active roster | | | Before |
| 5/11/2015 | Oak | Petricka | Promoted to active roster | | | Before |
| 5/11/2015 | Sea | Gee | Demoted to reserve roster | | | Before |
| 5/11/2015 | Sea | McAllister | Promoted to active roster | | | Before |
| 5/11/2015 | Sea | Sullivan | Demoted to reserve roster | | | Before |
| 5/11/2015 | Sea | Warren | Promoted to active roster | | | Before |
| 5/11/2015 | Tor | Crisp | Promoted to active roster | | | Before |
| 5/11/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 5/11/2015 | Tor | Hernandez,E | Demoted to reserve roster | | | Before |
| 5/11/2015 | Tor | Jones,G | Promoted to active roster | | | Before |
| 5/11/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 5/11/2015 | Tor | Ruf | Demoted to reserve roster | | | Before |
| 5/15/2015 | Bos | Bandy | Signed | | | Before |
| 5/15/2015 | Bos | O'Conner | Released | | | Before |
| 5/15/2015 | Cle | Kiekhefer | Released | | | Before |
| 5/15/2015 | Det | Perez,W | Released | | | Before |
| 5/15/2015 | NYY | Sweeney,D | Signed | | | Before |
| 5/15/2015 | Tor | Andriese | Demoted to reserve roster | | | Before |
| 5/15/2015 | Tor | Ceciliani | Signed | | | Before |
| 5/15/2015 | Tor | Jones,G | Demoted to reserve roster | | | Before |
| 5/15/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 5/15/2015 | Tor | Ruf | Promoted to active roster | | | Before |
| 5/18/2015 | Bal | Cordell | Demoted to reserve roster | | | Before |
| 5/18/2015 | Bal | Gomez,C | Promoted to active roster | | | Before |
| 5/18/2015 | Bos | Bandy | Promoted to active roster | | | Before |
| 5/18/2015 | Bos | Margot | Demoted to reserve roster | | | Before |
| 5/18/2015 | Bos | Springer | Promoted to active roster | | | Before |
| 5/18/2015 | Bos | Victorino | Promoted to active roster | | | Before |
| 5/18/2015 | Cle | Baez,P | Demoted to reserve roster | | | Before |
| 5/18/2015 | Cle | Brett | Signed | | | Before |
| 5/18/2015 | Cle | Guerrero,G | Promoted to active roster | | | Before |
| 5/18/2015 | Cle | Martinez,N | Promoted to active roster | | | Before |
| 5/18/2015 | Det | Herrera,K | Promoted to active roster | | | Before |
| 5/18/2015 | Det | Mayers | Released | | | Before |
| 5/18/2015 | Det | O'Conner | Signed | | | Before |
| 5/18/2015 | Det | Redman | Demoted to reserve roster | | | Before |
| 5/18/2015 | KC | Polanco,J | Promoted to active roster | | | Before |
| 5/18/2015 | KC | Segura | Demoted to reserve roster | | | Before |
| 5/18/2015 | LAA | Gennett | Promoted to active roster | | | Before |
| 5/18/2015 | LAA | Maldonado | Demoted to reserve roster | | | Before |
| 5/18/2015 | LAA | McGee | Promoted to active roster | | | Before |
| 5/18/2015 | LAA | Perez,Ca | Promoted to active roster | | | Before |
| 5/18/2015 | Min | Jansen | Promoted to active roster | | | Before |
| 5/18/2015 | Min | Pence | Promoted to active roster | | | Before |
| 5/18/2015 | Min | Wilson,Br | Demoted to reserve roster | | | Before |
| 5/18/2015 | Oak | Brett | Released | | | Before |
| 5/18/2015 | Tor | Andriese | Promoted to active roster | | | Before |
| 5/18/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 5/19/2015 | NYY | Bradley,A | Promoted to active roster | | | Before |
| 5/22/2015 | Bal | Stanley | Signed | | | Before |
| 5/22/2015 | Det | Redman | Released | | | Before |
| 5/22/2015 | Hou | Capps,C | Demoted to reserve roster | | | Before |
| 5/22/2015 | Hou | Pierzynski | Promoted to active roster | | | Before |
| 5/22/2015 | LAA | Cunningham,T | Signed | | | Before |
| 5/22/2015 | LAA | Maldonado | Released | | | Before |
| 5/22/2015 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 5/22/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 5/25/2015 | Bal | Cordell | Promoted to active roster | | | Before |
| 5/25/2015 | Bal | Solis,S | Demoted to reserve roster | | | Before |
| 5/25/2015 | Bal | Stanley | Promoted to active roster | | | Before |
| 5/25/2015 | Bal | Travis | Demoted to reserve roster | | | Before |
| 5/25/2015 | Bos | McHugh | Demoted to reserve roster | | | Before |
| 5/25/2015 | Bos | Treinen | Promoted to active roster | | | Before |
| 5/25/2015 | CHW | Albers,M | Released | | | Before |
| 5/25/2015 | CHW | Cosart | Demoted to reserve roster | | | Before |
| 5/25/2015 | CHW | Perez,W | Signed | | | Before |
| 5/25/2015 | CHW | Perez,W | Promoted to active roster | | | Before |
| 5/25/2015 | Det | O'Conner | Promoted to active roster | | | Before |
| 5/25/2015 | Det | Perez,A | Released | | | Before |
| 5/25/2015 | KC | Billingsley | Demoted to reserve roster | | | Before |
| 5/25/2015 | KC | Gregerson | Promoted to active roster | | | Before |
| 5/25/2015 | KC | Martinez,V | Demoted to reserve roster | | | Before |
| 5/25/2015 | KC | Milone | Promoted to active roster | | | Before |
| 5/25/2015 | KC | Norris,B | Demoted to reserve roster | | | Before |
| 5/25/2015 | KC | Smith,Mal | Promoted to active roster | | | Before |
| 5/25/2015 | KC | Williams,Ta | Demoted to reserve roster | | | Before |
| 5/25/2015 | KC | Williams,Ta | Promoted to active roster | | | Before |
| 5/25/2015 | NYY | Dugan | Released | | | Before |
| 5/25/2015 | Oak | Peguero,C | Released | | | Before |
| 5/25/2015 | Sea | Dickerson,Co | Demoted to reserve roster | | | Before |
| 5/25/2015 | Tam | Flynn | Demoted to reserve roster | | | Before |
| 5/25/2015 | Tam | Wilhelmsen | Promoted to active roster | | | Before |
| 5/25/2015 | Tex | Kline | Released | | | Before |
| 5/25/2015 | Tor | Binford | Released | | | Before |
| 5/25/2015 | Tor | Chen,W | Promoted to active roster | | | Before |
| 5/25/2015 | Tor | Crisp | Demoted to reserve roster | | | Before |
| 5/25/2015 | Tor | Davis,I | Demoted to reserve roster | | | Before |
| 5/25/2015 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 5/25/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 5/25/2015 | Tor | Hernandez,E | Promoted to active roster | | | Before |
| 5/25/2015 | Tor | Jones,G | Promoted to active roster | | | Before |
| 5/25/2015 | Tor | Wada | Promoted to active roster | | | Before |
| 5/29/2015 | Bos | Garcia,R | Released | | | Before |
| 5/29/2015 | LAA | Cunningham,T | Promoted to active roster | | | Before |
| 5/29/2015 | LAA | Eickhoff | Demoted to reserve roster | | | Before |
| 5/29/2015 | LAA | Eickhoff | Promoted to active roster | | | Before |
| 5/29/2015 | LAA | Gennett | Promoted to active roster | | | Before |
| 5/29/2015 | LAA | House,T | Promoted to active roster | | | Before |
| 5/29/2015 | LAA | McGee | Promoted to active roster | | | Before |
| 5/29/2015 | LAA | Navarro,R | Demoted to reserve roster | | | Before |
| 5/29/2015 | LAA | Paredes | Demoted to reserve roster | | | Before |
| 5/29/2015 | LAA | Perez,Ca | Promoted to active roster | | | Before |
| 5/29/2015 | Oak | Getz | Signed | | | Before |
| 5/29/2015 | Oak | Montgomery,Mi | Signed | | | Before |
| 5/29/2015 | Tor | Andriese | Demoted to reserve roster | | | Before |
| 5/29/2015 | Tor | Fiers | Promoted to active roster | | | Before |
| 6/1/2015 | Bos | Bernard | Signed | | | Before |
| 6/1/2015 | Bos | Hamilton,J | Promoted to active roster | | | Before |
| 6/1/2015 | Bos | Margot | Promoted to active roster | | | Before |
| 6/1/2015 | Bos | Victorino | Demoted to reserve roster | | | Before |
| 6/1/2015 | CHW | Davies,Z | Demoted to reserve roster | | | Before |
| 6/1/2015 | CHW | Morton | Promoted to active roster | | | Before |
| 6/1/2015 | Cle | Brett | Promoted to active roster | | | Before |
| 6/1/2015 | Cle | Guerrero,G | Demoted to reserve roster | | | Before |
| 6/1/2015 | Cle | Martinez,N | Demoted to reserve roster | | | Before |
| 6/1/2015 | Cle | Webster | Promoted to active roster | | | Before |
| 6/1/2015 | Det | Gomes,Y | Promoted to active roster | | | Before |
| 6/1/2015 | Det | O'Conner | Demoted to reserve roster | | | Before |
| 6/1/2015 | KC | Cecchini,Gar | Demoted to reserve roster | | | Before |
| 6/1/2015 | KC | Faulkner | Released | | | Before |
| 6/1/2015 | KC | Hicks,A | Demoted to reserve roster | | | Before |
| 6/1/2015 | KC | Hicks,A | Promoted to active roster | | | Before |
| 6/1/2015 | KC | Johnson,C | Promoted to active roster | | | Before |
| 6/1/2015 | KC | Milone | Demoted to reserve roster | | | Before |
| 6/1/2015 | KC | Polanco,J | Demoted to reserve roster | | | Before |
| 6/1/2015 | KC | Segovia | Signed | | | Before |
| 6/1/2015 | KC | Segovia | Promoted to active roster | | | Before |
| 6/1/2015 | KC | Segura | Promoted to active roster | | | Before |
| 6/1/2015 | KC | Smith,Mal | Demoted to reserve roster | | | Before |
| 6/1/2015 | KC | Zobrist | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Bettis | Signed | | | Before |
| 6/1/2015 | LAA | Bettis | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Blazek | Released | | | Before |
| 6/1/2015 | LAA | Blazek | Signed | | | Before |
| 6/1/2015 | LAA | Bonifacio,E | Released | | | Before |
| 6/1/2015 | LAA | Cunningham,T | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Gennett | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Guthrie | Released | | | Before |
| 6/1/2015 | LAA | McGee | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Perez,Ca | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Petrick | Signed | | | Before |
| 6/1/2015 | LAA | Petrick | Promoted to active roster | | | Before |
| 6/1/2015 | LAA | Torreyes | Released | | | Before |
| 6/1/2015 | Oak | Cabrera,Ev | Promoted to active roster | | | Before |
| 6/1/2015 | Oak | Feliz,N | Demoted to reserve roster | | | Before |
| 6/1/2015 | Oak | Hudson,D | Promoted to active roster | | | Before |
| 6/1/2015 | Sea | Paxton | Demoted to reserve roster | | | Before |
| 6/1/2015 | Tam | Corcino | Released | | | Before |
| 6/1/2015 | Tam | Flynn | Released | | | Before |
| 6/1/2015 | Tor | Andriese | Promoted to active roster | | | Before |
| 6/1/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 6/2/2015 | Bos | Bernard | Signed | | | Before |
| 6/2/2015 | NYY | Cordier | Promoted to active roster | | | Before |
| 6/2/2015 | NYY | Sherfy | Promoted to active roster | | | Before |
| 6/2/2015 | NYY | Strasburg | Demoted to reserve roster | | | Before |
| 6/2/2015 | Oak | Getz | Released | | | Before |
| 6/3/2015 | Hou | Loney | Demoted to reserve roster | | | Before |
| 6/4/2015 | Cle | Almora | Promoted to active roster | | | Before |
| 6/4/2015 | Cle | Martinez,N | Promoted to active roster | | | Before |
| 6/4/2015 | Cle | Northcraft | Released | | | Before |
| 6/4/2015 | Cle | Schebler | Demoted to reserve roster | | | Before |
| 6/4/2015 | Cle | Ynoa,G | Signed | | | Before |
| 6/4/2015 | Cle | Almora | Acquired via trade | Oak | | After |
| 6/4/2015 | Cle | Bell,J | Acquired via trade | Oak | | After |
| 6/4/2015 | Cle | Frazier,C | Traded away | Oak | | After |
| 6/4/2015 | Cle | Peterson,J | Traded away | Oak | | After |
| 6/4/2015 | LAA | Bundy | Demoted to reserve roster | | | Before |
| 6/4/2015 | LAA | Eickhoff | Promoted to active roster | | | Before |
| 6/4/2015 | LAA | House,T | Promoted to active roster | | | Before |
| 6/4/2015 | LAA | Lyles | Demoted to reserve roster | | | Before |
| 6/4/2015 | LAA | Trahan | Released | | | Before |
| 6/4/2015 | Min | Boyer | Signed | | | Before |
| 6/4/2015 | Min | Stauffer | Released | | | Before |
| 6/4/2015 | NYY | Dozier,H | Traded away | Oak | | After |
| 6/4/2015 | NYY | Wright,M | Traded away | Oak | | After |
| 6/4/2015 | Oak | Axford | Released | | | Before |
| 6/4/2015 | Oak | Almora | Traded away | Cle | | After |
| 6/4/2015 | Oak | Arrieta | Traded away | SF | | After |
| 6/4/2015 | Oak | Bailey,H | Acquired via trade | Phi | | After |
| 6/4/2015 | Oak | Bell,J | Traded away | Cle | | After |
| 6/4/2015 | Oak | Dozier,H | Acquired via trade | NYY | | After |
| 6/4/2015 | Oak | Frazier,C | Acquired via trade | Cle | | After |
| 6/4/2015 | Oak | Harrison,J | Traded away | Phi | | After |
| 6/4/2015 | Oak | Peterson,J | Acquired via trade | Cle | | After |
| 6/4/2015 | Oak | Wright,M | Acquired via trade | NYY | | After |
| 6/4/2015 | Tam | Butler,J | Released | | | Before |
| 6/4/2015 | Tam | Butler,J | Signed | | | Before |
| 6/4/2015 | Tam | Butler,J | Signed | | | Before |
| 6/4/2015 | Tam | Ynoa,G | Released | | | Before |
| 6/4/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 6/4/2015 | Tor | Mercer | Demoted to reserve roster | | | Before |
| 6/6/2015 | CHW | Shaw,T | Released | | | Before |
| 6/8/2015 | Bos | Hamilton,J | Demoted to reserve roster | | | Before |
| 6/8/2015 | CHW | Naquin | Promoted to active roster | | | Before |
| 6/8/2015 | CHW | Romero,A | Promoted to active roster | | | Before |
| 6/8/2015 | CHW | Szczur | Demoted to reserve roster | | | Before |
| 6/8/2015 | Cle | Dull | Signed | | | Before |
| 6/8/2015 | Cle | Dull | Promoted to active roster | | | Before |
| 6/8/2015 | Cle | Martinez,N | Demoted to reserve roster | | | Before |
| 6/8/2015 | Cle | Nesbitt | Released | | | Before |
| 6/8/2015 | Det | Beltre,A | Demoted to reserve roster | | | Before |
| 6/8/2015 | Det | Choice | Demoted to reserve roster | | | Before |
| 6/8/2015 | Det | Choice | Promoted to active roster | | | Before |
| 6/8/2015 | Det | Seager,C | Promoted to active roster | | | Before |
| 6/8/2015 | KC | Arcia,Os | Promoted to active roster | | | Before |
| 6/8/2015 | KC | Hicks,A | Demoted to reserve roster | | | Before |
| 6/8/2015 | Min | Fien | Promoted to active roster | | | Before |
| 6/8/2015 | Min | Jackson,A | Promoted to active roster | | | Before |
| 6/8/2015 | Min | Joseph,T | Demoted to reserve roster | | | Before |
| 6/8/2015 | Min | Soler | Demoted to reserve roster | | | Before |
| 6/8/2015 | NYY | Venditte | Signed | | | Before |
| 6/8/2015 | Oak | Wright,S | Signed | | | Before |
| 6/8/2015 | Tex | Black,R | Demoted to reserve roster | | | Before |
| 6/8/2015 | Tex | Wieters | Promoted to active roster | | | Before |
| 6/8/2015 | Tor | Ceciliani | Released | | | Before |
| 6/9/2015 | Hou | Puig | Promoted to active roster | | | Before |
| 6/9/2015 | NYY | Bradley,A | Demoted to reserve roster | | | Before |
| 6/9/2015 | NYY | Tanaka,M | Promoted to active roster | | | Before |
| 6/9/2015 | Tor | Davis,Kh | Demoted to reserve roster | | | Before |
| 6/9/2015 | Tor | Mercer | Promoted to active roster | | | Before |
| 6/12/2015 | CHW | Szczur | Released | | | Before |
| 6/12/2015 | CHW | Walker,C | Signed | | | Before |
| 6/12/2015 | Cle | Gonzalez,Ma | Released | | | Before |
| 6/12/2015 | Cle | Guerrero,G | Promoted to active roster | | | Before |
| 6/15/2015 | Bos | Flores,K | Released | | | Before |
| 6/15/2015 | Bos | Veras | Signed | | | Before |
| 6/15/2015 | Bos | Veras | Demoted to reserve roster | | | Before |
| 6/15/2015 | CHW | Flores,K | Signed | | | Before |
| 6/15/2015 | CHW | Yates | Promoted to active roster | | | Before |
| 6/15/2015 | Det | Escobar,Edw | Promoted to active roster | | | Before |
| 6/15/2015 | Det | Seager,C | Demoted to reserve roster | | | Before |
| 6/15/2015 | KC | Norris,B | Promoted to active roster | | | Before |
| 6/15/2015 | KC | Segovia | Demoted to reserve roster | | | Before |
| 6/15/2015 | NYY | Baez,J | Demoted to reserve roster | | | Before |
| 6/15/2015 | NYY | Venditte | Demoted to reserve roster | | | Before |
| 6/15/2015 | Tam | Miller,A | Demoted to reserve roster | | | Before |
| 6/17/2015 | Tam | Barrett,A | Demoted to reserve roster | | | Before |
| 6/17/2015 | Tam | Morris,B | Demoted to reserve roster | | | Before |
| 6/18/2015 | Det | Hunter,Tom | Acquired via trade | Oak | | After |
| 6/18/2015 | Oak | Hunter,Tom | Traded away | Det | | After |
| 6/19/2015 | CHW | Dosch | Signed | | | Before |
| 6/19/2015 | CHW | Ynoa,R | Released | | | Before |
| 6/19/2015 | Det | Escobar,Edw | Demoted to reserve roster | | | Before |
| 6/19/2015 | Det | Kelly,J | Demoted to reserve roster | | | Before |
| 6/19/2015 | Det | Kelly,J | Promoted to active roster | | | Before |
| 6/22/2015 | Cle | Inciarte | Demoted to reserve roster | | | Before |
| 6/22/2015 | Cle | Schebler | Promoted to active roster | | | Before |
| 6/22/2015 | KC | Johnson,C | Demoted to reserve roster | | | Before |
| 6/22/2015 | KC | Martinez,V | Promoted to active roster | | | Before |
| 6/22/2015 | Min | Jennings,Da | Demoted to reserve roster | | | Before |
| 6/22/2015 | Min | Pence | Demoted to reserve roster | | | Before |
| 6/22/2015 | Min | Smith Jr. | Promoted to active roster | | | Before |
| 6/22/2015 | Min | Wilson,Br | Promoted to active roster | | | Before |
| 6/22/2015 | Oak | Wright,S | Released | | | Before |
| 6/22/2015 | Tam | Anderson,Ty | Promoted to active roster | | | Before |
| 6/22/2015 | Tam | Feliz,M | Demoted to reserve roster | | | Before |
| 6/22/2015 | Tam | Feliz,M | Promoted to active roster | | | Before |
| 6/22/2015 | Tam | Rios | Promoted to active roster | | | Before |
| 6/22/2015 | Tam | Voth | Promoted to active roster | | | Before |
| 6/22/2015 | Tex | Lewis | Signed | | | Before |
| 6/22/2015 | Tor | Andriese | Demoted to reserve roster | | | Before |
| 6/22/2015 | Tor | Davis,I | Promoted to active roster | | | Before |
| 6/23/2015 | NYY | Gausman | Promoted to active roster | | | Before |
| 6/23/2015 | Oak | Alfaro | Demoted to reserve roster | | | Before |
| 6/23/2015 | Oak | Mujica | Demoted to reserve roster | | | Before |
| 6/24/2015 | Tex | Ventura | Demoted to reserve roster | | | Before |
| 6/26/2015 | Bos | Veras | Released | | | Before |
| 6/26/2015 | CHW | Flores,K | Released | | | Before |
| 6/26/2015 | CHW | Johnson,Er | Signed | | | Before |
| 6/26/2015 | Cle | Ynoa,G | Released | | | Before |
| 6/26/2015 | Det | Muncy | Released | | | Before |
| 6/26/2015 | Oak | Leon,S | Signed | | | Before |
| 6/26/2015 | Oak | Sanchez,T | Released | | | Before |
| 6/26/2015 | Tor | Rumbelow | Signed | | | Before |
| 6/28/2015 | Det | Escobar,Edw | Traded away | Atl | | After |
| 6/28/2015 | Det | Markakis | Acquired via trade | Atl | | After |
| 6/29/2015 | CHW | Cosart | Promoted to active roster | | | Before |
| 6/29/2015 | CHW | Dosch | Promoted to active roster | | | Before |
| 6/29/2015 | CHW | Perez,W | Demoted to reserve roster | | | Before |
| 6/29/2015 | CHW | Romero,A | Demoted to reserve roster | | | Before |
| 6/29/2015 | CHW | Walker,C | Promoted to active roster | | | Before |
| 6/29/2015 | CHW | Yates | Demoted to reserve roster | | | Before |
| 6/29/2015 | Cle | Flores,K | Signed | | | Before |
| 6/29/2015 | Det | Aoki | Demoted to reserve roster | | | Before |
| 6/29/2015 | Det | Barnes,B | Signed | | | Before |
| 6/29/2015 | Det | Barnes,B | Promoted to active roster | | | Before |
| 6/29/2015 | Det | Beltre,A | Promoted to active roster | | | Before |
| 6/29/2015 | Det | Kelly,J | Demoted to reserve roster | | | Before |
| 6/29/2015 | Det | Stanton | Demoted to reserve roster | | | Before |
| 6/29/2015 | KC | Hart | Demoted to reserve roster | | | Before |
| 6/29/2015 | KC | Martinez,V | Promoted to active roster | | | Before |
| 6/29/2015 | Sea | Buxton | Demoted to reserve roster | | | Before |
| 6/29/2015 | Sea | Dietrich | Promoted to active roster | | | Before |
| 6/29/2015 | Tam | Urena | Promoted to active roster | | | Before |
| 6/29/2015 | Tam | Weaver | Demoted to reserve roster | | | Before |
| 6/29/2015 | Tor | Andriese | Promoted to active roster | | | Before |
| 6/29/2015 | Tor | Wada | Demoted to reserve roster | | | Before |
| 7/2/2015 | Det | Cabrera,Me | Acquired via trade | Ari | | After |
| 7/2/2015 | Det | Coulter | Traded away | Ari | | After |
| 7/3/2015 | CHW | Saladino | Signed | | | Before |
| 7/3/2015 | CHW | Yates | Released | | | Before |
| 7/3/2015 | Det | Burns,B | Demoted to reserve roster | | | Before |
| 7/3/2015 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 7/3/2015 | Tor | Wada | Promoted to active roster | | | Before |
| 7/5/2015 | Bos | Garrett | Acquired via trade | Cin | | After |
| 7/5/2015 | Bos | Reynolds,Mat(P) | Traded away | Cin | | After |
| 7/5/2015 | Bos | Urshela | Acquired via trade | Cin | | After |
| 7/5/2015 | Bos | Walker,N | Traded away | Cin | | After |
| 7/5/2015 | Cle | Martinez,N | Traded away | Was | | After |
| 7/5/2015 | Cle | Sims | Acquired via trade | Was | | After |
| 7/5/2015 | KC | Almonte,M | Acquired via trade | STL | | After |
| 7/5/2015 | KC | Cain,L | Acquired via trade | Col | | After |
| 7/5/2015 | KC | LaRoche,Ad | Traded away | STL | | After |
| 7/5/2015 | KC | Rodon | Traded away | Col | | After |
| 7/5/2015 | KC | Rodriguez,Fr | Acquired via trade | Col | | After |
| 7/5/2015 | Oak | Alcantara,A | Traded away | Was | | After |
| 7/5/2015 | Oak | Piscotty | Acquired via trade | Was | | After |
| 7/5/2015 | Oak | Tejada | Traded away | Was | | After |
| 7/5/2015 | Oak | Tuivailala | Acquired via trade | Was | | After |
| 7/6/2015 | Bal | Avila | Promoted to active roster | | | Before |
| 7/6/2015 | Bal | Cordell | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bal | Fernandez,J | Promoted to active roster | | | Before |
| 7/6/2015 | Bal | Marisnick | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bal | Soriano,R | Promoted to active roster | | | Before |
| 7/6/2015 | Bal | Stanley | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bal | Travis | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bal | Travis | Promoted to active roster | | | Before |
| 7/6/2015 | Bal | Valera | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bal | Valera | Promoted to active roster | | | Before |
| 7/6/2015 | Bos | Belisle | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bos | Burnett,A | Promoted to active roster | | | Before |
| 7/6/2015 | Bos | Hamilton,J | Promoted to active roster | | | Before |
| 7/6/2015 | Bos | Hudson,T | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bos | Masterson | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bos | Masterson | Promoted to active roster | | | Before |
| 7/6/2015 | Bos | Matzek | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bos | McHugh | Promoted to active roster | | | Before |
| 7/6/2015 | Bos | Springer | Demoted to reserve roster | | | Before |
| 7/6/2015 | Bos | Urshela | Promoted to active roster | | | Before |
| 7/6/2015 | Bos | Victorino | Promoted to active roster | | | Before |
| 7/6/2015 | Cle | Baez,P | Promoted to active roster | | | Before |
| 7/6/2015 | Cle | Johnson,B | Demoted to reserve roster | | | Before |
| 7/6/2015 | Cle | Sims | Promoted to active roster | | | Before |
| 7/6/2015 | Cle | Wieland | Demoted to reserve roster | | | Before |
| 7/6/2015 | KC | Billingsley | Promoted to active roster | | | Before |
| 7/6/2015 | KC | Gregerson | Demoted to reserve roster | | | Before |
| 7/6/2015 | KC | Hart | Released | | | Before |
| 7/6/2015 | KC | Tropeano | Demoted to reserve roster | | | Before |
| 7/6/2015 | Oak | Cabrera,Ev | Demoted to reserve roster | | | Before |
| 7/6/2015 | Oak | Dozier,H | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Feliz,N | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Frazier,C | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Law | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Mujica | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Petricka | Demoted to reserve roster | | | Before |
| 7/6/2015 | Oak | Petricka | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Rondon,B | Demoted to reserve roster | | | Before |
| 7/6/2015 | Oak | Rondon,B | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Rondon,B | Promoted to active roster | | | Before |
| 7/6/2015 | Oak | Wright,M | Demoted to reserve roster | | | Before |
| 7/6/2015 | Tam | Corbin | Promoted to active roster | | | Before |
| 7/6/2015 | Tam | Jepsen | Demoted to reserve roster | | | Before |
| 7/6/2015 | Tam | Jungmann | Demoted to reserve roster | | | Before |
| 7/6/2015 | Tam | Morris,B | Promoted to active roster | | | Before |
| 7/6/2015 | Tex | Black,R | Promoted to active roster | | | Before |
| 7/6/2015 | Tex | Cabrera,Mi | Demoted to reserve roster | | | Before |
| 7/6/2015 | Tex | Klein | Released | | | Before |
| 7/6/2015 | Tex | Lewis | Promoted to active roster | | | Before |
| 7/6/2015 | Tex | Lincecum | Demoted to reserve roster | | | Before |
| 7/6/2015 | Tex | Olivera | Demoted to reserve roster | | | Before |
| 7/6/2015 | Tex | Olivera | Promoted to active roster | | | Before |
| 7/9/2015 | Bos | Bernard | Released | | | Before |
| 7/9/2015 | Bos | Hernandez,M | Signed | | | Before |
| 7/9/2015 | Min | Barney | Demoted to reserve roster | | | Before |
| 7/9/2015 | Min | Hanigan | Promoted to active roster | | | Before |
| 7/9/2015 | Min | Pence | Promoted to active roster | | | Before |
| 7/9/2015 | Min | Smith Jr. | Demoted to reserve roster | | | Before |
| 7/9/2015 | Min | Soler | Promoted to active roster | | | Before |
| 7/9/2015 | Min | Teheran | Demoted to reserve roster | | | Before |
| 7/9/2015 | Tor | Chen,W | Promoted to active roster | | | Before |
| 7/9/2015 | Tor | Davis,Kh | Promoted to active roster | | | Before |
| 7/9/2015 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 7/9/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 7/9/2015 | Tor | Jones,G | Demoted to reserve roster | | | Before |
| 7/9/2015 | Tor | Wada | Demoted to reserve roster | | | Before |
| 7/12/2015 | Bos | Duffy,MM | Acquired via trade | Pit | | After |
| 7/12/2015 | Bos | Napoli | Traded away | Pit | | After |
| 7/12/2015 | Det | Jennings,De | Traded away | Min | | After |
| 7/12/2015 | Det | Teheran | Acquired via trade | Min | | After |
| 7/12/2015 | Hou | Carpenter,M | Traded away | Pit | | After |
| 7/12/2015 | Hou | Colon,B | Traded away | Pit | | After |
| 7/12/2015 | Hou | Wainwright | Acquired via trade | Pit | | After |
| 7/12/2015 | Min | Jennings,De | Acquired via trade | Det | | After |
| 7/12/2015 | Min | Teheran | Traded away | Det | | After |
| 7/12/2015 | Tor | Danish | Traded away | NYM | | After |
| 7/12/2015 | Tor | Kennedy | Acquired via trade | NYM | | After |
| 7/17/2015 | CHW | Romero,E | Released | | | Before |
| 7/17/2015 | Cle | Schebler | Demoted to reserve roster | | | Before |
| 7/17/2015 | Cle | Sims | Demoted to reserve roster | | | Before |
| 7/17/2015 | Cle | Waldrop | Signed | | | Before |
| 7/17/2015 | Cle | Waldrop | Promoted to active roster | | | Before |
| 7/17/2015 | Cle | Wieland | Promoted to active roster | | | Before |
| 7/17/2015 | Det | Lopez,Ja | Demoted to reserve roster | | | Before |
| 7/17/2015 | Det | Shaw,B | Demoted to reserve roster | | | Before |
| 7/17/2015 | Det | Wright,W | Promoted to active roster | | | Before |
| 7/17/2015 | KC | Billingsley | Demoted to reserve roster | | | Before |
| 7/17/2015 | KC | Iwakuma | Promoted to active roster | | | Before |
| 7/17/2015 | Min | Barney | Demoted to reserve roster | | | Before |
| 7/17/2015 | Min | Hanigan | Promoted to active roster | | | Before |
| 7/17/2015 | Min | Jennings,Da | Demoted to reserve roster | | | Before |
| 7/17/2015 | Min | Jennings,Da | Promoted to active roster | | | Before |
| 7/17/2015 | Min | Pence | Promoted to active roster | | | Before |
| 7/17/2015 | Min | Smith Jr. | Demoted to reserve roster | | | Before |
| 7/17/2015 | Min | Soler | Promoted to active roster | | | Before |
| 7/17/2015 | NYY | Chamberlain | Released | | | Before |
| 7/17/2015 | Tam | Anderson,Ty | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tam | Asher | Promoted to active roster | | | Before |
| 7/17/2015 | Tam | Barrett,A | Promoted to active roster | | | Before |
| 7/17/2015 | Tam | Hahn | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tam | Miller,A | Promoted to active roster | | | Before |
| 7/17/2015 | Tam | Phillips,Bre | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tex | Gordon,A | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tex | Ventura | Promoted to active roster | | | Before |
| 7/17/2015 | Tor | Andriese | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tor | Fiers | Promoted to active roster | | | Before |
| 7/17/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tor | Jones,G | Promoted to active roster | | | Before |
| 7/17/2015 | Tor | Kennedy | Demoted to reserve roster | | | Before |
| 7/17/2015 | Tor | Machado,D | Released | | | Before |
| 7/19/2015 | Bos | Betances | Acquired via trade | Phi | | After |
| 7/19/2015 | Bos | deGrom | Acquired via trade | Phi | | After |
| 7/19/2015 | Bos | Guyer | Acquired via trade | Phi | | After |
| 7/19/2015 | Bos | Hamilton,J | Traded away | Phi | | After |
| 7/19/2015 | Bos | Harrison,J | Acquired via trade | Phi | | After |
| 7/19/2015 | Bos | Iannetta | Traded away | Phi | | After |
| 7/19/2015 | Bos | Joseph,Ca | Acquired via trade | Phi | | After |
| 7/19/2015 | Bos | Kimbrel | Traded away | Phi | | After |
| 7/19/2015 | Bos | Kingham | Acquired via trade | Phi | | After |
| 7/19/2015 | Bos | Luebke | Traded away | Phi | | After |
| 7/19/2015 | Bos | Scherzer | Traded away | Phi | | After |
| 7/19/2015 | Hou | Kinsler | Traded away | Phi | | After |
| 7/19/2015 | Hou | Strop | Traded away | Phi | | After |
| 7/19/2015 | KC | Almonte,M | Traded away | Phi | | After |
| 7/19/2015 | KC | Suzuki,K | Acquired via trade | Phi | | After |
| 7/20/2015 | Bos | Hernandez,M | Promoted to active roster | | | Before |
| 7/20/2015 | Bos | Joseph,Ca | Promoted to active roster | | | Before |
| 7/20/2015 | Bos | Masterson | Demoted to reserve roster | | | Before |
| 7/20/2015 | Bos | Masterson | Promoted to active roster | | | Before |
| 7/20/2015 | Cle | Waldrop | Released | | | Before |
| 7/20/2015 | KC | Montero,M | Demoted to reserve roster | | | Before |
| 7/20/2015 | LAA | Cunningham,T | Released | | | Before |
| 7/20/2015 | LAA | Merritt | Signed | | | Before |
| 7/20/2015 | Tam | Cabrera,As | Demoted to reserve roster | | | Before |
| 7/20/2015 | Tam | Ryan,B | Promoted to active roster | | | Before |
| 7/20/2015 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 7/20/2015 | Tor | Kennedy | Promoted to active roster | | | Before |
| 7/23/2015 | Cle | Inciarte | Promoted to active roster | | | Before |
| 7/23/2015 | Det | Russell,J | Demoted to reserve roster | | | Before |
| 7/23/2015 | Det | Russell,J | Acquired via trade | Oak | | After |
| 7/23/2015 | KC | Perez,O | Acquired via trade | LAA | | After |
| 7/23/2015 | LAA | Paulsen | Traded away | Was | | After |
| 7/23/2015 | LAA | Perez,O | Traded away | KC | | After |
| 7/23/2015 | Oak | Bailey,H | Traded away | Was | | After |
| 7/23/2015 | Oak | Renfroe | Acquired via trade | Was | | After |
| 7/23/2015 | Oak | Russell,J | Traded away | Det | | After |
| 7/23/2015 | Oak | Teixeira | Traded away | Was | | After |
| 7/23/2015 | Tor | Andriese | Promoted to active roster | | | Before |
| 7/23/2015 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 7/23/2015 | Tor | Fiers | Promoted to active roster | | | Before |
| 7/23/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 7/23/2015 | Tor | Wendle | Released | | | Before |
| 7/27/2015 | Tor | Jones,G | Released | | | Before |
| 7/30/2015 | Bos | Martin,L | Traded away | Cin | | After |
| 7/30/2015 | Hou | Gutierrez,F | Signed | | | Before |
| 7/30/2015 | Hou | Skipworth | Signed | | | Before |
| 7/31/2015 | Hou | Robles | Signed | | | Before |
| 7/31/2015 | Sea | Chapman,K | Promoted to active roster | | | Before |
| 7/31/2015 | Sea | Kubitza | Promoted to active roster | | | Before |
| 7/31/2015 | Sea | Leathersich | Demoted to reserve roster | | | Before |
| 7/31/2015 | Sea | Marte,K | Promoted to active roster | | | Before |
| 7/31/2015 | Sea | Susac | Demoted to reserve roster | | | Before |
| 8/3/2015 | Bos | Burnett,A | Demoted to reserve roster | | | Before |
| 8/3/2015 | Bos | Karns | Promoted to active roster | | | Before |
| 8/3/2015 | Bos | Masterson | Promoted to active roster | | | Before |
| 8/3/2015 | Cle | Reynolds,Mat(B) | Released | | | Before |
| 8/3/2015 | Det | Aoki | Promoted to active roster | | | Before |
| 8/3/2015 | Det | Ellis,A | Demoted to reserve roster | | | Before |
| 8/3/2015 | Det | O'Conner | Promoted to active roster | | | Before |
| 8/3/2015 | Det | Turner,Ju | Demoted to reserve roster | | | Before |
| 8/3/2015 | Hou | Bailey,A | Signed | | | Before |
| 8/3/2015 | Hou | Robles | Released | | | Before |
| 8/3/2015 | KC | Pineda | Demoted to reserve roster | | | Before |
| 8/3/2015 | Tor | Chen,W | Promoted to active roster | | | Before |
| 8/3/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 8/3/2015 | Tor | Kennedy | Demoted to reserve roster | | | Before |
| 8/3/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 8/3/2015 | Tor | Mercer | Demoted to reserve roster | | | Before |
| 8/7/2015 | Cle | Marshall,E | Released | | | Before |
| 8/7/2015 | Cle | Rivero,F | Signed | | | Before |
| 8/7/2015 | Cle | Sims | Promoted to active roster | | | Before |
| 8/7/2015 | Sea | Prime | Released | | | Before |
| 8/7/2015 | Tor | Andriese | Demoted to reserve roster | | | Before |
| 8/7/2015 | Tor | Kennedy | Promoted to active roster | | | Before |
| 8/8/2015 | NYY | Alcantara,R | Promoted to active roster | | | Before |
| 8/8/2015 | NYY | Baez,J | Promoted to active roster | | | Before |
| 8/8/2015 | NYY | Sweeney,D | Promoted to active roster | | | Before |
| 8/9/2015 | NYY | Lee,H | Promoted to active roster | | | Before |
| 8/9/2015 | NYY | Rondon,Jos | Demoted to reserve roster | | | Before |
| 8/9/2015 | NYY | Sanchez,Gar | Demoted to reserve roster | | | Before |
| 8/9/2015 | NYY | Sanchez,Gar | Promoted to active roster | | | Before |
| 8/10/2015 | Bal | Marisnick | Promoted to active roster | | | Before |
| 8/10/2015 | Bal | Porcello | Demoted to reserve roster | | | Before |
| 8/10/2015 | Bal | Solis,S | Promoted to active roster | | | Before |
| 8/10/2015 | Bal | Soriano,R | Demoted to reserve roster | | | Before |
| 8/10/2015 | CHW | Cosart | Demoted to reserve roster | | | Before |
| 8/10/2015 | CHW | Kahnle | Signed | | | Before |
| 8/10/2015 | CHW | Kahnle | Promoted to active roster | | | Before |
| 8/10/2015 | CHW | Medlen | Promoted to active roster | | | Before |
| 8/10/2015 | CHW | Pestano | Released | | | Before |
| 8/10/2015 | CHW | Saladino | Promoted to active roster | | | Before |
| 8/10/2015 | CHW | Souza,S | Demoted to reserve roster | | | Before |
| 8/10/2015 | Det | Ellis,A | Promoted to active roster | | | Before |
| 8/10/2015 | Det | O'Conner | Demoted to reserve roster | | | Before |
| 8/10/2015 | KC | Conger | Demoted to reserve roster | | | Before |
| 8/10/2015 | KC | Montero,M | Promoted to active roster | | | Before |
| 8/10/2015 | KC | Tropeano | Demoted to reserve roster | | | Before |
| 8/10/2015 | KC | Tropeano | Promoted to active roster | | | Before |
| 8/10/2015 | Oak | Wright,S | Signed | | | Before |
| 8/10/2015 | Tex | Banuelos | Demoted to reserve roster | | | Before |
| 8/10/2015 | Tex | Chirinos | Demoted to reserve roster | | | Before |
| 8/10/2015 | Tex | Colome | Promoted to active roster | | | Before |
| 8/10/2015 | Tex | Cuthbert | Promoted to active roster | | | Before |
| 8/10/2015 | Tex | Freese | Demoted to reserve roster | | | Before |
| 8/10/2015 | Tex | Mondesi Jr. | Promoted to active roster | | | Before |
| 8/10/2015 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 8/10/2015 | Tor | Crisp | Promoted to active roster | | | Before |
| 8/10/2015 | Tor | Gonzalez,MAng | Demoted to reserve roster | | | Before |
| 8/10/2015 | Tor | Jones,N | Promoted to active roster | | | Before |
| 8/10/2015 | Tor | Smith,S | Demoted to reserve roster | | | Before |
| 8/10/2015 | Tor | Smith,S | Promoted to active roster | | | Before |
| 8/11/2015 | Min | Panik | Demoted to reserve roster | | | Before |
| 8/11/2015 | NYY | Strasburg | Promoted to active roster | | | Before |
| 8/11/2015 | NYY | Venditte | Promoted to active roster | | | Before |
| 8/13/2015 | Bos | Ravelo | Acquired via trade | Pit | | After |
| 8/13/2015 | Bos | Urshela | Traded away | Cle | | After |
| 8/13/2015 | Bos | Victorino | Traded away | Pit | | After |
| 8/13/2015 | Bos | Williamson | Acquired via trade | Cle | | After |
| 8/13/2015 | Cle | Urshela | Acquired via trade | Bos | | After |
| 8/13/2015 | Cle | Williamson | Traded away | Bos | | After |
| 8/13/2015 | Det | Banuelos | Acquired via trade | Tex | | After |
| 8/13/2015 | Det | Cecil | Acquired via trade | Tex | | After |
| 8/13/2015 | Det | Markakis | Traded away | Tex | | After |
| 8/13/2015 | Det | Ramirez,H | Acquired via trade | Tex | | After |
| 8/13/2015 | Det | Ross,J | Traded away | Tex | | After |
| 8/13/2015 | Hou | Ackley | Acquired via trade | Pit | | After |
| 8/13/2015 | Hou | Dickey | Traded away | KC | | After |
| 8/13/2015 | Hou | Polanco,G | Acquired via trade | NYY | | After |
| 8/13/2015 | Hou | Polanco,J | Acquired via trade | KC | | After |
| 8/13/2015 | Hou | Puig | Traded away | NYY | | After |
| 8/13/2015 | Hou | Stubbs | Traded away | Pit | | After |
| 8/13/2015 | KC | Dickey | Acquired via trade | Hou | | After |
| 8/13/2015 | KC | Polanco,J | Traded away | Hou | | After |
| 8/13/2015 | NYY | Polanco,G | Traded away | Hou | | After |
| 8/13/2015 | NYY | Polanco,G | Acquired via trade | Tex | | After |
| 8/13/2015 | NYY | Profar | Traded away | Tex | | After |
| 8/13/2015 | NYY | Puig | Acquired via trade | Hou | | After |
| 8/13/2015 | Oak | Ruiz,R | Acquired via trade | Col | | After |
| 8/13/2015 | Tex | Banuelos | Traded away | Det | | After |
| 8/13/2015 | Tex | Buchholz | Acquired via trade | Cin | | After |
| 8/13/2015 | Tex | Cecil | Traded away | Det | | After |
| 8/13/2015 | Tex | Cingrani | Acquired via trade | Cin | | After |
| 8/13/2015 | Tex | Clippard | Traded away | Cin | | After |
| 8/13/2015 | Tex | Hughes,P | Traded away | Cin | | After |
| 8/13/2015 | Tex | Markakis | Acquired via trade | Det | | After |
| 8/13/2015 | Tex | McKinney | Acquired via trade | Pit | | After |
| 8/13/2015 | Tex | Mondesi Jr. | Traded away | Pit | | After |
| 8/13/2015 | Tex | Osuna | Acquired via trade | Cin | | After |
| 8/13/2015 | Tex | Polanco,G | Traded away | NYY | | After |
| 8/13/2015 | Tex | Profar | Acquired via trade | NYY | | After |
| 8/13/2015 | Tex | Ramirez,H | Traded away | Det | | After |
| 8/13/2015 | Tex | Ross,J | Acquired via trade | Det | | After |
| 8/13/2015 | Tex | Shields | Traded away | Cin | | After |
| 8/14/2015 | Cle | Brito | Signed | | | Before |
| 8/14/2015 | Cle | Centeno | Released | | | Before |
| 8/14/2015 | Cle | Flores,K | Promoted to active roster | | | Before |
| 8/14/2015 | Cle | Goodwin | Released | | | Before |
| 8/14/2015 | Det | Barnes,B | Released | | | Before |
| 8/14/2015 | Det | Burns,B | Promoted to active roster | | | Before |
| 8/14/2015 | Det | Thatcher | Demoted to reserve roster | | | Before |
| 8/14/2015 | Hou | Bailey,A | Released | | | Before |
| 8/14/2015 | KC | Johnson,C | Demoted to reserve roster | | | Before |
| 8/14/2015 | LAA | Broxton,K | Promoted to active roster | | | Before |
| 8/14/2015 | LAA | House,T | Demoted to reserve roster | | | Before |
| 8/14/2015 | LAA | Merritt | Promoted to active roster | | | Before |
| 8/14/2015 | LAA | Shipley | Promoted to active roster | | | Before |
| 8/14/2015 | Tex | Armstrong | Signed | | | Before |
| 8/14/2015 | Tex | Dickerson,A | Signed | | | Before |
| 8/14/2015 | Tex | Gonzalez,Er | Released | | | Before |
| 8/14/2015 | Tex | Guerrero,T | Signed | | | Before |
| 8/14/2015 | Tor | Chen,W | Promoted to active roster | | | Before |
| 8/14/2015 | Tor | Kennedy | Demoted to reserve roster | | | Before |
| 8/14/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 8/14/2015 | Tor | Wada | Promoted to active roster | | | Before |
| 8/16/2015 | LAA | McGee | Traded away | Pit | | After |
| 8/16/2015 | LAA | Pham | Acquired via trade | Pit | | After |
| 8/17/2015 | Bal | Fernandez,J | Demoted to reserve roster | | | Before |
| 8/17/2015 | Bal | Kaminsky | Promoted to active roster | | | Before |
| 8/17/2015 | Bos | Holdzkom | Released | | | Before |
| 8/17/2015 | Bos | Karns | Demoted to reserve roster | | | Before |
| 8/17/2015 | Bos | Masterson | Demoted to reserve roster | | | Before |
| 8/17/2015 | Bos | Matzek | Promoted to active roster | | | Before |
| 8/17/2015 | Bos | Rodriguez,Fe | Signed | | | Before |
| 8/17/2015 | Bos | Rodriguez,Fe | Promoted to active roster | | | Before |
| 8/17/2015 | Det | Aoki | Demoted to reserve roster | | | Before |
| 8/17/2015 | Det | Russell,J | Promoted to active roster | | | Before |
| 8/17/2015 | Det | Turner,Ju | Promoted to active roster | | | Before |
| 8/17/2015 | Det | Wright,W | Released | | | Before |
| 8/17/2015 | Det | Wright,W | Demoted to reserve roster | | | Before |
| 8/17/2015 | Min | Jennings,Da | Promoted to active roster | | | Before |
| 8/17/2015 | Min | Jennings,De | Promoted to active roster | | | Before |
| 8/17/2015 | Min | Logan | Demoted to reserve roster | | | Before |
| 8/17/2015 | Oak | Wright,S | Released | | | Before |
| 8/17/2015 | Tam | Asher | Demoted to reserve roster | | | Before |
| 8/17/2015 | Tam | Barrett,A | Demoted to reserve roster | | | Before |
| 8/17/2015 | Tam | Feliz,M | Promoted to active roster | | | Before |
| 8/17/2015 | Tam | Ryan,B | Promoted to active roster | | | Before |
| 8/17/2015 | Tam | Urena | Demoted to reserve roster | | | Before |
| 8/17/2015 | Tam | Weaver | Promoted to active roster | | | Before |
| 8/17/2015 | Tex | Armstrong | Promoted to active roster | | | Before |
| 8/17/2015 | Tex | Cabrera,Mi | Promoted to active roster | | | Before |
| 8/17/2015 | Tex | Cuthbert | Demoted to reserve roster | | | Before |
| 8/17/2015 | Tex | Guerrero,T | Released | | | Before |
| 8/17/2015 | Tex | McKinney | Demoted to reserve roster | | | Before |
| 8/17/2015 | Tex | Olivera | Promoted to active roster | | | Before |
| 8/17/2015 | Tex | Osuna | Promoted to active roster | | | Before |
| 8/17/2015 | Tex | Ross,J | Promoted to active roster | | | Before |
| 8/18/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 8/18/2015 | Tor | Wada | Demoted to reserve roster | | | Before |
| 8/20/2015 | Bos | Johnson,D | Signed | | | Before |
| 8/20/2015 | Cle | Chacin | Signed | | | Before |
| 8/20/2015 | Cle | Chacin | Promoted to active roster | | | Before |
| 8/20/2015 | Cle | Collins,Ty | Signed | | | Before |
| 8/20/2015 | Cle | Rivero,F | Promoted to active roster | | | Before |
| 8/20/2015 | Cle | Webster | Released | | | Before |
| 8/20/2015 | Cle | Wieland | Released | | | Before |
| 8/20/2015 | Det | Aoki | Demoted to reserve roster | | | Before |
| 8/20/2015 | Det | Nay | Demoted to reserve roster | | | Before |
| 8/20/2015 | Det | Seager,C | Promoted to active roster | | | Before |
| 8/20/2015 | Det | Beltre,A | Traded away | NYY | | After |
| 8/20/2015 | Det | Nay | Acquired via trade | NYY | | After |
| 8/20/2015 | Det | Shaw,B | Traded away | NYY | | After |
| 8/20/2015 | Det | Thatcher | Traded away | NYY | | After |
| 8/20/2015 | Det | Winker | Acquired via trade | NYY | | After |
| 8/20/2015 | KC | Farmer,B | Released | | | Before |
| 8/20/2015 | KC | Blackburn | Acquired via trade | Was | | After |
| 8/20/2015 | LAA | Bettis | Demoted to reserve roster | | | Before |
| 8/20/2015 | LAA | Dyson,J | Traded away | SF | | After |
| 8/20/2015 | NYY | Beltre,A | Acquired via trade | Det | | After |
| 8/20/2015 | NYY | Nay | Traded away | Det | | After |
| 8/20/2015 | NYY | Piscotty | Acquired via trade | Oak | | After |
| 8/20/2015 | NYY | Sanchez,Gar | Traded away | Oak | | After |
| 8/20/2015 | NYY | Shaw,B | Acquired via trade | Det | | After |
| 8/20/2015 | NYY | Thatcher | Acquired via trade | Det | | After |
| 8/20/2015 | NYY | Tuivailala | Acquired via trade | Oak | | After |
| 8/20/2015 | NYY | Winker | Traded away | Det | | After |
| 8/20/2015 | Oak | Leon,S | Released | | | Before |
| 8/20/2015 | Oak | Morales,F | Signed | | | Before |
| 8/20/2015 | Oak | Piscotty | Traded away | NYY | | After |
| 8/20/2015 | Oak | Sanchez,Gar | Acquired via trade | NYY | | After |
| 8/20/2015 | Oak | Tuivailala | Traded away | NYY | | After |
| 8/20/2015 | Tor | Gonzalez,MAng | Promoted to active roster | | | Before |
| 8/20/2015 | Tor | Kennedy | Promoted to active roster | | | Before |
| 8/20/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 8/20/2015 | Tor | Uehara | Demoted to reserve roster | | | Before |
| 8/23/2015 | Cle | Choice | Acquired via trade | Det | | After |
| 8/23/2015 | Cle | Rivero,F | Traded away | Det | | After |
| 8/23/2015 | Det | Choice | Traded away | Cle | | After |
| 8/23/2015 | Det | Kelly,J | Traded away | Mil | | After |
| 8/23/2015 | Det | Prado | Acquired via trade | Mil | | After |
| 8/23/2015 | Det | Rivero,F | Acquired via trade | Cle | | After |
| 8/24/2015 | Bos | Belisle | Released | | | Before |
| 8/24/2015 | Bos | Harrison,J | Promoted to active roster | | | Before |
| 8/24/2015 | Bos | Johnson,D | Promoted to active roster | | | Before |
| 8/24/2015 | Cle | Choice | Promoted to active roster | | | Before |
| 8/24/2015 | Det | Rivero,F | Demoted to reserve roster | | | Before |
| 8/24/2015 | Det | Seager,C | Demoted to reserve roster | | | Before |
| 8/24/2015 | KC | Blackburn | Demoted to reserve roster | | | Before |
| 8/24/2015 | Min | Barnes,M | Promoted to active roster | | | Before |
| 8/24/2015 | Min | Barney | Promoted to active roster | | | Before |
| 8/24/2015 | Min | Norris,Da | Demoted to reserve roster | | | Before |
| 8/24/2015 | Min | Pence | Demoted to reserve roster | | | Before |
| 8/24/2015 | Tam | Butler,J | Released | | | Before |
| 8/24/2015 | Tam | Knudson | Signed | | | Before |
| 8/24/2015 | Tor | Davis,I | Demoted to reserve roster | | | Before |
| 8/24/2015 | Tor | Kennedy | Demoted to reserve roster | | | Before |
| 8/24/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 8/24/2015 | Tor | Shaffer | Promoted to active roster | | | Before |
| 8/27/2015 | KC | Farquhar | Acquired via trade | Ari | | After |
| 8/27/2015 | KC | Smith,Mal | Traded away | Ari | | After |
| 8/28/2015 | Bal | Carrasco | Demoted to reserve roster | | | Before |
| 8/28/2015 | Bal | Porcello | Promoted to active roster | | | Before |
| 8/28/2015 | CHW | Collins,Ty | Signed | | | Before |
| 8/28/2015 | CHW | Torres,Al | Released | | | Before |
| 8/28/2015 | Cle | Collins,Ty | Released | | | Before |
| 8/28/2015 | Cle | Flores,K | Demoted to reserve roster | | | Before |
| 8/28/2015 | Cle | Gilmartin | Signed | | | Before |
| 8/28/2015 | Cle | Gilmartin | Promoted to active roster | | | Before |
| 8/28/2015 | Cle | Paredes | Signed | | | Before |
| 8/28/2015 | Cle | Paredes | Promoted to active roster | | | Before |
| 8/28/2015 | Cle | Pirela | Released | | | Before |
| 8/28/2015 | KC | Williams,Ta | Released | | | Before |
| 8/28/2015 | LAA | Albers,M | Signed | | | Before |
| 8/28/2015 | LAA | Paredes | Released | | | Before |
| 8/28/2015 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 8/28/2015 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 8/28/2015 | Tor | Kennedy | Promoted to active roster | | | Before |
| 8/28/2015 | Tor | Wada | Promoted to active roster | | | Before |
| 8/30/2015 | Det | Banuelos | Traded away | Ari | | After |
| 8/30/2015 | Det | Gattis | Acquired via trade | Ari | | After |
| 8/31/2015 | CHW | Mejia,A | Released | | | Before |
| 8/31/2015 | Cle | Colon,C | Released | | | Before |
| 8/31/2015 | Cle | Mejia,A | Signed | | | Before |
| 8/31/2015 | Cle | Mejia,A | Promoted to active roster | | | Before |
| 8/31/2015 | Cle | Paredes | Released | | | Before |
| 8/31/2015 | Cle | Pirela | Signed | | | Before |
| 8/31/2015 | Cle | Pirela | Promoted to active roster | | | Before |
| 8/31/2015 | Det | Aoki | Promoted to active roster | | | Before |
| 8/31/2015 | Det | Burns,B | Demoted to reserve roster | | | Before |
| 8/31/2015 | Det | Burns,B | Promoted to active roster | | | Before |
| 8/31/2015 | Det | Ellis,A | Demoted to reserve roster | | | Before |
| 8/31/2015 | Det | Ellis,A | Promoted to active roster | | | Before |
| 8/31/2015 | Det | Lopez,Ja | Promoted to active roster | | | Before |
| 8/31/2015 | Det | Seager,C | Promoted to active roster | | | Before |
| 8/31/2015 | Det | Turner,Ju | Promoted to active roster | | | Before |
| 8/31/2015 | KC | Norris,B | Demoted to reserve roster | | | Before |
| 8/31/2015 | KC | Pineda | Promoted to active roster | | | Before |
| 8/31/2015 | KC | Reed,Ad | Demoted to reserve roster | | | Before |
| 8/31/2015 | LAA | Bettis | Promoted to active roster | | | Before |
| 8/31/2015 | LAA | Story | Promoted to active roster | | | Before |
| 8/31/2015 | Min | Castro,J | Demoted to reserve roster | | | Before |
| 8/31/2015 | Min | Jennings,De | Demoted to reserve roster | | | Before |
| 8/31/2015 | Min | Joseph,T | Promoted to active roster | | | Before |
| 8/31/2015 | Min | Smith Jr. | Promoted to active roster | | | Before |
| 8/31/2015 | Min | Soler | Demoted to reserve roster | | | Before |
| 8/31/2015 | NYY | Bradley,A | Promoted to active roster | | | Before |
| 8/31/2015 | NYY | Puig | Demoted to reserve roster | | | Before |
| 8/31/2015 | Tex | Faulkner | Signed | | | Before |
| 8/31/2015 | Tor | Chen,W | Promoted to active roster | | | Before |
| 8/31/2015 | Tor | Fiers | Promoted to active roster | | | Before |
| 8/31/2015 | Tor | Hendriks | Signed | | | Before |
| 8/31/2015 | Tor | Keuchel | Demoted to reserve roster | | | Before |
| 8/31/2015 | Tor | Mercer | Promoted to active roster | | | Before |
| 8/31/2015 | Tor | Shaffer | Demoted to reserve roster | | | Before |
| 8/31/2015 | Tor | Wada | Demoted to reserve roster | | | Before |
| 9/2/2015 | Hou | Flores,R | Demoted to reserve roster | | | Before |
| 9/2/2015 | Hou | Greene,S | Demoted to reserve roster | | | Before |
| 9/2/2015 | Hou | Socolovich | Promoted to active roster | | | Before |
| 9/3/2015 | Cle | Nicolino | Traded away | Oak | | After |
| 9/3/2015 | Oak | Nicolino | Acquired via trade | Cle | | After |
| 9/4/2015 | CHW | Cosart | Released | | | Before |
| 9/4/2015 | CHW | Garcia,W | Signed | | | Before |
| 9/4/2015 | CHW | Perez,W | Released | | | Before |
| 9/4/2015 | CHW | Withrow | Released | | | Before |
| 9/4/2015 | CHW | Yates | Signed | | | Before |
| 9/4/2015 | Cle | Brito | Promoted to active roster | | | Before |
| 9/4/2015 | Cle | Cosart | Signed | | | Before |
| 9/4/2015 | Cle | Nunez,R | Promoted to active roster | | | Before |
| 9/4/2015 | Cle | Parker,K | Released | | | Before |
| 9/4/2015 | Cle | Schebler | Released | | | Before |
| 9/4/2015 | Hou | Skipworth | Released | | | Before |
| 9/4/2015 | LAA | Navarro,R | Released | | | Before |
| 9/4/2015 | Oak | Frieri | Released | | | Before |
| 9/4/2015 | Oak | Withrow | Signed | | | Before |
| 9/4/2015 | Tor | Andriese | Promoted to active roster | | | Before |
| 9/4/2015 | Tor | Hendriks | Promoted to active roster | | | Before |
| 9/4/2015 | Tor | Keuchel | Promoted to active roster | | | Before |
| 9/4/2015 | Tor | Rumbelow | Released | | | Before |
| 9/4/2015 | Tor | Shaffer | Promoted to active roster | | | Before |
| 9/4/2015 | Tor | Wada | Promoted to active roster | | | Before |
| 9/7/2015 | Bos | Hader | Promoted to active roster | | | Before |
| 9/7/2015 | Bos | Hudson,T | Promoted to active roster | | | Before |
| 9/7/2015 | Bos | Karns | Promoted to active roster | | | Before |
| 9/7/2015 | Bos | Masterson | Released | | | Before |
| 9/7/2015 | Bos | Montas | Promoted to active roster | | | Before |
| 9/7/2015 | Bos | Springer | Promoted to active roster | | | Before |
| 9/7/2015 | CHW | Schebler | Signed | | | Before |
| 9/7/2015 | CHW | Yates | Released | | | Before |
| 9/7/2015 | Det | Ramirez,H | Demoted to reserve roster | | | Before |
| 9/7/2015 | Det | Tovar | Demoted to reserve roster | | | Before |
| 9/7/2015 | KC | Conger | Promoted to active roster | | | Before |
| 9/7/2015 | KC | Crawford,C | Promoted to active roster | | | Before |
| 9/7/2015 | KC | Gregerson | Promoted to active roster | | | Before |
| 9/7/2015 | KC | Hicks,A | Promoted to active roster | | | Before |
| 9/7/2015 | KC | Johnson,C | Promoted to active roster | | | Before |
| 9/7/2015 | KC | Reed,Ad | Promoted to active roster | | | Before |
| 9/7/2015 | NYY | Foltynewicz | Demoted to reserve roster | | | Before |
| 9/7/2015 | Tex | Freese | Promoted to active roster | | | Before |
| 9/7/2015 | Tex | Gordon,A | Promoted to active roster | | | Before |
| 9/7/2015 | Tor | Gonzalez,MAng | Released | | | Before |
| 9/7/2015 | Tor | Happ | Signed | | | Before |
| 9/7/2015 | Tor | Hernandez,E | Demoted to reserve roster | | | Before |
| 9/11/2015 | Min | Boyer | Released | | | Before |
| 9/11/2015 | Min | Montgomery,Ma | Signed | | | Before |
| 9/14/2015 | Bal | Carrasco | Promoted to active roster | | | Before |
| 9/14/2015 | Bal | Cordell | Promoted to active roster | | | Before |
| 9/14/2015 | Bal | Fernandez,J | Promoted to active roster | | | Before |
| 9/14/2015 | Bal | Jenkins,T | Promoted to active roster | | | Before |
| 9/14/2015 | Bal | Paulino,D | Promoted to active roster | | | Before |
| 9/14/2015 | Bal | Soriano,R | Promoted to active roster | | | Before |
| 9/14/2015 | Bal | Starling | Promoted to active roster | | | Before |
| 9/14/2015 | Bos | Miller,Ju | Signed | | | Before |
| 9/14/2015 | Cle | Liriano,R | Promoted to active roster | | | Before |
| 9/14/2015 | Cle | Urshela | Demoted to reserve roster | | | Before |
| 9/14/2015 | Det | Storen | Demoted to reserve roster | | | Before |
| 9/14/2015 | Min | Austin | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Gibson,K | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Kepler | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Montgomery,Ma | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Panik | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Rosario,E | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Turner,S | Promoted to active roster | | | Before |
| 9/14/2015 | Min | Wilson,Br | Demoted to reserve roster | | | Before |
| 9/14/2015 | Min | Winkler | Promoted to active roster | | | Before |
| 9/18/2015 | Bal | Stanley | Released | | | Before |
| 9/18/2015 | Bos | Hader | Demoted to reserve roster | | | Before |
| 9/18/2015 | Bos | Karns | Demoted to reserve roster | | | Before |
| 9/18/2015 | Bos | Karns | Promoted to active roster | | | Before |
| 9/18/2015 | Bos | Matzek | Demoted to reserve roster | | | Before |
| 9/18/2015 | Bos | Montas | Demoted to reserve roster | | | Before |
| 9/18/2015 | CHW | Elias | Released | | | Before |
| 9/18/2015 | CHW | Wilson,T | Signed | | | Before |
| 9/18/2015 | Cle | Jordan | Released | | | Before |
| 9/18/2015 | Cle | Worley | Signed | | | Before |
| 9/18/2015 | Oak | Hembree | Signed | | | Before |
| 9/18/2015 | Oak | Olt | Released | | | Before |
| 9/18/2015 | Oak | Olt | Signed | | | Before |
| 9/18/2015 | Tor | Happ | Promoted to active roster | | | Before |
| 9/21/2015 | CHW | Garcia,W | Released | | | Before |
| 9/21/2015 | CHW | Olt | Signed | | | Before |
| 9/21/2015 | Cle | Cosart | Promoted to active roster | | | Before |
| 9/21/2015 | Cle | Urshela | Demoted to reserve roster | | | Before |
| 9/21/2015 | Cle | Urshela | Promoted to active roster | | | Before |
| 9/21/2015 | Min | Castro,J | Promoted to active roster | | | Before |
| 9/21/2015 | Min | Logan | Promoted to active roster | | | Before |
| 9/21/2015 | Min | Moran | Promoted to active roster | | | Before |
| 9/21/2015 | Min | Norris,Da | Promoted to active roster | | | Before |
| 9/21/2015 | Min | Panik | Demoted to reserve roster | | | Before |
| 9/21/2015 | Min | Soler | Promoted to active roster | | | Before |
| 9/21/2015 | Oak | Simon | Released | | | Before |
| 9/21/2015 | Tor | Kang,J | Demoted to reserve roster | | | Before |
| 9/25/2015 | Bos | Burnett,A | Released | | | Before |
| 9/25/2015 | Bos | Clevinger | Signed | | | Before |
| 9/25/2015 | Bos | Cotts | Released | | | Before |
| 9/25/2015 | Bos | Hoyt | Signed | | | Before |
| 9/25/2015 | Bos | Hudson,T | Released | | | Before |
| 9/25/2015 | Bos | Johnson,D | Released | | | Before |
| 9/25/2015 | CHW | Cole,A | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Collins,Ty | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Davies,Z | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Johnson,Er | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Olt | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Pena,B | Released | | | Before |
| 9/25/2015 | CHW | Romero,A | Released | | | Before |
| 9/25/2015 | CHW | Schebler | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Wagner,T | Promoted to active roster | | | Before |
| 9/25/2015 | CHW | Wilson,T | Promoted to active roster | | | Before |
| 9/28/2015 | Bos | Rodriguez,Fe | Released | | | Before |
| 9/28/2015 | CHW | Almonte,A | Signed | | | Before |
| 9/28/2015 | CHW | Collins,Ty | Released | | | Before |
| 9/28/2015 | CHW | Cotts | Signed | | | Before |
| 9/28/2015 | CHW | Thielbar | Released | | | Before |
| 10/2/2015 | Det | Russell,J | Released | | | Before |
| 10/2/2015 | LAA | Cahill | Signed | | | Before |
| 10/2/2015 | LAA | Dominguez,J | Released | | | Before |
| 10/2/2015 | Min | Bumgarner | Demoted to reserve roster | | | Before |
| 10/2/2015 | Min | McCullers | Promoted to active roster | | | Before |
| 10/2/2015 | Min | Richards | Demoted to reserve roster | | | Before |
| 10/2/2015 | Min | Syndergaard | Demoted to reserve roster | | | Before |
| 10/2/2015 | Min | Wacha | Demoted to reserve roster | | | Before |
| 10/2/2015 | Oak | Toscano | Released | | | Before |
| 10/2/2015 | Tex | Black,R | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tex | Chirinos | Promoted to active roster | | | Before |
| 10/2/2015 | Tex | Cuthbert | Promoted to active roster | | | Before |
| 10/2/2015 | Tex | Dickerson,A | Promoted to active roster | | | Before |
| 10/2/2015 | Tex | Odor | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tex | Romo | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tex | Russell,Add | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tex | Ventura | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tex | Wieters | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tor | Andriese | Demoted to reserve roster | | | Before |
| 10/2/2015 | Tor | Happ | Demoted to reserve roster | | | Before |
| 10/6/2015 | Det | Aoki | Demoted to reserve roster | | | Before |
| 10/6/2015 | Det | Seager,C | Demoted to reserve roster | | | Before |
| 10/6/2015 | Det | Seager,C | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Barnes,M | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Bumgarner | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Gibson,K | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Joseph,T | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Joseph,T | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Joseph,T | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Kepler | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | McCullers | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Montgomery,Ma | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Moran | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Moran | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Norris,Da | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Richards | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Richards | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Richards | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Rosario,E | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Smith Jr. | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Smith Jr. | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Syndergaard | Promoted to active roster | | | Before |
| 10/6/2015 | Min | Turner,S | Demoted to reserve roster | | | Before |
| 10/6/2015 | Min | Winkler | Demoted to reserve roster | | | Before |
