| Earned run average | | Strikeouts | | Walks |
| | | | | | | | | | | |
| Oswalt | LAN | 2.25 | | Chamberlain | NYA | 275 | | Ceda | Det | 109 |
| Cruz,Ju | LAN | 2.94 | | Liriano | LAN | 245 | | Lincecum | Pit | 108 |
| DiFelice,Ma | Oak | 2.97 | | Santana,J | Tor | 245 | | Volquez | KC | 106 |
| Matsuzaka | SD | 3.10 | | Lincecum | Pit | 236 | | Cain,M | Cin | 106 |
| Peavy | SF | 3.11 | | Hamels | SD | 234 | | Marmol | Bal | 103 |
| Myers,B | Oak | 3.21 | | Peavy | SF | 229 | | Morales,F | Ari | 103 |
| Hamels | SD | 3.23 | | Burnett | Sea | 228 | | Jimenez,U | NYN | 100 |
| Sampson | Det | 3.24 | | Kuo | Cin | 222 | | Adenhart | ANA | 99 |
| Kuo | Cin | 3.24 | | Myers,B | Oak | 222 | | Billingsley | Hou | 99 |
| Gorzelanny | Phi | 3.40 | | DiFelice,Ma | Oak | 216 | | Zambrano,C | NYA | 98 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Wins | | Winning percentage | | Average run support |
| | | | | | | | | | | |
| Myers,B | Oak | 20-5 | | Kuo | Cin | .941 | | Santana,J | Tor | 7.2 |
| DiFelice,Ma | Oak | 19-7 | | Kuroda | Cin | .810 | | Kuo | Cin | 7.2 |
| Chamberlain | NYA | 18-5 | | Myers,B | Oak | .800 | | Hernandez,Fe | NYA | 7.1 |
| Santana,J | Tor | 18-6 | | Chamberlain | NYA | .783 | | Snell | Tor | 7.0 |
| Sonnanstine | Tor | 18-6 | | Kazmir | NYA | .773 | | Kuroda | Cin | 6.9 |
| Halladay | Cin | 18-8 | | Bonser | Flo | .765 | | Duensing | Bos | 6.5 |
| Kuroda | Cin | 17-4 | | Santana,J | Tor | .750 | | Meche | Oak | 6.3 |
| Kazmir | NYA | 17-5 | | Sonnanstine | Tor | .750 | | Misch | Cle | 6.3 |
| Kuo | Cin | 16-1 | | Cain,M | Cin | .750 | | Chamberlain | NYA | 6.2 |
| Burnett | Sea | 16-10 | | Kennedy,I | NYA | .750 | | Villanueva | Bal | 6.1 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Batting average | | On-base percentage | | Slugging percentage |
| | | | | | | | | | | |
| Cruz,Ju | LAN | .189 | | Chamberlain | NYA | .262 | | Cruz,Ju | LAN | .313 |
| Chamberlain | NYA | .202 | | DiFelice,Ma | Oak | .264 | | Oswalt | LAN | .324 |
| Myers,B | Oak | .214 | | Myers,B | Oak | .271 | | Marmol | Bal | .327 |
| Marmol | Bal | .218 | | Oswalt | LAN | .279 | | Morales,F | Ari | .328 |
| Hamels | SD | .227 | | Hamels | SD | .282 | | Webb | Bos | .331 |
| Oswalt | LAN | .227 | | Cruz,Ju | LAN | .290 | | Hamels | SD | .348 |
| DiFelice,Ma | Oak | .229 | | Peavy | SF | .290 | | Bray,S | Flo | .367 |
| Peavy | SF | .230 | | Santana,J | Tor | .293 | | DiFelice,Ma | Oak | .368 |
| Sanchez,J | Sea | .233 | | Sabathia | SD | .295 | | Burnett | Sea | .371 |
| Gorzelanny | Phi | .237 | | Vazquez,J | Bal | .297 | | Peavy | SF | .374 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Hits per 9 innings | | Walks per 9 innings | | Runners per 9 innings |
| | | | | | | | | | | |
| Cruz,Ju | LAN | 6.1 | | Silva | Cle | 1.4 | | Chamberlain | NYA | 9.4 |
| Chamberlain | NYA | 6.7 | | DiFelice,Ma | Oak | 1.4 | | DiFelice,Ma | Oak | 9.5 |
| Myers,B | Oak | 7.1 | | Maddux | Phi | 1.5 | | Myers,B | Oak | 9.8 |
| Marmol | Bal | 7.3 | | Buehrle | Bos | 1.6 | | Hamels | SD | 10.2 |
| Hamels | SD | 7.5 | | Halladay | Cin | 1.6 | | Oswalt | LAN | 10.2 |
| Oswalt | LAN | 7.7 | | Sonnanstine | Tor | 1.6 | | Peavy | SF | 10.7 |
| Peavy | SF | 7.7 | | Sabathia | SD | 1.8 | | Cruz,Ju | LAN | 10.8 |
| DiFelice,Ma | Oak | 7.8 | | Lowe,D | Phi | 1.8 | | Sabathia | SD | 10.8 |
| Sanchez,J | Sea | 8.0 | | Slowey | Was | 1.9 | | Santana,J | Tor | 11.0 |
| Gorzelanny | Phi | 8.0 | | Mussina | Tam | 1.9 | | Vazquez,J | Bal | 11.2 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Strikeouts per 9 innings | | Homeruns per 9 innings | | Stolen bases per 9 innings |
| | | | | | | | | | | |
| Chamberlain | NYA | 13.6 | | Webb | Bos | 0.3 | | Rogers,K | Atl | 0.1 |
| Kuo | Cin | 10.7 | | Oswalt | LAN | 0.5 | | Smith,G | Bal | 0.1 |
| Liriano | LAN | 10.6 | | Morales,F | Ari | 0.6 | | Sampson | Det | 0.2 |
| Sanchez,J | Sea | 10.2 | | Cruz,Ju | LAN | 0.6 | | Sabathia | SD | 0.2 |
| Marmol | Bal | 10.2 | | Parra,M | Ari | 0.6 | | Buehrle | Bos | 0.2 |
| Peavy | SF | 10.2 | | Blanton | Ari | 0.7 | | Meche | Oak | 0.2 |
| Cruz,Ju | LAN | 10.1 | | Billingsley | Hou | 0.7 | | Washburn | Pit | 0.2 |
| Buchholz,C | Hou | 10.1 | | Hamels | SD | 0.7 | | Arroyo | Was | 0.3 |
| Santana,J | Tor | 9.7 | | DiNardo | Col | 0.7 | | Sonnanstine | Tor | 0.3 |
| McDonald,Ja | Hou | 9.4 | | Peavy | SF | 0.7 | | Hernandez,Fe | NYA | 0.3 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Shutouts | | Quality starts | | Quality start percentage |
| | | | | | | | | | | |
| Bedard | Phi | 3 | | DiFelice,Ma | Oak | 26 | | Oswalt | LAN | .759 |
| Washburn | Pit | 3 | | Myers,B | Oak | 24 | | Peavy | SF | .759 |
| Beckett | Bos | 2 | | Lowe,D | Phi | 23 | | Chamberlain | NYA | .750 |
| McDonald,Ja | Hou | 2 | | Webb | Bos | 23 | | Myers,B | Oak | .727 |
| Gorzelanny | Phi | 2 | | Oswalt | LAN | 22 | | Lowe,D | Phi | .719 |
| Weaver,Jer | Min | 2 | | Peavy | SF | 22 | | Gorzelanny | Phi | .710 |
| Shields,J | Det | 2 | | Gorzelanny | Phi | 22 | | DiFelice,Ma | Oak | .684 |
| Arroyo | Was | 2 | | Halladay | Cin | 22 | | Webb | Bos | .657 |
| Meche | Oak | 2 | | Burnett | Sea | 22 | | Cruz,Ju | LAN | .655 |
| Sonnanstine | Tor | 2 | | Chamberlain | NYA | 21 | | Matsuzaka | SD | .655 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Save Opportunities | | Saves | | Save percentage |
| | | | | | | | | | | |
| Rivera,Ma | NYA | 44 | | Rivera,Ma | NYA | 37 | | Okajima | Bos | .900 |
| Street | Oak | 41 | | Rodriguez,F | Cin | 34 | | Wagner,B | Min | .885 |
| Jenks | Ari | 41 | | Valverde | SD | 32 | | Nathan | Atl | .875 |
| Rodriguez,F | Cin | 40 | | Hoffman | Flo | 32 | | Valverde | SD | .865 |
| Hoffman | Flo | 40 | | Jenks | Ari | 32 | | Corpas | Was | .852 |
| Cordero,F | Phi | 37 | | Street | Oak | 32 | | Rodriguez,F | Cin | .850 |
| Valverde | SD | 37 | | Cordero,F | Phi | 29 | | Rivera,Ma | NYA | .841 |
| Soria | LAN | 35 | | Nathan | Atl | 28 | | Saito | Tor | .833 |
| Crain | SF | 34 | | Soria | LAN | 28 | | Feliciano | Col | .815 |
| Nathan | Atl | 32 | | Okajima | Bos | 27 | | Hoffman | Flo | .800 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Holds | | Blown saves | | Blown save percentage |
| | | | | | | | | | | |
| Ryan,BJ | NYA | 21 | | Balfour | Bos | 12 | | Schroder | ANA | .440 |
| Betancourt,R | Min | 21 | | Schroder | ANA | 11 | | Wuertz | Bal | .423 |
| Shields,S | Cin | 20 | | Wuertz | Bal | 11 | | Crain | SF | .324 |
| Papelbon | NYA | 20 | | Crain | SF | 11 | | Thatcher | LAN | .240 |
| Downs | StL | 19 | | Street | Oak | 9 | | Street | Oak | .220 |
| Broxton | Atl | 19 | | Cordero,F | Phi | 8 | | Cordero,F | Phi | .216 |
| Lugo,R | Tex | 19 | | Hoffman | Flo | 8 | | Hoffman | Flo | .200 |
| Balfour | Bos | 18 | | Jenks | Ari | 8 | | Soria | LAN | .200 |
| Qualls | Oak | 17 | | Broxton | Atl | 7 | | Jenks | Ari | .195 |
| Lindstrom | Sea | 17 | | Riske | ChA | 7 | | Feliciano | Col | .185 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Innings | | Batters faced per game | | Complete games |
| | | | | | | | | | | |
| DiFelice,Ma | Oak | 248.1 | | Shields,J | Det | 31.19 | | Washburn | Pit | 7 |
| Webb | Bos | 243.1 | | Halladay | Cin | 29.68 | | Buehrle | Bos | 6 |
| Burnett | Sea | 242.0 | | Oswalt | LAN | 29.48 | | Beckett | Bos | 5 |
| Halladay | Cin | 241.1 | | Webb | Bos | 29.31 | | Oswalt | LAN | 5 |
| Hamels | SD | 239.1 | | Litsch | KC | 29.28 | | Shields,J | Det | 5 |
| Cook,AL | Was | 239.0 | | Washburn | Pit | 29.22 | | Bedard | Phi | 4 |
| Haren | Oak | 236.2 | | Lowe,D | Phi | 28.72 | | Howell | NYN | 4 |
| Shields,J | Det | 234.1 | | Cook,AL | Was | 28.66 | | Sampson | Det | 4 |
| Lincecum | Pit | 229.2 | | Slowey | Was | 28.39 | | Villanueva | Bal | 4 |
| Sabathia | SD | 227.1 | | Buehrle | Bos | 28.38 | | Sonnanstine | Tor | 4 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Doubles | | Triples | | Homeruns |
| | | | | | | | | | | |
| Buehrle | Bos | 67 | | Masterson | Mil | 13 | | Sonnanstine | Tor | 42 |
| Shields,J | Det | 63 | | Cook,AL | Was | 13 | | Haren | Oak | 37 |
| Mussina | Tam | 61 | | Santana,E | Tex | 12 | | Chamberlain | NYA | 33 |
| Santana,J | Tor | 58 | | Garza | Ari | 11 | | Villanueva | Bal | 32 |
| Guthrie | Bos | 55 | | Hammel | ChN | 10 | | Gonzalez,Gi | Flo | 31 |
| Guerra | ANA | 55 | | Gaudin | Col | 10 | | Santana,J | Tor | 31 |
| Petit,Y | StL | 54 | | Parra,M | Ari | 10 | | Thompson,D | Det | 30 |
| Masterson | Mil | 54 | | Haren | Oak | 10 | | Liriano | LAN | 30 |
| Scherzer | Mil | 53 | | Garland | StL | 9 | | Shields,J | Det | 30 |
| Saunders | KC | 53 | | Peavy | SF | 9 | | Slowey | Was | 29 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Stolen bases | | Steal percentage | | Pickoffs |
| | | | | | | | | | | |
| Mussina | Tam | 36 | | Haren | Oak | .458 | | Peavy | SF | 7 |
| Webb | Bos | 32 | | Hamels | SD | .500 | | Blanton | Ari | 5 |
| Sheets | Flo | 28 | | Rodriguez,W | Tex | .500 | | Laffey | ChN | 4 |
| Bailey,A | Cle | 25 | | Shields,J | Det | .500 | | Cruz,Ju | LAN | 4 |
| Morales,F | Ari | 24 | | Miller,An | Tam | .524 | | Miller,Ju | Flo | 3 |
| Dempster | Phi | 24 | | Burnett | Sea | .548 | | Vermilyea | | 3 |
| Maddux | Phi | 24 | | Maholm | ChA | .550 | | Wood,K | Tex | 3 |
| Adenhart | ANA | 22 | | Davis,W | Ari | .556 | | Buehrle | Bos | 3 |
| Silva | Cle | 21 | | Guerra | ANA | .556 | | Harrison | NYN | 3 |
| Masterson | Mil | 21 | | Cruz,Ju | LAN | .565 | | Beckett | Bos | 3 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Hit by pitch | | Wild pitches | | Balks |
| | | | | | | | | | | |
| Cueto | NYA | 22 | | Ceda | Det | 32 | | Morales,F | Ari | 8 |
| Germano | Phi | 17 | | Adenhart | ANA | 20 | | Thompson,D | Det | 7 |
| Masterson | Mil | 17 | | Morales,F | Ari | 18 | | Smith,G | Bal | 7 |
| Verlander | Flo | 16 | | Shields,J | Det | 17 | | Verlander | Flo | 7 |
| Bush,D | Hou | 14 | | Batista,M | Cle | 16 | | Jimenez,U | NYN | 6 |
| Stanford | Atl | 14 | | Lincecum | Pit | 16 | | Romero,D | Was | 5 |
| Adenhart | ANA | 14 | | Snell | Tor | 14 | | Harrison | NYN | 5 |
| Zito | SD | 14 | | Medders | ANA | 13 | | Laffey | ChN | 5 |
| Eveland | Bal | 12 | | Garcia,Ja | Tam | 13 | | Parra,M | Ari | 5 |
| Willis | Sea | 12 | | Lidge | Col | 12 | | Cueto | NYA | 4 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Games | | Starts | | Batters faced |
| | | | | | | | | | | |
| Lugo,R | Tex | 116 | | Haren | Oak | 39 | | Haren | Oak | 1026 |
| Mastny | ANA | 91 | | DiFelice,Ma | Oak | 38 | | Webb | Bos | 1026 |
| Wood,K | Tex | 85 | | Burnett | Sea | 37 | | Burnett | Sea | 1021 |
| Broxton | Atl | 84 | | Hamels | SD | 37 | | Halladay | Cin | 1009 |
| Ledezma | ChN | 81 | | Zito | SD | 37 | | Lincecum | Pit | 1006 |
| Lyon | ChN | 79 | | Blanton | Ari | 35 | | Cook,AL | Was | 1003 |
| Meloan | LAN | 79 | | Cook,AL | Was | 35 | | Shields,J | Det | 998 |
| Schroder | ANA | 78 | | Sabathia | SD | 35 | | DiFelice,Ma | Oak | 988 |
| Borowski | Tex | 77 | | Santana,J | Tor | 35 | | Verlander | Flo | 974 |
| Littleton | ANA | 77 | | Verlander | Flo | 35 | | Hamels | SD | 971 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Games finished | | Runners left scored percentage | | Inherited runners scored pct |
| | | | | | | | | | | |
| Valverde | SD | 58 | | Peavy | SF | .083 | | Wagner,B | Min | .083 |
| Nathan | Atl | 58 | | Oswalt | LAN | .111 | | Jenks | Ari | .091 |
| Schroder | ANA | 57 | | Lilly | LAN | .143 | | Saito | Tor | .111 |
| Street | Oak | 56 | | Smith,G | Bal | .154 | | Reyes,D | Oak | .143 |
| Soria | LAN | 56 | | Reyes,JJ | ANA | .160 | | Villone | ChA | .154 |
| Crain | SF | 55 | | Chamberlain | NYA | .167 | | Wheeler | Tam | .167 |
| Jenks | Ari | 54 | | Sabathia | SD | .167 | | Papelbon | NYA | .171 |
| Hoffman | Flo | 52 | | DiFelice,Ma | Oak | .188 | | Valverde | SD | .182 |
| Feliciano | Col | 52 | | Saunders | KC | .190 | | Murray | Det | .185 |
| Wagner,B | Min | 51 | | Lester | ANA | .192 | | Stetter | LAN | .188 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Ground ball DP | | Decisions | | Losses |
| | | | | | | | | | | |
| Maholm | ChA | 31 | | Shields,J | Det | 27 | | Lincecum | Pit | 5-21 |
| DiNardo | Col | 29 | | Hamels | SD | 27 | | Adenhart | ANA | 4-20 |
| Adenhart | ANA | 29 | | Lowe,D | Phi | 26 | | Guerra | ANA | 2-19 |
| Cook,AL | Was | 29 | | Halladay | Cin | 26 | | Bailey,A | Cle | 5-18 |
| Webb | Bos | 29 | | Lincecum | Pit | 26 | | Lester | ANA | 6-18 |
| Batista,M | Cle | 27 | | Burnett | Sea | 26 | | Santana,E | Tex | 4-16 |
| Billingsley | Hou | 27 | | DiFelice,Ma | Oak | 26 | | Guthrie | Bos | 7-16 |
| Francis | Min | 26 | | Weaver,Jer | Min | 25 | | Bannister | Atl | 8-15 |
| Morales,F | Ari | 26 | | Myers,B | Oak | 25 | | Rodriguez,W | Tex | 3-14 |
| Silva | Cle | 25 | | Webb | Bos | 25 | | Nolasco | NYN | 4-14 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| On-base plus slugging | | Walks plus hits per inning | | Strikeout/walk ratio |
| | | | | | | | | | | |
| Cruz,Ju | LAN | .602 | | Chamberlain | NYA | 1.02 | | Chamberlain | NYA | 5.5 |
| Oswalt | LAN | .603 | | DiFelice,Ma | Oak | 1.03 | | DiFelice,Ma | Oak | 5.4 |
| Hamels | SD | .630 | | Myers,B | Oak | 1.06 | | Santana,J | Tor | 5.0 |
| DiFelice,Ma | Oak | .632 | | Oswalt | LAN | 1.08 | | Sonnanstine | Tor | 4.3 |
| Chamberlain | NYA | .649 | | Hamels | SD | 1.13 | | Sabathia | SD | 4.1 |
| Webb | Bos | .650 | | Cruz,Ju | LAN | 1.14 | | Halladay | Cin | 4.1 |
| Myers,B | Oak | .651 | | Peavy | SF | 1.15 | | Shields,J | Det | 3.9 |
| Marmol | Bal | .655 | | Sabathia | SD | 1.18 | | Peavy | SF | 3.8 |
| Peavy | SF | .664 | | Santana,J | Tor | 1.20 | | Myers,B | Oak | 3.7 |
| Morales,F | Ari | .670 | | Sonnanstine | Tor | 1.22 | | Liriano | LAN | 3.6 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Runs created per 27 outs | | Runs created ERA | | Component ERA |
| | | | | | | | | | | |
| Oswalt | LAN | 2.9 | | Oswalt | LAN | 2.72 | | Cruz,Ju | LAN | 2.54 |
| Cruz,Ju | LAN | 3.1 | | Cruz,Ju | LAN | 2.85 | | Oswalt | LAN | 2.57 |
| Hamels | SD | 3.2 | | Hamels | SD | 2.90 | | DiFelice,Ma | Oak | 2.61 |
| DiFelice,Ma | Oak | 3.2 | | DiFelice,Ma | Oak | 2.93 | | Hamels | SD | 2.68 |
| Chamberlain | NYA | 3.4 | | Chamberlain | NYA | 3.05 | | Myers,B | Oak | 2.69 |
| Myers,B | Oak | 3.5 | | Myers,B | Oak | 3.16 | | Chamberlain | NYA | 2.86 |
| Webb | Bos | 3.7 | | Webb | Bos | 3.32 | | Peavy | SF | 2.89 |
| Peavy | SF | 3.8 | | Peavy | SF | 3.41 | | Sabathia | SD | 3.23 |
| Marmol | Bal | 3.8 | | Sabathia | SD | 3.48 | | Webb | Bos | 3.29 |
| Vazquez,J | Bal | 3.8 | | Vazquez,J | Bal | 3.48 | | Vazquez,J | Bal | 3.35 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| In-play average | | Balls in park | | Extra-base hit rate |
| | | | | | | | | | | |
| Cruz,Ju | LAN | .248 | | Cook,AL | Was | 821 | | Morales,F | Ari | .042 |
| Myers,B | Oak | .257 | | Webb | Bos | 768 | | Marmol | Bal | .051 |
| Oswalt | LAN | .260 | | Buehrle | Bos | 765 | | Webb | Bos | .051 |
| Washburn | Pit | .262 | | Halladay | Cin | 755 | | Oswalt | LAN | .057 |
| Smith,G | Bal | .263 | | Blanton | Ari | 748 | | Blanton | Ari | .059 |
| Gorzelanny | Phi | .263 | | Lowe,D | Phi | 713 | | Bray,S | Flo | .060 |
| Zito | SD | .266 | | Mussina | Tam | 712 | | Billingsley | Hou | .061 |
| Sampson | Det | .267 | | Haren | Oak | 712 | | Dempster | Phi | .066 |
| DiFelice,Ma | Oak | .269 | | Shields,J | Det | 709 | | Kuroda | Cin | .066 |
| Petit,Y | StL | .271 | | DiFelice,Ma | Oak | 699 | | Burnett | Sea | .067 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Total bases + BB + HBP | | TB+BB+HBP rate | | Single rate |
| | | | | | | | | | | |
| Haren | Oak | 500 | | Oswalt | LAN | .366 | | Cruz,Ju | LAN | .092 |
| Lincecum | Pit | 485 | | Webb | Bos | .388 | | Myers,B | Oak | .112 |
| Masterson | Mil | 472 | | Hamels | SD | .390 | | Chamberlain | NYA | .113 |
| Shields,J | Det | 465 | | Cruz,Ju | LAN | .393 | | Petit,Y | StL | .125 |
| Verlander | Flo | 462 | | DiFelice,Ma | Oak | .396 | | Peavy | SF | .127 |
| Buehrle | Bos | 460 | | Morales,F | Ari | .411 | | Zito | SD | .130 |
| Guerra | ANA | 458 | | Blanton | Ari | .412 | | Volquez | KC | .130 |
| Lester | ANA | 457 | | Peavy | SF | .417 | | Smith,G | Bal | .132 |
| Sonnanstine | Tor | 457 | | Marmol | Bal | .420 | | Santana,J | Tor | .134 |
| Villanueva | Bal | 452 | | Vazquez,J | Bal | .420 | | Marmol | Bal | .134 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Total bases plus walks | | TB+BB rate | | Double rate |
| | | | | | | | | | | |
| Haren | Oak | 493 | | Oswalt | LAN | .352 | | Chamberlain | NYA | .022 |
| Lincecum | Pit | 480 | | Cruz,Ju | LAN | .378 | | Morales,F | Ari | .026 |
| Masterson | Mil | 455 | | Webb | Bos | .382 | | Marmol | Bal | .029 |
| Shields,J | Det | 454 | | Hamels | SD | .389 | | Sanchez,J | Sea | .030 |
| Lester | ANA | 451 | | DiFelice,Ma | Oak | .390 | | Gonzalez,Gi | Flo | .030 |
| Sonnanstine | Tor | 450 | | Morales,F | Ari | .401 | | Bray,S | Flo | .031 |
| Buehrle | Bos | 449 | | Marmol | Bal | .407 | | Thompson,D | Det | .032 |
| Guerra | ANA | 447 | | Blanton | Ari | .409 | | McDonald,Ja | Hou | .034 |
| Verlander | Flo | 446 | | Peavy | SF | .410 | | Billingsley | Hou | .035 |
| Villanueva | Bal | 445 | | Myers,B | Oak | .413 | | Kuroda | Cin | .036 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Batting average vs LHB | | On-base percentage vs LHB | | Slugging percentage vs LHB |
| | | | | | | | | | | |
| Chamberlain | NYA | .162 | | Wuertz | Bal | .225 | | Kazmir | NYA | .203 |
| Francis | Min | .171 | | Chamberlain | NYA | .236 | | Francis | Min | .215 |
| Wuertz | Bal | .173 | | Soria | LAN | .237 | | Maholm | ChA | .221 |
| Soria | LAN | .177 | | Francis | Min | .241 | | Soria | LAN | .255 |
| Gorzelanny | Phi | .182 | | Gorzelanny | Phi | .249 | | Sanchez,J | Sea | .257 |
| Marmol | Bal | .184 | | Kazmir | NYA | .262 | | Gorzelanny | Phi | .273 |
| Sanchez,J | Sea | .187 | | Lilly | LAN | .264 | | Marmol | Bal | .276 |
| Kazmir | NYA | .196 | | Liriano | LAN | .267 | | Morales,F | Ari | .280 |
| Nippert | Tam | .199 | | Kuo | Cin | .268 | | Meloan | LAN | .280 |
| Meloan | LAN | .200 | | Hamels | SD | .272 | | Duensing | Bos | .294 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Hits vs LHB | | Runs batted in vs LHB | | On-base plus slugging vs LHB |
| | | | | | | | | | | |
| Masterson | Mil | 138 | | Adenhart | ANA | 80 | | Francis | Min | .457 |
| Blackburn | Min | 137 | | Ceda | Det | 75 | | Kazmir | NYA | .464 |
| DiFelice,Ma | Oak | 134 | | Mussina | Tam | 68 | | Soria | LAN | .492 |
| Cook,AL | Was | 126 | | Hernandez,Fe | NYA | 66 | | Maholm | ChA | .507 |
| Webb | Bos | 125 | | Villanueva | Bal | 65 | | Gorzelanny | Phi | .521 |
| Blanton | Ari | 124 | | Gonzalez,En | Tex | 63 | | Wuertz | Bal | .534 |
| Lowe,D | Phi | 124 | | Masterson | Mil | 63 | | Sanchez,J | Sea | .541 |
| Haren | Oak | 123 | | Verlander | Flo | 63 | | Liriano | LAN | .567 |
| Mussina | Tam | 120 | | Lincecum | Pit | 62 | | Kuo | Cin | .567 |
| Lincecum | Pit | 119 | | Cook,AL | Was | 62 | | Chamberlain | NYA | .577 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Doubles vs LHB | | Triples vs LHB | | Homeruns vs LHB |
| | | | | | | | | | | |
| Vazquez,J | Bal | 35 | | Buchholz,C | Hou | 8 | | Lincecum | Pit | 20 |
| Shields,J | Det | 35 | | Masterson | Mil | 8 | | Sonnanstine | Tor | 20 |
| DiFelice,Ma | Oak | 34 | | Garza | Ari | 7 | | Santana,E | Tex | 19 |
| Guthrie | Bos | 32 | | Garland | StL | 7 | | Verlander | Flo | 19 |
| Greinke | StL | 32 | | Hammel | ChN | 7 | | Chamberlain | NYA | 18 |
| Maddux | Phi | 30 | | Santana,E | Tex | 7 | | Weaver,Jer | Min | 17 |
| Bannister | Atl | 29 | | Cook,AL | Was | 7 | | DiFelice,Ma | Oak | 17 |
| Guerra | ANA | 29 | | Balfour | Bos | 6 | | Burnett | Sea | 16 |
| Masterson | Mil | 27 | | Gaudin | Col | 6 | | Mulvey | Oak | 15 |
| Sonnanstine | Tor | 27 | | Pettitte | Min | 6 | | Gonzalez,En | Tex | 15 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Extra base hits vs LHB | | Total bases vs LHB | | Isolated power vs LHB |
| | | | | | | | | | | |
| DiFelice,Ma | Oak | 52 | | DiFelice,Ma | Oak | 221 | | Kazmir | NYA | .006 |
| Vazquez,J | Bal | 51 | | Masterson | Mil | 217 | | Maholm | ChA | .010 |
| Sonnanstine | Tor | 50 | | Sonnanstine | Tor | 211 | | Francis | Min | .044 |
| Shields,J | Det | 50 | | Lincecum | Pit | 205 | | Duensing | Bos | .050 |
| Bannister | Atl | 47 | | Cook,AL | Was | 201 | | Hill,R | Pit | .055 |
| Guthrie | Bos | 47 | | Verlander | Flo | 200 | | Hendrickson,M | ChA | .065 |
| Masterson | Mil | 47 | | Vazquez,J | Bal | 197 | | Blanton | Ari | .067 |
| Verlander | Flo | 47 | | Burnett | Sea | 197 | | Betancourt,R | Min | .068 |
| Lincecum | Pit | 45 | | Shields,J | Det | 195 | | Wang | NYA | .070 |
| Burnett | Sea | 45 | | Blackburn | Min | 194 | | Sanchez,J | Sea | .070 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Walks vs LHB | | Strikeouts vs LHB | | Hit by pitch vs LHB |
| | | | | | | | | | | |
| Zambrano,C | NYA | 69 | | Chamberlain | NYA | 175 | | Buehrle | Bos | 9 |
| Adenhart | ANA | 63 | | Burnett | Sea | 132 | | Johnson,Ra | Cin | 7 |
| Ceda | Det | 62 | | Myers,B | Oak | 122 | | Cramer | Tor | 7 |
| Snell | Tor | 62 | | Haren | Oak | 114 | | Bennett,J | Atl | 6 |
| Webb | Bos | 62 | | Marmol | Bal | 108 | | Fuentes | Was | 6 |
| Cain,M | Cin | 61 | | Shields,J | Det | 107 | | Wassermann | ChA | 6 |
| Marmol | Bal | 61 | | DiFelice,Ma | Oak | 106 | | DiNardo | Col | 6 |
| Billingsley | Hou | 54 | | Lincecum | Pit | 103 | | Morales,F | Ari | 6 |
| Scherzer | Mil | 53 | | Meche | Oak | 101 | | Hill,R | Pit | 6 |
| Burnett | Sea | 53 | | McDonald,Ja | Hou | 96 | | Sanchez,J | Sea | 6 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Sacrifice bunts vs LHB | | Sacrifice flies vs LHB | | Atbats vs LHB |
| | | | | | | | | | | |
| Sampson | Det | 7 | | Haren | Oak | 7 | | Burnett | Sea | 509 |
| Bush,D | Hou | 6 | | Stockman | Mil | 6 | | DiFelice,Ma | Oak | 504 |
| Marquis | Mil | 5 | | Bailey,H | ANA | 6 | | Haren | Oak | 494 |
| Willis | Sea | 4 | | Kuroda | Cin | 6 | | Shields,J | Det | 486 |
| Washburn | Pit | 4 | | Ceda | Det | 6 | | Webb | Bos | 484 |
| Speier,J | Phi | 4 | | Blanton | Ari | 6 | | Blackburn | Min | 450 |
| DiNardo | Col | 4 | | Mussina | Tam | 6 | | Vazquez,J | Bal | 445 |
| Morales,F | Ari | 4 | | Lester | ANA | 5 | | Mussina | Tam | 443 |
| Zito | SD | 4 | | Garland | StL | 5 | | Cook,AL | Was | 441 |
| Medders | ANA | 4 | | Mastny | ANA | 5 | | Lowe,D | Phi | 435 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| AB per homerun vs LHB | | AB per double vs LHB | | Plate appearances vs LHB |
| | | | | | | | | | | |
| Roe | Det | 10.8 | | Buchholz,T | KC | 9.4 | | Burnett | Sea | 575 |
| Owings | Flo | 14.7 | | Owings | Flo | 10.1 | | Haren | Oak | 558 |
| Schroder | ANA | 17.3 | | Oliver | Cle | 10.7 | | Webb | Bos | 554 |
| Hochevar | Hou | 17.6 | | Hansack | Tex | 10.7 | | DiFelice,Ma | Oak | 532 |
| Morlan | Mil | 18.1 | | Kendrick,K | SD | 11.1 | | Shields,J | Det | 523 |
| Lopez,A | Cle | 18.4 | | Millwood | Tex | 11.3 | | Blackburn | Min | 482 |
| Mujica | Hou | 19.1 | | Guthrie | Bos | 11.4 | | Mussina | Tam | 482 |
| Wainwright | StL | 19.2 | | Hill,S | Col | 11.4 | | Cook,AL | Was | 479 |
| Crain | SF | 19.3 | | Badenhop | | 11.5 | | Vazquez,J | Bal | 478 |
| Kensing | NYN | 19.3 | | Manship | ChN | 11.6 | | Blanton | Ari | 468 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Batting average vs RHB | | On-base percentage vs RHB | | Slugging percentage vs RHB |
| | | | | | | | | | | |
| Cruz,Ju | LAN | .156 | | DiFelice,Ma | Oak | .226 | | Cruz,Ju | LAN | .264 |
| DiFelice,Ma | Oak | .187 | | Cruz,Ju | LAN | .233 | | DiFelice,Ma | Oak | .286 |
| Cain,M | Cin | .205 | | Peavy | SF | .267 | | Webb | Bos | .308 |
| Davis,W | Ari | .212 | | Myers,B | Oak | .268 | | Dempster | Phi | .310 |
| Peavy | SF | .212 | | Kendrick,K | SD | .272 | | Kuroda | Cin | .310 |
| Kendrick,K | SD | .213 | | Vazquez,J | Bal | .280 | | Vazquez,J | Bal | .311 |
| Zambrano,C | NYA | .221 | | Bedard | Phi | .282 | | Oswalt | LAN | .326 |
| Vazquez,J | Bal | .226 | | Oswalt | LAN | .284 | | Cain,M | Cin | .330 |
| Myers,B | Oak | .228 | | Hamels | SD | .285 | | Peavy | SF | .331 |
| Verlander | Flo | .228 | | Santana,J | Tor | .285 | | Kendrick,K | SD | .336 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Hits vs RHB | | Runs batted in vs RHB | | On-base plus slugging vs RHB |
| | | | | | | | | | | |
| Buehrle | Bos | 199 | | Sabathia | SD | 96 | | Cruz,Ju | LAN | .497 |
| Maholm | ChA | 196 | | Maholm | ChA | 93 | | DiFelice,Ma | Oak | .512 |
| Sabathia | SD | 183 | | Liriano | LAN | 86 | | Vazquez,J | Bal | .591 |
| Rogers,K | Atl | 177 | | Lester | ANA | 84 | | Webb | Bos | .597 |
| Parra,M | Ari | 173 | | Stanford | Atl | 83 | | Peavy | SF | .597 |
| Liriano | LAN | 170 | | Rogers,K | Atl | 82 | | Kuroda | Cin | .602 |
| Hamels | SD | 163 | | Buehrle | Bos | 82 | | Kendrick,K | SD | .607 |
| Lilly | LAN | 162 | | Duensing | Bos | 80 | | Dempster | Phi | .609 |
| Wolf,Ra | SF | 158 | | Lilly | LAN | 79 | | Oswalt | LAN | .609 |
| Misch | Cle | 156 | | Laffey | ChN | 78 | | Cain,M | Cin | .618 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Doubles vs RHB | | Triples vs RHB | | Homeruns vs RHB |
| | | | | | | | | | | |
| Buehrle | Bos | 53 | | Parra,M | Ari | 7 | | Liriano | LAN | 26 |
| Wolf,Ra | SF | 41 | | Cook,AL | Was | 6 | | Robertson,N | Flo | 25 |
| Santana,J | Tor | 41 | | Kuo | Cin | 6 | | Gonzalez,Gi | Flo | 25 |
| Sabathia | SD | 41 | | Hamels | SD | 6 | | Sanchez,J | Sea | 24 |
| Saunders | KC | 40 | | Affeldt | Flo | 5 | | James,C | Min | 24 |
| Hendrickson,M | ChA | 39 | | Blevins | NYN | 5 | | Hill,R | Pit | 23 |
| Reyes,JJ | ANA | 39 | | Hudson,T | Col | 5 | | Haren | Oak | 23 |
| Misch | Cle | 39 | | Santana,E | Tex | 5 | | Duensing | Bos | 23 |
| Stanford | Atl | 38 | | Olsen | SF | 5 | | Smith,G | Bal | 23 |
| Gorzelanny | Phi | 38 | | Myers,B | Oak | 5 | | Danks | ChN | 22 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Extra base hits vs RHB | | Total bases vs RHB | | Isolated power vs RHB |
| | | | | | | | | | | |
| Buehrle | Bos | 79 | | Buehrle | Bos | 325 | | Webb | Bos | .061 |
| Santana,J | Tor | 67 | | Maholm | ChA | 295 | | Dempster | Phi | .079 |
| Sabathia | SD | 62 | | Liriano | LAN | 284 | | Looper | Pit | .081 |
| Duensing | Bos | 61 | | Sabathia | SD | 284 | | Kuroda | Cin | .082 |
| Reyes,JJ | ANA | 60 | | Rogers,K | Atl | 280 | | Vazquez,J | Bal | .085 |
| Rogers,K | Atl | 60 | | Duensing | Bos | 265 | | Morales,F | Ari | .089 |
| Liriano | LAN | 60 | | Santana,J | Tor | 263 | | Hernandez,Fe | NYA | .092 |
| Stanford | Atl | 59 | | Zito | SD | 259 | | Oswalt | LAN | .096 |
| Wolf,Ra | SF | 59 | | Lilly | LAN | 257 | | Mulvey | Oak | .098 |
| Lilly | LAN | 57 | | Stanford | Atl | 252 | | Burnett | Sea | .099 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Walks vs RHB | | Strikeouts vs RHB | | Hit by pitch vs RHB |
| | | | | | | | | | | |
| Morales,F | Ari | 86 | | Liriano | LAN | 197 | | Cueto | NYA | 19 |
| Zito | SD | 80 | | Hamels | SD | 177 | | Masterson | Mil | 17 |
| Lester | ANA | 71 | | Santana,J | Tor | 170 | | Germano | Phi | 16 |
| Kuo | Cin | 69 | | Kuo | Cin | 157 | | Verlander | Flo | 15 |
| Maholm | ChA | 68 | | Gonzalez,Gi | Flo | 156 | | Kendrick,K | SD | 11 |
| Wolf,Ra | SF | 65 | | Sabathia | SD | 142 | | Bush,D | Hou | 11 |
| Perez,Ol | KC | 64 | | Peavy | SF | 133 | | Oswalt | LAN | 11 |
| Reyes,JJ | ANA | 63 | | Lincecum | Pit | 133 | | Cook,AL | Was | 11 |
| Jimenez,U | NYN | 61 | | Lilly | LAN | 133 | | Stanford | Atl | 11 |
| Smith,G | Bal | 60 | | Cruz,Ju | LAN | 132 | | Snell | Tor | 10 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| Sacrifice bunts vs RHB | | Sacrifice flies vs RHB | | Atbats vs RHB |
| | | | | | | | | | | |
| Liriano | LAN | 13 | | Billingsley | Hou | 8 | | Hamels | SD | 706 |
| Sheets | Flo | 9 | | Stanford | Atl | 8 | | Sabathia | SD | 704 |
| Egbert | NYN | 8 | | Wainwright | StL | 7 | | Buehrle | Bos | 670 |
| Cook,AL | Was | 8 | | Masterson | Mil | 7 | | Liriano | LAN | 629 |
| Stanford | Atl | 8 | | Rogers,K | Atl | 7 | | Santana,J | Tor | 617 |
| Hudson,T | Col | 7 | | Hamels | SD | 7 | | Zito | SD | 613 |
| Germano | Phi | 7 | | Marshall,S | Ari | 6 | | Wolf,Ra | SF | 591 |
| Petit,Y | StL | 7 | | Litsch | KC | 6 | | Gorzelanny | Phi | 588 |
| Jimenez,U | NYN | 7 | | Hammel | ChN | 6 | | Parra,M | Ari | 582 |
| Arroyo | Was | 7 | | Harrison | NYN | 6 | | Rogers,K | Atl | 582 |
| | | | | | | | | | | |
| | | | | | | | | | | |
| AB per homerun vs RHB | | AB per double vs RHB | | Plate appearances vs RHB |
| | | | | | | | | | | |
| Danks | ChN | 15.7 | | Scherzer | Mil | 10.6 | | Hamels | SD | 773 |
| Hill,R | Pit | 17.0 | | Hendrickson,M | ChA | 10.6 | | Sabathia | SD | 752 |
| Redding | Mil | 17.2 | | Perez,Ol | KC | 11.4 | | Zito | SD | 713 |
| Guerra | ANA | 18.2 | | Mussina | Tam | 11.6 | | Buehrle | Bos | 709 |
| Sanchez,J | Sea | 18.8 | | Santana,E | Tex | 11.6 | | Liriano | LAN | 699 |
| James,C | Min | 18.9 | | Rodriguez,W | Tex | 11.7 | | Wolf,Ra | SF | 671 |
| Thompson,D | Det | 18.9 | | Sowers | ANA | 12.3 | | Santana,J | Tor | 663 |
| Haren | Oak | 19.1 | | Saunders | KC | 12.4 | | Morales,F | Ari | 662 |
| Sonnanstine | Tor | 19.1 | | Batista,M | Cle | 12.5 | | Gorzelanny | Phi | 658 |
| Robertson,N | Flo | 19.5 | | Guerra | ANA | 12.6 | | Parra,M | Ari | 640 |