| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/30/2013 | Det | Morse | Traded away | NYN | | After |
| 3/30/2013 | Det | Pierre | Acquired via trade | NYN | | After |
| 3/30/2013 | Det | Sanchez,AA | Acquired via trade | NYN | | After |
| 4/2/2013 | Bal | Adrianza | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Beckham,T | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Bethancourt | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Blanks | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Brentz | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Britton,Z | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Carrasco | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Mahtook | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Matusz | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | McNutt | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Mendez | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Smoak | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Stewart,Z | Demoted to reserve roster | | | Before |
| 4/2/2013 | Bal | Zunino | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Carp | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Dickerson,Co | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Happ | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Hunter,Tom | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Marshall,B | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Marshall,E | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Martinez,Fr | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Morban | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Morris,H | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Nava | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Sogard | Demoted to reserve roster | | | Before |
| 4/2/2013 | Cle | Wallace | Demoted to reserve roster | | | Before |
| 4/2/2013 | NYA | Jeter | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Amarista | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Bray | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Castro,Si | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Florimon | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | LaMarre | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Mier | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Morris,B | Demoted to reserve roster | | | Before |
| 4/2/2013 | Tam | Spruill | Demoted to reserve roster | | | Before |
| 4/4/2013 | LAA | Bundy | Demoted to reserve roster | | | Before |
| 4/4/2013 | LAA | Mendoza | Promoted to active roster | | | Before |
| 4/4/2013 | Tam | McCann | Demoted to reserve roster | | | Before |
| 4/5/2013 | Cle | Rolen | Demoted to reserve roster | | | Before |
| 4/7/2013 | Bos | Bruce | Traded away | Cin | | After |
| 4/7/2013 | Bos | Kimbrel | Acquired via trade | Cin | | After |
| 4/7/2013 | Bos | Oliver,B | Acquired via trade | Cin | | After |
| 4/7/2013 | Bos | Valdes | Traded away | Cin | | After |
| 4/7/2013 | Det | Maldonado,M | Traded away | LAA | | After |
| 4/7/2013 | Det | Sipp | Traded away | LAA | | After |
| 4/7/2013 | Det | Viciedo | Acquired via trade | LAA | | After |
| 4/7/2013 | KC | Crain | Traded away | Atl | | After |
| 4/7/2013 | KC | Lester | Traded away | Atl | | After |
| 4/7/2013 | KC | Pedroia | Acquired via trade | Atl | | After |
| 4/7/2013 | KC | Plouffe | Traded away | Atl | | After |
| 4/7/2013 | LAA | Maldonado,M | Acquired via trade | Det | | After |
| 4/7/2013 | LAA | Sipp | Acquired via trade | Det | | After |
| 4/7/2013 | LAA | Viciedo | Traded away | Det | | After |
| 4/7/2013 | Tam | Madson | Demoted to reserve roster | | | Before |
| 4/8/2013 | Det | Luetge | Signed | | | Before |
| 4/8/2013 | Hou | Ludwick | Demoted to reserve roster | | | Before |
| 4/8/2013 | Hou | Moore,T | Promoted to active roster | | | Before |
| 4/8/2013 | KC | Bauer | Promoted to active roster | | | Before |
| 4/8/2013 | KC | Kelly,J | Promoted to active roster | | | Before |
| 4/8/2013 | LAA | Chen,C | Demoted to reserve roster | | | Before |
| 4/8/2013 | LAA | Sipp | Promoted to active roster | | | Before |
| 4/8/2013 | Oak | Crawford,B | Demoted to reserve roster | | | Before |
| 4/8/2013 | Oak | Curtis,J | Signed | | | Before |
| 4/8/2013 | Oak | Curtis,J | Promoted to active roster | | | Before |
| 4/8/2013 | Oak | House | Promoted to active roster | | | Before |
| 4/8/2013 | Oak | Owings,M | Signed | | | Before |
| 4/8/2013 | Oak | Roberts,B | Released | | | Before |
| 4/8/2013 | Oak | Rondon,H | Demoted to reserve roster | | | Before |
| 4/8/2013 | Tam | Florimon | Released | | | Before |
| 4/8/2013 | Tam | Polanco | Signed | | | Before |
| 4/8/2013 | Tam | Santos,S | Demoted to reserve roster | | | Before |
| 4/8/2013 | Tam | Snyder,C | Signed | | | Before |
| 4/8/2013 | Tex | Pina | Signed | | | Before |
| 4/8/2013 | Tex | Rogers,E | Released | | | Before |
| 4/8/2013 | Tor | Escobar,Y | Demoted to reserve roster | | | Before |
| 4/8/2013 | Tor | Johnson,D | Promoted to active roster | | | Before |
| 4/8/2013 | Tor | Johnson,Re | Released | | | Before |
| 4/12/2013 | Bos | Fujikawa | Demoted to reserve roster | | | Before |
| 4/12/2013 | Bos | Wells,V | Promoted to active roster | | | Before |
| 4/14/2013 | NYA | Olt | Traded away | Cin | | After |
| 4/14/2013 | NYA | Webster | Acquired via trade | Cin | | After |
| 4/14/2013 | Tam | Dominguez,M | Acquired via trade | Cin | | After |
| 4/14/2013 | Tam | Graham,JR | Traded away | Cin | | After |
| 4/15/2013 | Bos | Hanrahan | Demoted to reserve roster | | | Before |
| 4/15/2013 | Bos | Valle | Promoted to active roster | | | Before |
| 4/15/2013 | ChA | Beckham,G | Demoted to reserve roster | | | Before |
| 4/15/2013 | ChA | Escobar,Edu | Signed | | | Before |
| 4/15/2013 | ChA | Escobar,Edu | Promoted to active roster | | | Before |
| 4/15/2013 | Det | Moreland | Demoted to reserve roster | | | Before |
| 4/15/2013 | Det | Realmuto | Promoted to active roster | | | Before |
| 4/15/2013 | Hou | Martinez,C | Demoted to reserve roster | | | Before |
| 4/15/2013 | Hou | Veras | Promoted to active roster | | | Before |
| 4/15/2013 | NYA | Roberts,B | Signed | | | Before |
| 4/15/2013 | Oak | Blanco,G | Demoted to reserve roster | | | Before |
| 4/15/2013 | Oak | Moss | Demoted to reserve roster | | | Before |
| 4/15/2013 | Oak | Owings,M | Promoted to active roster | | | Before |
| 4/15/2013 | Oak | Ross,C | Promoted to active roster | | | Before |
| 4/15/2013 | Sea | Jepsen | Demoted to reserve roster | | | Before |
| 4/15/2013 | Sea | Ottavino | Promoted to active roster | | | Before |
| 4/15/2013 | Tam | Castro,Si | Promoted to active roster | | | Before |
| 4/15/2013 | Tam | Cooper | Demoted to reserve roster | | | Before |
| 4/15/2013 | Tam | Dayton | Signed | | | Before |
| 4/15/2013 | Tam | Dayton | Promoted to active roster | | | Before |
| 4/15/2013 | Tam | Spruill | Promoted to active roster | | | Before |
| 4/15/2013 | Tam | Torres,C | Signed | | | Before |
| 4/15/2013 | Tam | Torres,C | Promoted to active roster | | | Before |
| 4/15/2013 | Tam | Weaver | Demoted to reserve roster | | | Before |
| 4/15/2013 | Tor | Chirinos | Signed | | | Before |
| 4/15/2013 | Tor | Chirinos | Promoted to active roster | | | Before |
| 4/15/2013 | Tor | Johnson,D | Demoted to reserve roster | | | Before |
| 4/18/2013 | Oak | Moss | Promoted to active roster | | | Before |
| 4/18/2013 | Oak | Owings,M | Demoted to reserve roster | | | Before |
| 4/21/2013 | Bos | Ortiz,D | Promoted to active roster | | | Before |
| 4/21/2013 | Bos | Zimmerman | Demoted to reserve roster | | | Before |
| 4/21/2013 | ChA | Pressly | Promoted to active roster | | | Before |
| 4/21/2013 | ChA | Quentin | Demoted to reserve roster | | | Before |
| 4/21/2013 | Oak | Miller,C | Signed | | | Before |
| 4/21/2013 | Tex | Bourn | Demoted to reserve roster | | | Before |
| 4/21/2013 | Tex | Sweeney,R | Signed | | | Before |
| 4/21/2013 | Tor | Escobar,Y | Demoted to reserve roster | | | Before |
| 4/21/2013 | Tor | Escobar,Y | Promoted to active roster | | | Before |
| 4/21/2013 | Tor | Fields,JDe | Demoted to reserve roster | | | Before |
| 4/21/2013 | Tor | Fields,JDe | Promoted to active roster | | | Before |
| 4/21/2013 | Tor | Johnson,D | Promoted to active roster | | | Before |
| 4/21/2013 | Tor | Martinez,JD | Demoted to reserve roster | | | Before |
| 4/26/2013 | Det | Barney | Promoted to active roster | | | Before |
| 4/26/2013 | Det | Jones,G | Demoted to reserve roster | | | Before |
| 4/26/2013 | Det | Jones,G | Promoted to active roster | | | Before |
| 4/26/2013 | Det | Moreland | Promoted to active roster | | | Before |
| 4/26/2013 | Det | Roberts,R | Demoted to reserve roster | | | Before |
| 4/26/2013 | Det | Viciedo | Demoted to reserve roster | | | Before |
| 4/28/2013 | Det | Choice | Acquired via trade | Was | | After |
| 4/28/2013 | Det | Head | Traded away | Was | | After |
| 4/28/2013 | Det | Santana,Do | Traded away | Was | | After |
| 4/29/2013 | Bos | Valle | Released | | | Before |
| 4/29/2013 | ChA | Escobar,Edu | Demoted to reserve roster | | | Before |
| 4/29/2013 | ChA | Headley | Promoted to active roster | | | Before |
| 4/29/2013 | ChA | Pressly | Demoted to reserve roster | | | Before |
| 4/29/2013 | ChA | Quentin | Promoted to active roster | | | Before |
| 4/29/2013 | Det | Choice | Demoted to reserve roster | | | Before |
| 4/29/2013 | Det | Tolleson,Sh | Signed | | | Before |
| 4/29/2013 | Hou | Gutierrez,F | Demoted to reserve roster | | | Before |
| 4/29/2013 | Hou | Paredes | Promoted to active roster | | | Before |
| 4/29/2013 | LAA | Beltre,E | Promoted to active roster | | | Before |
| 4/29/2013 | LAA | Chen,C | Demoted to reserve roster | | | Before |
| 4/29/2013 | LAA | Chen,C | Promoted to active roster | | | Before |
| 4/29/2013 | LAA | Myers,B | Demoted to reserve roster | | | Before |
| 4/29/2013 | LAA | Perez,O | Promoted to active roster | | | Before |
| 4/29/2013 | LAA | Torres,Al | Demoted to reserve roster | | | Before |
| 4/29/2013 | Min | Forsythe | Demoted to reserve roster | | | Before |
| 4/29/2013 | Min | Forsythe | Promoted to active roster | | | Before |
| 4/29/2013 | Min | Gregorius | Demoted to reserve roster | | | Before |
| 4/29/2013 | Min | Gregorius | Promoted to active roster | | | Before |
| 4/29/2013 | Min | Romero,E | Demoted to reserve roster | | | Before |
| 4/29/2013 | Min | Romero,E | Promoted to active roster | | | Before |
| 4/29/2013 | Min | Singleton | Demoted to reserve roster | | | Before |
| 4/29/2013 | Min | Singleton | Promoted to active roster | | | Before |
| 4/29/2013 | NYA | Carrera | Promoted to active roster | | | Before |
| 4/29/2013 | NYA | Valverde | Promoted to active roster | | | Before |
| 4/29/2013 | Tam | Tuiasosopo | Signed | | | Before |
| 4/29/2013 | Tor | Chirinos | Demoted to reserve roster | | | Before |
| 4/29/2013 | Tor | Escobar,Y | Promoted to active roster | | | Before |
| 4/29/2013 | Tor | Maxwell | Demoted to reserve roster | | | Before |
| 4/29/2013 | Tor | Maxwell | Promoted to active roster | | | Before |
| 4/29/2013 | Tor | Maxwell | Demoted to reserve roster | | | Before |
| 4/29/2013 | Tor | Ruiz | Promoted to active roster | | | Before |
| 4/29/2013 | Tor | Semien | Signed | | | Before |
| 5/1/2013 | Oak | Helton | Demoted to reserve roster | | | Before |
| 5/1/2013 | Oak | Miller,C | Promoted to active roster | | | Before |
| 5/1/2013 | Oak | Owings,M | Promoted to active roster | | | Before |
| 5/1/2013 | Oak | Sanchez,H | Demoted to reserve roster | | | Before |
| 5/2/2013 | Sea | Cabrera,As | Traded away | Tam | | After |
| 5/2/2013 | Sea | Ellsbury | Acquired via trade | Tam | | After |
| 5/2/2013 | Sea | Jepsen | Traded away | Tam | | After |
| 5/2/2013 | Sea | Madson | Acquired via trade | Tam | | After |
| 5/2/2013 | Tam | Cabrera,As | Acquired via trade | Sea | | After |
| 5/2/2013 | Tam | Ellsbury | Traded away | Sea | | After |
| 5/2/2013 | Tam | Jepsen | Acquired via trade | Sea | | After |
| 5/2/2013 | Tam | Madson | Traded away | Sea | | After |
| 5/3/2013 | ChA | Niemann | Released | | | Before |
| 5/3/2013 | ChA | Pressly | Released | | | Before |
| 5/3/2013 | Det | Joseph,Co | Signed | | | Before |
| 5/3/2013 | Det | Tolleson,Sh | Released | | | Before |
| 5/3/2013 | NYA | Roberts,B | Released | | | Before |
| 5/3/2013 | NYA | Valencia | Signed | | | Before |
| 5/3/2013 | Sea | Gonzalez,S | Signed | | | Before |
| 5/3/2013 | Sea | Gonzalez,S | Promoted to active roster | | | Before |
| 5/3/2013 | Sea | Santiago,R | Released | | | Before |
| 5/3/2013 | Sea | Sherrill | Demoted to reserve roster | | | Before |
| 5/3/2013 | Sea | Sherrill | Promoted to active roster | | | Before |
| 5/3/2013 | Tex | Chirinos | Signed | | | Before |
| 5/3/2013 | Tex | Pina | Released | | | Before |
| 5/3/2013 | Tor | Chirinos | Released | | | Before |
| 5/3/2013 | Tor | de la Rosa,D | Signed | | | Before |
| 5/5/2013 | Bal | Bochy | Acquired via trade | Det | | After |
| 5/5/2013 | Bal | Kendrick,K | Traded away | Det | | After |
| 5/5/2013 | Det | Bochy | Traded away | Bal | | After |
| 5/5/2013 | Det | Kendrick,K | Acquired via trade | Bal | | After |
| 5/5/2013 | Det | Moreland | Traded away | Ari | | After |
| 5/5/2013 | NYA | Dirks | Traded away | Pit | | After |
| 5/5/2013 | NYA | Kemp | Acquired via trade | Pit | | After |
| 5/5/2013 | NYA | Mauer | Traded away | Pit | | After |
| 5/5/2013 | NYA | Valverde | Traded away | Pit | | After |
| 5/6/2013 | Bos | Zimmerman | Promoted to active roster | | | Before |
| 5/6/2013 | Det | Joseph,Co | Promoted to active roster | | | Before |
| 5/6/2013 | Det | Luetge | Promoted to active roster | | | Before |
| 5/6/2013 | Det | Roberts,R | Promoted to active roster | | | Before |
| 5/6/2013 | Det | Walker,N | Demoted to reserve roster | | | Before |
| 5/6/2013 | Det | Wright,W | Demoted to reserve roster | | | Before |
| 5/6/2013 | KC | Chamberlain | Demoted to reserve roster | | | Before |
| 5/6/2013 | KC | Decker | Promoted to active roster | | | Before |
| 5/6/2013 | LAA | Beltre,E | Demoted to reserve roster | | | Before |
| 5/6/2013 | LAA | Bourjos | Demoted to reserve roster | | | Before |
| 5/6/2013 | LAA | Pill | Signed | | | Before |
| 5/6/2013 | LAA | Pill | Promoted to active roster | | | Before |
| 5/6/2013 | LAA | Rivera,J | Promoted to active roster | | | Before |
| 5/6/2013 | Min | Gregorius | Promoted to active roster | | | Before |
| 5/6/2013 | Min | Romero,E | Demoted to reserve roster | | | Before |
| 5/6/2013 | NYA | Carrera | Demoted to reserve roster | | | Before |
| 5/6/2013 | NYA | Lutz,D | Promoted to active roster | | | Before |
| 5/6/2013 | NYA | Sanchez,Gar | Promoted to active roster | | | Before |
| 5/6/2013 | NYA | Valencia | Promoted to active roster | | | Before |
| 5/6/2013 | NYA | Webster | Demoted to reserve roster | | | Before |
| 5/6/2013 | NYA | Webster | Promoted to active roster | | | Before |
| 5/6/2013 | NYA | Youkilis | Demoted to reserve roster | | | Before |
| 5/6/2013 | Tex | Chirinos | Promoted to active roster | | | Before |
| 5/6/2013 | Tex | Sweeney,R | Promoted to active roster | | | Before |
| 5/6/2013 | Tex | Young,CB | Demoted to reserve roster | | | Before |
| 5/6/2013 | Tor | Bernadina | Signed | | | Before |
| 5/6/2013 | Tor | Bernadina | Promoted to active roster | | | Before |
| 5/6/2013 | Tor | Crisp | Demoted to reserve roster | | | Before |
| 5/6/2013 | Tor | de la Rosa,D | Released | | | Before |
| 5/6/2013 | Tor | Escobar,Y | Demoted to reserve roster | | | Before |
| 5/6/2013 | Tor | Escobar,Y | Promoted to active roster | | | Before |
| 5/6/2013 | Tor | Escobar,Y | Demoted to reserve roster | | | Before |
| 5/6/2013 | Tor | Mustelier | Promoted to active roster | | | Before |
| 5/7/2013 | Cle | Hill,A | Demoted to reserve roster | | | Before |
| 5/7/2013 | Cle | Sogard | Promoted to active roster | | | Before |
| 5/7/2013 | Oak | Helton | Promoted to active roster | | | Before |
| 5/7/2013 | Oak | Stanton | Demoted to reserve roster | | | Before |
| 5/9/2013 | Det | Newby | Signed | | | Before |
| 5/9/2013 | Det | Shaw,T | Released | | | Before |
| 5/9/2013 | Hou | Lotzkar | Released | | | Before |
| 5/9/2013 | KC | Decker | Released | | | Before |
| 5/9/2013 | KC | Wright,J | Signed | | | Before |
| 5/9/2013 | KC | Wright,J | Promoted to active roster | | | Before |
| 5/9/2013 | LAA | Torreyes | Signed | | | Before |
| 5/9/2013 | Min | Dozier | Signed | | | Before |
| 5/9/2013 | Min | Harrison,M | Acquired via trade | Cin | | After |
| 5/9/2013 | Min | LaRoche,Ad | Traded away | Cin | | After |
| 5/9/2013 | Min | Young,Mi | Traded away | Cin | | After |
| 5/9/2013 | NYA | Machi | Signed | | | Before |
| 5/9/2013 | Tam | Tuiasosopo | Released | | | Before |
| 5/9/2013 | Tex | Mercer | Signed | | | Before |
| 5/10/2013 | Cle | Zambrano | Demoted to reserve roster | | | Before |
| 5/12/2013 | Oak | Blackley | Acquired via trade | Cin | | After |
| 5/12/2013 | Oak | Vogelsong | Traded away | Cin | | After |
| 5/13/2013 | Bal | Gonzalez,E | Released | | | Before |
| 5/13/2013 | Bal | Outman | Signed | | | Before |
| 5/13/2013 | Bos | Werth | Demoted to reserve roster | | | Before |
| 5/13/2013 | Det | Pestano | Demoted to reserve roster | | | Before |
| 5/13/2013 | Det | Roberts,R | Demoted to reserve roster | | | Before |
| 5/13/2013 | Det | Viciedo | Promoted to active roster | | | Before |
| 5/13/2013 | Min | Dozier | Released | | | Before |
| 5/13/2013 | Min | Gomes,B | Demoted to reserve roster | | | Before |
| 5/13/2013 | Min | Hairston,J | Demoted to reserve roster | | | Before |
| 5/13/2013 | Min | Overbay | Signed | | | Before |
| 5/13/2013 | Min | Overbay | Promoted to active roster | | | Before |
| 5/13/2013 | Min | Romero,E | Promoted to active roster | | | Before |
| 5/13/2013 | NYA | Halladay | Demoted to reserve roster | | | Before |
| 5/13/2013 | NYA | Machi | Released | | | Before |
| 5/13/2013 | NYA | Webster | Promoted to active roster | | | Before |
| 5/13/2013 | Sea | Brown,G | Demoted to reserve roster | | | Before |
| 5/13/2013 | Sea | Sherrill | Promoted to active roster | | | Before |
| 5/13/2013 | Tam | Bray | Promoted to active roster | | | Before |
| 5/13/2013 | Tam | Davis,R | Demoted to reserve roster | | | Before |
| 5/13/2013 | Tam | Floyd | Demoted to reserve roster | | | Before |
| 5/13/2013 | Tam | Hudson,O | Demoted to reserve roster | | | Before |
| 5/13/2013 | Tam | McCann | Promoted to active roster | | | Before |
| 5/13/2013 | Tam | Morris,B | Promoted to active roster | | | Before |
| 5/13/2013 | Tex | Bourn | Promoted to active roster | | | Before |
| 5/13/2013 | Tor | Fields,JDe | Promoted to active roster | | | Before |
| 5/13/2013 | Tor | Martinez,JD | Promoted to active roster | | | Before |
| 5/13/2013 | Tor | Pierzynski | Demoted to reserve roster | | | Before |
| 5/14/2013 | LAA | Ayala | Demoted to reserve roster | | | Before |
| 5/16/2013 | Bos | Fields,D | Signed | | | Before |
| 5/16/2013 | ChA | Cloyd | Signed | | | Before |
| 5/16/2013 | ChA | Cloyd | Promoted to active roster | | | Before |
| 5/16/2013 | ChA | McDonald,Ja | Demoted to reserve roster | | | Before |
| 5/16/2013 | ChA | Rogers,M | Released | | | Before |
| 5/16/2013 | Det | Dempster | Acquired via trade | Sea | | After |
| 5/16/2013 | Det | Estrada | Traded away | Sea | | After |
| 5/16/2013 | Det | Lindstrom | Traded away | Sea | | After |
| 5/16/2013 | Det | Madson | Acquired via trade | Sea | | After |
| 5/16/2013 | Det | Swisher | Acquired via trade | Sea | | After |
| 5/16/2013 | Det | Viciedo | Traded away | Sea | | After |
| 5/16/2013 | KC | Beavan | Released | | | Before |
| 5/16/2013 | KC | Clevenger | Demoted to reserve roster | | | Before |
| 5/16/2013 | KC | Horst | Demoted to reserve roster | | | Before |
| 5/16/2013 | KC | Bradley,Je | Traded away | Was | | After |
| 5/16/2013 | KC | Cutler | Acquired via trade | Was | | After |
| 5/16/2013 | KC | Horst | Acquired via trade | Was | | After |
| 5/16/2013 | KC | O'Neill | Acquired via trade | Was | | After |
| 5/16/2013 | LAA | Torres,Al | Promoted to active roster | | | Before |
| 5/16/2013 | Min | de Vries | Released | | | Before |
| 5/16/2013 | Min | Laird,B | Signed | | | Before |
| 5/16/2013 | Min | Laird,B | Promoted to active roster | | | Before |
| 5/16/2013 | NYA | Adams,Mi | Traded away | ChN | | After |
| 5/16/2013 | NYA | Grimm | Acquired via trade | ChN | | After |
| 5/16/2013 | NYA | Hanson | Traded away | ChN | | After |
| 5/16/2013 | NYA | Youkilis | Traded away | ChN | | After |
| 5/16/2013 | Oak | Blackley | Promoted to active roster | | | Before |
| 5/16/2013 | Oak | Blanco,G | Demoted to reserve roster | | | Before |
| 5/16/2013 | Oak | Blanco,G | Promoted to active roster | | | Before |
| 5/16/2013 | Oak | Coke | Demoted to reserve roster | | | Before |
| 5/16/2013 | Oak | Ellis,M | Demoted to reserve roster | | | Before |
| 5/16/2013 | Oak | Marcum | Promoted to active roster | | | Before |
| 5/16/2013 | Oak | Turner,Ju | Signed | | | Before |
| 5/16/2013 | Oak | Turner,Ju | Promoted to active roster | | | Before |
| 5/16/2013 | Sea | Paxton | Demoted to reserve roster | | | Before |
| 5/16/2013 | Sea | Dempster | Traded away | Det | | After |
| 5/16/2013 | Sea | Estrada | Acquired via trade | Det | | After |
| 5/16/2013 | Sea | Lindstrom | Acquired via trade | Det | | After |
| 5/16/2013 | Sea | Madson | Traded away | Det | | After |
| 5/16/2013 | Sea | Paxton | Acquired via trade | Was | | After |
| 5/16/2013 | Sea | Swisher | Traded away | Det | | After |
| 5/16/2013 | Sea | Viciedo | Acquired via trade | Det | | After |
| 5/16/2013 | Tam | Dayton | Released | | | Before |
| 5/16/2013 | Tam | Matsuzaka | Demoted to reserve roster | | | Before |
| 5/16/2013 | Tam | Polanco | Promoted to active roster | | | Before |
| 5/16/2013 | Tam | Runzler | Signed | | | Before |
| 5/16/2013 | Tor | Fields,JDe | Demoted to reserve roster | | | Before |
| 5/18/2013 | Cle | Francisco,F | Demoted to reserve roster | | | Before |
| 5/19/2013 | Det | Duensing | Signed | | | Before |
| 5/19/2013 | Det | Luetge | Released | | | Before |
| 5/19/2013 | KC | Burnett,S | Acquired via trade | Pit | | After |
| 5/19/2013 | KC | Cain,M | Traded away | Pit | | After |
| 5/19/2013 | KC | Colon,C | Traded away | Pit | | After |
| 5/19/2013 | KC | Iwakuma | Acquired via trade | Pit | | After |
| 5/19/2013 | KC | Lombardozzi | Traded away | Pit | | After |
| 5/19/2013 | KC | Zobrist | Acquired via trade | Pit | | After |
| 5/19/2013 | Sea | Medlen | Traded away | Cin | | After |
| 5/19/2013 | Sea | Olt | Acquired via trade | Cin | | After |
| 5/19/2013 | Sea | Stammen | Traded away | Cin | | After |
| 5/19/2013 | Tex | McKenry | Signed | | | Before |
| 5/20/2013 | Bos | Fields,D | Promoted to active roster | | | Before |
| 5/20/2013 | Bos | Northcraft | Promoted to active roster | | | Before |
| 5/20/2013 | Bos | Price | Demoted to reserve roster | | | Before |
| 5/20/2013 | ChA | Escobar,Edu | Promoted to active roster | | | Before |
| 5/20/2013 | ChA | Ross,D | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Dempster | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Duensing | Promoted to active roster | | | Before |
| 5/20/2013 | Det | Montero,R | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Montero,R | Promoted to active roster | | | Before |
| 5/20/2013 | Det | Newby | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Newby | Promoted to active roster | | | Before |
| 5/20/2013 | Det | Newby | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Newby | Promoted to active roster | | | Before |
| 5/20/2013 | Det | Pestano | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Pestano | Promoted to active roster | | | Before |
| 5/20/2013 | Det | Pestano | Promoted to active roster | | | Before |
| 5/20/2013 | Det | Pierre | Demoted to reserve roster | | | Before |
| 5/20/2013 | Det | Walker,N | Promoted to active roster | | | Before |
| 5/20/2013 | Hou | Breslow | Promoted to active roster | | | Before |
| 5/20/2013 | Hou | Gomes,Y | Promoted to active roster | | | Before |
| 5/20/2013 | Hou | Pettitte | Demoted to reserve roster | | | Before |
| 5/20/2013 | Hou | Walden | Demoted to reserve roster | | | Before |
| 5/20/2013 | KC | Gorzelanny | Demoted to reserve roster | | | Before |
| 5/20/2013 | KC | Horst | Promoted to active roster | | | Before |
| 5/20/2013 | Min | Jackson,A | Demoted to reserve roster | | | Before |
| 5/20/2013 | NYA | Ahmed | Promoted to active roster | | | Before |
| 5/20/2013 | NYA | Carrera | Promoted to active roster | | | Before |
| 5/20/2013 | NYA | Grimm | Promoted to active roster | | | Before |
| 5/20/2013 | NYA | Nunez,E | Demoted to reserve roster | | | Before |
| 5/20/2013 | NYA | Perez,R | Promoted to active roster | | | Before |
| 5/20/2013 | Sea | Lindstrom | Promoted to active roster | | | Before |
| 5/20/2013 | Sea | Paxton | Promoted to active roster | | | Before |
| 5/20/2013 | Tor | Bernadina | Demoted to reserve roster | | | Before |
| 5/20/2013 | Tor | Capuano | Promoted to active roster | | | Before |
| 5/20/2013 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 5/20/2013 | Tor | Crisp | Promoted to active roster | | | Before |
| 5/20/2013 | Tor | Escobar,Y | Promoted to active roster | | | Before |
| 5/20/2013 | Tor | Freitas | Signed | | | Before |
| 5/20/2013 | Tor | Granderson | Promoted to active roster | | | Before |
| 5/20/2013 | Tor | Johnson,D | Demoted to reserve roster | | | Before |
| 5/20/2013 | Tor | Kelly,T | Demoted to reserve roster | | | Before |
| 5/21/2013 | Tex | Beckett | Demoted to reserve roster | | | Before |
| 5/21/2013 | Tex | Ogando | Demoted to reserve roster | | | Before |
| 5/23/2013 | ChA | Volquez | Acquired via trade | Ari | | After |
| 5/23/2013 | Det | Butler,B | Acquired via trade | Tam | | After |
| 5/23/2013 | Det | Gallardo | Traded away | Tam | | After |
| 5/23/2013 | NYA | Grimm | Traded away | Was | | After |
| 5/23/2013 | NYA | Hechavarria | Acquired via trade | Was | | After |
| 5/23/2013 | NYA | Marisnick | Acquired via trade | Was | | After |
| 5/23/2013 | NYA | Romine,Au | Traded away | Was | | After |
| 5/23/2013 | Sea | Medina | Acquired via trade | Ari | | After |
| 5/23/2013 | Sea | Mijares | Traded away | Ari | | After |
| 5/23/2013 | Sea | Pryor | Acquired via trade | Ari | | After |
| 5/23/2013 | Tam | Butler,B | Traded away | Det | | After |
| 5/23/2013 | Tam | Gallardo | Acquired via trade | Det | | After |
| 5/24/2013 | ChA | Belfiore | Demoted to reserve roster | | | Before |
| 5/24/2013 | ChA | Edgin | Signed | | | Before |
| 5/24/2013 | ChA | Edgin | Promoted to active roster | | | Before |
| 5/24/2013 | ChA | Irwin | Released | | | Before |
| 5/24/2013 | ChA | Irwin | Signed | | | Before |
| 5/24/2013 | ChA | Magill | Demoted to reserve roster | | | Before |
| 5/24/2013 | ChA | Volquez | Promoted to active roster | | | Before |
| 5/24/2013 | Det | Barney | Demoted to reserve roster | | | Before |
| 5/24/2013 | Det | Dempster | Promoted to active roster | | | Before |
| 5/24/2013 | NYA | Ahmed | Demoted to reserve roster | | | Before |
| 5/24/2013 | Sea | Danks,JC | Released | | | Before |
| 5/24/2013 | Tor | Bernadina | Released | | | Before |
| 5/24/2013 | Tor | Burgos | Released | | | Before |
| 5/27/2013 | Bos | Victorino | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Aceves | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Aceves | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Capps,M | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Carp | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Dickerson,Co | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Dickerson,Co | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Dickerson,Co | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Dickerson,Co | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Hill,A | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Hill,A | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Hunter,Tom | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Morban | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Morban | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Nava | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Reimold | Demoted to reserve roster | | | Before |
| 5/27/2013 | Cle | Rolen | Released | | | Before |
| 5/27/2013 | Cle | Wallace | Promoted to active roster | | | Before |
| 5/27/2013 | Cle | Zambrano | Promoted to active roster | | | Before |
| 5/27/2013 | Det | Dempster | Demoted to reserve roster | | | Before |
| 5/27/2013 | Det | Dempster | Promoted to active roster | | | Before |
| 5/27/2013 | Det | Grandal | Promoted to active roster | | | Before |
| 5/27/2013 | Det | Newby | Released | | | Before |
| 5/27/2013 | Det | Realmuto | Demoted to reserve roster | | | Before |
| 5/27/2013 | KC | Burnett,S | Promoted to active roster | | | Before |
| 5/27/2013 | KC | Casilla,S | Demoted to reserve roster | | | Before |
| 5/27/2013 | KC | Gorzelanny | Promoted to active roster | | | Before |
| 5/27/2013 | KC | Horst | Demoted to reserve roster | | | Before |
| 5/27/2013 | NYA | Ahmed | Promoted to active roster | | | Before |
| 5/27/2013 | NYA | Marisnick | Demoted to reserve roster | | | Before |
| 5/27/2013 | Oak | Bonderman | Signed | | | Before |
| 5/27/2013 | Oak | Hendriks | Released | | | Before |
| 5/27/2013 | Oak | Tuiasosopo | Signed | | | Before |
| 5/27/2013 | Oak | Turner,Ju | Released | | | Before |
| 5/27/2013 | Tex | Utley | Demoted to reserve roster | | | Before |
| 5/27/2013 | Tex | Young,CB | Promoted to active roster | | | Before |
| 5/27/2013 | Tor | Black | Promoted to active roster | | | Before |
| 5/27/2013 | Tor | Camp | Demoted to reserve roster | | | Before |
| 5/27/2013 | Tor | Capuano | Demoted to reserve roster | | | Before |
| 5/27/2013 | Tor | Capuano | Promoted to active roster | | | Before |
| 5/27/2013 | Tor | Escobar,Y | Demoted to reserve roster | | | Before |
| 5/27/2013 | Tor | Freitas | Promoted to active roster | | | Before |
| 5/27/2013 | Tor | Granderson | Demoted to reserve roster | | | Before |
| 5/27/2013 | Tor | Johnson,D | Promoted to active roster | | | Before |
| 5/27/2013 | Tor | Pierzynski | Promoted to active roster | | | Before |
| 5/27/2013 | Tor | Ruiz | Demoted to reserve roster | | | Before |
| 5/28/2013 | Cle | Nava | Demoted to reserve roster | | | Before |
| 5/28/2013 | Cle | Nava | Promoted to active roster | | | Before |
| 5/28/2013 | Cle | Reimold | Demoted to reserve roster | | | Before |
| 5/28/2013 | Det | Duensing | Demoted to reserve roster | | | Before |
| 5/28/2013 | Det | Wright,W | Promoted to active roster | | | Before |
| 5/29/2013 | Cle | Rolen | Released | | | Before |
| 5/29/2013 | Det | Duensing | Promoted to active roster | | | Before |
| 5/29/2013 | Det | Jones,G | Demoted to reserve roster | | | Before |
| 5/31/2013 | Bal | Elbert | Demoted to reserve roster | | | Before |
| 5/31/2013 | Oak | Bonderman | Released | | | Before |
| 5/31/2013 | Oak | Bonderman | Signed | | | Before |
| 5/31/2013 | Oak | Crosby | Released | | | Before |
| 5/31/2013 | Oak | Kluber | Signed | | | Before |
| 5/31/2013 | Tex | Braden | Released | | | Before |
| 5/31/2013 | Tor | Black | Demoted to reserve roster | | | Before |
| 5/31/2013 | Tor | Quackenbush | Promoted to active roster | | | Before |
| 6/2/2013 | Cle | Konerko | Traded away | NYA | | After |
| 6/2/2013 | NYA | Konerko | Acquired via trade | Cle | | After |
| 6/3/2013 | Bos | Davis,W | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Fields,D | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Karns | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Karns | Promoted to active roster | | | Before |
| 6/3/2013 | Bos | Lilly | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Lilly | Promoted to active roster | | | Before |
| 6/3/2013 | Bos | Lilly | Promoted to active roster | | | Before |
| 6/3/2013 | Bos | Northcraft | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Oliver,B | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Ortiz,D | Demoted to reserve roster | | | Before |
| 6/3/2013 | Bos | Ortiz,D | Promoted to active roster | | | Before |
| 6/3/2013 | Cle | Capps,M | Released | | | Before |
| 6/3/2013 | Cle | Cardenas | Demoted to reserve roster | | | Before |
| 6/3/2013 | Cle | Dickerson,Co | Promoted to active roster | | | Before |
| 6/3/2013 | Cle | Francisco,J | Signed | | | Before |
| 6/3/2013 | Cle | Francisco,J | Promoted to active roster | | | Before |
| 6/3/2013 | Cle | Gomez,J | Demoted to reserve roster | | | Before |
| 6/3/2013 | Cle | Marshall,B | Promoted to active roster | | | Before |
| 6/3/2013 | Cle | Marshall,E | Released | | | Before |
| 6/3/2013 | Cle | Martinez,Fr | Released | | | Before |
| 6/3/2013 | Hou | Veras | Demoted to reserve roster | | | Before |
| 6/3/2013 | Hou | Walden | Promoted to active roster | | | Before |
| 6/3/2013 | KC | Burnett,S | Demoted to reserve roster | | | Before |
| 6/3/2013 | KC | Chamberlain | Promoted to active roster | | | Before |
| 6/3/2013 | KC | Morrow | Demoted to reserve roster | | | Before |
| 6/3/2013 | KC | Wright,J | Promoted to active roster | | | Before |
| 6/3/2013 | Min | Hairston,J | Promoted to active roster | | | Before |
| 6/3/2013 | Min | Singleton | Promoted to active roster | | | Before |
| 6/3/2013 | NYA | Harper | Demoted to reserve roster | | | Before |
| 6/3/2013 | NYA | Kemp | Demoted to reserve roster | | | Before |
| 6/3/2013 | NYA | Marisnick | Promoted to active roster | | | Before |
| 6/3/2013 | NYA | Newby | Signed | | | Before |
| 6/3/2013 | NYA | Newby | Promoted to active roster | | | Before |
| 6/3/2013 | Oak | Bonderman | Promoted to active roster | | | Before |
| 6/3/2013 | Oak | Ellis,M | Promoted to active roster | | | Before |
| 6/3/2013 | Oak | McCarthy | Demoted to reserve roster | | | Before |
| 6/3/2013 | Oak | Rondon,H | Promoted to active roster | | | Before |
| 6/3/2013 | Oak | Street | Demoted to reserve roster | | | Before |
| 6/3/2013 | Tam | Jepsen | Promoted to active roster | | | Before |
| 6/3/2013 | Tam | Morris,B | Demoted to reserve roster | | | Before |
| 6/3/2013 | Tam | Snyder,C | Demoted to reserve roster | | | Before |
| 6/3/2013 | Tam | Weaver | Promoted to active roster | | | Before |
| 6/3/2013 | Tor | Gonzalez,Mig | Promoted to active roster | | | Before |
| 6/3/2013 | Tor | Kelly,T | Promoted to active roster | | | Before |
| 6/3/2013 | Tor | Lutz,Z | Demoted to reserve roster | | | Before |
| 6/3/2013 | Tor | Perez,C | Demoted to reserve roster | | | Before |
| 6/6/2013 | Cle | Berkman | Traded away | Oak | | After |
| 6/6/2013 | Cle | Thatcher | Traded away | Det | | After |
| 6/6/2013 | Det | Thatcher | Acquired via trade | Cle | | After |
| 6/6/2013 | Hou | Arenado | Acquired via trade | Phi | | After |
| 6/6/2013 | Hou | Austin | Acquired via trade | Phi | | After |
| 6/6/2013 | Hou | Dolis | Traded away | Phi | | After |
| 6/6/2013 | Hou | Donaldson | Traded away | Phi | | After |
| 6/6/2013 | Hou | Feldman | Traded away | Phi | | After |
| 6/6/2013 | Oak | Berkman | Acquired via trade | Cle | | After |
| 6/7/2013 | ChA | Beckham,G | Promoted to active roster | | | Before |
| 6/7/2013 | ChA | Cloyd | Demoted to reserve roster | | | Before |
| 6/7/2013 | ChA | Danks,JW | Promoted to active roster | | | Before |
| 6/7/2013 | ChA | Giavotella | Demoted to reserve roster | | | Before |
| 6/7/2013 | ChA | Phegley | Demoted to reserve roster | | | Before |
| 6/7/2013 | ChA | Ross,D | Promoted to active roster | | | Before |
| 6/7/2013 | Cle | Cardenas | Released | | | Before |
| 6/7/2013 | Det | Barnhart | Signed | | | Before |
| 6/7/2013 | Det | Roberts,R | Released | | | Before |
| 6/7/2013 | Det | Saunders,J | Released | | | Before |
| 6/7/2013 | Oak | Helton | Demoted to reserve roster | | | Before |
| 6/7/2013 | Tam | Ruffin | Signed | | | Before |
| 6/7/2013 | Tor | Capuano | Demoted to reserve roster | | | Before |
| 6/7/2013 | Tor | Ortiz,J | Released | | | Before |
| 6/7/2013 | Tor | Otero | Signed | | | Before |
| 6/7/2013 | Tor | Otero | Promoted to active roster | | | Before |
| 6/10/2013 | Bal | Alonso | Demoted to reserve roster | | | Before |
| 6/10/2013 | Bos | Fields,D | Demoted to reserve roster | | | Before |
| 6/10/2013 | Bos | Fields,D | Promoted to active roster | | | Before |
| 6/10/2013 | Bos | Karns | Demoted to reserve roster | | | Before |
| 6/10/2013 | Bos | Karns | Promoted to active roster | | | Before |
| 6/10/2013 | Bos | Oliver,B | Demoted to reserve roster | | | Before |
| 6/10/2013 | Bos | Victorino | Promoted to active roster | | | Before |
| 6/10/2013 | Bos | Werth | Promoted to active roster | | | Before |
| 6/10/2013 | ChA | Cloyd | Promoted to active roster | | | Before |
| 6/10/2013 | ChA | Gilmartin | Demoted to reserve roster | | | Before |
| 6/10/2013 | ChA | Magill | Promoted to active roster | | | Before |
| 6/10/2013 | ChA | Peavy | Demoted to reserve roster | | | Before |
| 6/10/2013 | ChA | Phegley | Promoted to active roster | | | Before |
| 6/10/2013 | ChA | Sanchez,C | Demoted to reserve roster | | | Before |
| 6/10/2013 | Cle | Morban | Promoted to active roster | | | Before |
| 6/10/2013 | Cle | Morris,H | Promoted to active roster | | | Before |
| 6/10/2013 | Cle | Wallace | Demoted to reserve roster | | | Before |
| 6/10/2013 | Det | Barney | Promoted to active roster | | | Before |
| 6/10/2013 | Det | Joseph,Co | Released | | | Before |
| 6/10/2013 | Det | Valbuena | Signed | | | Before |
| 6/10/2013 | Det | Wright,W | Demoted to reserve roster | | | Before |
| 6/10/2013 | Hou | Gomes,Y | Demoted to reserve roster | | | Before |
| 6/10/2013 | Hou | Pettitte | Promoted to active roster | | | Before |
| 6/10/2013 | Min | Forsythe | Promoted to active roster | | | Before |
| 6/10/2013 | Min | Romero,E | Demoted to reserve roster | | | Before |
| 6/10/2013 | NYA | Betancourt,R | Demoted to reserve roster | | | Before |
| 6/10/2013 | NYA | Marte,A | Promoted to active roster | | | Before |
| 6/10/2013 | Oak | Bonderman | Released | | | Before |
| 6/10/2013 | Oak | Saunders,J | Signed | | | Before |
| 6/10/2013 | Oak | Saunders,J | Promoted to active roster | | | Before |
| 6/10/2013 | Sea | Estrada | Demoted to reserve roster | | | Before |
| 6/10/2013 | Sea | Gee | Promoted to active roster | | | Before |
| 6/10/2013 | Sea | Guerra,J | Demoted to reserve roster | | | Before |
| 6/10/2013 | Sea | Olt | Promoted to active roster | | | Before |
| 6/10/2013 | Sea | Ramirez,Er | Promoted to active roster | | | Before |
| 6/10/2013 | Sea | Worley | Promoted to active roster | | | Before |
| 6/10/2013 | Tam | Cabrera,As | Demoted to reserve roster | | | Before |
| 6/10/2013 | Tam | Davis,R | Promoted to active roster | | | Before |
| 6/10/2013 | Tam | Hudson,O | Released | | | Before |
| 6/10/2013 | Tex | Ogando | Promoted to active roster | | | Before |
| 6/10/2013 | Tex | Ramirez,Ha | Promoted to active roster | | | Before |
| 6/10/2013 | Tor | Fedroff | Released | | | Before |
| 6/14/2013 | Cle | Duvall | Signed | | | Before |
| 6/14/2013 | Cle | Duvall | Demoted to reserve roster | | | Before |
| 6/14/2013 | Cle | Duvall | Promoted to active roster | | | Before |
| 6/14/2013 | Cle | Francisco,F | Released | | | Before |
| 6/14/2013 | Cle | Kobernus | Signed | | | Before |
| 6/14/2013 | Cle | Kobernus | Promoted to active roster | | | Before |
| 6/14/2013 | Cle | Wallace | Released | | | Before |
| 6/14/2013 | Hou | Guillon | Released | | | Before |
| 6/14/2013 | Hou | Wallace | Signed | | | Before |
| 6/17/2013 | Bos | DeJesus,D | Demoted to reserve roster | | | Before |
| 6/17/2013 | Bos | Lilly | Released | | | Before |
| 6/17/2013 | Bos | Oliver,B | Promoted to active roster | | | Before |
| 6/17/2013 | Bos | Reynolds,MP | Demoted to reserve roster | | | Before |
| 6/17/2013 | Cle | Aceves | Released | | | Before |
| 6/17/2013 | Cle | Crosby | Signed | | | Before |
| 6/17/2013 | Cle | Crosby | Promoted to active roster | | | Before |
| 6/17/2013 | Cle | Duvall | Demoted to reserve roster | | | Before |
| 6/17/2013 | Cle | Duvall | Promoted to active roster | | | Before |
| 6/17/2013 | Cle | Happ | Released | | | Before |
| 6/17/2013 | Cle | Marshall,B | Released | | | Before |
| 6/17/2013 | Cle | Rincon | Signed | | | Before |
| 6/17/2013 | Cle | Rincon | Promoted to active roster | | | Before |
| 6/17/2013 | Det | Dempster | Demoted to reserve roster | | | Before |
| 6/17/2013 | Det | Diamond | Promoted to active roster | | | Before |
| 6/17/2013 | LAA | Bourjos | Promoted to active roster | | | Before |
| 6/17/2013 | LAA | Soto,N | Demoted to reserve roster | | | Before |
| 6/17/2013 | Min | Jackson,A | Promoted to active roster | | | Before |
| 6/17/2013 | Min | Joseph,T | Demoted to reserve roster | | | Before |
| 6/17/2013 | NYA | Berry | Released | | | Before |
| 6/17/2013 | Oak | Blanco,G | Released | | | Before |
| 6/17/2013 | Oak | Bonderman | Signed | | | Before |
| 6/17/2013 | Oak | Owings,M | Released | | | Before |
| 6/17/2013 | Oak | Santiago,H | Demoted to reserve roster | | | Before |
| 6/17/2013 | Oak | Stanton | Promoted to active roster | | | Before |
| 6/17/2013 | Oak | Street | Promoted to active roster | | | Before |
| 6/17/2013 | Sea | Sandoval,P | Demoted to reserve roster | | | Before |
| 6/17/2013 | Tex | Ogando | Demoted to reserve roster | | | Before |
| 6/17/2013 | Tor | Camp | Promoted to active roster | | | Before |
| 6/17/2013 | Tor | Johnson,D | Demoted to reserve roster | | | Before |
| 6/17/2013 | Tor | Lutz,Z | Promoted to active roster | | | Before |
| 6/17/2013 | Tor | Otero | Demoted to reserve roster | | | Before |
| 6/20/2013 | Cle | Lake | Acquired via trade | Phi | | After |
| 6/20/2013 | Cle | Rivero,F | Acquired via trade | Phi | | After |
| 6/21/2013 | Cle | Carp | Released | | | Before |
| 6/21/2013 | Cle | Duvall | Promoted to active roster | | | Before |
| 6/21/2013 | Cle | Hunter,Tom | Released | | | Before |
| 6/21/2013 | Cle | Lake | Promoted to active roster | | | Before |
| 6/21/2013 | Cle | Rincon | Demoted to reserve roster | | | Before |
| 6/21/2013 | Cle | Rivero,F | Promoted to active roster | | | Before |
| 6/21/2013 | Tor | Fields,JDe | Released | | | Before |
| 6/24/2013 | ChA | Belfiore | Promoted to active roster | | | Before |
| 6/24/2013 | ChA | Ross,D | Demoted to reserve roster | | | Before |
| 6/24/2013 | Cle | Avilan | Signed | | | Before |
| 6/24/2013 | Cle | Avilan | Promoted to active roster | | | Before |
| 6/24/2013 | Cle | Duvall | Demoted to reserve roster | | | Before |
| 6/24/2013 | Det | Holmberg | Promoted to active roster | | | Before |
| 6/24/2013 | Det | Sanchez,AA | Demoted to reserve roster | | | Before |
| 6/24/2013 | Det | Valbuena | Demoted to reserve roster | | | Before |
| 6/24/2013 | Det | Valbuena | Promoted to active roster | | | Before |
| 6/24/2013 | LAA | Cobb | Demoted to reserve roster | | | Before |
| 6/24/2013 | LAA | Niese | Demoted to reserve roster | | | Before |
| 6/24/2013 | LAA | Pimentel | Promoted to active roster | | | Before |
| 6/24/2013 | LAA | Soto,N | Promoted to active roster | | | Before |
| 6/24/2013 | Oak | Coke | Promoted to active roster | | | Before |
| 6/24/2013 | Oak | Vargas,J | Demoted to reserve roster | | | Before |
| 6/24/2013 | Tor | Capuano | Promoted to active roster | | | Before |
| 6/24/2013 | Tor | Freitas | Demoted to reserve roster | | | Before |
| 6/24/2013 | Tor | Gonzalez,Mig | Demoted to reserve roster | | | Before |
| 6/24/2013 | Tor | Martinez,JD | Demoted to reserve roster | | | Before |
| 6/24/2013 | Tor | Maxwell | Promoted to active roster | | | Before |
| 6/24/2013 | Tor | Ruiz | Promoted to active roster | | | Before |
| 6/25/2013 | Bal | Avila | Demoted to reserve roster | | | Before |
| 6/25/2013 | KC | Buchholz | Demoted to reserve roster | | | Before |
| 6/25/2013 | KC | Matzek | Promoted to active roster | | | Before |
| 6/27/2013 | KC | Nova | Acquired via trade | Cin | | After |
| 6/27/2013 | KC | Pennington | Traded away | Cin | | After |
| 6/28/2013 | Cle | Cisnero | Signed | | | Before |
| 6/28/2013 | Cle | Cisnero | Promoted to active roster | | | Before |
| 6/28/2013 | Cle | Crosby | Released | | | Before |
| 6/28/2013 | Det | Blanco,G | Signed | | | Before |
| 6/28/2013 | Det | Blanco,G | Promoted to active roster | | | Before |
| 6/28/2013 | Det | Pierre | Released | | | Before |
| 6/28/2013 | Det | Revere | Demoted to reserve roster | | | Before |
| 6/28/2013 | Min | Jurrjens | Signed | | | Before |
| 6/28/2013 | NYA | Lee,Ch | Signed | | | Before |
| 6/28/2013 | NYA | Lutz,D | Released | | | Before |
| 6/30/2013 | NYA | Hamilton,B | Acquired via trade | Cin | | After |
| 6/30/2013 | NYA | Hamilton,J | Traded away | Cin | | After |
| 7/1/2013 | Cle | Gomez,J | Promoted to active roster | | | Before |
| 7/1/2013 | Cle | Hill,A | Promoted to active roster | | | Before |
| 7/1/2013 | Cle | Kobernus | Demoted to reserve roster | | | Before |
| 7/1/2013 | Cle | Zambrano | Demoted to reserve roster | | | Before |
| 7/1/2013 | KC | Haren | Demoted to reserve roster | | | Before |
| 7/1/2013 | KC | Liddi | Promoted to active roster | | | Before |
| 7/1/2013 | KC | Nova | Promoted to active roster | | | Before |
| 7/1/2013 | NYA | Betancourt,R | Promoted to active roster | | | Before |
| 7/1/2013 | NYA | Kemp | Promoted to active roster | | | Before |
| 7/1/2013 | Tam | Amarista | Promoted to active roster | | | Before |
| 7/1/2013 | Tam | Cabrera,As | Demoted to reserve roster | | | Before |
| 7/1/2013 | Tam | Cabrera,As | Promoted to active roster | | | Before |
| 7/1/2013 | Tam | Spruill | Demoted to reserve roster | | | Before |
| 7/4/2013 | Cle | Gearrin | Traded away | Atl | | After |
| 7/4/2013 | Oak | Sandoval,P | Acquired via trade | Sea | | After |
| 7/4/2013 | Sea | Sandoval,P | Traded away | Oak | | After |
| 7/4/2013 | Tam | Cabrera,Me | Demoted to reserve roster | | | Before |
| 7/5/2013 | Bos | Byrdak | Signed | | | Before |
| 7/5/2013 | Bos | Fife | Signed | | | Before |
| 7/5/2013 | Cle | Blazek | Signed | | | Before |
| 7/5/2013 | Cle | Blazek | Promoted to active roster | | | Before |
| 7/5/2013 | Cle | Dickerson,Co | Demoted to reserve roster | | | Before |
| 7/5/2013 | Cle | Kohn | Signed | | | Before |
| 7/5/2013 | Cle | Kohn | Promoted to active roster | | | Before |
| 7/5/2013 | Cle | Zambrano | Released | | | Before |
| 7/5/2013 | Det | Dempster | Promoted to active roster | | | Before |
| 7/5/2013 | Det | Diamond | Demoted to reserve roster | | | Before |
| 7/5/2013 | Oak | Abreu,T | Signed | | | Before |
| 7/5/2013 | Oak | Bonderman | Released | | | Before |
| 7/5/2013 | Oak | Curtis,J | Released | | | Before |
| 7/5/2013 | Oak | Sandoval,P | Promoted to active roster | | | Before |
| 7/5/2013 | Sea | Sherrill | Released | | | Before |
| 7/5/2013 | Tex | McKenry | Released | | | Before |
| 7/5/2013 | Tex | Villarreal,B | Released | | | Before |
| 7/7/2013 | Bos | Jackson,E | Acquired via trade | Cle | | After |
| 7/7/2013 | Bos | Northcraft | Traded away | Cle | | After |
| 7/7/2013 | Cle | Jackson,E | Traded away | Bos | | After |
| 7/7/2013 | Cle | Northcraft | Acquired via trade | Bos | | After |
| 7/7/2013 | Det | Gordon,A | Traded away | Tex | | After |
| 7/7/2013 | Det | Jennings,De | Acquired via trade | Tex | | After |
| 7/7/2013 | Tex | Gordon,A | Acquired via trade | Det | | After |
| 7/7/2013 | Tex | Jennings,De | Traded away | Det | | After |
| 7/7/2013 | Tex | Utley | Traded away | Pit | | After |
| 7/7/2013 | Tex | Wood,Tr | Acquired via trade | Pit | | After |
| 7/8/2013 | Bos | Byrdak | Promoted to active roster | | | Before |
| 7/8/2013 | Bos | Davis,W | Demoted to reserve roster | | | Before |
| 7/8/2013 | Bos | Price | Promoted to active roster | | | Before |
| 7/8/2013 | Det | Dempster | Demoted to reserve roster | | | Before |
| 7/8/2013 | Det | Sanchez,AA | Promoted to active roster | | | Before |
| 7/8/2013 | LAA | Bourjos | Demoted to reserve roster | | | Before |
| 7/8/2013 | LAA | Chen,C | Promoted to active roster | | | Before |
| 7/8/2013 | NYA | Marte,A | Released | | | Before |
| 7/8/2013 | Tex | Drew | Demoted to reserve roster | | | Before |
| 7/8/2013 | Tex | Sweeney,R | Demoted to reserve roster | | | Before |
| 7/8/2013 | Tex | Willingham | Demoted to reserve roster | | | Before |
| 7/8/2013 | Tor | Escobar,Y | Promoted to active roster | | | Before |
| 7/8/2013 | Tor | Johnson,D | Promoted to active roster | | | Before |
| 7/8/2013 | Tor | Maxwell | Demoted to reserve roster | | | Before |
| 7/8/2013 | Tor | Mustelier | Demoted to reserve roster | | | Before |
| 7/8/2013 | Tor | Perez,C | Promoted to active roster | | | Before |
| 7/8/2013 | Tor | Quackenbush | Demoted to reserve roster | | | Before |
| 7/9/2013 | NYA | Harper | Promoted to active roster | | | Before |
| 7/9/2013 | NYA | Konerko | Demoted to reserve roster | | | Before |
| 7/11/2013 | Cle | Altuve | Acquired via trade | Sea | | After |
| 7/11/2013 | Cle | Dickerson,Co | Traded away | Sea | | After |
| 7/11/2013 | Cle | Doumit | Traded away | Cin | | After |
| 7/11/2013 | Cle | Hill,A | Traded away | Sea | | After |
| 7/11/2013 | Cle | Jaso | Traded away | Det | | After |
| 7/11/2013 | Cle | Realmuto | Acquired via trade | Det | | After |
| 7/11/2013 | Cle | Rios | Traded away | Det | | After |
| 7/11/2013 | Cle | van Slyke | Acquired via trade | Cin | | After |
| 7/11/2013 | Det | Jaso | Acquired via trade | Cle | | After |
| 7/11/2013 | Det | Realmuto | Traded away | Cle | | After |
| 7/11/2013 | Det | Rios | Acquired via trade | Cle | | After |
| 7/11/2013 | Sea | Altuve | Traded away | Cle | | After |
| 7/11/2013 | Sea | Dickerson,Co | Acquired via trade | Cle | | After |
| 7/11/2013 | Sea | Hill,A | Acquired via trade | Cle | | After |
| 7/12/2013 | Cle | Cabrera,R | Released | | | Before |
| 7/12/2013 | Cle | Cabrera,R | Signed | | | Before |
| 7/12/2013 | Cle | Cabrera,R | Promoted to active roster | | | Before |
| 7/12/2013 | Cle | Duvall | Released | | | Before |
| 7/12/2013 | Cle | Lagares | Signed | | | Before |
| 7/12/2013 | Cle | Lagares | Promoted to active roster | | | Before |
| 7/12/2013 | Cle | Realmuto | Promoted to active roster | | | Before |
| 7/12/2013 | Cle | van Slyke | Promoted to active roster | | | Before |
| 7/12/2013 | KC | Taylor,M | Signed | | | Before |
| 7/12/2013 | Min | Dozier | Signed | | | Before |
| 7/12/2013 | Min | Jurrjens | Released | | | Before |
| 7/12/2013 | Oak | Abreu,T | Released | | | Before |
| 7/12/2013 | Oak | Okajima | Released | | | Before |
| 7/12/2013 | Oak | Parra,M | Signed | | | Before |
| 7/12/2013 | Oak | Parra,M | Promoted to active roster | | | Before |
| 7/12/2013 | Sea | Krauss | Signed | | | Before |
| 7/14/2013 | KC | Axford | Traded away | Cin | | After |
| 7/14/2013 | KC | LaRoche,Ad | Acquired via trade | Cin | | After |
| 7/19/2013 | Bos | Barton | Released | | | Before |
| 7/19/2013 | Cle | Schafer,L | Signed | | | Before |
| 7/19/2013 | Cle | Sogard | Released | | | Before |
| 7/19/2013 | Det | Ames | Demoted to reserve roster | | | Before |
| 7/19/2013 | Det | Blanco,G | Demoted to reserve roster | | | Before |
| 7/19/2013 | Det | Blanco,G | Promoted to active roster | | | Before |
| 7/19/2013 | Det | Grandal | Demoted to reserve roster | | | Before |
| 7/19/2013 | Det | Valbuena | Promoted to active roster | | | Before |
| 7/19/2013 | Det | Walker,N | Demoted to reserve roster | | | Before |
| 7/19/2013 | LAA | Ayala | Promoted to active roster | | | Before |
| 7/19/2013 | LAA | Chen,C | Demoted to reserve roster | | | Before |
| 7/19/2013 | NYA | Jeter | Promoted to active roster | | | Before |
| 7/19/2013 | NYA | Kemp | Demoted to reserve roster | | | Before |
| 7/19/2013 | Oak | Berkman | Demoted to reserve roster | | | Before |
| 7/19/2013 | Oak | Helton | Promoted to active roster | | | Before |
| 7/19/2013 | Oak | Marcum | Demoted to reserve roster | | | Before |
| 7/19/2013 | Oak | Santiago,H | Promoted to active roster | | | Before |
| 7/19/2013 | Tex | Darvish | Demoted to reserve roster | | | Before |
| 7/19/2013 | Tex | Siegrist | Promoted to active roster | | | Before |
| 7/19/2013 | Tor | Bogusevic | Signed | | | Before |
| 7/19/2013 | Tor | Chen,W | Promoted to active roster | | | Before |
| 7/19/2013 | Tor | Fiers | Demoted to reserve roster | | | Before |
| 7/19/2013 | Tor | Johnson,D | Demoted to reserve roster | | | Before |
| 7/19/2013 | Tor | Maxwell | Promoted to active roster | | | Before |
| 7/19/2013 | Tor | Watkins | Released | | | Before |
| 7/20/2013 | KC | Casilla,S | Promoted to active roster | | | Before |
| 7/20/2013 | KC | Matzek | Demoted to reserve roster | | | Before |
| 7/22/2013 | ChA | Giavotella | Released | | | Before |
| 7/22/2013 | ChA | Peavy | Promoted to active roster | | | Before |
| 7/22/2013 | ChA | Volquez | Demoted to reserve roster | | | Before |
| 7/22/2013 | Cle | Kobernus | Promoted to active roster | | | Before |
| 7/22/2013 | Cle | Morban | Demoted to reserve roster | | | Before |
| 7/22/2013 | Cle | Schafer,L | Promoted to active roster | | | Before |
| 7/22/2013 | NYA | Betancourt,R | Demoted to reserve roster | | | Before |
| 7/22/2013 | NYA | Jeter | Demoted to reserve roster | | | Before |
| 7/22/2013 | NYA | Nunez,E | Promoted to active roster | | | Before |
| 7/22/2013 | Sea | Guerra,J | Promoted to active roster | | | Before |
| 7/22/2013 | Sea | Rondon,B | Promoted to active roster | | | Before |
| 7/22/2013 | Sea | Worley | Demoted to reserve roster | | | Before |
| 7/24/2013 | ChA | Lee,Ch | Acquired via trade | NYA | | After |
| 7/24/2013 | Hou | Austin | Demoted to reserve roster | | | Before |
| 7/24/2013 | NYA | Lee,Ch | Released | | | Before |
| 7/24/2013 | NYA | Lee,Ch | Signed | | | Before |
| 7/24/2013 | NYA | Lee,Ch | Traded away | ChA | | After |
| 7/25/2013 | Bos | Lewis,C | Acquired via trade | StL | | After |
| 7/25/2013 | Bos | Salas | Acquired via trade | StL | | After |
| 7/25/2013 | Cle | Scutaro | Traded away | Hou | | After |
| 7/25/2013 | Hou | Pettitte | Traded away | NYA | | After |
| 7/25/2013 | Hou | Scutaro | Acquired via trade | Cle | | After |
| 7/25/2013 | NYA | Pettitte | Acquired via trade | Hou | | After |
| 7/26/2013 | Bos | Salas | Promoted to active roster | | | Before |
| 7/26/2013 | ChA | Gregerson | Demoted to reserve roster | | | Before |
| 7/26/2013 | ChA | Lee,Ch | Promoted to active roster | | | Before |
| 7/26/2013 | Cle | Morban | Promoted to active roster | | | Before |
| 7/26/2013 | Cle | Reimold | Released | | | Before |
| 7/26/2013 | KC | Giavotella | Signed | | | Before |
| 7/26/2013 | KC | Haren | Promoted to active roster | | | Before |
| 7/26/2013 | KC | Liddi | Released | | | Before |
| 7/28/2013 | Bos | Aviles | Acquired via trade | Min | | After |
| 7/28/2013 | Bos | Fields,D | Traded away | Min | | After |
| 7/28/2013 | Cle | Nava | Traded away | StL | | After |
| 7/28/2013 | Det | Plouffe | Acquired via trade | Atl | | After |
| 7/28/2013 | Det | Revere | Traded away | Atl | | After |
| 7/28/2013 | KC | Gattis | Acquired via trade | Phi | | After |
| 7/28/2013 | KC | Gorzelanny | Traded away | Phi | | After |
| 7/28/2013 | KC | Haren | Traded away | Phi | | After |
| 7/28/2013 | KC | Lyon | Traded away | Phi | | After |
| 7/28/2013 | KC | Maurer | Acquired via trade | Phi | | After |
| 7/28/2013 | KC | Phelps,D | Acquired via trade | Phi | | After |
| 7/28/2013 | LAA | Frieri | Traded away | Pit | | After |
| 7/28/2013 | LAA | Janssen | Traded away | Phi | | After |
| 7/28/2013 | LAA | Lyles | Acquired via trade | Phi | | After |
| 7/28/2013 | Min | Aviles | Traded away | Bos | | After |
| 7/28/2013 | Min | Fields,D | Acquired via trade | Bos | | After |
| 7/29/2013 | Bos | DeJesus,D | Promoted to active roster | | | Before |
| 7/29/2013 | Bos | Hudson,T | Demoted to reserve roster | | | Before |
| 7/29/2013 | ChA | Gilmartin | Promoted to active roster | | | Before |
| 7/29/2013 | ChA | Gregerson | Promoted to active roster | | | Before |
| 7/29/2013 | ChA | Lynn | Demoted to reserve roster | | | Before |
| 7/29/2013 | ChA | Magill | Demoted to reserve roster | | | Before |
| 7/29/2013 | ChA | Reed,A | Demoted to reserve roster | | | Before |
| 7/29/2013 | ChA | Volquez | Promoted to active roster | | | Before |
| 7/29/2013 | Cle | Adames | Signed | | | Before |
| 7/29/2013 | Cle | Adames | Promoted to active roster | | | Before |
| 7/29/2013 | Det | Barnhart | Promoted to active roster | | | Before |
| 7/29/2013 | Det | Jaso | Demoted to reserve roster | | | Before |
| 7/29/2013 | Det | Valbuena | Demoted to reserve roster | | | Before |
| 7/29/2013 | Det | Walker,N | Promoted to active roster | | | Before |
| 7/29/2013 | Hou | Alvarez,H | Promoted to active roster | | | Before |
| 7/29/2013 | Hou | Paredes | Demoted to reserve roster | | | Before |
| 7/29/2013 | Hou | Wallace | Promoted to active roster | | | Before |
| 7/29/2013 | KC | Giavotella | Promoted to active roster | | | Before |
| 7/29/2013 | KC | Maurer | Promoted to active roster | | | Before |
| 7/29/2013 | KC | Phelps,D | Promoted to active roster | | | Before |
| 7/29/2013 | Min | Dozier | Promoted to active roster | | | Before |
| 7/29/2013 | Min | Fields,D | Demoted to reserve roster | | | Before |
| 7/29/2013 | NYA | Konerko | Promoted to active roster | | | Before |
| 7/29/2013 | Sea | McAllister | Promoted to active roster | | | Before |
| 7/29/2013 | Sea | Ozuna | Demoted to reserve roster | | | Before |
| 7/29/2013 | Tex | Darvish | Promoted to active roster | | | Before |
| 7/29/2013 | Tex | Drew | Promoted to active roster | | | Before |
| 7/29/2013 | Tex | Ogando | Promoted to active roster | | | Before |
| 7/29/2013 | Tor | Bogusevic | Released | | | Before |
| 7/29/2013 | Tor | Gonzalez,Mig | Promoted to active roster | | | Before |
| 7/29/2013 | Tor | Maholm | Demoted to reserve roster | | | Before |
| 8/1/2013 | ChA | Arcia | Traded away | Was | | After |
| 8/1/2013 | ChA | Grimm | Acquired via trade | Was | | After |
| 8/1/2013 | ChA | Lagares | Acquired via trade | Cle | | After |
| 8/1/2013 | ChA | Martin,L | Traded away | Cle | | After |
| 8/1/2013 | ChA | Soriano,A | Acquired via trade | Cle | | After |
| 8/1/2013 | Cle | Lagares | Traded away | ChA | | After |
| 8/1/2013 | Cle | Martin,L | Acquired via trade | ChA | | After |
| 8/1/2013 | Cle | Soriano,A | Traded away | ChA | | After |
| 8/2/2013 | ChA | Belfiore | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Cloyd | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Danks,JW | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Edgin | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Escobar,Edu | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Escobar,Edu | Promoted to active roster | | | Before |
| 8/2/2013 | ChA | Grimm | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Lee,Ch | Demoted to reserve roster | | | Before |
| 8/2/2013 | ChA | Lee,Ch | Promoted to active roster | | | Before |
| 8/2/2013 | ChA | Lynn | Promoted to active roster | | | Before |
| 8/2/2013 | ChA | Magill | Promoted to active roster | | | Before |
| 8/2/2013 | ChA | Reed,A | Promoted to active roster | | | Before |
| 8/2/2013 | ChA | Sanchez,C | Released | | | Before |
| 8/2/2013 | ChA | Wilson,Br | Promoted to active roster | | | Before |
| 8/2/2013 | Cle | Adames | Released | | | Before |
| 8/2/2013 | Cle | Culberson | Signed | | | Before |
| 8/2/2013 | Cle | Gast | Signed | | | Before |
| 8/2/2013 | Cle | Hassan | Signed | | | Before |
| 8/2/2013 | Cle | Rincon | Released | | | Before |
| 8/2/2013 | Cle | Rusin | Signed | | | Before |
| 8/2/2013 | Cle | Schafer,L | Released | | | Before |
| 8/2/2013 | Det | Ames | Promoted to active roster | | | Before |
| 8/2/2013 | Det | Barney | Demoted to reserve roster | | | Before |
| 8/2/2013 | Det | Blanco,G | Demoted to reserve roster | | | Before |
| 8/2/2013 | Det | Jones,G | Promoted to active roster | | | Before |
| 8/2/2013 | Det | Kendrick,K | Demoted to reserve roster | | | Before |
| 8/2/2013 | Min | Laird,B | Released | | | Before |
| 8/2/2013 | Oak | Smith,W | Signed | | | Before |
| 8/2/2013 | Tex | Chirinos | Released | | | Before |
| 8/4/2013 | NYA | Marisnick | Traded away | Col | | After |
| 8/4/2013 | NYA | Sabathia | Traded away | Col | | After |
| 8/4/2013 | NYA | Wheeler,Za | Acquired via trade | Col | | After |
| 8/5/2013 | ChA | Danks,JW | Promoted to active roster | | | Before |
| 8/5/2013 | ChA | McDonald,Ja | Released | | | Before |
| 8/5/2013 | ChA | Peralta,W | Demoted to reserve roster | | | Before |
| 8/5/2013 | ChA | Ross,D | Released | | | Before |
| 8/5/2013 | Cle | Culberson | Promoted to active roster | | | Before |
| 8/5/2013 | Cle | Hafner | Demoted to reserve roster | | | Before |
| 8/5/2013 | Cle | Hassan | Promoted to active roster | | | Before |
| 8/5/2013 | Cle | Rusin | Promoted to active roster | | | Before |
| 8/5/2013 | Det | Jackson,R | Released | | | Before |
| 8/5/2013 | Det | Ross,D | Signed | | | Before |
| 8/5/2013 | KC | Taylor,M | Released | | | Before |
| 8/5/2013 | LAA | Rodriguez,HAlb | Demoted to reserve roster | | | Before |
| 8/5/2013 | Min | Dozier | Promoted to active roster | | | Before |
| 8/5/2013 | Min | Mazzoni | Demoted to reserve roster | | | Before |
| 8/5/2013 | Min | Romero,E | Promoted to active roster | | | Before |
| 8/5/2013 | NYA | Jeter | Promoted to active roster | | | Before |
| 8/5/2013 | NYA | Pujols | Demoted to reserve roster | | | Before |
| 8/5/2013 | Sea | Dickerson,Co | Promoted to active roster | | | Before |
| 8/5/2013 | Sea | Krauss | Promoted to active roster | | | Before |
| 8/5/2013 | Sea | Sanchez,T | Demoted to reserve roster | | | Before |
| 8/5/2013 | Tor | Chen,W | Demoted to reserve roster | | | Before |
| 8/5/2013 | Tor | Escobar,Y | Demoted to reserve roster | | | Before |
| 8/5/2013 | Tor | Granderson | Promoted to active roster | | | Before |
| 8/5/2013 | Tor | Johnson,D | Promoted to active roster | | | Before |
| 8/5/2013 | Tor | Kelly,T | Demoted to reserve roster | | | Before |
| 8/5/2013 | Tor | Mustelier | Promoted to active roster | | | Before |
| 8/6/2013 | Tam | Gallardo | Demoted to reserve roster | | | Before |
| 8/6/2013 | Tam | Miller,A | Demoted to reserve roster | | | Before |
| 8/8/2013 | Det | Wright,W | Traded away | Ari | | After |
| 8/8/2013 | KC | Gattis | Traded away | NYN | | After |
| 8/8/2013 | KC | Montero,M | Acquired via trade | NYN | | After |
| 8/8/2013 | NYA | Rivera,Ma | Traded away | Pit | | After |
| 8/9/2013 | Bos | Carpenter,D | Signed | | | Before |
| 8/9/2013 | Cle | Kohn | Released | | | Before |
| 8/9/2013 | Cle | Mercedes | Signed | | | Before |
| 8/9/2013 | Cle | Mercedes | Promoted to active roster | | | Before |
| 8/9/2013 | Cle | Santana,Da | Signed | | | Before |
| 8/9/2013 | Cle | Santana,Da | Promoted to active roster | | | Before |
| 8/9/2013 | KC | Cruz,N | Demoted to reserve roster | | | Before |
| 8/9/2013 | NYA | Berg,Je | Signed | | | Before |
| 8/9/2013 | NYA | Berg,Je | Promoted to active roster | | | Before |
| 8/9/2013 | Tor | Chen,W | Promoted to active roster | | | Before |
| 8/9/2013 | Tor | Johnson,D | Demoted to reserve roster | | | Before |
| 8/11/2013 | Bos | Carroll,J | Traded away | Phi | | After |
| 8/11/2013 | Cle | Altuve | Traded away | Det | | After |
| 8/11/2013 | Cle | Holmberg | Acquired via trade | Det | | After |
| 8/11/2013 | Det | Altuve | Acquired via trade | Cle | | After |
| 8/11/2013 | Det | Holmberg | Traded away | Cle | | After |
| 8/11/2013 | KC | Boxberger | Acquired via trade | Pit | | After |
| 8/11/2013 | KC | Brach | Acquired via trade | Pit | | After |
| 8/11/2013 | Min | Gonzalez,Mik | Traded away | Pit | | After |
| 8/12/2013 | Bos | Morton | Signed | | | Before |
| 8/12/2013 | ChA | Edgin | Released | | | Before |
| 8/12/2013 | ChA | Grimm | Promoted to active roster | | | Before |
| 8/12/2013 | ChA | Peralta,W | Promoted to active roster | | | Before |
| 8/12/2013 | ChA | Quentin | Demoted to reserve roster | | | Before |
| 8/12/2013 | ChA | Smith,W | Signed | | | Before |
| 8/12/2013 | ChA | Smith,W | Promoted to active roster | | | Before |
| 8/12/2013 | ChA | Volquez | Demoted to reserve roster | | | Before |
| 8/12/2013 | ChA | Wilson,Br | Demoted to reserve roster | | | Before |
| 8/12/2013 | Cle | Rusin | Released | | | Before |
| 8/12/2013 | Det | Blanco,G | Promoted to active roster | | | Before |
| 8/12/2013 | Det | Cain,L | Demoted to reserve roster | | | Before |
| 8/12/2013 | Det | Jennings,De | Demoted to reserve roster | | | Before |
| 8/12/2013 | Det | Montero,R | Promoted to active roster | | | Before |
| 8/12/2013 | KC | Boxberger | Promoted to active roster | | | Before |
| 8/12/2013 | KC | Maurer | Demoted to reserve roster | | | Before |
| 8/12/2013 | NYA | Jeter | Demoted to reserve roster | | | Before |
| 8/12/2013 | NYA | Rodriguez,Al | Promoted to active roster | | | Before |
| 8/12/2013 | NYA | Valencia | Released | | | Before |
| 8/12/2013 | Oak | McCarthy | Promoted to active roster | | | Before |
| 8/12/2013 | Oak | Miller,C | Demoted to reserve roster | | | Before |
| 8/12/2013 | Oak | Sanchez,H | Promoted to active roster | | | Before |
| 8/12/2013 | Oak | Santiago,H | Demoted to reserve roster | | | Before |
| 8/12/2013 | Oak | Smith,W | Released | | | Before |
| 8/12/2013 | Tex | Willingham | Promoted to active roster | | | Before |
| 8/12/2013 | Tor | Black | Promoted to active roster | | | Before |
| 8/12/2013 | Tor | Chen,B | Signed | | | Before |
| 8/12/2013 | Tor | Freitas | Released | | | Before |
| 8/12/2013 | Tor | Thornton | Demoted to reserve roster | | | Before |
| 8/13/2013 | Hou | Kendrick,H | Demoted to reserve roster | | | Before |
| 8/15/2013 | Cle | Morban | Traded away | Ari | | After |
| 8/15/2013 | Cle | Ross,T | Acquired via trade | Ari | | After |
| 8/15/2013 | Det | Niese | Acquired via trade | LAA | | After |
| 8/15/2013 | LAA | Niese | Traded away | Det | | After |
| 8/16/2013 | Bos | Byrdak | Released | | | Before |
| 8/16/2013 | Cle | Realmuto | Demoted to reserve roster | | | Before |
| 8/16/2013 | Cle | Robinson,D | Signed | | | Before |
| 8/16/2013 | Cle | Robinson,D | Promoted to active roster | | | Before |
| 8/16/2013 | Cle | Ross,T | Promoted to active roster | | | Before |
| 8/16/2013 | Det | Montero,R | Demoted to reserve roster | | | Before |
| 8/16/2013 | Det | Niese | Promoted to active roster | | | Before |
| 8/16/2013 | KC | Maurer | Promoted to active roster | | | Before |
| 8/16/2013 | KC | Phelps,D | Demoted to reserve roster | | | Before |
| 8/16/2013 | Oak | Molina,J | Signed | | | Before |
| 8/16/2013 | Tam | Dykstra | Signed | | | Before |
| 8/16/2013 | Tam | Mier | Released | | | Before |
| 8/18/2013 | Det | Ellsbury | Acquired via trade | Sea | | After |
| 8/18/2013 | Det | Estrada | Acquired via trade | Sea | | After |
| 8/18/2013 | Det | Montero,R | Traded away | Sea | | After |
| 8/18/2013 | Sea | Ellsbury | Traded away | Det | | After |
| 8/18/2013 | Sea | Estrada | Traded away | Det | | After |
| 8/18/2013 | Sea | Montero,R | Acquired via trade | Det | | After |
| 8/19/2013 | Bal | Anderson,La | Released | | | Before |
| 8/19/2013 | Bal | McNutt | Released | | | Before |
| 8/19/2013 | Bos | Carpenter,D | Promoted to active roster | | | Before |
| 8/19/2013 | Bos | Davis,W | Promoted to active roster | | | Before |
| 8/19/2013 | Cle | Hassan | Demoted to reserve roster | | | Before |
| 8/19/2013 | Cle | Realmuto | Promoted to active roster | | | Before |
| 8/19/2013 | Cle | Worley | Signed | | | Before |
| 8/19/2013 | Det | Jones,G | Demoted to reserve roster | | | Before |
| 8/19/2013 | Det | Madson | Released | | | Before |
| 8/19/2013 | Hou | Ludwick | Promoted to active roster | | | Before |
| 8/19/2013 | LAA | Bourjos | Promoted to active roster | | | Before |
| 8/19/2013 | LAA | Cobb | Promoted to active roster | | | Before |
| 8/19/2013 | NYA | Betancourt,R | Promoted to active roster | | | Before |
| 8/19/2013 | Sea | Brown,G | Promoted to active roster | | | Before |
| 8/19/2013 | Sea | Worley | Released | | | Before |
| 8/19/2013 | Tam | Cabrera,As | Promoted to active roster | | | Before |
| 8/19/2013 | Tam | Gallardo | Promoted to active roster | | | Before |
| 8/19/2013 | Tam | Santos,S | Promoted to active roster | | | Before |
| 8/22/2013 | Det | Grandal | Traded away | SF | | After |
| 8/22/2013 | Det | Heyward | Acquired via trade | SF | | After |
| 8/22/2013 | Det | Walker,N | Traded away | SF | | After |
| 8/22/2013 | Det | Zimmermann | Traded away | SF | | After |
| 8/22/2013 | KC | Dunn,M | Acquired via trade | Col | | After |
| 8/22/2013 | KC | Freese | Acquired via trade | Col | | After |
| 8/22/2013 | KC | Sabathia | Acquired via trade | Col | | After |
| 8/22/2013 | NYA | Boggs,M | Acquired via trade | StL | | After |
| 8/23/2013 | Cle | Campana | Signed | | | Before |
| 8/23/2013 | Cle | Campana | Promoted to active roster | | | Before |
| 8/23/2013 | Det | Estrada | Promoted to active roster | | | Before |
| 8/23/2013 | KC | Borchering | Released | | | Before |
| 8/23/2013 | KC | Horst | Released | | | Before |
| 8/23/2013 | NYA | Berg,Je | Released | | | Before |
| 8/23/2013 | Oak | Golson | Signed | | | Before |
| 8/23/2013 | Oak | Golson | Demoted to reserve roster | | | Before |
| 8/23/2013 | Oak | Golson | Promoted to active roster | | | Before |
| 8/23/2013 | Oak | Miller,C | Released | | | Before |
| 8/23/2013 | Oak | Molina,J | Promoted to active roster | | | Before |
| 8/23/2013 | Oak | Ross,C | Demoted to reserve roster | | | Before |
| 8/23/2013 | Oak | Sanchez,H | Demoted to reserve roster | | | Before |
| 8/23/2013 | Tex | Madson | Signed | | | Before |
| 8/24/2013 | KC | Giavotella | Demoted to reserve roster | | | Before |
| 8/24/2013 | KC | Maurer | Demoted to reserve roster | | | Before |
| 8/24/2013 | KC | O'Neill | Demoted to reserve roster | | | Before |
| 8/24/2013 | KC | Punto | Demoted to reserve roster | | | Before |
| 8/24/2013 | KC | Punto | Promoted to active roster | | | Before |
| 8/26/2013 | Bos | Davis,W | Demoted to reserve roster | | | Before |
| 8/26/2013 | Bos | Davis,W | Promoted to active roster | | | Before |
| 8/26/2013 | Bos | Gillies | Signed | | | Before |
| 8/26/2013 | Bos | Gillies | Promoted to active roster | | | Before |
| 8/26/2013 | Bos | Izturis,M | Demoted to reserve roster | | | Before |
| 8/26/2013 | Bos | Torres,An | Demoted to reserve roster | | | Before |
| 8/26/2013 | Det | Barnhart | Demoted to reserve roster | | | Before |
| 8/26/2013 | Det | Blanco,G | Demoted to reserve roster | | | Before |
| 8/26/2013 | Det | Diamond | Released | | | Before |
| 8/26/2013 | Det | Heyward | Demoted to reserve roster | | | Before |
| 8/26/2013 | Det | Jennings,De | Promoted to active roster | | | Before |
| 8/26/2013 | Det | Jones,G | Promoted to active roster | | | Before |
| 8/26/2013 | Det | Roark | Signed | | | Before |
| 8/26/2013 | Det | Ross,D | Promoted to active roster | | | Before |
| 8/26/2013 | NYA | Ahmed | Released | | | Before |
| 8/26/2013 | NYA | Betancourt,R | Demoted to reserve roster | | | Before |
| 8/26/2013 | Tam | Jepsen | Demoted to reserve roster | | | Before |
| 8/26/2013 | Tam | Polanco | Demoted to reserve roster | | | Before |
| 8/26/2013 | Tex | Ogando | Demoted to reserve roster | | | Before |
| 8/26/2013 | Tor | Bogusevic | Signed | | | Before |
| 8/26/2013 | Tor | Bogusevic | Promoted to active roster | | | Before |
| 8/26/2013 | Tor | Camp | Released | | | Before |
| 8/26/2013 | Tor | Maholm | Promoted to active roster | | | Before |
| 8/26/2013 | Tor | Mustelier | Released | | | Before |
| 8/27/2013 | Bal | Rasmus,CR | Demoted to reserve roster | | | Before |
| 8/27/2013 | Hou | Marte,S | Demoted to reserve roster | | | Before |
| 8/29/2013 | Bos | Escobar,Edu | Acquired via trade | ChA | | After |
| 8/29/2013 | Bos | Fife | Traded away | ChA | | After |
| 8/29/2013 | Bos | Howell | Acquired via trade | ChA | | After |
| 8/29/2013 | ChA | Butler,B | Acquired via trade | Det | | After |
| 8/29/2013 | ChA | Escobar,Edu | Traded away | Bos | | After |
| 8/29/2013 | ChA | Fife | Acquired via trade | Bos | | After |
| 8/29/2013 | ChA | Gregerson | Traded away | Det | | After |
| 8/29/2013 | ChA | Howell | Traded away | Bos | | After |
| 8/29/2013 | ChA | Lynn | Traded away | Det | | After |
| 8/29/2013 | ChA | Niese | Acquired via trade | Det | | After |
| 8/29/2013 | Cle | Francisco,J | Traded away | Cin | | After |
| 8/29/2013 | Cle | Szczur | Acquired via trade | Cin | | After |
| 8/29/2013 | Det | Barney | Traded away | Ari | | After |
| 8/29/2013 | Det | Butler,B | Traded away | ChA | | After |
| 8/29/2013 | Det | Gregerson | Acquired via trade | ChA | | After |
| 8/29/2013 | Det | Lynn | Acquired via trade | ChA | | After |
| 8/29/2013 | Det | Niese | Traded away | ChA | | After |
| 8/30/2013 | Bos | Escobar,Edu | Released | | | Before |
| 8/30/2013 | Bos | Herrera,J | Signed | | | Before |
| 8/30/2013 | Bos | Herrera,J | Promoted to active roster | | | Before |
| 8/30/2013 | Bos | Izturis,M | Released | | | Before |
| 8/30/2013 | Bos | Karns | Promoted to active roster | | | Before |
| 8/30/2013 | Bos | Lobaton | Signed | | | Before |
| 8/30/2013 | Bos | Lobaton | Promoted to active roster | | | Before |
| 8/30/2013 | Bos | Torres,An | Released | | | Before |
| 8/30/2013 | ChA | Belfiore | Promoted to active roster | | | Before |
| 8/30/2013 | ChA | Cloyd | Promoted to active roster | | | Before |
| 8/30/2013 | ChA | Fife | Promoted to active roster | | | Before |
| 8/30/2013 | ChA | Gilmartin | Demoted to reserve roster | | | Before |
| 8/30/2013 | ChA | Smith,W | Demoted to reserve roster | | | Before |
| 8/30/2013 | ChA | Wilson,Br | Promoted to active roster | | | Before |
| 8/30/2013 | Cle | Halton | Signed | | | Before |
| 8/30/2013 | Cle | Halton | Promoted to active roster | | | Before |
| 8/30/2013 | Cle | Robinson,D | Released | | | Before |
| 8/30/2013 | Cle | Szczur | Promoted to active roster | | | Before |
| 8/30/2013 | Det | Tolleson,Sh | Signed | | | Before |
| 8/30/2013 | Oak | Coke | Released | | | Before |
| 8/30/2013 | Oak | Feliciano,P | Signed | | | Before |
| 8/30/2013 | Tor | Pena,C | Released | | | Before |
| 9/1/2013 | Oak | Espinosa | Acquired via trade | StL | | After |
| 9/1/2013 | Oak | Thayer | Traded away | StL | | After |
| 9/2/2013 | Bos | Angle | Signed | | | Before |
| 9/2/2013 | Bos | Angle | Promoted to active roster | | | Before |
| 9/2/2013 | Bos | Fujikawa | Released | | | Before |
| 9/2/2013 | Bos | Gillies | Released | | | Before |
| 9/2/2013 | Bos | Morton | Promoted to active roster | | | Before |
| 9/2/2013 | ChA | Escobar,Edu | Signed | | | Before |
| 9/2/2013 | ChA | Escobar,Edu | Promoted to active roster | | | Before |
| 9/2/2013 | ChA | Gilmartin | Promoted to active roster | | | Before |
| 9/2/2013 | ChA | Smith,W | Promoted to active roster | | | Before |
| 9/2/2013 | ChA | Volquez | Promoted to active roster | | | Before |
| 9/2/2013 | Det | Solarte | Signed | | | Before |
| 9/2/2013 | Det | Tolleson,Sh | Released | | | Before |
| 9/2/2013 | NYA | Halladay | Promoted to active roster | | | Before |
| 9/2/2013 | NYA | Jeter | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Bogaerts | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Britton,D | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Chafin | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Crawford,B | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Feliciano,P | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Sanchez,H | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Santiago,H | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Tuiasosopo | Promoted to active roster | | | Before |
| 9/2/2013 | Oak | Vargas,J | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Calhoun | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Escobar,Y | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Johnson,D | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Kelly,T | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Otero | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Peacock | Promoted to active roster | | | Before |
| 9/2/2013 | Tor | Thornton | Promoted to active roster | | | Before |
| 9/6/2013 | Bos | Harris,WT | Signed | | | Before |
| 9/6/2013 | Bos | Harris,WT | Promoted to active roster | | | Before |
| 9/6/2013 | Bos | Karns | Demoted to reserve roster | | | Before |
| 9/6/2013 | Bos | Morton | Demoted to reserve roster | | | Before |
| 9/6/2013 | Cle | Albers | Released | | | Before |
| 9/6/2013 | Cle | Campana | Released | | | Before |
| 9/6/2013 | Cle | Dyson,J | Signed | | | Before |
| 9/6/2013 | Cle | Dyson,J | Promoted to active roster | | | Before |
| 9/6/2013 | Cle | Goins | Signed | | | Before |
| 9/6/2013 | Cle | Goins | Promoted to active roster | | | Before |
| 9/6/2013 | Cle | Hafner | Released | | | Before |
| 9/6/2013 | Cle | LeBlanc | Released | | | Before |
| 9/6/2013 | Cle | Ortiz,J | Signed | | | Before |
| 9/6/2013 | Cle | Ortiz,J | Promoted to active roster | | | Before |
| 9/6/2013 | LAA | Dyson,S | Signed | | | Before |
| 9/6/2013 | LAA | Myers,B | Released | | | Before |
| 9/6/2013 | LAA | Perez,L | Signed | | | Before |
| 9/6/2013 | Oak | Petit,Y | Signed | | | Before |
| 9/6/2013 | Sea | Thole | Released | | | Before |
| 9/9/2013 | Cle | Cabrera,R | Released | | | Before |
| 9/9/2013 | Cle | Hassan | Promoted to active roster | | | Before |
| 9/9/2013 | Cle | Thole | Signed | | | Before |
| 9/9/2013 | Cle | Thole | Promoted to active roster | | | Before |
| 9/9/2013 | Det | Blanco,G | Promoted to active roster | | | Before |
| 9/9/2013 | Det | Cain,L | Promoted to active roster | | | Before |
| 9/9/2013 | Det | Ellsbury | Demoted to reserve roster | | | Before |
| 9/9/2013 | Det | Solarte | Promoted to active roster | | | Before |
| 9/9/2013 | Hou | Austin | Promoted to active roster | | | Before |
| 9/9/2013 | Hou | Catricala | Demoted to reserve roster | | | Before |
| 9/9/2013 | Hou | Marte,S | Promoted to active roster | | | Before |
| 9/9/2013 | KC | Cutler | Demoted to reserve roster | | | Before |
| 9/9/2013 | KC | Montero,M | Promoted to active roster | | | Before |
| 9/9/2013 | LAA | Beltre,E | Promoted to active roster | | | Before |
| 9/9/2013 | LAA | Chen,C | Promoted to active roster | | | Before |
| 9/9/2013 | LAA | Dyson,S | Promoted to active roster | | | Before |
| 9/9/2013 | LAA | Green,G | Promoted to active roster | | | Before |
| 9/9/2013 | LAA | Torreyes | Promoted to active roster | | | Before |
| 9/9/2013 | LAA | Villar,J | Promoted to active roster | | | Before |
| 9/9/2013 | Tex | Ogando | Promoted to active roster | | | Before |
| 9/9/2013 | Tex | Sweeney,R | Promoted to active roster | | | Before |
| 9/12/2013 | Oak | Berkman | Promoted to active roster | | | Before |
| 9/13/2013 | Cle | Dyson,J | Released | | | Before |
| 9/13/2013 | Cle | Jungmann | Signed | | | Before |
| 9/14/2013 | Hou | Masterson | Demoted to reserve roster | | | Before |
| 9/16/2013 | Hou | Kendrick,H | Promoted to active roster | | | Before |
| 9/16/2013 | Hou | Veras | Promoted to active roster | | | Before |
| 9/16/2013 | Hou | Wong | Demoted to reserve roster | | | Before |
| 9/16/2013 | KC | Buchholz | Promoted to active roster | | | Before |
| 9/16/2013 | NYA | Jeter | Demoted to reserve roster | | | Before |
| 9/16/2013 | Tor | Capuano | Demoted to reserve roster | | | Before |
| 9/16/2013 | Tor | Martinez,JD | Promoted to active roster | | | Before |
| 9/16/2013 | Tor | Quackenbush | Demoted to reserve roster | | | Before |
| 9/16/2013 | Tor | Quackenbush | Promoted to active roster | | | Before |
| 9/20/2013 | Cle | Guthrie | Released | | | Before |
| 9/20/2013 | Det | Heyward | Promoted to active roster | | | Before |
| 9/20/2013 | LAA | Bourjos | Demoted to reserve roster | | | Before |
| 9/20/2013 | Tam | Encarnacion | Demoted to reserve roster | | | Before |
| 9/20/2013 | Tam | Matsuzaka | Promoted to active roster | | | Before |
| 9/20/2013 | Tam | Polanco | Promoted to active roster | | | Before |
| 9/20/2013 | Tam | Snyder,C | Promoted to active roster | | | Before |
| 9/23/2013 | Det | Ellsbury | Promoted to active roster | | | Before |
| 9/23/2013 | Det | Heyward | Promoted to active roster | | | Before |
| 9/23/2013 | KC | Sabathia | Demoted to reserve roster | | | Before |
| 9/23/2013 | Min | Castro,J | Demoted to reserve roster | | | Before |
| 9/23/2013 | Min | Forsythe | Demoted to reserve roster | | | Before |
| 9/23/2013 | Min | Gomes,B | Promoted to active roster | | | Before |
| 9/23/2013 | NYA | Kemp | Promoted to active roster | | | Before |
| 9/23/2013 | Tex | Cecil | Demoted to reserve roster | | | Before |
| 9/23/2013 | Tex | Ventura | Promoted to active roster | | | Before |
